A 0.013 ${\hbox {mm}}^{2}$, 5 $\mu\hbox{W}$, DC-Coupled Neural Signal Acquisition IC With 0.5 V Supply

Muller, Rikky; Gambini, Simone; Rabaey, Jan M.

doi:10.1109/jssc.2011.2163552

Cited by 338Analog and Mixed-Signal Circuit DesignRadio Frequency Integrated Circuit DesignNeuroscience and Neural Engineering

A 0.013 ${\hbox {mm}}^{2}$, 5 $\mu\hbox{W}$, DC-Coupled Neural Signal Acquisition IC With 0.5 V Supply

Muller, Rikky, Gambini, Simone, Rabaey, Jan M.·2012·IEEE Journal of Solid-State Circuits

DOI 10.1109/jssc.2011.2163552

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Abstract

We present an area-efficient neural signal-acquisition system that uses a digitally intensive architecture to reduce system area and enable operation from a 0.5 V supply. The architecture replaces ac coupling capacitors and analog filters with a dual mixed-signal servo loop, which allows simultaneous digitization of the action and local field potentials. A noise-efficient DAC topology and an compact, boxcar sampling ADC are used to cancel input offset and prevent noise folding while enabling “per-pixel” digitization, alleviating system-level complexity. Implemented in a 65 nm CMOS process, the prototype occupies 0.013 mm2while consuming 5 μW and achieving 4.9 μVrms of input-referred noise in a 10 kHz bandwidth.

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Modern circuit designs and IC fabrication technologies have produced innovative designs that allow designers to relax the size-functionality compromises.
“However, modern circuit designs [77, 92] and IC fabrication technologies [18, 86] have resulted in innovative designs, enabling designers to relax such compromises.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]
Neural amplifier ICs have been created that capture both action potentials and local field potentials, with separate filtering, amplification and output for each signal type.
“CNS amplifiers have also been developed that can acquire both types of signals, separately filtering, amplifying and outputting each signal type [46, 86, 100].”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]
Muller et al. introduced the power efficiency factor, which accounts for both operating current and supply voltage and therefore provides a better comparison of amplifier performance.
“Recently, Muller et al. [86] introduced the power efficiency factor (PEF), which takes into account both the operating current and the supply voltage and therefore provides a better comparison of the amplifier’s performance.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [86]

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Authors: Muller, R., Gambini, S., & Rabaey, J. M.
Affiliations: University of California, Berkeley (US)
ORCID: Muller, Rikky
Rabaey, Jan M.
Venue: IEEE Journal of Solid-State Circuits
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Published: 2012-01
Volume: 47
Issue: 1
Pages: 232-243
ISSN: 0018-9200 (ISSN-L)
1558-173X
DOI: 10.1109/jssc.2011.2163552
OpenAlex: W2003444784
Cited by: 338
References: 27
Citations by year: 2026: 11 · 2025: 23 · 2024: 18 · 2023: 21 · 2022: 22 · 2021: 26 · 2020: 26 · 2019: 25 · 2018: 34 · 2017: 28 · 2016: 25 · 2015: 26 · 2014: 26 · 2013: 20 · 2012: 7
FWCI: 10.04
Type: journal article
Language: en
Open access: closed
Licence: ieeexplore.ieee.org/Xplorehelp/downloads/license-information/IEEE.html (vor)
Locations: IEEE Journal of Solid-State Circuits (publishedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: neural signal acquisition, low-power integrated circuits, local field potentials, digital-to-analog converter, noise folding, low-voltage operation, 65 nm CMOS, area-efficient circuit design

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A 0.013 ${\hbox {mm}}^{2}$, 5 $\mu\hbox{W}$, DC-Coupled Neural Signal Acquisition IC With 0.5 V Supply

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