ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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Items 101–200 of 945

1. Focus on histone variant H2AX: To be or not to be
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2. Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis
   E.Randal Hofmann, Stuart Milstein, Simon J. Boulton, Mianjia Ye, Jen Hofmann, Lilli Stergiou, Anton Gartner, Marc Vidal, Michael Otmar Hengartner · 2002 · Current Biology
3. Common mechanisms of PIKK regulation
   Lovejoy, Courtney A., Cortez, David · 2009 · DNA Repair
4. Functional links between telomeres and proteins of the DNA-damage response
   d'Adda di Fagagna, Fabrizio, Teo, Soo-Hwang, Jackson, Stephen P. · 2004 · Genes & Development
5. Apoptosis and non-apoptotic deaths in cancer development and treatment response
   Elza C. de Bruin, Jan Paul Medema · 2008 · Cancer Treatment Reviews
6. DNA Damage Response: Three Levels of DNA Repair Regulation
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7. An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival
   Wentian Yang, Lori D. Klaman, Binbin Chen, Toshiyuki Araki, Hisashi Harada, Sheila Μ. Thomas, Elizabeth L. George, Benjamin G. Neel · 2006 · Developmental Cell
8. First-in-Human Trial of the Oral Ataxia Telangiectasia and RAD3-Related (ATR) Inhibitor BAY 1895344 in Patients with Advanced Solid Tumors
   Timothy Anthony Yap, David S.P. Tan, Angelika Terbuch, Reece Caldwell, Christina W. Guo, Boon Cher Goh, Valerie Yue Ming Heong, Noor R. Md. Haris, Saira Bashir, Yvette Drew et al. · 2020 · Cancer Discovery
9. Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest
   Xiaofen Ye, Alexa A. Franco, Hidelita Santos, David M. Nelson, Paul D. Kaufman, Peter D. Adams · 2003 · Molecular Cell
10. DNA damage kinase signaling: checkpoint and repair at 30 years
    Michael Charles Lanz, Diego Dibitetto, Marcus Bustamante Smolka · 2019 · The EMBO Journal
11. The ATR pathway: Fine-tuning the fork
    R PAULSEN, Karlene A. Cimprich · 2007 · DNA repair
12. Activation of the ATR kinase by the RPA-binding protein ETAA1
    Peter Haahr, Saskia Hoffmann, Maxim A. X. Tollenaere, Teresa Ho, Luis Ignacio Toledo, Matthias Mann, Simon Bekker‐Jensen, Markus Räschle, Niels Mailand · 2016 · Nature Cell Biology
13. Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
    Duy, Cihangir, Li, Meng, Teater, Matt, Meydan, Cem, Garrett-Bakelman, Francine E., Lee, Tak C., Chin, Christopher R., Durmaz, Ceyda, Kawabata, Kimihito C., Dhimolea, Eugen et al. · 2021 · Cancer Discovery
14. ATM, a central controller of cellular responses to DNA damage
    Kum Kum Khanna, Martin Francis Lavin, Stephen P. Jackson, Terrence D. Mulhern · 2001 · Cell Death and Differentiation
15. An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
    Heffernan, Timothy P., Simpson, Dennis A., Frank, Alexandra R., Heinloth, Alexandra N., Paules, Richard S., Cordeiro-Stone, Marila, Kaufmann, William K. · 2002 · Molecular and Cellular Biology
16. A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein
    Nicolas Foray, Didier Marot, Anastasia Gabriel, Voahangy Randrianarison-Huetz, Antony M. Carr, Michel Perricaudet, Alan Ashworth, Penny Ann Jeggo · 2003 · The EMBO Journal
17. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress
    Yan, Shan, Sorrell, Melanie, Berman, Zachary · 2014 · Cellular and Molecular Life Sciences
18. Nucleoside analogs: molecular mechanisms signaling cell death
    Brett Ewald, Deepa Sampath, William K. Plunkett · 2008 · Oncogene
19. Human Claspin Is Required for Replication Checkpoint Control
    Chini, Claudia Christiano Silva, Chen, Junjie · 2003 · Journal of Biological Chemistry
20. ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 Phosphorylation
    Heather L. Ball, Jeremy S. Myers, David Cortez · 2005 · Molecular Biology of the Cell
21. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancerin vivo
    Frank P. Vendetti, Alan Lau, Sandra Schamus, Thomas P. Conrads, Mark J. O’Connor, Christopher J. Bakkenist · 2015 · Oncotarget
22. Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication
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23. ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
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24. Targeting the ATR-CHK1 Axis in Cancer Therapy
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25. Biomarker-Guided Development of DNA Repair Inhibitors
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26. Replication Catastrophe: When a Checkpoint Fails because of Exhaustion
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27. Ionizing Radiation–dependent γ-H2AX Focus Formation Requires Ataxia Telangiectasia Mutated and Ataxia Telangiectasia Mutated and Rad3-related
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28. Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner
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29. Preventing replication fork collapse to maintain genome integrity
