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PreprintCited by 129Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

Melatonin and Human Chronobiology

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Lewy, A. J.·2007·Cold Spring Harbor Symposia on Quantitative Biology
DOI 10.1101/sqb.2007.72.055
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Abstract

With the development of accurate and sensitive assays for measuring melatonin in plasma and saliva, it has been possible to advance our understanding of human chronobiology. In particular, the dim light melatonin onset (DLMO) is expected to have an increasingly important role in the diagnosis of circadian phase disorders and their treatment with appropriately timed bright light exposure and/or low-dose melatonin administration. The phase angle difference (PAD) between DLMO and mid-sleep can be used as a marker for internal circadian alignment and may also be used to differentiate individuals who are phase advanced from those who are phase delayed (a long interval indicates the former and a short interval indicates the latter). To provide a corrective phase delay, light exposure should be scheduled in the evening and melatonin should be administered in the morning. To provide a corrective phase advance, light exposure should be scheduled in the morning and melatonin should be administered in the afternoon/evening. The study of patients with seasonal affective disorder (SAD), as well as individuals who are totally blind, has resulted in several findings of interest to basic scientists, as well as psychiatrists and sleep specialists.

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  1. Klerman E.B. 2001. Non-photic effects on the circadian system: Results from experiments in blind and sighted individuals. In Zeitgebers, entrainment and masking of the circadian system (ed. K. Honma and S. Honma), p. 155. Hokkaido University Press, Sapporo, Japan.
  2. ---. 1983. Biochemistry and regulation of mammalian mela- tonin production. In The pineal gland (ed. R.M. Relkin), p. 77. Elsevier, North-Holland, New York.

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Authors
Lewy, A. J.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Lewy, A. J.
Venue
Cold Spring Harbor Symposia on Quantitative Biology
Publisher
Cold Spring Harbor Laboratory
Published
2007-01
Volume
72
Issue
1
Pages
623-636
ISSN
0091-7451 (ISSN-L)
DOI
10.1101/sqb.2007.72.055
OpenAlex
W2171656883
Cited by
129
References
130
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 9 · 2015: 11 · 2014: 10 · 2013: 14 · 2012: 8
Type
posted content
Language
en
Open access
Locations
  • Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Oregon Health and Science University
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (5r01mh055703-05)
  • National Institute on Aging (R01 AG21826, R01AG021826)
  • National Institute of Mental Health (R01MH056874, R01 MH 56874, R01 MH55703)
  • National Center for Research Resources (M01RR000334, K23RR017636)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD042125, R01 HD42125)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
melatonin, dim light melatonin onset, phase difference, circadian alignment, phase advance, phase lag, bright light therapy, seasonal affective disorder, blind people, circadian rhythm
MeSH terms
Blindness, Chronobiology Phenomena, Circadian Rhythm, Dose-Response Relationship, Drug, Female, Humans, Male, Melatonin, Models, Biological, Phototherapy, Pregnancy, Social Behavior, Seasonal Affective Disorder, Photoperiod, Photobiology

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