A Fully Integrated Stimulator With High Stimulation Voltage Compliance Using Dynamic Bulk Biasing Technique in a Bulk CMOS Technology
Abstract
This paper presents a fully integrated stimulator using a dynamic bulk biasing technique and a dynamic control scheme in a 180-nm bulk CMOS technology. Unlike the conventional bulk biasing method, the bulk bias voltage is dynamically set according to the different stimulation phases. It avoids the underlying leakage current paths, and improves the maximum stimulation voltage compliance (MSVC). Together with dynamic bulk biasing scheme, a high voltage interface is designed to overcome the limitation of the breakdown voltage of the substrate diode ( V$_{\mathbf{BD}}$) between the high and low voltage domains. An all-NMOS dynamic charge pump is also proposed as a dynamic power supply above V$_{\mathbf{BD}}$and provides dynamic bulk-biasing voltages. Fabricated in a 180-nm standard CMOS technology, the stimulator achieves an MSVC of$\pm$16.5 V under a 3.3-V supply, and the achieved MSVC is$\sim$1.11 times higher than the V$_{\mathbf{BD}}$($\sim$14.8 V) of the substrate diode. The stimulator is also measured in a continuous output test mode for over 10 million cycles, the variation of$\vert$MSVC$\vert$is less than 200 mV.
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Dynamic bulk biasing techniques have been studied to enable a higher stimulator compliance voltage that is not limited by the diode breakdown level with the aid of charge pumps.
“In addition to the implementation of thick-oxide devices to achieve a fully isolated active output [140], [150], dynamic bulk biasing techniques have been studied to enable a higher stimulator compliance voltage [151] that is not limited by the diode breakdown level with the aid of charge pumps [152].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [151]
Cites
Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation
Fasano, A. A., Daniele, A., & Albanese, A. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70049-2 · Cited by 436 · see citing works
Introduction to the programming of deep brain stimulators
Volkmann, J., Herzog, J., Kopper, F., & Deuschl, G. (2002) · Movement Disorders · doi:10.1002/mds.10162 · Cited by 372 · see citing works
Deep brain stimulation for essential tremor: a systematic review
Flora, E. D., Perera, C. L., Cameron, A. L., & Maddern, G. J. (2010) · Movement Disorders · doi:10.1002/mds.23195 · Cited by 323 · see citing works
Responsive Cortical Stimulation for the Treatment of Epilepsy
Sun, F. T., Morrell, M. J., & Wharen, R. E. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2007.10.069 · Cited by 310 · see citing works
A mm-Sized Wireless Implantable Device for Electrical Stimulation of Peripheral Nerves
Charthad, J., Chang, T. C., Liu, Z., Sawaby, A., Weber, M. J., Baker, S., Gore, F., Felt, S. A., & Arbabian, A. (2018) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2018.2799623 · Cited by 230 · see citing works
Sivaprakasam, M., Liu, W., Humayun, M. S., & Weiland, J. D. (2005) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2005.843630 · Cited by 155 · see citing works
Sit, J.-J., & Sarpeshkar, R. (2007) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2007.911631 · Cited by 155 · see citing works
Cheng, C.-H., Tsai, P.-Y., Yang, T.-Y., Cheng, W.-H., Yen, T.-Y., Luo, Z., Qian, X.-H., Chen, Z., Lin, T., Chen, W., et al. (2018) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2018.2867293 · Cited by 143 · see citing works
Weber, M. J., Yoshihara, Y., Sawaby, A., Charthad, J., Chang, T. C., & Arbabian, A. (2018) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2017.2782086 · Cited by 135 · see citing works
Jiménez-Ponce, F., Velasco‐Campos, F., Castro-Farfán, G., Nicolini, H., Velasco, A. L., Salín-Pascual, R. J., Trejo, D., & Criales, J. L. (2009) · Operative Neurosurgery · doi:10.1227/01.neu.0000345938.39199.90 · Cited by 131 · see citing works
Shin, U., Ding, C., Zhu, B., Vyza, Y., Trouillet, A., Revol, E. C. M., Lacour, S. P., & Shoaran, M. (2022) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2022.3204508 · Cited by 124 · see citing works
