Instability of the faecal microbiota in diarrhoea-predominant irritable bowel syndrome
Open accessAbstract
The irritable bowel syndrome (IBS) is a functional gastrointestinal disorder with a largely unknown aetiology and a wide range of symptoms. Most cross-sectional studies carried out so far suggest subtle alterations in the structure of the intestinal microbiota that are barely reproduced, partly because of the high inter-subject variation in the community composition and disorder-specific features. We performed a longitudinal study to explore the within-subject variation in the faecal microbiota in two patients with IBS classified into the diarrhoea subtype and the healthy spouse of one of them. Faecal communities were monitored over 6-8 weeks and analysed through metagenomic and metatranscriptomic approaches. We found a higher temporal instability in the fraction of active microbiota related to the IBS condition and fluctuating symptoms. Strong and quick shifts in the distribution of the active microbiota and changes in the global pattern of gene expression were detected in association with acute diarrhoea, whereas microbial composition and encoded functions were more stable. The specific alterations in the microbiota were barely reproduced within and between patients. Further research is needed to assess whether these changes are a consequence of the abnormal gut function in acute diarrhoeic episodes and the potential usefulness of tackling them.
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The colonic microbiome is altered in patients with IBS compared with healthy controls.
“others have shown that the colonic microbiome is altered in patients with IBS, when compared with healthy controls. 15 - 18”
From Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis (2023) · cites this paper as [15]
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- Authors
- Durbán, A., Abellán, J. J., Jiménez-Hernández, N., Artacho, A., Garrigues, V., Ortiz, V., Ponce, J., Latorre, A., & Moya, A.
- Affiliations
- Universitat de València (ES)
- Joint Research Unit on Genomics and Health Centro Superior de Investigación en Salud Pública (CSISP) - Instituto Cavanilles de Biodiversidad y Biología Evolutiva (ICBiBE); Universitat de València; València Spain
- Hospital Universitari i Politècnic La Fe (ES)
- Venue
- FEMS Microbiology Ecology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-23
- Volume
- 86
- Issue
- 3
- Pages
- 581-589
- ISSN
- 0168-6496 (ISSN-L)
- OpenAlex
- W2032102844
- Cited by
- 83
- References
- 35
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 6 · 2015: 9 · 2014: 8
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Microbiology Ecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat Valenciana (Prometeo/2009/092)
- Instituto de Salud Carlos III
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- diarrhea-predominant irritable bowel syndrome, fecal microbiota, within-person variability, acute diarrhea, metatranscriptomics, metagenomics, interindividual variability, functional gastrointestinal disorders
- MeSH terms
- Aged, Bacteria, Colon, Diarrhea, Feces, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Irritable Bowel Syndrome, Young Adult, Microbiota
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