Cited by 951DNA Repair MechanismsDevelopmental Biology and Gene RegulationCancer-related Molecular Pathways

The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Open access

Brown, Eric J., Baltimore, David·2000·Genes & Development

Open this paper in CoChat — free account Open PDF

Abstract

Although a small decrease in survival and increase in tumor incidence was observed in ATR +/− mice, ATR −/− embryos die early in development, subsequent to the blastocyst stage and prior to 7.5 days p.c. In culture, ATR −/− blastocysts cells continue to cycle into mitosis for 2 days but subsequently fail to expand and die of caspase-dependent apoptosis. Importantly, caspase-independent chromosome breaks are observed in ATR −/− cells prior to widespread apoptosis, implying that apoptosis is caused by a loss of genomic integrity. These data show that ATR is essential for early embryonic development and must function in processes other than regulation of p53.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/gad.14.4.397

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A mammalian protein targeted by G1-arresting rapamycin–receptor complex
Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053
Self-citation
Tumor spectrum analysis in p53-mutant mice
Jacks, T., Remington, L., Williams, B. O., Schmitt, E. M., Halachmi, S., Bronson, R. T., & Weinberg, R. A. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00002-6 · Cited by 2,051
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
Matsuoka, S. (1998) · Science · doi:10.1126/science.282.5395.1893 · Cited by 1,322
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087
A role for ATR in the DNA damage-induced phosphorylation of p53
Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046
Untitled work
(1999) · PubMed · Cited by 1,030
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900
14-3-3σ is required to prevent mitotic catastrophe after DNA damage
Chan, T. A., Hermeking, H., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1999) · Nature · doi:10.1038/44188 · Cited by 895

