The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A Neural Stimulator Frontend With High-Voltage Compliance and Programmable Pulse Shape for Epiretinal Implants
Abstract
This paper presents an integrated neural stimulator with highly efficient and flexible frontend which is intended for an epiretinal implant with 1024 electrodes. It features programmable stimulation pulse shapes, a high-voltage (HV) output driver with compliance monitor for supply voltage adaptation, active and passive charge balancers, and electrode impedance measurement. Area and power efficiency is achieved by global timing assignment and local amplitude control over a bus at the local stimulation units. Major power savings in the distributed digital control units are realized by implementing global and local clock gating. Two stimulator frontends have been fabricated in a 0.35 μm HVCMOS process. Each frontend features four demultiplexed outputs and consumes 0.2 mm2core area. A maximum voltage compliance of 20 V is achieved and up to 1 mA of output current can be adjusted with up to 50 dB dynamic range. In vitro experimental results performed on a platinum black electrode in 0.9% saline solution are given.
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In the citing paper
“Real-time monitoring of the voltage compliance enables operation with the minimum supply necessary for stimulation, which improves the power efficiency of the HV stimulus pulse driver circuit [44], [129].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [129]
In the citing paper
“Alternatively, the VCR topology can maintain a high output impedance with little voltage overhead by introducing regulated cascode current mirrors, as shown in Fig. 5(b). These structures avoid reliance on linearity compensation circuits [129].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [129]
Citations
Cites
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078
Cochlear Implants: System Design, Integration, and Evaluation
Zeng, F.-G., Rebscher, S., Harrison, W., Sun, X., & Feng, H. (2008) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2008.2008250 · Cited by 878
Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Humayun, M. S., Weiland, J. D., Fujii, G. Y., Greenberg, R., Williamson, R., Little, J., Mech, B., Cimmarusti, V., Van Boemel, G., Dagnelie, G., et al. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00457-7 · Cited by 856
Will Retinal Implants Restore Vision?
Zrenner, E. (2002) · Science · doi:10.1126/science.1067996 · Cited by 736
A very low-power CMOS mixed-signal IC for implantable pacemaker applications
Wong, L. S. Y., Hossain, S., Ta, A., Edvinsson, J., Rivas, D. H., & Naas, H. (2004) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2004.837027 · Cited by 395
Stimulus waveforms for selective neural stimulation
Grill, W. M., & Mortimer, J. T. (1995) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/51.395310 · Cited by 291
An Integrated 256-Channel Epiretinal Prosthesis
Chen, K., Yang, Z., Hoang, L., Weiland, J. D., Humayun, M. S., & Liu, W. (2010) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2010.2055371 · Cited by 266
A 232-Channel Epiretinal Stimulator ASIC
Ortmanns, M., Rocke, A., Gehrke, M., & Tiedtke, H. J. (2007) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2007.908693 · Cited by 225
Self-citationPerceptual thresholds and electrode impedance in three retinal prosthesis subjects
Mahadevappa, M., Weiland, J. D., Yanai, D., Fine, I., Greenberg, R. J., & Humayun, M. S. (2005) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2005.848687 · Cited by 187
Weiland, J. D., & Humayun, M. S. (2008) · Proceedings of the IEEE · doi:10.1109/jproc.2008.922589 · Cited by 179
An active approach for charge balancing in functional electrical stimulation.
