Oxytocin receptor-deficient mice developed late-onset obesity
Abstract
The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis.
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Oxytocin and oxytocin receptor knockout mice develop late-onset obesity in the absence of hyperphagia.
“These mice develop late-onset obesity in the absence of hyperphagia (65, 66).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [65]
Oxytocin promotes energy expenditure.
“These studies suggest that oxytocin promotes energy expenditure.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]
Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake.
“Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake(6, 32).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]
Oxytocin has been implicated in the regulation of energy metabolism.
“In addition to its role in food intake, oxytocin has been implicated in the regulation of energy metabolism.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]
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- Authors
- Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K.
- Affiliations
- Jichi Medical University (JP)
- Tohoku University (JP)
- Kyoto University (JP)
- Corresponding author
- Takayanagi, Yuki
- Kasahara, Yoshiyuki
- ORCID
- Venue
- Neuroreport
- Published
- 2008-06-11
- Volume
- 19
- Issue
- 9
- Pages
- 951-955
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2023780399
- Cited by
- 294
- References
- 25
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 22 · 2023: 18 · 2022: 12 · 2021: 22 · 2020: 17 · 2019: 19 · 2018: 20 · 2017: 20 · 2016: 20 · 2015: 25 · 2014: 20 · 2013: 12 · 2012: 10
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jichi Medical University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oxytocin receptor, late-onset obesity, energy homeostasis, brown adipose tissue, cold-induced thermogenesis, lipid droplets, fasting plasma triglycerides, abdominal fat, dietary intake, spontaneous motor activity
- MeSH terms
- Age Factors, Animals, Blood Glucose, Cholesterol, Eating, Male, Mice, Inbred C57BL, Motor Activity, Obesity, Thermosensing, Triglycerides, Receptors, Oxytocin, Mice, Knockout, Mice, Adipocytes, Brown
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