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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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Multiple Guardians of the Epithelial Stage IV Meiotic Checkpoint

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Stopping DNA Damage: A Newly Discovered Protein-Enhancing DNA Repair Mechanisms

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Structural mechanism of TOPBP1 activating the ATR–ATRIP replication checkpoint kinase

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A multiparametric screen uncovers FDA-approved small molecules that potentiate the nuclear mechano-dysfunctions in ATR-defective cells

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REV7 associates with ATRIP and inhibits ATR kinase activity

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An updated view on lagging strand DNA replication: implications for the replication stress response

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PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse

Mihuț, A., Ghosh, D., Kószó, A., Szüts, D., Salajkova, S. A., Andrš, M., Dobrovolná, J., Fajka‐Boja, R., & Timinszky, G. (2026) · EMBO Reports · doi:10.1038/s44319-026-00848-8 · Cited by 1

Regulatory Mechanisms of Homologous Recombination in Higher Plants

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Combining Chk1/2 inhibition with radiation in head and neck cancer

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Ataxia telangiectasia and Rad3-related protein inhibitors

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Lung cancer drug resistance and DNA damage signaling

Zhang, P. (2005) · Therapy · doi:10.1586/14750708.2.3.381 · Cited by 1

Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light

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Chromosome Break ☆

Cannan, W. J., & Pederson, D. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.06208-7 · Cited by 2

DNA Damage: Sensing

Yang, X. H., & Zou, L. (2008) · Wiley eBooks · doi:10.1002/9780470048672.wecb132 · Cited by 1

DNA damage signalling in eukaryotes: learning from budding yeast

Menacho-Márquez, M., & Ibañez, J. R. M. (2003) · Revista de Oncología · doi:10.1007/bf02712848 · Cited by 1

Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice

Kurimasa, A., Burma, S., Wren, M. S., Ouyang, H., Osaki, M., Ito, H., Nagasawa, H., Little, J. B., Oshimura, M., Li, G. C., et al. (2002) · doi:10.2172/943450 · Cited by 1

Analysis of Rad9 Functions; Roles in the Checkpoint Response, DNA Damage Processing, and Prevention of Genomic Instability

Nyberg, K. A., & Weinert, T. A. (2003) · Defense Technical Information Center (DTIC) · doi:10.21236/ada418042 · Cited by 1

DNA damage checkpoint pathways and the maintenance of genome stability in C. elegans

Alpi, A. F. (2004) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2448 · Cited by 1

The Function of BRCA1 in DNA Damage ResponsePreprint

LEE, J.-S., COLLINS, K., Brown, A. L., LEE, C.-H., & Chung, J. H. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.547 · Cited by 1

Relationship between abnormalities of genes involved in DNA damage responses and malignant tumors/autoimmune diseases

Yoo, S. K., Onishi, N., Kato, N., Yoda, A., & Minami, Y. (2006) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.29.136 · Cited by 1

HUMAN DNA POLYMERASE ε

Tuusa, J. T., & Oulu, B. (2001) · Cited by 1

Editorial: Grappling with the Multifaceted World of the DNA Damage Response

Porro, A. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00091 · Cited by 1

Telomerase Regulation in Arabidopsis thaliana

Nelson, A. D. L. (2012) · OakTrust (Texas A&M University Libraries) · Cited by 1

Effects of chronic radiation exposure on Daphnia: from individuals to populations

Goodman, J. (2019) · Stirling Online Research Repository (University of Stirling) · Cited by 1

ATR Kinase Inhibition Induces Thymineless Death in Proliferating CD8 + T CellsPreprint

Sugitani, N., Vendetti, F. P., Cipriano, A. J., Deppas, J. J., Moiseeva, T. N., Schamus-Haynes, S., Wang, Y., Palmer, D., Osmanbeyoglu, H. U., Bostwick, A., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4093292 · Cited by 1

A phosphorylation code coordinating transcription condensate dynamics with DNA replicationPreprint

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Yeast as a Model System for Studying Cell Cycle Checkpoints

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Chromatin Modifications and Orchestration of Checkpoint Response in Cancer

Nakanishi, M. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_6 · Cited by 1

ATR as a Therapeutic Target

Middleton, F. K., & Curtin, N. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4741-2_10

Targeting cell cycle checkpoints to specifically kill cancer

Burgess, A. (2004) · The University of Queensland · doi:10.14264/107006

Estudo da integridade genômica durante o processo de diferenciação de células-tronco adultas em células com características neurais

