ATR disruption leads to chromosomal fragmentation and early embryonic lethality

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

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Tumor spectrum analysis in p53-mutant mice

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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

Untitled work

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Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Nature · doi:10.1038/44188 · Cited by 895

Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression

Goto, H., Natsume, T., Kanemaki, M. T., Kaito, A., Wang, S., Gabazza, E. C., Inagaki, M., & Mizoguchi, A. (2019) · Journal of Cell Science · doi:10.1242/jcs.223123 · Cited by 57

Disruption of the Pelota Gene Causes Early Embryonic Lethality and Defects in Cell Cycle Progression

Adham, I. M., Sallam, M. A., Steding, G., Korabiowska, M., Brinck, U., Hoyer‐Fender, S., Oh, C., & Engel, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1470-1476.2003 · Cited by 56

ATR Enforces the Topoisomerase II-dependent G2 Checkpoint through Inhibition of Plk1 Kinase

Deming, P. B., Flores, K. G., Downes, C. S., Paules, R. S., & Kaufmann, W. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206109200 · Cited by 56

The role of DNA damage and repair in atherosclerosis: A review

Shah, N. R., & Mahmoudi, M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.07.005 · Cited by 56

Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress

Davuluri, G., Gong, W., Yusuff, S., Lorent, K., Muthumani, M., Dolan, A. C., & Pack, M. A. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000240 · Cited by 56

Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

Durocher, F., Labrie, Y., Soucy, P., Sinilnikova, O. M., Labuda, D., Bessette, P., Chiquette, J., Laframboise, R., Lépine, J., Lespérance, B., et al. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-230 · Cited by 56

Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites

Das, K. C., & Ravi, D. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00203.2002 · Cited by 55

Animal Models of Tumor-Suppressor Genes

Hakem, R., & Mak, T. W. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090432 · Cited by 57

Cancer chemoprevention by the antioxidant tempol acts partially via the p53 tumor suppressor

Erker, L. R. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi181 · Cited by 55

ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

Rainey, M. D., Bennett, D., O’Dea, R., Zanchetta, M. E., Voisin, M., Seoighe, C., & Santocanale, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108096 · Cited by 54

G2E3 Is a Dual Function Ubiquitin Ligase Required for Early Embryonic Development

Brooks, W. S., Helton, E. S., Banerjee, S., Venable, M., Johnson, L., Schoeb, T. R., Kesterson, R. A., & Crawford, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803238200 · Cited by 54

The Essential Function of the MRN Complex in the Resolution of Endogenous Replication Intermediates

Bruhn, C., Zhou, Z., Ai, H., & Wang, Z. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.018 · Cited by 57

ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance

Wang, M., Guo, L., Wu, Q., Zeng, T., Lin, Q., Qiao, Y., Wang, Q., Liu, M., Zhang, X., Ren, L., et al. (2014) · Nature Communications · doi:10.1038/ncomms5901 · Cited by 56

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis

Feehan, R. P., & Shantz, L. M. (2016) · Biochemical Journal · doi:10.1042/bcj20160471 · Cited by 54

Activation of DNA damage signaling

Ljungman, M. E. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.02.014 · Cited by 54

Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 5

Friedberg, E. C. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00005-3 · Cited by 54

Harnessing DNA Replication Stress for Novel Cancer Therapy

Zhu, H., Swami, U., Preet, R., & Zhang, J. (2020) · Genes · doi:10.3390/genes11090990 · Cited by 56

DNA mismatch repair and infertility

Mukherjee, S., Ridgeway, A., & Lamb, D. J. (2010) · Current Opinion in Urology · doi:10.1097/mou.0b013e32833f1c21 · Cited by 53

ATR protects the genome against CGG{middle dot}CCG-repeat expansion in Fragile X premutation mice

Entezam, A., & Usdin, K. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1136 · Cited by 53

The Drosophila chk2 Gene loki Is Essential for Embryonic DNA Double-Strand-Break Checkpoints Induced in S Phase or G2