    Cortez, David · 2015 · DNA Repair
30. DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics
    Mrinal Srivastava, Sathees C. Raghavan · 2015 · Chemistry & Biology
31. ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks
    Kristina Trenz, Eloise Smith, Sarah J. Smith, Vincenzo Costanzo · 2006 · The EMBO Journal
32. ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
    Demis Menolfi, Shan Zha · 2020 · Cell & Bioscience
33. Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
    Nick Rhind, Paul R. Russell · 2000 · Journal of Cell Science
34. CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase
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35. The current state of eukaryotic DNA base damage and repair
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36. Tel2 Regulates the Stability of PI3K-Related Protein Kinases
    Hiroyuki Takai, Richard C. Wang, Kaori Takai, Haijuan Yang, Titia de Lange · 2007 · Cell
37. Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest
    Sally L. Davies, Phillip S. North, D. Alwyn Dart, Nick D. Lakin, Ian David Hickson · 2004 · Molecular and Cellular Biology
38. S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function
    Cliby, William A., Lewis, Kriste A., Lilly, Kia K., Kaufmann, Scott H. · 2002 · Journal of Biological Chemistry
39. DNA damage tolerance: a double-edged sword guarding the genome.
    Gargi Ghosal, Junjie Chen · 2013 · PubMed
40. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    Mark O’Driscoll, Andrew Richard Gennery, J. Seidel, PATRICK J. CONCANNON, Penelope Ann Jeggo · 2004 · DNA repair
41. Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R
    Mikhail Roshal, Baek Kim, Yonghong Zhu, Paul Nghiem, Vicente Planelles · 2003 · Journal of Biological Chemistry
42. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation
    Vendetti, Frank P., Karukonda, Pooja, Clump, David A., Teo, Troy, Lalonde, Ronald, Nugent, Katriana, Ballew, Matthew, Kiesel, Brian F., Beumer, Jan H., Sarkar, Saumendra N. et al. · 2018 · Journal of Clinical Investigation
43. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines
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44. Embryonic Cleavage Cycles: How Is a Mouse Like a Fly?
    Patrick H. O’Farrell, Jason K. Stumpff, Tin Tin Su · 2004 · Current Biology
45. DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications
    Yvette Drew, Frank T. Zenke, Nicola J. Curtin · 2024 · Nature Reviews Drug Discovery
46. DNA replication and progression through S phase
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47. Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
    Mohammad Hekmat-Nejad, Zhongsheng You, Muh‐Ching Yee, John W. Newport, Karlene A. Cimprich · 2000 · Current Biology
48. Regulation of DNA replication by ATR: signaling in response to DNA intermediates
    David Shechter, Vincenzo Costanzo, Jean Gautier · 2004 · DNA repair
49. Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites
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50. Common fragile sites
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51. SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest ofAtm-/- spermatocytes
    Marina A. Bellani, Peter J. Romanienko, Damian A. Cairatti, R. Daniel Camerini‐Otero · 2005 · Journal of Cell Science
52. The Recombinases DMC1 and RAD51 Are Functionally and Spatially Separated during Meiosis in Arabidopsis
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53. ATR signaling can drive cells into senescence in the absence of DNA breaks
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54. The human decatenation checkpoint
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55. A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
    Kazuhiko Yamane, Xianglin Wu, Junjie Chen · 2002 · Molecular and Cellular Biology
56. Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR
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57. Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells
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58. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
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59. Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1
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60. DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals
    Kaoru Yoshiyama, Kengo Sakaguchi, Seisuke Kimura · 2013 · Biology
61. Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
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62. The ATM signaling network in development and disease
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63. Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway
    Stephanie A. Yazinski, Lee Zou · 2016 · Annual Review of Genetics
64. Impaired Nonhomologous End-Joining Provokes Soft Tissue Sarcomas Harboring Chromosomal Translocations, Amplifications, and Deletions
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65. DSB repair: the yeast paradigm