Show all 38 references

Sorted by citations

Items 701–800 of 945

Knockdown of Toe1 causes developmental arrest during the morula-to-blastocyst transition in mice
Wang, H., Ming, X., Zhang, S., Chen, J., Liu, X., Wu, X., Zhang, S., Zhang, Y., Cui, W., Li, W., et al. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.10.011 · Cited by 9
Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428)
Chandris, P., Giannouli, C. C., Panayotou, G., & Kletsas, D. (2010) · Biogerontology · doi:10.1007/s10522-010-9261-z · Cited by 9
Identification of dAven, aDrosophila melanogasterortholog of the cell cycle regulator Aven
Zou, S., Chang, J. W., LaFever, L., Tang, W., Johnson, E. L., Hu, J., Wilk, R., Krause, H. M., Drummond‐Barbosa, D., & Irusta, P. M. (2011) · Cell Cycle · doi:10.4161/cc.10.6.15080 · Cited by 9
A novel role for ATR/Rad3 in G1 phase
Bøe, C. A., Håland, T. W., Boye, E., Syljuåsen, R. G., & Grallert, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-25238-6 · Cited by 9
Impairment of Base Excision Repair in Dermal Fibroblasts Isolated From Nevoid Basal Cell Carcinoma Patients
Charazac, A., Fayyad, N., Beal, D. M., Bourgoin‐Voillard, S., Seve, M., Sauvaigo, S., Lamartine, J., Soularue, P., Moratille, S., Martin, M. T., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01551 · Cited by 9
UV‐induced activation of ATR is mediated by UHRF2
Hanaki, S., Habara, M., & Shimada, M. (2021) · Genes to Cells · doi:10.1111/gtc.12851 · Cited by 9
Genomic Instability and Replicative Stress in Multiple Myeloma: The Final Curtain?
Botrugno, O. A., & Tonon, G. (2021) · Cancers · doi:10.3390/cancers14010025 · Cited by 9
Protein Phosphatase 2A–Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere Capping
Sui, J.-D., Tang, Z., Chen, B. P. C., Huang, P., Yang, M.-Q., Wang, N.-H., Yang, H.-N., Tu, H.-L., Jiang, Q.-M., Zhang, J., et al. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0581 · Cited by 9
Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance
Suetomi, K., Mereiter, S., Mori, C., Takanami, T., & Higashitani, A. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.02.004 · Cited by 9
Defining ATM-Independent Functions of the Mre11 Complex with a Novel Mouse Model
Balestrini, A., Nicolás, L., Yang-lott, K., Guryanova, O. A., Levine, R. L., Bassing, C. H., Chaudhuri, J., & Petrini, J. H. J. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0281 · Cited by 10
Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis
Daitoku, H., Kaneko, Y., Yoshimochi, K., Matsumoto, K., Araoi, S., Sakamaki, J.-I., Takahashi, Y., & Fukamizu, A. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00265-16 · Cited by 10
AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice
Kim, D., Kim, S., Oh, Y., Park, S., Jeon, Y., Kim, H., Lee, H., & Kim, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-33303-3 · Cited by 9
Cell cycle inhibitors in cancer: current status and future directions
Fischer, P. M. (2008) · Elsevier eBooks · doi:10.1016/b978-012369448-5.50014-8 · Cited by 9
Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts
Brown, E. J. (2004) · Humana Press eBooks · doi:10.1385/1-59259-788-2:201 · Cited by 9
Self-citation
Chemo-Phosphoproteomic Profiling with ATR Inhibitors Berzosertib and Gartisertib Uncovers New Biomarkers and DNA Damage Response Regulators
Jadav, R. S., Weiland, F., Noordermeer, S. M., Carroll, T. D., Gao, Y., Wang, J., Zhou, H., Lamoliatte, F., Munoz, I. M., Toth, R., et al. (2024) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2024.100802 · Cited by 9
Molecular architecture and inhibition mechanism of human ATR-ATRIP
Wang, G., Wang, P., Zheng, Z., Zhang, Q.-J., Xu, C., Xu, X., Jian, L., Zhao, Z., Cai, G., & Wang, X. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.05.009 · Cited by 8
Drugging the DNA damage response in the clinic: going beyond PARP
Torrado, C., González-Ortiz, Á., Xavier, C. B., Tan, H. N., Ngoi, N. Y. L., & Yap, T. A. (2025) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2025.2575825 · Cited by 8
Inactivation of a Macronuclear Intra-S-phase Checkpoint in Tetrahymena thermophila with Caffeine Affects the Integrity of the Micronuclear Genome
Kaczanowski, A., & Kiersnowska, M. (2011) · Protist · doi:10.1016/j.protis.2011.01.004 · Cited by 8
Heterochromatin DNA replication and Rif1
Buonomo, S. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.03.015 · Cited by 8
Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants
Lefebvre, F. A., Bouvrette, L. P. B., Bergalet, J., & Lécuyer, É. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.01.022 · Cited by 8
Signalling DNA Damage
Joaquin, A., & Fernández-Capetillo, Ó. (2012) · InTech eBooks · doi:10.5772/50863 · Cited by 14
Cell Cycle: Check for Asynchrony
Schumacher, B., Alpi, A. F., & Garter, A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00473-1 · Cited by 8
DNA Repair in Despair—Vitamin D Is Not Fair
Gocek, E., & Studzinski, G. P. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25552 · Cited by 8
Ubiquitin and the DNA double-strand break repair pathway
Nowsheen, S., Deng, M., & Lou, Z. (2019) · Genome Instability & Disease · doi:10.1007/s42764-019-00007-5 · Cited by 8