Masrouha, N., Yang, L., Hijal, S., Larochelle, S., & Suter, B. (2003) · Genetics · doi:10.1093/genetics/163.3.973 · Cited by 54

DNA double-strand break repair and development

Phillips, E. R., & McKinnon, P. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210877 · Cited by 56

The human intra-S checkpoint response to UVC-induced DNA damage

Kaufmann, W. K. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp230 · Cited by 56

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

Kim, D.-S., Liu, Y., Oberly, S., Freire, R., & Smolka, M. B. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky625 · Cited by 53

Relationships between stem cell exhaustion, tumour suppression and ageing

Ruzankina, Y., & Brown, E. J. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604029 · Cited by 53

Mouse models of DNA double-strand break repair and neurological disease

Frappart, P., & McKinnon, P. J. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.007 · Cited by 53

Threonine-11, Phosphorylated by Rad3 and ATM In Vitro, Is Required for Activation of Fission Yeast Checkpoint Kinase Cds1

Tanaka, K., Boddy, M. N., Chen, X., McGowan, C. H., & Russell, P. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3398-3404.2001 · Cited by 52

Loss of Cell Cycle Checkpoint Control in Drosophila Rfc4 Mutants

Krause, S. A., Loupart, M., Vass, S., Schoenfelder, S., Harrison, S., & Heck, M. M. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5156-5168.2001 · Cited by 52

Molecular Anatomy of the DNA Damage and Replication Checkpoints

Qin, J., & Li, L. (2003) · Radiation Research · doi:10.1667/0033-7587(2003)159[0139:maotdd]2.0.co;2 · Cited by 52

Cellular Responses to DNA Damage

Wang, J. Y. J., & Ki, S. W. (2002) · Elsevier eBooks · doi:10.1016/b0-12-227555-1/00047-2 · Cited by 52

Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA

Speroni, J., Federico, M. B., Mansilla, S. F., Soria, G., & Gottifredi, V. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116345109 · Cited by 51

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response

Chen, E., Ahn, J. S., Massie, C. E., Clynes, D., Godfrey, A. L., Li, J., Park, H. J., Nangalia, J., Silber, Y., Mullally, A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401873111 · Cited by 53

p53 Protects renal inner medullary cells from hypertonic stress by restricting DNA replication

Dmitrieva, N. I., Michea, L., & Burg, M. B. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.3.f522 · Cited by 51

ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Szydzik, J., Lind, D. E., Arefin, B., Kurhe, Y., Umapathy, G., Siaw, J. T., Claeys, A., Gabre, J. L., den Eynden, J. V., Hallberg, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27057-2 · Cited by 51

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

Menolfi, D., Jiang, W., Lee, B. J., Moiseeva, T. N., Shao, Z., Estes, V. M., Frattini, M. G., Bakkenist, C. J., & Zha, S. (2018) · Nature Communications · doi:10.1038/s41467-018-07798-3 · Cited by 50

The ATR-p53 pathway is suppressed in noncycling normal and malignant lymphocytes

Jones, G. G., Reaper, P. M., Pettitt, A. R., & Sherrington, P. D. (2004) · Oncogene · doi:10.1038/sj.onc.1207318 · Cited by 52

ATR contributes to telomere maintenance in human cells

Pennarun, G., Hoffschir, F., Revaud, D., Granotier-Beckers, C., Gauthier, L., Mailliet, P., Biard, D. S. F., & Boussin, F. D. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1248 · Cited by 56

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation

Pan‐Hammarström, Q., Lähdesmäki, A., Zhao, Y., Du, L., Zhao, Z., Wen, S., Ruiz‐Pérez, V. L., Dunn‐Walters, D. K., Goodship, J. A., & Hammarström, L. L. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050595 · Cited by 58

Psoralen-Induced DNA Interstrand Cross-Links Block Transcription and Induce p53 in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner

Derheimer, F. A., Hicks, J. K., Paulsen, M. T., Canman, C. E., & Ljungman, M. E. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051698 · Cited by 52

Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy

Ahmed, S., Alam, W., Aschner, M., Alsharif, K. F., Albrakati, A., Saso, L., & Khan, H. Z. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113797 · Cited by 51

Intrauterine programming of ageing

Fernández-Capetillo, Ó. (2009) · EMBO Reports · doi:10.1038/embor.2009.262 · Cited by 51

p300/CREB-binding Protein Interacts with ATR and Is Required for the DNA Replication Checkpoint

Stauffer, D. R., Chang, B. H., Huang, J., Dunn, A., & Thayer, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609261200 · Cited by 50

Cryo-EM Structure of human ATR-ATRIP complex

Rao, Q., Liu, M., Tian, Y., Wu, Z., Wang, H., Wang, J., & Xu, Y. (2017) · Worldwide Protein Data Bank · doi:10.2210/pdb5yz0/pdb · Cited by 49

Maternal BCAS2 protects genomic integrity in mouse early embryonic development

Xu, Q., Wang, F., Xiang, Y., Zhang, X., Zhao, Z., Gao, Z., Liu, W., Lu, X., Liu, Y., Yu, X., et al. (2015) · Development · doi:10.1242/dev.129841 · Cited by 48

Bovine Embryo-Secreted microRNA-30c Is a Potential Non-invasive Biomarker for Hampered Preimplantation Developmental Competence

Lin, X., Beckers, E., Cafferty, S. M., Gansemans, Y., Szymańska, K. J., Pavani, K. C., Catani, J. P., Nieuwerburgh, F. V., Deforce, D. L. D., Sutter, P. D., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00315 · Cited by 48

Early Events in the DNA Damage Response

Ward, I. M., & Chen, J. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)63001-8 · Cited by 50

The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR

Zhang, X. H., Zhao, C., & Ma, Z. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.015834 · Cited by 48

Lessons from knockout and transgenic mice for infertility in men

Venables, J. P., & Cooke, H. J. (2000) · Journal of Endocrinological Investigation · doi:10.1007/bf03343780 · Cited by 48

Studying the DNA damage response using in vitro model systems

Garner, E., & Costanzo, V. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.015 · Cited by 47

The effect of caffeine on cisplatin-induced apoptosis of lung cancer cells

Wang, G., Bhoopalan, V., Wang, D., Wang, L., & Xu, X. (2015) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-4-5 · Cited by 47

Cell cycle regulation during early mouse embryogenesis

Artus, J., & Cohen‐Tannoudji, M. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.11.008 · Cited by 47

Comparison of checkpoint responses triggered by DNA polymerase inhibition versus DNA damaging agents

Liu, J.-S., Kuo, S.-R., & Melendy, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.018 · Cited by 47

ATM protein is deficient in over 40% of lung adenocarcinomas

Villaruz, L. C., Jones, H., Đačić, S., Abberbock, S. R., Kurland, B. F., Stabile, L. P., Siegfried, J. M., Conrads, T. P., Smith, N. R., O’Connor, M. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9757 · Cited by 46

ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation

Lang, P. Y., Nanjangud, G. J., Sokolsky‐Papkov, M., Shaw, C., Hwang, D., Parker, J. S., Kabanov, A. V., & Gershon, T. R. (2016) · Development · doi:10.1242/dev.139022 · Cited by 46

A novel WEE1 pathway for replication stress responses

Pan, T., Qin, Q., Nong, C., Gao, S., Wang, L., Cai, B., Zhang, M., Wu, C., Chen, H., Li, T., et al. (2021) · Nature Plants · doi:10.1038/s41477-021-00855-8 · Cited by 46

