NeuroBus - Architecture for an Ultra-Flexible Neural Interface
Open accessAbstract
This article presents the system architecture for an implant concept called NeuroBus. Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344 μm × 294 μm) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility. We introduce the architecture, the integrated building blocks, and the post-CMOS processes required to realize a NeuroBus, and we characterize the prototyped direct digitizing neural recorder front-end as well as polyimide-based ECoG brain interface. A rodent animal model is further used to validate the joint capability of the recording front-end and thin-film electrode array.
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Implementation of a remote wireless hub with tethered contacts to electrode sites helps overcome safety limitations of wireless powering and communication due to tissue heating and enables easy access to deeper tissue regions, while active, in-situ control of high-density electrodes enables use of fewer wires that improves interconnect reliability.
“The implementation of a remote wireless hub with tethered contacts to the electrode sites helps overcome the safety limitations of wireless powering and communication due to tissue heating and enables easy access to deeper tissue regions, while the active, in-situ control of high-density electrodes enables the use of fewer wires that improves interconnect reliability [76].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [76]
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“…sites helps overcome the safety limitations of wireless powering and communication due to tissue heating and enables easy access to deeper tissue regions, while the active, in-situ control of high-density electrodes enables the use of fewer wires that improves interconnect reliability [76].”
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- Authors
- Sporer, M., Vasilaş, I.-G., Adžemović, A., Graber, N., Reich, S., Gueli, C., Eickenscheidt, M., Diester, I., Stieglitz, T., & Ortmanns, M.
- Affiliations
- Universität Ulm (DE)
- BrainLinks-BrainTools//IMBIT, Freiburg, Germany
- University of Freiburg (DE)
- ORCID
- Venue
- IEEE Transactions on Biomedical Circuits and Systems
- Published
- 2024-04
- Volume
- 18
- Issue
- 2
- Pages
- 247-262
- ISSN
- 1932-4545 (ISSN-L)
- 1940-9990
- OpenAlex
- W4390908050
- Cited by
- 13
- References
- 71
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- IEEE Transactions on Biomedical Circuits and Systems (publishedVersion, cc-by)
- PubMed (publishedVersion)
- OPen Access Repositorium der Universität Ulm (OPARU) (Ulm University) (submittedVersion, cc-by)
- Funders
- German National Science Foundation (OR 245/15-1, EI 1078/1-1)
- European School of Network Neuroscience
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
- Keywords
- neural interfaces, implantable neural recording, ASIC, thin film electrodes, electrocorticography, biocompatibility, rodent models
- MeSH terms
- Electrocorticography, Animals, Brain, Electrodes, Head
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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