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Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

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A role for ATR in the DNA damage-induced phosphorylation of p53

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Untitled work

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Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

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Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage

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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis

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Claspin, a regulator of Chk1 in DNA replication stress pathway

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Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation

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Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.

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The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation

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Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

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DNA double-strand break signaling and human disorders

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Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

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Importance of DNA damage checkpoints in the pathogenesis of human cancers

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DNA strand break repair and neurodegeneration

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Hsp90 Inhibitor–Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

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Diverse system stresses: common mechanisms of chromosome fragmentation

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How ATR turns on: TopBP1 goes on ATRIP with ATR: Figure 1.Preprint

Burrows, A. E., & Elledge, S. J. (2008) · Genes & Development · doi:10.1101/gad.1685108 · Cited by 79

Targeting DNA Damage Response in Prostate and Breast Cancer

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Germline Mutation in ATR in Autosomal- Dominant Oropharyngeal Cancer Syndrome

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Replication checkpoint: Preventing mitotic catastrophe

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BRCT Domain-Containing Protein PTIP Is Essential for Progression through Mitosis

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ATR maintains select progenitors during nervous system development

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ATRIP Oligomerization Is Required for ATR-dependent Checkpoint Signaling

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Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition

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Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1

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An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

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Spontaneous Chromosome Loss in Saccharomyces cerevisiae Is Suppressed by DNA Damage Checkpoint Functions

Klein, H. L. (2001) · Genetics · doi:10.1093/genetics/159.4.1501 · Cited by 76

Targeting ATM and ATR for cancer therapeutics: Inhibitors in clinic

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Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling

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Phenotypic Analysis of Separation-of-Function Alleles of MEI-41, Drosophila ATM/ATR

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Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53

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Thresholds of replication stress signaling in cancer development and treatment

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The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models

Attardi, L. D. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.04.019 · Cited by 73

Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

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Replicative stress, stem cells and aging

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Initiation of eukaryotic DNA replication: Regulation and mechanisms

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The molecular control of DNA damage-induced cell death

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

Kim, J. J., Lee, S. Y., Choi, J. H., Woo, H. G., Xhemalçe, B., & Miller, K. M. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.08.018 · Cited by 71

Development of Synthetic Lethality Anticancer Therapeutics

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DNA Structure and Integrity Checkpoints during the Cell Cycle and Their Role in Drug Targeting and Sensitivity of Tumor Cells to Anticancer Treatment

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An Overactivated ATR/CHK1 Pathway Is Responsible for the Prolonged G2 Accumulation in Irradiated AT Cells

Wang, X., Khadpe, J. D., Hu, B., Iliakis, G. E., & Wang, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301876200 · Cited by 71

DNA replication and mitotic entry: A brake model for cell cycle progression

Lemmens, B. B. L. G., & Lindqvist, A. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201909032 · Cited by 75

DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity

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Gene regulation in response to DNA damage

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ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage

Gamper, A. M., Rofougaran, R., Watkins, S. C., Greenberger, J. S., Beumer, J. H., & Bakkenist, C. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt833 · Cited by 71

ATR Mutation in Endometrioid Endometrial Cancer Is Associated With Poor Clinical Outcomes

Zighelboim, I., Schmidt, A. P., Gao, F., Thaker, P. H., Powell, M. A., Rader, J. S., Gibb, R. K., Mutch, D. G., & Goodfellow, P. J. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.19.9802 · Cited by 69

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

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Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G 1 /S checkpoint activation in response to DNA damage

Post, S. M., Weng, Y., Cimprich, K. A., Chen, L. B., Xu, Y., & Lee, E. Y.-H. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231364598 · Cited by 69

DNA repair as a shared hallmark in cancer and ageing

Clarke, T. L., & Mostoslavsky, R. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13285 · Cited by 74

Non-homologous end joining in class switch recombination: the beginning of the end

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DNA polymerase stalling, sister chromatid recombination and the BRCA genes

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53BP1 Mediates ATR-Chk1 Signaling and Protects Replication Forks under Conditions of Replication Stress

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Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase

Mladenov, E., Fan, X., Dueva, R., Soni, A., & Iliakis, G. E. (2019) · Scientific Reports · doi:10.1038/s41598-019-44771-6 · Cited by 67

14-3-3 Family Members Act Coordinately to Regulate Mitotic Progression

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Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines

Nunnari, G., Argyris, E. G., Fang, J., Mehlman, K. E., Pomerantz, R. J., & Daniel, R. (2005) · Virology · doi:10.1016/j.virol.2005.02.015 · Cited by 66

Cyclin-Dependent Kinase 2–Dependent Phosphorylation of ATRIP Regulates the G2-M Checkpoint Response to DNA Damage

Myers, J. S., Zhao, R., Xu, X., Ham, A. L., & Cortez, D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0495 · Cited by 66

Deregulated CDC25A Expression Promotes Mammary Tumorigenesis with Genomic Instability

Ray, D., Terao, Y., Fuhrken, P. G., Ma, Z.-Q., DeMayo, F. J., Christov, K. T., Heerema, N. A., Franks, R. R., Tsai, S. Y., Papoutsakis, E. T., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3927 · Cited by 66

Caffeine Promotes Ultraviolet B-induced Apoptosis in Human Keratinocytes without Complete DNA Repair

Han, W., Ming, M., & He, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222349 · Cited by 69

Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint.

Yamane, K., Chen, J., & Kinsella, T. J. (2003) · PubMed · Cited by 66

The human checkpoint sensor Rad9–Rad1–Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase

Guan, X., Madabushi, A., Chang, D.-Y., Fitzgerald, M. E., Shi, G., Drohat, A. C., & Lu, A.-L. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm678 · Cited by 65

ATR expands embryonic stem cell fate potential in response to replication stress

Atashpaz, S., Shams, S. S., Gonzalez, J. M., Sebestyén, E., Arghavanifard, N., Gnocchi, A., Albers, E., Minardi, S. P., Fagà, G., Soffientini, P., et al. (2020) · eLife · doi:10.7554/elife.54756 · Cited by 66

Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress

Furusawa, Y., Iizumi, T., Fujiwara, Y., Zhao, Q., Tabuchi, Y., Nomura, T., & Kondo, T. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0660-7 · Cited by 65

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

Zhang, H., Head, P. E., Daddacha, W. B., Park, S., Li, X., Pan, Y., Madden, M. Z., Duong, D. M., Xie, M., Yu, B., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.018 · Cited by 69

Functional genomic screens identify CINP as a genome maintenance protein

Lovejoy, C. A., Xu, X., Bansbach, C. E., Glick, G. G., Zhao, R., Ye, F., Sirbu, B. M., Titus, L. C., Shyr, Y., & Cortez, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909345106 · Cited by 64

CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress

Sarmento, L. M., Póvoa, V., Nascimento, R., Real, G., Antunes, I., Martins, L. R., Moita, C. F., Alves, P. M., Abecasis, M., Moita, L. F., et al. (2014) · Oncogene · doi:10.1038/onc.2014.248 · Cited by 68

Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?

Goto, H., Izawa, I., Li, P., & Inagaki, M. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02280.x · Cited by 68

Ras Induces Chromosome Instability and Abrogation of the DNA Damage Response

Abulaiti, A., Fikaris, A. J., Tsygankova, O. M., & Meinkoth, J. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2351 · Cited by 67

A role for cdk9-cyclin k in maintaining genome integrity

Yu, D. S., & Cortez, D. (2011) · Cell Cycle · doi:10.4161/cc.10.1.14364 · Cited by 64

High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library

Ishikawa, T., Kamei, Y., Otozai, S., Kim, J., Sato, A., Kuwahara, Y., Tanaka, M., Deguchi, T., Inohara, H., Tsujimura, T., et al. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-70 · Cited by 63

Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage

Deshpande, I., Seeber, A., Shimada, K., Keusch, J. J., Gut, H., & Gasser, S. M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.019 · Cited by 68

Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer

Doerr, F., George, J., Schmitt, A., Beleggia, F., Rehkämper, T., Hermann, S., Walter, V., Weber, J.-P. D., Thomas, R. K., Wittersheim, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15840-5 · Cited by 63

Checkpoint genes in cancer

McDonald, E. R., & El‐Deiry, W. S. (2001) · Annals of Medicine · doi:10.3109/07853890109002066 · Cited by 64

IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant micePreprint

Lopez-Contreras, A. J., Specks, J., Barlow, J. H., Ambrogio, C., Desler, C., Vikingsson, S., Rodrigo-Perez, S., Gréen, H., Rasmussen, L. J., Murga, M., et al. (2015) · Genes & Development · doi:10.1101/gad.256958.114 · Cited by 68

Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin

Kemp, M. G., Spandau, D. F., & Travers, J. B. (2017) · Molecules · doi:10.3390/molecules22030356 · Cited by 65

Translational research in radiation-induced DNA damage signaling and repair

Nickoloff, J. A., Boss, M., Allen, C., & LaRue, S. Μ. (2017) · Translational Cancer Research · doi:10.21037/tcr.2017.06.02 · Cited by 68

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe

Nakamura, K.-I., Okamoto, A., Katou, Y., Yadani, C., Shitanda, T., Kaweeteerawat, C., Takahashi, T. S., Itoh, T., Shirahige, K., Masukata, H., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.215 · Cited by 64

ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication

Sowd, G. A., Li, N. Y., & Fanning, E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003283 · Cited by 63

ATR is a multifunctional regulator of male mouse meiosis

Widger, A., Mahadevaiah, S. K., Lange, J., Elinati, E., Zohren, J., Hirota, T., Pacheco, S., Maldonado-Linares, A., Stanzione, M., Ojarikre, O. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04850-0 · Cited by 65

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage‐dependent recombination

Budzowska, M., Jaspers-Dekker, I., Essers, J., de Waard, H., van Drunen, E., Hanada, K., Beverloo, B., Hendriks, R. W., de Klein, A., Kanaar, R., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600353 · Cited by 62

Random walks and cell size

Agutter, P. S., & Wheatley, D. N. (2000) · BioEssays · doi:10.1002/1521-1878(200011)22:11 · Cited by 56

ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in ArabidopsisPreprint

Vespa, L., Couvillion, M., Spangler, E. A., & Shippen, D. E. (2005) · Genes & Development · doi:10.1101/gad.1333805 · Cited by 63

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

Jiang, H., Wu, J., He, C., Yang, W., & Li, H. (2009) · Cell Research · doi:10.1038/cr.2009.14 · Cited by 60

PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis

Kleinridders, A., Pogoda, H., Irlenbusch, S., Smyth, N. R., Koncz, C., Hammerschmidt, M., & Brüning, J. C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01807-08 · Cited by 60

Cell cycle roles for two 14-3-3 proteins duringDrosophiladevelopment

Su, T. T., Parry, D. H., Donahoe, B., Chien, C., O’Farrell, P. H., & Purdy, A. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.19.3445 · Cited by 60

Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors

Lee, Y., Katyal, S., Downing, S. M., Zhao, J., Russell, H. R., & McKinnon, P. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3097 · Cited by 59

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

Kawasumi, M., Lemos, B. D., Bradner, J. E., Thibodeau, R. M., Kim, Y.-S., Schmidt, M. N., Higgins, E., Koo, S., Angle-Zahn, A., Chen, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111378108 · Cited by 59

Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability

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Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks

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Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)