Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients
Open accessAbstract
Alemtuzumab depletes malignant T cells but spares skin resident effector memory T cells, treating L-CTCL without increased risk of infection.
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Both CD8+ and CD4+ Trm have been identified in human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes.
“Both CD8+ and CD4+ Trm have been identified in the human skin, lung, intestines, salivary glands, bone marrow, brain, spleen, tonsils, and lymph nodes [241, 244, 246, 253-259].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
The Results section ('Alemtuzumab therapy leaves intact a diverse population of skin resident TEM'; page unavailable) identifies both CD4+ and CD8+ memory T cells remaining in human skin. The Discussion says residence in lung and gastrointestinal tissue is only suggested and 'remains to be demonstrated'; it does not establish the claim for the other listed organs. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTrm have been defined as independent populations by tissue retention in parabiosis experiments, by distinguishing transcriptional profiles, by exclusive Ag receptor repertoires and specificities, and by exclusive persistence in transplanted tissues.
“They have been defined as independent populations by tissue retention in parabiosis experiments [239, 240], by distinguishing transcriptional profiles [230, 241-245], by exclusive Ag receptor repertoires and specificities [243, 244, 246], and by exclusive persistence in transplanted tissues [247, 248].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [246]
The Results and Discussion report that skin effector memory T cells remained after alemtuzumab treatment and appeared non-recirculating. The citation is attached to persistence in transplanted tissues, but our copy provides no transplantation evidence; searches for transplanted tissue, grafts, and donor–recipient persistence found none. (LLM, conf=0.75)
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- Authors
- Clark, R. A., Watanabe, R., Teague, J. E., Schlapbach, C., Tawa, M. C., Adams, N., Dorosario, A. A., Chaney, K. S., Cutler, C. S., LeBoeuf, N. R., Carter, J. B., Fisher, D. C., & Kupper, T. S.
- Affiliations
- Brigham and Women's Hospital (US)
- Dana-Farber Brigham Cancer Center (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Clark, Rachael A.
- Watanabe, Rei
- Kupper, Thomas S.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2012-01-18
- Volume
- 4
- Issue
- 117
- Pages
- 117ra7-117ra7
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3373186
- OpenAlex
- W2076870975
- Cited by
- 367
- References
- 53
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 17 · 2023: 18 · 2022: 25 · 2021: 38 · 2020: 27 · 2019: 27 · 2018: 33 · 2017: 26 · 2016: 31 · 2015: 37 · 2014: 25 · 2013: 20 · 2012: 19
- FWCI
- 40.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (R01 A1025082)
- National Cancer Institute (P50 CA9368305, P50CA093683)
- National Institute of Allergy and Infectious Diseases (R37AI025082, R01AI097128)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056720, R01AR065807)
- Topics
- Health Sciences › Medicine › Dermatology › Cutaneous lymphoproliferative disorders research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- cutaneous T-cell lymphoma, alemtuzumab, central memory T cells, effector memory T cells, mycosis fungoides, T cell recirculation, skin-homing T cells, neutrophils, IL-4, interferon-gamma, infection susceptibility, T cell depletion
- MeSH terms
- CD52 Antigen, Alemtuzumab, Aged, Aged, 80 and over, Antigens, Neoplasm, Antineoplastic Agents, Female, Glycoproteins, Humans, Immune System, Immunologic Memory, Male, Middle Aged, Mycosis Fungoides, Neutrophils, Phenotype, Skin, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Antigens, CD, Antibodies, Monoclonal, Humanized
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