TTT and PIKK Complex Genes Reverted to Single Copy Following Polyploidization and Retain Function Despite Massive Retrotransposition in Maize
Garcia, N., & Messing, J. W. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01723 · Cited by 8
Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan
Naeem, W., Nawab, F., Sarwar, M. T., Khalil, A. T., Gaber, D. A., Ahmad, H., Fazeel, M., Alorini, M., Khan, I. A., Irfan, M. I., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-91700-x · Cited by 7
A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation
Ascenção, C. F. R., Sims, J. R., Dziubek, A., Comstock, W. J., Fogarty, E. A., Badar, J., Freire, R., Grimson, A., Weiss, R. S., Cohen, P. E., et al. (2023) · eLife · doi:10.1101/2023.05.31.543071 · Cited by 7
ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells
Maëda, J., Chailapakul, P., & Kato, T. A. (2024) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2024.111871 · Cited by 7
Bid protects the mouse hematopoietic system following hydroxyurea-induced replicative stress
Liu, Y., Aiello, A., & Zinkel, S. S. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2012.38 · Cited by 7
Phosphorylation Sites on Tyr28 and the C-terminus of Rad9 are Required for Inhibition of Premature Chromosomal Condensation Across the Entire S Phase
Zhang, C., Zhang, C., He, Y., & Hang, H. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000149808 · Cited by 7
LC–MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma
Kiesel, B. F., Shogan, J. C., Rachid, M., Parise, R. A., Vendetti, F. P., Bakkenist, C. J., & Beumer, J. H. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.01.055 · Cited by 7
S phase block followingMEC1ATRinactivation occurs without severe dNTP depletion
Earp, C., Rowbotham, S. P., Merényi, G., Chabes, A., & Cha, R. S. (2015) · Biology Open · doi:10.1242/bio.015347 · Cited by 6
Kinetics of DNA Repair in Vicia faba Meristem Regeneration Following Replication Stress
Rybaczek, D., Musiałek, M. W., Vrána, J., Petrovská, B., Pikus, E., & Doležel, J. (2021) · Cells · doi:10.3390/cells10010088 · Cited by 6
Unpicking the Roles of DNA Damage Protein Kinases in Trypanosomatids
Silva, G. L. A., Tosi, L. R. O., McCulloch, R., & Black, J. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.636615 · Cited by 7
Testis‐specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization
Murakami, Y., Konishi, H., Fujiya, M., Takahashi, K., Ando, K., Ueno, N., Kashima, S., Moriichi, K., Tanabe, H., & Okumura, T. (2022) · Cancer Medicine · doi:10.1002/cam4.4738 · Cited by 6
Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer
Gulliver, C., Hoffmann, R., & Baillie, G. S. (2022) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2022.106230 · Cited by 7
NEK1 Protein Kinase as a Target for Anticancer Therapeutics
Chen, Y. (2012) · Chemotherapy Open access · doi:10.4172/2167-7700.1000e118 · Cited by 6
Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine
Matsuda, S., Matsuda, Y., Yanagisawa, S.-Y., Ikura, M., Ikura, T., & Matsuda, T. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw039 · Cited by 6
Initiation of Drosophila chorion gene amplification requires Claspin and mus101 , whereas Claspin , but not mus101 , plays a major role during elongation
Choi, S. H., Park, J., Nguyen, T. T. N., Shim, H. J., & Song, Y. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24499 · Cited by 6
Immortalizing the immortal
Cooke, H. J. (2002) · Nature Genetics · doi:10.1038/ng0902-90 · Cited by 6
Diverse functions of BRCA1 in the DNA damage response
Lee, J., & Chung, J. H. (2001) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399401003131 · Cited by 6
Down-regulation of cyclin E expression by caffeine promotes cancer cell entry into the S-phase of the cell cycle.
Qin, J., Tao, D., Chen, X., Feng, Y., Hu, J., Reed, E., Li, Q. Q., & Gong, J. (2004) · PubMed · Cited by 6
The organization of genome duplication is a critical determinant of the landscape of genome maintenancePreprint
Gómez‐Escoda, B., & Wu, P.-Y. J. (2018) · Genome Research · doi:10.1101/gr.224527.117 · Cited by 6
Recent advances in small molecule ATR kinase inhibitors as anticancer agents
Singh, G., Sharma, R., Gautam, V., Dhingra, A. K., Hsu, S., & Nepali, K. (2026) · Future Medicinal Chemistry · doi:10.1080/17568919.2026.2620367 · Cited by 6
Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients
Duthoo, E., Beyls, E., Backers, L., Guðjόnsson, Þ., Huang, P., Jonckheere, L., Riemann, S., Parton, B., Du, L., Debacker, V., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20241432 · Cited by 5
Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation
Roy, T., Ghosh, S., Piplani, N., Sthanam, L. K., Tiwary, N., Dhar, S., Konyak, W. C. W., Panigrahi, S. S., Singh, P., Sowpati, D. T., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf852 · Cited by 6
A novel role for Rad17 in homologous recombination
Nishino, K., Inoue, E., Takada, S., Abe, T., Akita, M., Yoshimura, A., Tada, S., Kobayashi, M., Yamamoto, K.-I., Seki, M., et al. (2008) · Genes & Genetic Systems · doi:10.1266/ggs.83.427 · Cited by 5
brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury
Kouprianov, V. A., Selmek, A. A., Ferguson, J. L., Mo, X. M., & Shive, H. R. (2022) · Scientific Reports · doi:10.1038/s41598-022-04878-9 · Cited by 5
Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy
Schneider, H., Schmitt, L.-M., Job, A., Lankat–Buttgereit, B., Gress, T. M., Buchholz, M., & Gallmeier, E. (2024) · Neoplasia · doi:10.1016/j.neo.2024.101038 · Cited by 5
Effective intra‐S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines
Cordeiro‐Stone, M., McNulty, J. J., Sproul, C. D., Chastain, P. D., Gibbs-Flournoy, E. A., Zhou, Y., Carson, C. C., Rao, S., Mitchell, D. L., Simpson, D. A., et al. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12426 · Cited by 6
Novel targets for ATM-deficient malignancies
Winkler, J., Hofmann, K., & Chen, S. (2014) · Molecular & Cellular Oncology · doi:10.4161/mco.29905 · Cited by 5
The activation mechanisms of master kinases in the DNA damage response
Xiao, J., Rao, Q., & Xu, Y. (2021) · Genome Instability & Disease · doi:10.1007/s42764-021-00045-y · Cited by 5
Phosphoregulation of the checkpoint kinase Mec1ATR
Yates, L. A., & Zhang, X. (2023) · DNA repair · doi:10.1016/j.dnarep.2023.103543 · Cited by 5
Heterogeneous expression of ARID1A in colorectal cancer indicates distinguish immune landscape and efficacy of immunotherapy
Guan, X., Cui, L., Ruan, Y., Fang, L., Dang, T., Zhang, Y., & Liu, C. (2024) · Discover Oncology · doi:10.1007/s12672-024-00955-9 · Cited by 5
Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy
Johnson, D. P., Chandrasekharan, M. B., Dutreix, M., & Bhaskara, S. (2021) · Cancers · doi:10.3390/cancers13030381 · Cited by 5
Preimplantation Embryogenesis
Burns, K. H., & Matzuk, M. M. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50012-9 · Cited by 5
ATM , ATR and Mre11 complex genes in hereditary susceptibility to breast cancer
Pylkäs, K. (2007) · Cited by 5
Human DNA polymerase ε : expression, phosphorylation and protein-protein interactions
Tuusa, J. T. (2001) · Cited by 5
Stressed telomeres without POT1 enhance tumorigenesis
Sfeir, A. J., & Denchi, E. L. (2016) · Oncotarget · doi:10.18632/oncotarget.10600 · Cited by 5
Exploring DNA Damage Repair Therapeutics in Prostate Cancer beyond BRCAness
Costanzo, F. D., Williamson, J., Robson, C. N., Gaughan, L., Conteduca, V., Mansour, W. Y., Formisano, L., Demichelis, F., Oing, C., & Rescigno, P. (2026) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0724 · Cited by 4
Unraveling DNA Repair Processes In Vivo: Insights from Zebrafish Studies
Shin, U., & Lee, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713120 · Cited by 6
In and out of Replication Stress: PCNA/RPA1-Based Dynamics of Fork Stalling and Restart in the Same Cell
Dyankova-Danovska, T., Uzunova, S., Danovski, G., Stamatov, R., Kanev, P.-B., Atemin, A., Ivanova, A., Aleksandrov, R., & Stoynov, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020667 · Cited by 4
Life can be stressful without ATR
O’Driscoll, M. (2009) · Nature Genetics · doi:10.1038/ng0809-866 · Cited by 4
Mitotic Catastrophe
Chow, J. P. H., & Poon, R. Y. C. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1770-6_5 · Cited by 4
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
Siddik, Z. H. (2009) · Springer eBooks · doi:10.1007/978-0-387-89445-4_9 · Cited by 4
The DNA Damage Response: Roles in Cancer Etiology and Treatment
Butler, L. R., Gilad, O., & Brown, E. J. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_2 · Cited by 4
Self-citation
Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer
Bedford, J. S., & Liber, H. L. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00044-0 · Cited by 4
DNA damage repair and transcription
El‐Osta, A. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4173-1 · Cited by 4
Ionizing irradiation effects on S-phase in checkpoint mutants of the yeast Saccharomyces cerevisiae
King, W. R., Rowley, R., & Schroeder, A. L. (2003) · Current Genetics · doi:10.1007/s00294-002-0361-4 · Cited by 4
Nucleosomes represent a crucial target for the intra-S phase checkpoint in response to replication stress
Liu, X., Zhang, B., Yu, H., Li, C., Li, X., & Kong, D. (2025) · Science Advances · doi:10.1126/sciadv.adr3673 · Cited by 3
Shining light on drug discovery: optogenetic screening for TopBP1 biomolecular condensate inhibitors
Morano, L., Vié, N., Aissanou, A., Hodroj, D., Garambois, V., Fauvre, A., Promonet, A., Egger, T., Bordignon, B., Hassen‐Khodja, C., et al. (2025) · NAR Cancer · doi:10.1093/narcan/zcaf041 · Cited by 3
Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?
Sproul, C. D., Rao, S., Ibrahim, J. G., Kaufmann, W. K., & Cordeiro‐Stone, M. (2013) · Cell Cycle · doi:10.4161/cc.26590 · Cited by 3
Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates
Dillon, M. T., & Harrington, K. J. (2018) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-75836-7_5 · Cited by 3
The Application of ATR Kinase Inhibitor AZD6738 in Combination with Radiotherapy for the Treatment of Melanoma
Talebpoor, M. (2022) · Journal of Biomedical Physics and Engineering · doi:10.31661/jbpe.v0i0.1912-1000 · Cited by 3