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66. Targeting the S and G2 checkpoint to treat cancer
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67. Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX
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68. The Inherited Basis of Human Radiosensitivity
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69. Roles of BRCA1 in DNA damage repair: a link between development and cancer
    Chu‐Xia Deng · 2003 · Human Molecular Genetics
70. Specific Role of Chk1 Phosphorylations in Cell Survival and Checkpoint Activation
    Hiroyuki Niida, Yuko Katsuno, Birendranath Banerjee, Manoor Prakash Hande, Makoto Nakanishi · 2007 · Molecular and Cellular Biology
71. Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpoint
    Anja Groth, Jiří Lukáš, Erich A. Nigg, Herman H.W. Silljé, Christer Wernstedt, Jiri Jr Bartek, Klaus H. Hansen · 2003 · The EMBO Journal
72. ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing
    Hélène Royo, Haydn M. Prosser, Yaroslava Ruzankina, Shantha K. Mahadevaiah, Jeffrey M. Cloutier, Marek Baumann, Tomoyuki Fukuda, Christer Höög, Attila Tóth, Dirk G. de Rooij et al. · 2013 · Genes & Development
73. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
    Adams, K E, Medhurst, A L, Dart, D A, Lakin, N D · 2006 · Oncogene
74. Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase
    Eva Petermann, Keith W. Caldecott · 2006 · Cell Cycle
75. Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans
    Tatiana García‐Muse, Simon J. Boulton · 2005 · The EMBO Journal
76. Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand
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77. A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
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78. Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7
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79. Elg1 Forms an Alternative PCNA-Interacting RFC Complex Required to Maintain Genome Stability
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80. Genome integrity and disease prevention in the nervous system
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81. Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights
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82. Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements
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83. DNA Damage-Dependent Cell Cycle Checkpoints and Genomic Stability
    Kazuhiro Ishikawa, Hideshi Ishii, Toshiyuki Saito · 2006 · DNA and Cell Biology
84. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
    Alan Lau, Karra M. Swinbank, Parvin S. Ahmed, Debra L. Taylor, Stephen P. Jackson, Graeme C.M. Smith, Mark J. O’Connor · 2005 · Nature Cell Biology
85. Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.
    Anna Menoyo, Hafid Alazzouzi, Eloy Espín, Manel Armengol, Hiroyuki Yamamoto, Simó Schwartz · 2001 · PubMed
86. Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
    Gwenola Manic, Florine Obrist, Antonella Sistigu, Ilio Vitale · 2015 · Molecular & Cellular Oncology
87. Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases
    David Cortez · 2003 · Journal of Biological Chemistry
88. Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest
    Holly Capasso, Carmela Palermo, Shanhong Wan, Hui Rao, Ulrik P. John, Matthew J. O’Connell, Nancy C. Walworth · 2002 · Journal of Cell Science
89. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response
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90. Cell-cycle checkpoint kinases: checking in on the cell cycle
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91. PTEN in DNA damage repair
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92. Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
    Kyungjae Myung, Richard David Kolodner · 2002 · Proceedings of the National Academy of Sciences
93. Checking Your Breaks: Surveillance Mechanisms of Meiotic Recombination
    Andreas Hochwagen, Angelika Amon · 2006 · Current Biology
94. The ribotoxic stress response drives UV-mediated cell death
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95. Synthetic lethality between mutation in Atm and DNA-PK cs during murine embryogenesis
    Kay E. Gurley, Christopher J. Kemp · 2001 · Current Biology
96. Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response
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97. Mammalian Rif1 contributes to replication stress survival and homology-directed repair
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98. Common fragile sites
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99. Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
    Deborah F. Wilsker, Eva Petermann, Thomas Helleday, Fred Bunz · 2008 · Proceedings of the National Academy of Sciences
100. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes
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