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response

Pavan, I. C. B., de Oliveira, A. P., Dias, P. R. F., Basei, F. L., Issayama, L. K., Ferezin, C. D. C., Silva, F. R., de Oliveira, A. L., Moura, L. A. R., Martins, M. B., et al. (2021) · Cells · doi:10.3390/cells10030507 · Cited by 46

Cleavage of Claspin by Caspase-7 during Apoptosis Inhibits the Chk1 Pathway

Clarke, C., Bennett, L. N., & Clarke, P. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506460200 · Cited by 46

Stem cell ageing and non-random chromosome segregation

Charville, G. W., & Rando, T. A. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0279 · Cited by 45

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

DNA Damage Checkpoints and Cancer

Shimada, M., & Nakanishi, M. (2006) · Journal of Molecular Histology · doi:10.1007/s10735-006-9039-4 · Cited by 45

Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci

Gibaud, A., Vogt, N., Hadj-Hamou, N.-S., Meyniel, J.-P., Hupé, P., Debatisse, M., & Malfoy, B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq004 · Cited by 45

Fragile Sites: Breaking up over a Slowdown

Cimprich, K. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00158-1 · Cited by 45

RBMX is required for activation of ATR on repetitive DNAs to maintain genome stability

Zheng, T., Zhou, H., Li, X., Peng, D., Yang, Y., Zeng, Y., Liu, H., Ren, J. M., & Zhao, Y. B. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0570-8 · Cited by 47

Exploiting Synthetic Lethal Interactions Between DNA Damage Signaling, Checkpoint Control, and p53 for Targeted Cancer Therapy

Morandell, S., & Yaffe, M. B. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-387665-2.00011-0 · Cited by 45

Control of histone methylation and genome stability by PTIP

Munoz, I. M., & Rouse, J. W. (2009) · EMBO Reports · doi:10.1038/embor.2009.21 · Cited by 44

Reduced ATR or Chk1 Expression Leads to Chromosome Instability and Chemosensitization of Mismatch Repair–deficient Colorectal Cancer Cells

Jardim, M. J., Wang, Q., Furumai, R., Wakeman, T. P., Goodman, B. K., & Wang, X. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0303 · Cited by 44

Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition

Ekpenyong‐Akiba, A. E., Poblocka, M., Althubiti, M., Rada, M., Jurk, D., Germano, S., Kocsis‐Fodor, G., Shi, Y., Canales, J. J., & Macip, S. (2019) · Aging Cell · doi:10.1111/acel.13079 · Cited by 45

The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response

Wang, L., Li, Z., Zhao, Y., Huang, Y., Wu, C., Pan, T., Qin, Q., Xu, Y., Deng, Z., Li, J., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa1082 · Cited by 44

Critical role for chicken Rad17 and Rad9 in the cellular response to DNA damage and stalled DNA replication

Kobayashi, M., Hirano, A., Kumano, T., Xiang, S., Mihara, K. L., Haseda, Y., Matsui, O., Shimizu, H., & Yamamoto, K. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00728.x · Cited by 45

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase

Post, S. M. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg765 · Cited by 46

G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization

Brooks, W. S., Banerjee, S., & Crawford, D. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.11.020 · Cited by 43

Deregulation of XPC and CypA by Cyclosporin A: An Immunosuppression-Independent Mechanism of Skin Carcinogenesis

Han, W., Soltani, K., Ming, M., & He, Y. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0185-t · Cited by 44

ATR, PML, and CHK2 Play a Role in Arsenic Trioxide-induced Apoptosis

Joe, Y., Jeong, J., Yang, S., Kang, H., Motoyama, N., Pandolfi, P. P., Chung, J. H., & Kim, M. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604392200 · Cited by 43

ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven

Wang, J., Wiltshire, T. D., Wang, Y., Mikell, C., Burks, J., Cunningham, C., Laar, E. S. V., Waters, S. J., Reed, E., & Wang, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400015200 · Cited by 44

Antitumor mechanisms and future clinical applications of the natural product triptolide

Bao, S., Yi, M., Xiang, B., & Chen, P. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03336-y · Cited by 42

Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death

Chen, L.-H., Chu, P., Lee, Y., Tu, P., Chi, C., Lee, H., & Chiou, S. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13011209 · Cited by 43

ATR-mediated regulation of nuclear and cellular plasticity

Kidiyoor, G. R., Kumar, A., & Foiani, M. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.020 · Cited by 45

ATR and MKP 1 play distinct roles in response to UV ‐B stress in Arabidopsis

Besteiro, M. A. G., & Ulm, R. (2012) · The Plant Journal · doi:10.1111/tpj.12095 · Cited by 44

Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM

Carballo, J. A., & Rita, S. (2007) · Chromosome Research · doi:10.1007/s10577-007-1145-y · Cited by 42

DNA Replication Stress and Cancer: Cause or Cure?

Taylor, E. M., & Lindsay, H. D. (2015) · Future Oncology · doi:10.2217/fon.15.292 · Cited by 44

Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1

Wang, J., Han, X., & Zhang, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0523 · Cited by 43

Mouse models for ATR deficiency

O’Driscoll, M. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.09.001 · Cited by 40

ATR-CHK1 pathway as a therapeutic target for acute and chronic leukemias

Boudný, M., & Trbušek, M. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102026 · Cited by 41

Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks

Henson, S. E., Tsai, S.-C., Malone, C. S., Soghomonian, S. V., Ouyang, Y., Wall, R., Marahrens, Y., & Teitell, M. A. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.06.016 · Cited by 40

Developmentally Regulated Elimination of Damaged Nuclei Involves a Chk2-Dependent Mechanism of mRNA Nuclear Retention

Iampietro, C., Bergalet, J., Wang, X., Cody, N. A. L., Chin, A., Lefebvre, F. A., Douziech, M., Krause, H. M., & Lécuyer, É. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.025 · Cited by 39

Disruption of Serine/Threonine Protein Phosphatase 5 (PP5:PPP5c) in Mice Reveals a Novel Role for PP5 in the Regulation of Ultraviolet Light-induced Phosphorylation of Serine/Threonine Protein Kinase Chk1 (CHEK1)

Amable, L., Grankvist, N., Largen, J. W., Ortsäter, H., Sjöholm, Å., & Honkanen, R. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.244053 · Cited by 41

Caffeine Inhibits Human Immunodeficiency Virus Type 1 Transduction of Nondividing Cells

Daniel, R., Marusich, E., Argyris, E. G., Zhao, Y., Skalka, A. M., & Pomerantz, R. J. (2005) · Journal of Virology · doi:10.1128/jvi.79.4.2058-2065.2005 · Cited by 39

Inhibition of ATR-Dependent Signaling by Protoapigenone and Its Derivative Sensitizes Cancer Cells to Interstrand Cross-link–Generating Agents In Vitro and In Vivo

Wang, H., Lee, A. Y., Chou, W., Wu, C., Tseng, C., Liu, K. Y.-T., Lin, W.-L., Chang, F., Chuang, D., Hunyadi, A., et al. (2012) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0921 · Cited by 39

Cycling through development in Drosophila and other metazoa

Vidwans, S. J., & Su, T. T. (2001) · Nature Cell Biology · doi:10.1038/35050681 · Cited by 39

Cyclers’ kinases in cell division: from molecules to cancer therapy

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ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion

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H2AX a Promising Biomarker for Lung Cancer: A Review

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Human Embryonic Stem Cells as a Model for Embryotoxicity Screening

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Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development

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Hormone-induced DNA damage response and repair mediated by cyclin D1 in breast and prostate cancer

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Telomere length regulation during cloning, embryogenesis and ageing

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Mutation analysis of the ATRgene in breast and ovarian cancer families

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Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability

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The relationship between DNA single-stranded damage response and double-stranded damage response

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DNA Damage and Replication Stress Checkpoints

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ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

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Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts

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p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc

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Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke

Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)