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Untitled work

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Progress towards a clinically-successful ATR inhibitor for cancer therapy

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Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding

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Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2

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Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

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Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses

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p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation

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An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

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Targeting ATR in patients with cancer

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ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background

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Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality

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RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cellsPreprint

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ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

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The Intra-S Checkpoint Responses to DNA Damage

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DNA stress checkpoint control and plant development

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HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

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Centrosomal localization of DNA damage checkpoint proteins

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MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX

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Exploiting synthetic lethal interactions for targeted cancer therapy

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Targeting the Checkpoint to Kill Cancer Cells

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Distinct Roles of the ATR Kinase and the Mre11-Rad50-Nbs1 Complex in the Maintenance of Chromosomal Stability in Arabidopsis

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MCPH1 Functions in an H2AX-dependent but MDC1-independent Pathway in Response to DNA Damage

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Cell-cycle responses to DNA damage in G2

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Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses

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Cryo-EM structure of human ATR-ATRIP complex

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Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

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SIRT2 directs the replication stress response through CDK9 deacetylation

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Selective Targeting of the G2/M Cell Cycle Checkpoint to Improve the Therapeutic Index of Radiotherapy

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Cdk12 is essential for embryonic development and the maintenance of genomic stability

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Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo

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ATM-Mediated Transcriptional and Developmental Responses to γ-rays in Arabidopsis

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The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

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Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities

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The S‐phase checkpoint: targeting the replication fork

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Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

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Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation

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The BRCA1 suppressor hypothesis: An explanation for the tissue-specific tumor development in BRCA1 patients

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Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

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Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage Response

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A germline chromothripsis event stably segregating in 11 individuals through three generations

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ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

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Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

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Ataxia-telangiectasia-mutated (ATM) Is a T-antigen Kinase That Controls SV40 Viral Replication in Vivo

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Mitotic Cell Death by Chromosome Fragmentation

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The consequences of structural genomic alterations in humans: Genomic Disorders, genomic instability and cancer

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A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress

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ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint

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Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency

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DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

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The Drosophila ATM Ortholog, dATM, Mediates the Response to Ionizing Radiation and to Spontaneous DNA Damage during Development

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Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells

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Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation

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Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

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SOG1: a master regulator of the DNA damage response in plants

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Mdm2 in the Response to Radiation

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Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition

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Developmental Regulation and In Vitro Culture Effects on Expression of DNA Repair and Cell Cycle Checkpoint Control Genes in Rhesus Monkey Oocytes and Embryos1

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Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis

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CK2 Inhibits Apoptosis and Changes Its Cellular Localization Following Ionizing Radiation

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Hus1 Acts Upstream of Chk1 in a Mammalian DNA Damage Response Pathway

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Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Preprint

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Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

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Genetic instability in cancer cells by impaired cell cycle checkpoints

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

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Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockouts

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p53-Independent Apoptosis Disrupts Early Organogenesis in Embryos Lacking Both Ataxia-Telangiectasia Mutated and Prkdc

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Cartwright, B. M. (2019) · Digital Commons - East Tennessee State University (East Tennessee State University)