Sooksood, K., Stieglitz, T., & Ortmanns, M. (2010) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2010.2040277 · Cited by 170
Self-citationAzin, M., Guggenmos, D. J., Barbay, S., Nudo, R. J., & Mohseni, P. (2011) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2011.2108770 · Cited by 168
Non-rectangular waveforms for neural stimulation with practical electrodes
Sahin, M., & Tie, Y. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/3/008 · Cited by 157
Development and Implantation of a Minimally Invasive Wireless Subretinal Neurostimulator
Shire, D. B., Kelly, S. K., Chen, J., Doyle, P., Gingerich, M. D., Cogan, S. F., Drohan, W. A., Mendoza, O., Theogarajan, L. S., Wyatt, J. L., et al. (2009) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2009.2021401 · Cited by 156
Sivaprakasam, M., Liu, W., Humayun, M. S., & Weiland, J. D. (2005) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2005.843630 · Cited by 155
A Modular 32-site wireless neural stimulation microsystem
Ghovanloo, M., & Najafi, K. (2004) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2004.837026 · Cited by 149
Ghovanloo, M., & Najafi, K. (2005) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2004.839797 · Cited by 137
A Highly Flexible System for Microstimulation of the Visual Cortex: Design and Implementation
Coulombe, J., Sawan, M., & Gervais, J.-F. (2007) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2007.916026 · Cited by 129
Asymmetric Pulses in Cochlear Implants: Effects of Pulse Shape, Polarity, and Rate
Macherey, O., Wieringen, A. V., Carlyon, R. P., Deeks, J. M., & Wouters, J. M. (2006) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-006-0040-0 · Cited by 123
A CMOS Chip With Active Pixel Array and Specific Test Features for Subretinal Implantation
Rothermel, A., Liu, L., Aryan, N. P., Fischer, M. D., Wuenschmann, J., Kibbel, S., & Harscher, A. (2009) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2008.2007436 · Cited by 109
Liu, W., & Hurnayun, M. S. (2004) · Digest of technical papers/Digest of technical papers - IEEE International Solid-State Circuits Conference · doi:10.1109/isscc.2004.1332672 · Cited by 97
A Wireless Integrated Circuit for 100-Channel Charge-Balanced Neural Stimulation
Thurgood, B., Warren, D. J., Ledbetter, N. M., Clark, G. A., & Harrison, R. R. (2009) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2009.2032268 · Cited by 93
Evoked cortical potentials after electrical stimulation of the inner retina in rabbits
Walter, P., & Heimann, K. (2000) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s004170050358 · Cited by 80
Retinal Neurostimulator for a Multifocal Vision Prosthesis
Wong, Y. T., Dommel, N., Preston, P., Hallum, L. E., Lehmann, T., Lovell, N. H., & Suaning, G. J. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.903958 · Cited by 79
Implantable selective stimulator to improve bladder voiding: design and chronic experiments in dogs
Boyer, S., Sawan, M., Abdel-Gawad, M., Robin, S., & ELHILALI, M. M. (2000) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.895949 · Cited by 77
Electronic design of a multichannel programmable implant for neuromuscular electrical stimulation
Arabi, K., & Sawan, M. (1999) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.769411 · Cited by 75
Architecture tradeoffs in high-density microstimulators for retinal prosthesis
Sivaprakasam, M., Liu, W., Wang, G., Weiland, J. D., & Humayun, M. S. (2005) · IEEE Transactions on Circuits and Systems I Fundamental Theory and Applications · doi:10.1109/tcsi.2005.857554 · Cited by 74
Kuncel, A. M., Cooper, S. E., Wolgamuth, B. R., & Grill, W. M. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.897004 · Cited by 73
High Dynamic Range CMOS Imager Technologies for Biomedical Applications
Graf, H., Harendt, C., Engelhardt, T., Scherjon, C., Warkentin, K., Richter, H. H., & Burghartz, J. N. (2009) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2008.2007437 · Cited by 55
Variable Patterned Pudendal Nerve Stimuli Improves Reflex Bladder Activation
Bruns, T. M., Bhadra, N., & Gustafson, K. J. (2008) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.914460 · Cited by 34
Enhancement of current driving capability in data driver ICs for plasma display panels
Choi, B. (2009) · IEEE Transactions on Consumer Electronics · doi:10.1109/tce.2009.5278054 · Cited by 27
A flexible high voltage biphasic current-controlled stimulator
Nadeau, P., & Sawan, M. (2006) · IEEE Biomedical Circuits and Systems Conference (BioCAS) · doi:10.1109/biocas.2006.4600344 · Cited by 26
Current Waveforms for Neural Stimulation-Charge Delivery With Reduced Maximum Electrode Voltage
Halpern, M. E., & Fallon, J. B. (2010) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2010.2053203 · Cited by 25
A completely programmable and very flexible implantable pain controller
Mouine, J., Ammar, K., & Chtourou, Z. (2002) · doi:10.1109/iembs.2000.897921 · Cited by 8
An architecture for a universal neural stimulator with almost arbitrary current waveform
Noorsal, E., & Ortmanns, M. (2010) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2010.5626293 · Cited by 4
Self-citationPower Efficient Multiple Voltage Stimulation for Implantable Retinal Prosthesis
Sivaprakasam, M., Liu, W., Weiland, J. D., & Humayun, M. S. (2005) · International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology (MMB) · doi:10.1109/mmb.2005.1548396 · Cited by 3
Flagged first, then by citations
Research works printed but not linked: 2
- sooksood, 2011, A neural stimulator front-end with arbitrary pulse shape, HV compliance and adaptive supply requiring 0.05 <ref_formula> <tex Notation="TeX">${\hbox{mm}}^{2}$</tex></ref_formula> in 0.35 <ref_formula> <tex Notation="TeX">$\mu\hbox{m}$</tex></ref_formula> HVCMOS, 2011 IEEE ISSCC Dig Tech Papers, 306
- lange, 2011, An ac-powered optical receiver consuming 270 <ref_formula><tex Notation="TeX">$\mu\hbox{W}$</tex> </ref_formula> for transcutaneous 2 Mb/s data transfer, 2011 IEEE ISSCC Dig Tech Papers, 304
Cited by
Sorted by citations
An artificial neural tactile sensing system
Chun, S., Kim, J.-S., Yoo, Y., Choi, Y. I., Jung, S. J., Jang, D., Lee, G., Song, K., Nam, K. S., Youn, I., et al. (2021) · Nature Electronics · doi:10.1038/s41928-021-00585-x · Cited by 439
A Power-Efficient Wireless System With Adaptive Supply Control for Deep Brain Stimulation
Lee, H., Park, H., & Ghovanloo, M. (2013) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2013.2266862 · Cited by 231
“The 5-bit current sources with binary-weighted transistors are placed at the output stage directly to reduce the stimulator power loss compared to using current mirrors after a 5-bit current DAC in [20].”
BackgroundMethodToward true closed-loop neuromodulation: artifact-free recording during stimulation.
Zhou, A., Johnson, B. C., & Muller, R. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.01.012 · Cited by 125
“Some systems monitor VOFFSET at the electrode from accumulated charge and calibrate the second phase current to minimize this offset [16].”
Shin, U., Ding, C., Zhu, B., Vyza, Y., Trouillet, A., Revol, E. C. M., Lacour, S. P., & Shoaran, M. (2022) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2022.3204508 · Cited by 124
“681 To ensure precise CB, an offset-regulation active CB tech- 682 nique combined with passive discharging is employed [67].”
MethodA Complete 256-Electrode Retinal Prosthesis Chip
Tran, N., Bai, S., Yang, J., Chun, H., Kavehei, O., Yang, Y., Muktamath, V., Ng, D., Meffin, H., Halpern, M., et al. (2014) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2014.2298037 · Cited by 90
“A compliance monitoring mechanism has been reported [40], where the supply voltage is adaptively changed due to out-of-compliance.”
Background
Metadata
- Authors
- Noorsal, E., Sooksood, K., Xu, H., Hornig, R., Becker, J., & Ortmanns, M.
- Affiliations
- Universität Ulm (DE)
- Bundesnetzagentur (DE)
- Venue
- IEEE Journal of Solid-State Circuits
- Published
- 2012-01
- Volume
- 47
- Issue
- 1
- Pages
- 244-256
- ISSN
- 0018-9200 (ISSN-L)
- 1558-173X
- OpenAlex
- W1971046436
- Cited by
- 212
- References
- 36
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 17 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 13 · 2016: 23 · 2015: 18 · 2014: 18 · 2013: 21 · 2012: 10
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Journal of Solid-State Circuits (publishedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
- Keywords
- epiretinal implants, voltage compliance, clock gating, power efficiency, retinal prosthesis, platinum black electrodes
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