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ATR Regulates Fragile Site Stability

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

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Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

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Homologous recombinational repair of DNA ensures mammalian chromosome stability

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Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 1: Background to spermatogenesis, spermatogonia, and spermatocytes

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ATR phosphorylates SMARCAL1 to prevent replication fork collapsePreprint

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The G2-phase DNA-damage checkpoint

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ATR and ATM regulate the timing of DNA replication origin firing

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ATR/CHK1 inhibitors and cancer therapy

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TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

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DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

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Loss of the Forkhead Transcription Factor FoxM1 Causes Centrosome Amplification and Mitotic Catastrophe

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RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

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Targeting ATR in cancer

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DNA repair deficiency and neurological disease

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DNA damage checkpoint kinases in cancer

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Suppression of Spontaneous Chromosomal Rearrangements by S Phase Checkpoint Functions in Saccharomyces cerevisiae

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Hypoxia Links ATR and p53 through Replication Arrest

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Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

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ATR signalling: more than meeting at the fork

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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

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A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

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The combined status of ATM and p53 link tumor development with therapeutic responsePreprint

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Repair of and checkpoint response to topoisomerase I-mediated DNA damage

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An intrinsic S/G 2 checkpoint enforced by ATR

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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

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CENTROSOMES IN CELLULAR REGULATION

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ATR inhibition selectively sensitizes G 1 checkpoint-deficient cells to lethal premature chromatin condensation

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Programmed induction of endoreduplication by DNA double-strand breaks in Arabidopsis

Adachi, S., Minamisawa, K., Okushima, Y., Inagaki, S., Yoshiyama, K., Kondou, Y., Kaminuma, E., Kawashima, M., Toyoda, T., Matsui, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103584108 · Cited by 289

ATR Regulates a G2-Phase Cell-Cycle Checkpoint in Arabidopsis thaliana

Culligan, K. M., Tissier, A. F., & Britt, A. (2004) · The Plant Cell · doi:10.1105/tpc.018903 · Cited by 296

ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212360200 · Cited by 288

ATR autophosphorylation as a molecular switch for checkpoint activation

Liu, S., Shiotani, B., Lahiri, M., Maréchal, A., Tse, A., Leung, C. C. Y., Glover, J. N. M., Yang, X. H., & Zou, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.019 · Cited by 281

The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

Zhao, X., Chabes, A., Domkin, V., Thelander, L., & Rothstein, R. J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.13.3544 · Cited by 281

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

de Klein, A., Muijtjens, M., van Os, R. P., Verhoeven, Y., Smit, B., Carr, A. M., Lehmann, A. R., & Hoeijmakers, J. H. J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00447-4 · Cited by 443

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

Yamamoto, K., Wang, Y., Jiang, W., Liu, X., Dubois, R. L., Lin, C., Ludwig, T., Bakkenist, C. J., & Zha, S. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201204098 · Cited by 118

Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts

Brown, E. J. (2004) · Humana Press eBooks · doi:10.1385/1-59259-788-2:201 · Cited by 9

p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc

Gladdy, R. A., Nutter, L. M. J., Kunath, T., Danska, J. S., & Guidos, C. J. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0258 · Cited by 17

Exploration of Ataxia Telangiectasia and Rad3-Related’s (ATR’s) Role in Cell Death Regulation: Implications in Development, Cancer, and Stroke

Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)