ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

Untitled work

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Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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14-3-3σ is required to prevent mitotic catastrophe after DNA damage

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Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation

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Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR’s Anti-apoptotic Function at Mitochondria, and the Implications in Cancer

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CHK1‐CDC25A‐CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos

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Haploinsufficiency in mouse models of DNA repair deficiency: modifiers of penetrance

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The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation

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Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides

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Genetic analysis of CHK1 and CHK2 homologues revealed a unique cross talk between ATM and ATR pathways in Neurospora crassa

Wakabayashi, M., Ishii, C., Inoue, H., & Tanaka, S. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.004 · Cited by 21

Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ

Koike, M., Mashino, M., Sugasawa, J., & Koike, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.080 · Cited by 21

Caffeine mimics adenine and 2′‐deoxyadenosine, both of which inhibit the guanine‐nucleotide exchange activity of RCC1 and the kinase activity of ATR

Nishijima, H., Nishitani, H., Saito, N., & Nishimoto, T. (2003) · Genes to Cells · doi:10.1046/j.1365-2443.2003.00644.x · Cited by 21

ATM, DNA-PKcs and ATR: shaping development through the regulation of the DNA damage responses

Menolfi, D., & Zha, S. (2019) · Genome Instability & Disease · doi:10.1007/s42764-019-00003-9 · Cited by 21

Replication stress in mammalian embryo development, differentiation, and reprogramming

Wang, N., Xu, S., & Egli, D. M. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.03.015 · Cited by 21

The ATR Signaling Pathway Is Disabled during Infection with the Parvovirus Minute Virus of Mice

Adeyemi, R. O., & Pintel, D. J. (2014) · Journal of Virology · doi:10.1128/jvi.01412-14 · Cited by 20

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

Vendetti, F. P., Leibowitz, B. J., Barnes, J., Schamus, S., Kiesel, B. F., Abberbock, S. R., Conrads, T. P., Clump, D. A., Cadogan, E. B., O’Connor, M. J., et al. (2017) · Scientific Reports · doi:10.1038/srep41892 · Cited by 21

A New Way to Treat Brain Tumors: Targeting Proteins Coded by Microcephaly Genes?

Lang, P. Y., & Gershon, T. R. (2018) · BioEssays · doi:10.1002/bies.201700243 · Cited by 20

The ATR–WEE1 kinase module promotes SUPPRESSOR OF GAMMA RESPONSE 1 translation to activate replication stress responses

Chen, H., Pan, T., Zheng, X., Huang, Y., Wu, C., Yang, T., Gao, S., Wang, L., & Yan, S. (2023) · The Plant Cell · doi:10.1093/plcell/koad126 · Cited by 20

Genome-wide profiling of forum domains in Drosophila melanogaster

Tchurikov, N. A., Kretova, O. V., Сосин, Д. В., Zykov, I. A., Zhimulev, I. F., & Kravatsky, Y. V. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1353 · Cited by 20

The ‘Pushmi-Pullyu’ of DNA REPAIR: Clinical Synthetic Lethality

Ivy, S. P., Bono, J. S. D., & Kohn, E. C. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.10.014 · Cited by 20

Checkpoint and Coordinated Cellular Responses to DNA Damage

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In vivo DNA replication dynamics unveil aging-dependent replication stress

Rossetti, G. G., Dommann, N., Karamichali, A., Dionellis, V. S., Aldave, A. A., Yarahmadov, T., Rodríguez-Carballo, E., Keogh, A., Candinas, D., Stroka, D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.034 · Cited by 22

Artemis‐dependent DNA double‐strand break formation at stalled replication forks

Unno, J., Takagi, M., Piao, J., Sugimoto, M., Honda, F., Maeda, D., Masutani, M., Kiyono, T., Watanabe, F., Morio, T., et al. (2013) · Cancer Science · doi:10.1111/cas.12144 · Cited by 19

Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila

Park, J., Na, H., Pyo, J.-H., Jeon, H.-J., Kim, Y.-S., & Yoo, M. (2015) · Aging · doi:10.18632/aging.100743 · Cited by 21

Stage-Specific Effects of Ionizing Radiation during Early Development

Honjo, Y., & Ichinohe, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113975 · Cited by 20

Phosphoproteomics of ATR signaling in mouse testes

Sims, J. R., Faça, V. M., Pereira, C., Ascenção, C., Comstock, W., Badar, J., Arroyo-Martinez, G. A., Freire, R., Cohen, P. E., Weiss, R. S., et al. (2021) · eLife · doi:10.7554/elife.68648 · Cited by 18

Inhibition of Arid1a increases stem/progenitor cell-like properties of liver cancer

Wang, L., Deng, C.-H., Luo, Q., Su, X., Shang, X., Song, S., Cheng, S., Qu, Y.-L., Zou, X., Shi, Y. Y., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215869 · Cited by 19

Mammalian DNA Damage Response Pathway

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Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure

Hübner, B., Strickfaden, H., Müller, S., Cremer, M., & Cremer, T. J. (2009) · European Biophysics Journal · doi:10.1007/s00249-009-0496-z · Cited by 19

Checkpoint Kinase 1 Is Cleaved in a Caspase-Dependent Pathway during Genotoxic Stress-Induced Apoptosis

Okita, N., Kudo, Y., & Tanuma, S. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.359 · Cited by 19

Function of the ATR N-terminal domain revealed by an ATM/ATR chimera

Chen, X., Zhao, R., Glick, G. G., & Cortez, D. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.02.015 · Cited by 19

Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival

Huang, S. H., Qu, L., Cuddihy, A. R., Ragheb, R., Taya, Y., & Koromilas, A. E. (2003) · Oncogene · doi:10.1038/sj.onc.1206490 · Cited by 19

Conditional inactivation of the mouse cell cycle checkpoint gene

Levitt, P. S., Liu, H., Manning, C., & WEISS, R. (2005) · Genomics · doi:10.1016/j.ygeno.2005.04.007 · Cited by 20

Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M-phase transition inXenopusoocytes

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Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

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The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase

Sokka, M., Koalick, D., Hemmerich, P. H., Syväoja, J. E., & Pospiech, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082376 · Cited by 18

Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress

Ackerson, S. M., Gable, C. I., & Stewart, J. A. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1849979 · Cited by 18

DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer

Bender, R. P., & Osheroff, N. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-274-8_3 · Cited by 18

Genome Maintenance Defects in Cultured Cells and Mice following Partial Inactivation of the Essential Cell Cycle Checkpoint Gene Hus1

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Alterations in ATR in nasal NK/T‐cell lymphoma and chronic active Epstein–Barr virus infection

Liu, A., Takakuwa, T., Luo, W., Fujita, S., & Aozasa, K. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00226.x · Cited by 18

Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome

Ouyang, Y., Salstrom, J. L., Diaz-Perez, S. V., Nahas, S., Matsuno, Y., Dawson, D. W., Teitell, M. A., Horvath, S., Riggs, A. D., Gatti, R. A., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.122 · Cited by 19

p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis

Elfar, G. A., Aning, O. A., Ngai, T. W., Yeo, P., Chan, J. W. K., Sim, S. H., Goh, L., Ju, Y., Phua, C. Z. J., Yeo, J. Z. Z., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae811 · Cited by 17

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

Waskiewicz, E., Vasiliou, M., Córcoles-Sáez, I., & Rita, S. (2021) · Communications Biology · doi:10.1038/s42003-021-01884-x · Cited by 17

Inhibition of poly(ADP‐ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks

Golla, R. M., Li, M., Shen, Y., Ji, M. H., Yan, Y., Fu, K., Greiner, T. C., McKeithan, T. W., & Chan, W. C. (2011) · Hematological Oncology · doi:10.1002/hon.1020 · Cited by 17

ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

Brown, A., Sager, B. W., Gorthi, A., Tonapi, S. S., Brown, E. J., & Bishop, A. J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091222 · Cited by 17

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

Ragland, R. L., Arlt, M. F., Hughes, E. D., Saunders, T. L., & Glover, T. W. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9195-4 · Cited by 17

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

Beumer, J. H., Fu, K. Y., Anyang, B. N., Siegfried, J. M., & Bakkenist, C. J. (2015) · BMC Cancer · doi:10.1186/s12885-015-1649-3 · Cited by 17

S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability

Crawley, C. D., Kang, S., Bernal, G. M., Wahlstrom, J. S., Voce, D. J., Cahill, K. E., Garofalo, A., Raleigh, D. R., Weichselbaum, R. R., & Yamini, B. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991166 · Cited by 16

Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms

Choi, J. E., & Chung, W. (2019) · The Journal of Microbiology · doi:10.1007/s12275-020-9520-x · Cited by 17

Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration

Yazinski, S. A., Westcott, P. M. K., Ong, K., Pinkas, J., Peters, R. M., & Weiss, R. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904965106 · Cited by 16

Stem Cells and the Rate of Living

Krishnamurthy, J., & Sharpless, N. E. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.004 · Cited by 16

The epigenetic modifier Fam208a is required to maintain epiblast cell fitness

Bhargava, S., Cox, B., Polydorou, C., Gresakova, V., Kořínek, V., Strnad, H., Sedláček, R., Epp, T. A., & Chawengsaksophak, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-09490-w · Cited by 17

Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage

da Silva, R. B., Machado, C. R., Rodrigues, A. R. A., & Pedrosa, A. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205033 · Cited by 16

The Ataxia telangiectasia-mutated and Rad3-related protein kinase regulates cellular hydrogen sulfide concentrations

Chen, J., Shen, X., Pardue, S., Meram, A. T., Rajendran, S., Ghali, G. E., Kevil, C. G., & Shackelford, R. E. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.11.002 · Cited by 16

Linking PCNA-dependent replication and ATR by human Claspin

Brondello, J., Ducommun, B., Fernandez, A., & Lamb, N. J. C. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.091 · Cited by 16

Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation

Martin, L., Rainey, M. D., Santocanale, C., & Gardner, L. B. (2011) · Oncogene · doi:10.1038/onc.2011.585 · Cited by 16

CBP-93872 Inhibits NBS1-Mediated ATR Activation, Abrogating Maintenance of the DNA Double-Strand Break–Specific G2 Checkpoint

Hirokawa, T., Shiotani, B., Shimada, M., Murata, K., Johmura, Y., Haruta, M., Tahara, H., Takeyama, H., & Nakanishi, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3604 · Cited by 15

Clamping down on mammalian meiosis

Lyndaker, A. M., Vasileva, A., Wolgemuth, D. J., Weiss, R. S., & Lieberman, H. B. (2013) · Cell Cycle · doi:10.4161/cc.26061 · Cited by 15

More than blood, a Novel Gene Required for Mammalian Postimplantation Development

Smith, E. D., Xu, Y., Tomson, B. N., Leung, C. G., Fujiwara, Y., Orkin, S. H., & Crispino, J. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1168-1173.2004 · Cited by 15

ATR protects centromere identity by promoting DAXX association with PML nuclear bodies

Trier, I., Black, E. M., Joo, Y. K., & Kabeche, L. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112495 · Cited by 14

DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors

Folly-Kossi, H., Graves, J. D., Garan, L. A. W., Lin, F., & Lin, W.-C. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0166 · Cited by 14

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei

Marín, P. M., Obonaga, R., Pavani, R., da Silva, M. S., de Araujo, C. B., Lima, A. A., Avila, C. C., Cestari, I. D. S., Machado, C. R., & Elias, M. C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602956 · Cited by 15

CPNE1 is a potential prognostic biomarker, associated with immune infiltrates and promotes progression of hepatocellular carcinoma

Su, J., Huang, Y., Wang, Y., Li, R., Deng, W., Zhang, H., & Xiong, H. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02485-2 · Cited by 14

Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase

Luzwick, J. W., Nam, E. A., Zhao, R., & Cortez, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099397 · Cited by 14

Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

Tatewaki, N., Nishida, H., Yoshida, M., Ando, H., Kondo, S., Sakamaki, T., & Konishi, T. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13048fp · Cited by 14

G1/S and G2/M Cyclin-Dependent Kinase Activities Commit Cells to Death in the Absence of the S-Phase Checkpoint

Manfrini, N., Gobbini, E., Baldo, V., Trovesi, C., Lucchini, G., & Longhese, M. P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00956-12 · Cited by 15

Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders

O’Driscoll, M. (2008) · Current Genomics · doi:10.2174/138920208784340795 · Cited by 15

Evidence for alternate splicing within the mRNA transcript encoding the DNA damage response kinase ATR

Mannino, J. L., Kim, W.-J., Wernick, M., Nguyen, S. V., Braquet, R., Adamson, A. W., Den, Z., Batzer, M. A., Collins, C. C., & Brown, K. D. (2001) · Gene · doi:10.1016/s0378-1119(01)00543-1 · Cited by 14

A DNA damage–induced phosphorylation circuit enhances Mec1 ATR Ddc2 ATRIP recruitment to Replication Protein A

Yates, L. A., Tannous, E., Morgan, R. M. L., Burgers, P., & Zhang, X. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300150120 · Cited by 13

Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to Tumorigenesis

Biswas, H., Makinwa, Y., & Zou, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411684 · Cited by 13

Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors

Smith, J. A., Nunnari, G., Bertoune, M., Pomerantz, R. J., & Daniel, R. (2007) · Intervirology · doi:10.1159/000109752 · Cited by 13

ATM and ATR homologes of Neurospora crassa are essential for normal cell growth and maintenance of chromosome integrity

Wakabayashi, M., Ishii, C., Hatakeyama, S., Inoue, H., & Tanaka, S. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.05.010 · Cited by 13

ATR function is indispensable to allow proper mammalian follicle development

Pacheco, S., Maldonado-Linares, A., Garcia-Caldés, M., & Roig, I. (2019) · Chromosoma · doi:10.1007/s00412-019-00723-7 · Cited by 12

Protective Mechanisms Against DNA Replication Stress in the Nervous System

Charlier, C. F., & Martins, R. A. P. (2020) · Genes · doi:10.3390/genes11070730 · Cited by 16

LAP2α preserves genome integrity through assisting RPA deposition on damaged chromatin

Bao, K., Zhang, Q., Liu, S., Song, N., Guo, Q., Liu, L., Tian, S., Hao, J., Zhu, Y., Zhang, K., et al. (2022) · Genome biology · doi:10.1186/s13059-022-02638-6 · Cited by 13

Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage

Ye, W., & Blain, S. W. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0579-z · Cited by 13

Naked Replication Forks Break apRPArt

Fernández-Capetillo, Ó., & Nussenzweig, A. (2013) · Cell · doi:10.1016/j.cell.2013.10.049 · Cited by 13

Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase

Nam, E. A., Zhao, R., & Cortez, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276113 · Cited by 13

Modeling the Study of DNA Damage Responses in Mice

Specks, J., Nieto-Soler, M., Lopez-Contreras, A. J., & Fernández-Capetillo, Ó. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2297-0_21 · Cited by 13

Mice lacking DCAF2 in placenta die at the gastrulation stage

Yang, M. G., Liu, M., Wang, Z., & Zhang, C. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03655-4 · Cited by 12

Epigallocatechin‐3‐gallate improves the quality of maternally aged oocytes

Zhang, H. W., Su, W. C., Zhao, R., Li, M., Zhao, S., Chen, Z., & Zhao, H. (2023) · Cell Proliferation · doi:10.1111/cpr.13575 · Cited by 12

What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses

Brosey, C. A., Ahmed, Z., Lees‐Miller, S. P., & Tainer, J. A. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.04.005 · Cited by 12

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Kafer, G. R., & Cesare, A. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00416 · Cited by 12

Hypoxia‐Responsive Prodrug of ATR Inhibitor, AZD6738, Selectively Eradicates Treatment‐Resistant Cancer Cells

Barnieh, F. M., Morais, G. R., Loadman, P. M., Falconer, R. A., & El‐Khamisy, S. F. (2024) · Advanced Science · doi:10.1002/advs.202403831 · Cited by 11

Superaugmented Eccentric Distance Sum Connectivity Indices: Novel Highly Discriminating Topological Descriptors for QSAR/QSPR

Gupta, M., Gupta, S. V., Dureja, H., & Madan, A. K. (2011) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2011.01264.x · Cited by 11

Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)

Tannous, E., & Burgers, P. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1925218 · Cited by 11

Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage–induced cytokine production

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ATR activity controls stem cell quiescence via the cyclin F–SCF complex

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HUS1 regulates in vivo responses to genotoxic chemotherapies

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ATRIP protects progenitor cells against DNA damage in vivo

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CHK1 affects cell sensitivity to microtubule‐targeted drugs

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Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

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ATM and ATR checkpoint kinase pathways: A concise review

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

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Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts

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p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc

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Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke

Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)