Lambert, A. P. F., & Bonatto, D. (2009) · Americanae (AECID Library) · doi:10.13140/rg.2.2.10637.15841

The Role of the ATR-CHEK1 Pathway in Therapeutic Resistance Resulting from Distal 11q Loss in Carcinoma Cells

Sankunny, M. (2013) · D-Scholarship@Pitt (University of Pittsburgh)

Cyclin A/CDK2 regulates multiple G2 phase pathways

Oakes, V. (2012)

Interaction of Cell-Cycle Checkpoints with Muscle Differentiation

Fiddler, T. A., Huang, J., Ostermeyer, E. A., Johnson‐Pais, T. L., & Thayer, M. J. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-095-7_12

Analysis of cell cycle surveillance mechanisms in meiosis

Hochwagen, A. (2006) · DSpace@MIT (Massachusetts Institute of Technology)

Cell Cycle Control

Matthews, D. J., & Gerritsen, M. E. (2010) · Wiley eBooks · doi:10.1002/9780470555293.ch6

Docking-dependent regulation of checkpoint kinase chk1 by the growth regulator p21WAF1

Toh, Y. K. (2009) · ERA

Cellular Responses to Replication Problems

Budzowska, M. (2008) · EUR Research Repository (Erasmus University Rotterdam)

DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells

Sperka, T., Nalapareddy, K., & Rudolph, K. L. (2010) · Else Kröner-Fresenius Symposia · doi:10.1159/000312653

DNA Damage Response

Khanna, K. K., & Tibbetts, R. S. (2006) · Wiley eBooks · doi:10.1038/npg.els.0006107

Role Of Hippocampal Neurogenesis In The Etiology And Treatment Of Mood & Anxiety Disorders

Onksen, J. L. (2011) · ScholarlyCommons (University of Pennsylvania)

A study into genes encoding longevity in humans

Kuningas, M. (2007) · Leiden Repository (Leiden University)

ATR (Ataxia‐Telangiectasia andR AD 3‐Related)

Thayer, M. J. (2002) · Wiley eBooks · doi:10.1002/0471203076.emm0813

Role of ATM (ataxia telangiectasia mutated) and Artemis proteins for the repair of DNA double-strand breaks by homologous recombination in mammalian cells

Köcher, S. (2011)

Mitotic Response to DNA Damage in Early Drosophila Embroyos: a Dissertation

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Involvement of p53 in the S-phase Checkpoint during Nucleotide Deficiencies

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Regulation of cellular signalling pathways by Adenovirus

Forrester, N. A. (2012) · University of Birmingham Institutional Research Archive (University of Birmingham)

Serine/Threonine Protein Phosphatase 5 - a Double-edged Sword - in the Progression towards Diabetes

Grankvist, N. (2012) · Figshare

Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae

Hashash, N. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

The Rad9-Rad1-Hus1 complex and Bif-1 regulate multiple mechanisms that affect sensitivity to DNA damage

Meyerkord, C. L. (2009) · Digital Commons - University of South Florida (University of South Florida)

Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence

Jalili, E. (2013)

Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging

Nalapareddy, K., & Rudolph, K. L. (2009) · Springer eBooks · doi:10.1007/978-1-4419-1075-2_9

Linking Human RecQ Helicases to DNA Damage Response and Aging

Cheng, W., Ahn, B., & Bohr, V. A. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_15

Signaling at Stalled Replication Forks

Mordes, D. A., & Cortez, D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_2

Generation and phenotypic analysis of conditionally inactivated mutant cells

Sonoda, E., Fukagawa, T., Kitao, A., & Takeda, S. (2002) · International Congress Series · doi:10.1016/s0531-5131(02)01146-9

ATR (ataxia telangiectasia and Rad3 related)

Gagou, M., & Meuth, M. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44954

Defects in the ATR-dependent DNA damage response pathway and human syndromes

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Role of DNA repair in class switch recombination and somatic hypermutation

Du, L. (2011) · Figshare

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Efficient support of DNA replication functions by DNA ligase 3 in vertebrate cells

Bednar, T. (2013) · DuEPublico (University of Duisburg-Essen)

Inhibiting Cell Cycle Kinases in Cancer Therapy

de Cárcer, G., de Castro, I. P., & Malumbres, M. (2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781608054640113060009

Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)

Reini, K. (2006)

Aberrations of DNA Damage in Checkpoints in Cancer

Laiho, M. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-200-7_5

LIM Protein Ajuba Participates in the Repression of ATR-Mediated DNA Damage Response in Human Cells

Kalan, S. (2016) · CUNY Academic Works (City University of New York)

Genetics of DNA replication and homologous recombination in arabidopsis

Schürmann, D. (2005) · edoc (University of Basel) · doi:10.5451/unibas-003646982

Mechanisms of Common Fragile Site Instability and Cancer.

Ragland, R. L. (2009) · Deep Blue (University of Michigan)

Telomere dynamics and telomerase-independent cell survival in Arabidopsis thaliana

Watson, J. M. (2009) · OakTrust (Texas A&M University Libraries)

immunoglobulin class switch recombination and somatic hypermutation

Pan‐Hammarström, Q., Lähdesmäki, A., Zhao, Y., Du, L., Zhao, Z., Wen, S., Ruiz‐Pérez, V. L., Dunn‐Walters, D. K., Goodship, J. A., & Hammarström, L. L. G. (2006)

Synthetic lethality and synthetic cytotoxicity strategies for selective killing of ATM deficient cells

Li, X. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072731

Analysis of the epigenetics of meiotic silencing and its role in germ cell loss

Cloutier, J. M. (2016) · UCL Discovery (University College London)

Signaling of DNA Replication Stress Through the ATR Checkpoint

Shiotani, B., & Zou, L. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_16 · Cited by 1

Mechanisms and Dynamics of Oxidative DNA Damage Repair in Nucleosomes

Cannan, W. J. (2016) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) · doi:10.13140/rg.2.2.10290.20165

Integration of ATM, ATR, and DNA-PKcs Signaling Maintains Genome Integrity During Neurogenesis

Enriquez-Rios, V. D. (2015) · doi:10.21007/etd.cghs.2015.0085

Chapter 6 Chromatin Modifications and Orchestration of Checkpoint Response in Cancer

Nakanishi, M. (2009)

The interaction between Rad9 and Tousled-like kinase 1 in the cell cycle and the DNA damage response

Kelly, R. M. (2013) · QSpace (Queen's University Library)

Rôle du complexe CUL4-DDB1 dans le contrôle du développement embryonnaire chez Arabidopsis thaliana

Dumbliauskas, E. (2010) · Serveur des thèses de l'Université de Strasbourg (University of Strasbourg)

PIKK-dependent activation of the DNA damage response by long wavelength ultraviolet radiation

Copley, J. (2018) · Lancaster EPrints (Lancaster University) · doi:10.17635/lancaster/thesis/230

Control of DNA Replication by ATR

Lecona, E., & Fernández-Capetillo, Ó. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_3

Targeting ATR for Cancer Therapy: Profile and Expectations for ATR Inhibitors

Curtin, N. J., & Pollard, J. R. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_4

Primary and Secondary Events in Oncogene-Driven Tumor Development

Herzig, M., & Christofori, G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-313-2_13

Evaluation of Maltose Binding Protein-Tagged hATR Kinase Domain Catalytic Activity with p53 Ser-15 Phosphorylation

Bhakuni, R., Shaik, A., & Kirubakaran, S. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00845

Deoxyribonucleic acid damage gene expression, ligase activity and correlation with coronary atherosclerotic plaque morphology.

Shah, N. R. (2019) · Surrey Research Insight Open Access (The University of Surrey) · doi:10.15126/thesis.00850963

Chapter 5 References

Urich, A. (2017)

Epigenetic mechanisms in dna replication

Loureiro, R. (2016) · Dialnet (Universidad de la Rioja)

Studies on Molecular Basis for FOXO1-DNA Damage Responses

悠太, 金. (2016) · Terrestrial Environment Research Center (University of Tsukuba)

Phospho-regulation of the DNA Damage Response Kinase ATR

Nam, E. A. (2011)

Regulation of the ATR Pathway in the Replication Stress Response

Luzwick, J. W. (2016)

Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA)

Sirbu, B. M. (2013)

Exploring novel therapeutic strategies in neuroblastoma

Szydzik, J. (2020) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model

Pribyl, L. J. (2020) · doi:10.21007/etd.cghs.2020.0515

XRCC1, un élément clef de la réparation des dommages de l'ADN couplée à la réplication

Lévy, N. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique)

Overview of the DNA Damage Checkpoint

Dupré, A., & Gautier, J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-221-2_11

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