Cited by 294Regulation of Appetite and ObesityNeuroendocrine regulation and behaviorAdipokines, Inflammation, and Metabolic Diseases

Oxytocin receptor-deficient mice developed late-onset obesity

Takayanagi, Yuki, Kasahara, Yoshiyuki, Onaka, Tatsushi, Takahashi, Nobuyuki, Kawada, Teruo, Nishimori, Katsuhiko·2008·Neuroreport

Abstract

The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid droplets and cold-induced thermogenesis was impaired. This study demonstrates that oxytocin receptor plays essential roles in the regulation of energy homeostasis.

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Crossref · 10.1097/wnr.0b013e3283021ca9

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Oxytocin and oxytocin receptor knockout mice develop late-onset obesity in the absence of hyperphagia.

    “These mice develop late-onset obesity in the absence of hyperphagia (65, 66).”
  • Oxytocin promotes energy expenditure.

    “These studies suggest that oxytocin promotes energy expenditure.”

    From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]

  • Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake.

    “Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake(6, 32).”

    From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]

  • Oxytocin has been implicated in the regulation of energy metabolism.

    “In addition to its role in food intake, oxytocin has been implicated in the regulation of energy metabolism.”

    From Oxytocin reduces caloric intake in men (2015) · cites this paper as [32]

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Authors
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K.
Affiliations
  • Jichi Medical University (JP)
  • Tohoku University (JP)
  • Kyoto University (JP)
Corresponding author
  • Takayanagi, Yuki
  • Kasahara, Yoshiyuki
Venue
Neuroreport
Published
2008-06-11
Volume
19
Issue
9
Pages
951-955
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2023780399
Cited by
294
References
25
Citations by year
2026: 10 · 2025: 13 · 2024: 22 · 2023: 18 · 2022: 12 · 2021: 22 · 2020: 17 · 2019: 19 · 2018: 20 · 2017: 20 · 2016: 20 · 2015: 25 · 2014: 20 · 2013: 12 · 2012: 10
FWCI
5.01
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Funders
Jichi Medical University
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
oxytocin receptor, late-onset obesity, energy homeostasis, brown adipose tissue, cold-induced thermogenesis, lipid droplets, fasting plasma triglycerides, abdominal fat, dietary intake, spontaneous motor activity
MeSH terms
Age Factors, Animals, Blood Glucose, Cholesterol, Eating, Male, Mice, Inbred C57BL, Motor Activity, Obesity, Thermosensing, Triglycerides, Receptors, Oxytocin, Mice, Knockout, Mice, Adipocytes, Brown

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