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Xia, D., Zhu, X., Wang, Y., Gong, P., Su, H.-S., & Xu, X. (2023) · Bioscience Reports · doi:10.1042/bsr20222591 · Cited by 3
Integration of the DNA Damage Response with Innate Immune Pathways
Gordon, M., & Gasser, S. (2011) · InTech eBooks · doi:10.5772/24735 · Cited by 3
Faithful DNA Replication Requires Regulation of CDK Activity by Checkpoint Kinases
Storgaard, C. D., Beck, H., Nähse, V., & Randi, G. (2011) · InTech eBooks · doi:10.5772/18616 · Cited by 3
Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis
Greenberg, R. A., & Rudolph, K. L. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_11 · Cited by 3
DNA-damage-induced apoptosis
Lee, S. J., O’Connor, B. F., Stuart, S. A., & Wang, J. Y. J. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.040 · Cited by 3
ATR signalling mediates the prosurvival function of phospho-NPM against PIDDosome mediated cell death
Hiregange, D., Naick, H., & Rao, B. J. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109602 · Cited by 3
In Vivo Live-Analysis of Cell Cycle Checkpoints in Drosophila Early Embryos
Takada, S., & Cha, B. J. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-273-1_7 · Cited by 3
Differentiating Chromosome Fragmentation and Premature Chromosome Condensation
Stevens, J. B., & Heng, H. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6558-4_5 · Cited by 3
Chromosome instability and tumor lethality suppression in carcinogenesis
Shen, C., Zhou, Y., Zhan, J., Reske, S. N., & Buck, A. K. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21937 · Cited by 3
The “extreme phenotype approach” applied to male breast cancer allows the identification of rare variants of ATR as potential breast cancer susceptibility alleles
Chevarin, M., Alcantara, D., Albuisson, J., Collonge‐Rame, M., Populaire, C., Selmani, Z., Baurand, A., Sawka, C., Bertolone, G., Callier, P., et al. (2023) · Oncotarget · doi:10.18632/oncotarget.28358 · Cited by 2
Receptor interacting protein 1 knockdown induces cell death in liver cancer by suppressing STAT3/ATR activation in a p53-dependent manner.
Jung, S.-Y., Park, J., Jeong, J., Song, K., Ahn, J., Hwang, S., Kim, J., Park, J.-K., Lim, D., & Song, J. Y. (2022) · PubMed Central · Cited by 2
Improving the Therapeutic Ratio of Radiotherapy by Targeting the DNA Damage Response
Carruthers, R., & Chalmers, A. J. (2016) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-40854-5_1 · Cited by 2
Sweet Wormwood and Tortoise Shell Decoction (Thanh Hao Miet Giap Thang) Induces DNA Damage, S-Phase Arrest, and Apoptosis in MCF-7 Cells via ATR-CHK1 Signaling Pathway
Thai, H. T. N., Nguyen, V., & Huynh, T. D. H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2358290 · Cited by 2
DNA Damage Sensing and Signaling
Wood, J. L., & Chen, J. (2007) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812706782_0001 · Cited by 2
ATM, ATR and DNA damage-induced cell cycle arrest
Hong, Z., Miao, Z., & Ding, J. (2007) · Shengming kexue · Cited by 2
DNA Damage Sensing and Signaling
Durocher, D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_1 · Cited by 2
Targeting DNA Damage Response Pathways in Cancer
Abdulrahman, G. O., & Curtin, N. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12394-7 · Cited by 2
Role of DNA Repair in Carcinogenesis and Cancer Therapeutics
Abbotts, R., Golato, T., & Wilson, D. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65170-x · Cited by 3
Metronomic dosing of ovarian cancer cells with the ATR inhibitor AZD6738 leads to loss of CDC25A expression and resistance to ATRi treatment
Ao, W., Kim, H. I., Tommarello, D., Conrads, K. A., Hood, B. L., Litzi, T. A., Abulez, T. S., Teng, P.-N., Dalgard, C. L., Zhang, X., et al. (2023) · Gynecologic Oncology · doi:10.1016/j.ygyno.2023.08.004 · Cited by 2
ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells
Yamamoto, K.-I., Kobayashi, M., & Shimizu, H. (2006) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-4896-8_19 · Cited by 2
The Fanconi Anemia Pathway and Interstrand Cross-Link Repair
Ishiai, M., Tomida, J., Itaya, A., Hejna, J., & Takata, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_8 · Cited by 2
An Eye in the Replication Stress Response: Lessons From Tissue-Specific Studies in vivo
Matos-Rodrigues, G. E., & Martins, R. A. P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.731308 · Cited by 2
Role of Tumor Suppressors in DNA Damage Response
Zhou, B. S., Mattern, M. R., & Khanna, K. K. (2003) · Humana Press eBooks · doi:10.1385/1-59259-329-1:39 · Cited by 2
Identifying the missing link between UV and p53: The role of phosphatidyl inositol kinase-related kinases
Nghiem, P. (2000) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2000.109275 · Cited by 2
Distinct Pathways Involved in S-Phase Checkpoint Control
Hurley, P. J., & Bunz, F. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-178-3_2 · Cited by 2
ATR-I774Yfs*5 promotes genomic instability through micronuclei formationPreprint
Holcomb, N., Dhar, B., Pu, H., Bautista, R., Overmann, A. H., Corum, L., Shelton, B. J., & D'Orazio, J. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.10.483800 · Cited by 2