A Fully Intraocular High-Density Self-Calibrating Epiretinal Prosthesis
Monge, M., Raj, M., Nazari, M. H., Chang, H.-C., Zhao, Y., Weiland, J. D., Humayun, M. S., Tai, Y.-C., & Emami, A. (2013) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2014.2298334 · Cited by 85 · see citing works
A High-Voltage-Tolerant and Precise Charge-Balanced Neuro-Stimulator in Low Voltage CMOS Process
Luo, Z., & Ker, M. (2016) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2015.2512443 · Cited by 84 · see citing works
Uehlin, J. P., Smith, W. A., Pamula, V. R., Pepin, E. P., Perlmutter, S., Sathe, V., & Rudell, J. C. (2020) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2020.2991524 · Cited by 81 · see citing works
A Fully Integrated Wireless SoC for Motor Function Recovery After Spinal Cord Injury
Lo, Y., Kuan, Y., Culaclii, S., Kim, B., Wang, P., Chang, C.-W., Massachi, J., Zhu, M., Chen, K., Gad, P. N., et al. (2017) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2017.2679441 · Cited by 78 · see citing works
Pu, H., Malekzadeh-Arasteh, O., Danesh, A. R., Nenadić, Z., Do, A. H., & Heydari, P. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2021.3108578 · Cited by 72 · see citing works
Butz, N., Taschwer, A., Nessler, S., Manoli, Y., & Kuhl, M. (2018) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2018.2828823 · Cited by 70 · see citing works
Deep Brain Stimulation for Psychiatric Disorders
Holtzheimer, P., & Mayberg, H. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113638 · Cited by 65 · see citing works
A Portable Wireless Online Closed-Loop Seizure Controller in Freely Moving Rats
Young, C.-P., Liang, S., Chang, D.-W., Liao, Y.-C., Shaw, F., & Hsieh, C.-H. (2010) · IEEE Transactions on Instrumentation and Measurement · doi:10.1109/tim.2010.2050358 · Cited by 64 · see citing works
22.2 A 176-channel 0.5cm3 0.7g wireless implant for motor function recovery after spinal cord injury
Lo, Y., Chang, C.-W., Kuan, Y., Culaclii, S., Kim, B., Chen, K., Gad, P. N., Edgerton, V. R., & Liu, W. (2016) · Digest of technical papers/Digest of technical papers - IEEE International Solid-State Circuits Conference · doi:10.1109/isscc.2016.7418067 · Cited by 50 · see citing works
Luo, Z., Ker, M., Yang, T.-Y., & Cheng, W.-H. (2017) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2017.2713122 · Cited by 50 · see citing works
An Embedded Deep Brain Stimulator for Biphasic Chronic Experiments in Freely Moving Rodents
Kölbl, F., N’Kaoua, G., Naudet, F., Berthier, F., Faggiani, E., Renaud, S., Benazzouz, A., & Lewis, N. (2014) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2014.2368788 · Cited by 48 · see citing works
Hsieh, C., & Ker, M. (2021) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2021.3087036 · Cited by 46 · see citing works
Wang, S.-H., Huang, Y.-K., Chen, C.-Y., Tang, L.-Y., Tu, Y.-F., Chang, P.-C., Lee, C.-F., Yang, C., Hung, C.-C., Liu, C., et al. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2021.3087629 · Cited by 46 · see citing works
Implantable Stimulator for Epileptic Seizure Suppression With Loading Impedance Adaptability
Lin, C., Chen, W., & Ker, M. (2012) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2012.2200481 · Cited by 44 · see citing works
A 36-V 49% Efficient Hybrid Charge Pump in Nanometer-Scale Bulk CMOS Technology
Ismail, Y., Lee, H., Pamarti, S., & Yang, C.-K. K. (2017) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2016.2636876 · Cited by 42 · see citing works
A High-Voltage Compliance, 32-Channel Digitally Interfaced Neuromodulation System on Chip
Reich, S., Sporer, M., Haas, M., Becker, J., Schüettler, M., & Ortmanns, M. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2021.3076510 · Cited by 41 · see citing works
Liu, X., Demosthenous, A., Vanhoestenberghe, A., Jiang, D., & Donaldson, N. (2012) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2011.2174360 · Cited by 39 · see citing works
A Fully Integrated RF-Powered Energy-Replenishing Current-Controlled Stimulator
Ha, S., Kim, C., Park, J., Cauwenberghs, G., & Mercier, P. P. (2019) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2018.2881800 · Cited by 35 · see citing works
An HV-CMOS Integrated Circuit for Neural Stimulation in Prosthetic Applications
Bisoni, L., Carboni, C., Raffo, L., Carta, N., & Barbaro, M. (2015) · IEEE Transactions on Circuits & Systems II Express Briefs · doi:10.1109/tcsii.2014.2387679 · Cited by 32 · see citing works
Retinal Stimulator ASIC Architecture Based on a Joint Power and Data Optical Link
Lemaire, W., Benhouria, M., Koua, K., Besrour, M., Gauthier, L.-P., Martin-Hardy, G., Rossignol, T., Roy, S., & Fontaine, R. (2021) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2020.3045141 · Cited by 32 · see citing works
John, S. E., Shivdasani, M. N., Williams, C. E., Morley, J. W., Shepherd, R. K., Rathbone, G. D., & Fallon, J. B. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056011 · Cited by 29 · see citing works
An Integrated Stimulator With DC-Isolation and Fine Current Control for Implanted Nerve Tripoles
Liu, X., Demosthenous, A., & Donaldson, N. (2011) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2011.2144310 · Cited by 21 · see citing works
Active Charge Balancer With Adaptive 3.3 V to 38 V Supply Compliance for Neural Stimulators
Butz, N., Kalita, U., & Manoli, Y. (2021) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2021.3101550 · Cited by 21 · see citing works
Design of Dual-Configuration Dual-Mode Stimulator in Low-Voltage CMOS Process for Neuro-Modulation
Hsieh, C., Wu, Y.-H., & Ker, M. (2023) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2023.3246164 · Cited by 18 · see citing works
Stimulus driver for epilepsy seizure suppression with adaptive loading impedance
Ker, M., Lin, C., & Chen, W.-L. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/6/066008 · Cited by 16 · see citing works
Zhou, Y., Ma, S., Wang, Z., Zhang, H. C., & Wang, K. (2022) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2022.3156272 · Cited by 16 · see citing works
Self-citationJeon, Y., Yao, L., Gao, Y., & Arasu, M. A. (2019) · IEEE Transactions on Circuits and Systems I Regular Papers · doi:10.1109/tcsi.2019.2919333 · Cited by 11 · see citing works
Lohse, A., von Platen, P., Benner, C.-F., Leonhardt, S. K., Walter, M., Deininger, M. M., Ziles, D., Seemann, T., & Breuer, T. (2022) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc48229.2022.9871563 · Cited by 8 · see citing works
A high-voltage compliant neural stimulator with HF wireless power and UHF backscatter communication
Ranganathan, V. N., Mahoney, B. J., Pepin, E., Sunshine, M. D., Moritz, C. T., Rudell, J. C., & Smith, J. R. (2016) · IEEE Wireless Power Transfer Conference · doi:10.1109/wpt.2016.7498826 · Cited by 5 · see citing works
High-Density Implantable Microelectrode Arrays for Brain-Machine Interface Applications
Ghane-Motlagh, B., & Sawan, M. (2014) · Advances in science and technology · doi:10.4028/www.scientific.net/ast.96.95 · Cited by 4 · see citing works
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- Authors
- Zhou, Y., Wang, K., Yin, S., Li, W.-Y., Meng, F., Wang, Z.-G., & Ma, K.
- Affiliations
- Southeast University (CN)
- Tianjin University (CN)
- Institute of RF- and OE-ICs, Southeast University, Nanjing, China
- Venue
- IEEE Transactions on Circuits and Systems I: Regular Papers
- Published
- 2024-06
- Volume
- 71
- Issue
- 6
- Pages
- 2525-2537
- ISSN
- 1549-8328 (ISSN-L)
- 1558-0806
- OpenAlex
- W4393139857
- Cited by
- 12
- References
- 41
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- IEEE Transactions on Circuits and Systems I Regular Papers (publishedVersion)
- Funders
- National Natural Science Funds of China (62371332, 61774035)
- Natural Science Foundation of Jiangsu Province (BK20191260)
- Tianjin University and the Agilic Joint Laboratory
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Radio Frequency Integrated Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Low-power high-performance VLSI design
- Keywords
- bulk CMOS, leakage current
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