One-year calorie restriction impacts gut microbial composition but not its metabolic performance in obese adolescents
Open accessAbstract
Recent evidence has disclosed a connection between gut microbial glycosidase activity and adiposity in obese. Here, we measured microbial α-glucosidase and β-galactosidase activities and sorted fluorescently labeled β-galactosidase containing (βGAL) microorganisms in faecal samples of eight lean and thirteen obese adolescents that followed a controlled calorie restriction program during one year. β-galactosidase is a highly distributed functional trait, mainly expressed by members of Blautia, Bacteroides, Alcaligenes, Acinetobacter and Propionibacterium. Only long-term calorie restriction induced clear changes in the microbiota of obese adolescents. Long-term calorie restriction induced significant shifts in total and βGAL gut microbiota, reducing the Firmicutes:Bacteroidetes ratio and enhancing the growth of beneficial microorganisms such as Bacteroides, Roseburia, Faecalibacterium and Clostridium XIVa. Moreover, the structure and composition of βGAL community in obese after long-term calorie restriction was highly similar to that of lean adolescents. However, despite this high compositional similarity, microbial metabolic performance was different, split in two metabolic states at a body mass index value of 25. Our study shows that calorie restriction is a strong environmental force reshaping gut microbiota though its metabolic performance is linked to host's adiposity, suggesting that functional redundancy and metabolic plasticity are fundamental properties of gut microbial ecosystem.
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Caloric restriction also results in increased relative abundance of Proteobacteria and increased Bacteroidetes to Firmicutes ratio, raising the possibility that decreased oral intake during influenza may contribute to changes in the microbiome.
“caloric restriction also results in increased relative abundance of Proteobacteria and increased Bacteroidetes to Firmicutes ratio, raising the possibility that decreased oral intake during influenza may contribute to changes in the microbiome”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [50]
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- Authors
- Ruiz, A., Cerdó, T., Jáuregui, R., Pieper, D. H., Marcos, A., Clemente, A., García, F., Margolles, A., Ferrer, M., Campoy, C., & Suárez, A.
- Affiliations
- Department of Biochemistry and Molecular Biology 2, Biomedical Research Centre University of Granada Spain
- Universidad de Granada (ES)
- AgResearch (NZ)
- Helmholtz Centre for Infection Research (DE)
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ES)
- Estación Experimental del Zaidín (ES)
- Department of Microbiology Complejo Hospitalario Universitario de Granada, Instituto de Investigación Biosanitaria (IBS) Granada Spain
- IPLA‐CSIC, Department of Microbiology and Biochemistry of Dairy Products Dairy Research Institute Villaviciosa Spain
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Suárez, Antonio
- ORCID
- Venue
- Environmental Microbiology
- Publisher
- Wiley
- Published
- 2017-04
- Volume
- 19
- Issue
- 4
- Pages
- 1536-1551
- ISSN
- 1462-2912 (ISSN-L)
- 1462-2920
- OpenAlex
- W2594381494
- Cited by
- 85
- References
- 68
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 14 · 2022: 6 · 2021: 29 · 2020: 8 · 2019: 1 · 2018: 10 · 2017: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Environmental Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Instituto de Salud Carlos III (PI 051579, PI021513)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- caloric restriction, gut microbiota, obesity, adolescents, beta-galactosidase, alpha-glucosidase, Firmicutes/Bacteroidetes ratio, Bacteroides, Faecalibacterium, Clostridium XIVa, Roseburia, functional redundancy, metabolic plasticity, adiposity
- MeSH terms
- Gastrointestinal Microbiome, Adolescent, Bacteroides, Clostridium, Feces, Humans, Obesity, Caloric Restriction, Bacteroidetes
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