Authors: Brown, E. J., & Baltimore, D.
Affiliations: California Institute of Technology (US)
ORCID: Brown, Eric J.
Baltimore, David
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2000-02-15
Volume: 14
Issue: 4
Pages: 397-402
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.14.4.397
PMC: PMC316378
OpenAlex: W2167196101
Cited by: 951
References: 38
Citations by year: 2026: 12 · 2025: 18 · 2024: 24 · 2023: 29 · 2022: 26 · 2021: 26 · 2020: 31 · 2019: 27 · 2018: 30 · 2017: 38 · 2016: 39 · 2015: 46 · 2014: 31 · 2013: 46 · 2012: 34
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
Funders: Cancer Research Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: ATR kinase, early embryonic lethality, chromosomal fragmentation, caspase-dependent apoptosis, blastocyst, genome stability, p53-independent function, mitotic cycle
MeSH terms: Animals, Blastocyst, Cell Transformation, Neoplastic, Chromosome Aberrations, DNA Repair, Fetal Death, Genotype, Mice, Inbred C57BL, Mitosis, Neoplasm Proteins, Neoplasms, Experimental, Transcription Factors, Apoptosis, Protein Serine-Threonine Kinases, Mice, Knockout, Gene Targeting, Gene Expression Regulation, Developmental, Cell Cycle Proteins, BRCA1 Protein, Caspases, BRCA2 Protein, Mice, Ataxia Telangiectasia Mutated Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks