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Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Open accessAbstract
The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting of two transmembrane regions (TM1 and TM2), intracellular N‐ and C‐termini, and a bulky extracellular loop. Crystallization allowed the identification of the 3D structure and gating cycle of P2X receptors. The agonist‐binding pocket is located at the intersection of two neighbouring subunits. In addition to the mammalian P2X receptors, their primitive ligand‐gated counterparts with little structural similarity have also been cloned. Selective agonists for P2X receptor subtypes are not available, but medicinal chemistry supplied a range of subtype‐selective antagonists, as well as positive and negative allosteric modulators. Knockout mice and selective antagonists helped to identify pathological functions due to defective P2X receptors, such as male infertility (P2X1), hearing loss (P2X2), pain/cough (P2X3), neuropathic pain (P2X4), inflammatory bone loss (P2X5), and faulty immune reactions (P2X7).
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Citations
Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
A conditional knockout resource for the genome-wide study of mouse gene function
Skarnes, W. C., Rosen, B., West, A. P., Koutsourakis, M., Bushell, W., Iyer, V., Mujica, A. O., Thomas, M., Harrow, J., Cox, T., et al. (2011) · Nature · doi:10.1038/nature10163 · Cited by 1,708
Is there a basis for distinguishing two types of P2-purinoceptor?
Burnstock, G., & Kennedy, C. (1985) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(85)90001-1 · Cited by 1,365
Self-citationAbbracchio, M. P., Burnstock, G., Boeynaems, J.-M., Barnard, E. A., Boyer, J. L., Kennedy, C., Knight, G. E., Fumagalli, M., Gachet, C., Jacobson, K. A., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.3 · Cited by 1,281
Self-citationThe P2X7 Receptor in Infection and Inflammation
Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267
A P2X purinoceptor expressed by a subset of sensory neurons
Chen, C.-C., Akopian, A. N., Sivilottit, L., Colquhoun, D., Burnstock, G., & Wood, J. N. (1995) · Nature · doi:10.1038/377428a0 · Cited by 1,016
Lewis, C., Neidhart, S., Holy, C., North, R. A., Buell, G., & Surprenant, A. (1995) · Nature · doi:10.1038/377432a0 · Cited by 997
Altered Cytokine Production in Mice Lacking P2X7Receptors
Solle, M., Labasi, J., Perregaux, D. G., Stam, E., Petrushova, N., Koller, B. H., Griffiths, R. J., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 930
Collo, G., North, R., Kawashima, E., Merlo-Pich, E., Neidhart, S., Surprenant, A., & Buell, G. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02495.1996 · Cited by 876
ATP Signaling Is Crucial for Communication from Taste Buds to Gustatory Nerves
Finger, T. E., Danilova, V., Barrows, J., Bartel, D. L., Vigers, A. J., Stone, L., Hellekant, G., & Kinnamon, S. C. (2005) · Science · doi:10.1126/science.1118435 · Cited by 818
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
Burnstock, G., & Knight, G. E. (2004) · International Review of Cytology · doi:10.1016/s0074-7696(04)40002-3 · Cited by 795
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
Kawate, T., Michel, J. C., Birdsong, W. T., & Gouaux, E. (2009) · Nature · doi:10.1038/nature08198 · Cited by 738
Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Di Virgilio, F., Sarti, A. C., Falzoni, S., De Marchi, E., & Adinolfi, E. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0037-0 · Cited by 723
Self-citationTHE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14748 · Cited by 702
Khakh, B. S., Burnstock, G., Kennedy, C., King, B. F., North, R. A., Séguéla, P., Voigt, M., & Humphrey, P. P. A. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01482-0 · Cited by 667
Self-citationDo some nerve cells release more than one transmitter?
Burnstock, G. (1976) · Neuroscience · doi:10.1016/0306-4522(76)90054-3 · Cited by 639
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels
Alexander, S. P. H., Mathie, A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14749 · Cited by 606
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
Valenzuela, D. M., Murphy, A. J., Frendewey, D., Gale, N. W., Economides, A. N., Auerbach, W., Poueymirou, W. T., Adams, N. C., Rojas, J., Yasenchak, J., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt822 · Cited by 584
P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand-gated ion channels
Nicke, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3016 · Cited by 554
Self-citationMolecular mechanism of ATP binding and ion channel activation in P2X receptors
Hattori, M., & Gouaux, E. (2012) · Nature · doi:10.1038/nature11010 · Cited by 551
Jarvis, M. F., Burgard, E. C., McGaraughty, S., Honore, P., Lynch, K., Brennan, T. J., Subieta, A., van Biesen, T., Cartmell, J., Bianchi, B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252537299 · Cited by 470
Self-citationNeutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Karmakar, M., Katsnelson, M. A., Dubyak, G. R., & Pearlman, E. (2016) · Nature Communications · doi:10.1038/ncomms10555 · Cited by 450
Purinergic signalling: From normal behaviour to pathological brain function
Burnstock, G., Krügel, U., Abbracchio, M. P., & Illes, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.006 · Cited by 397
Self-citationThe P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease
Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 393
Cockayne, D. A., Dunn, P. M., Zhong, Y., Rong, W., Hamilton, S. G., Knight, G. E., Ruan, H., Ma, B., Yip, P., Nunn, P., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.088435 · Cited by 381
Expression of P2X7 Receptor Increases In Vivo Tumor Growth
Adinolfi, E., Raffaghello, L., Giuliani, A. L., Cavazzini, L., Capece, M., Chiozzi, P., Bianchi, G., Kroemer, G., Pistoia, V., & Di Virgilio, F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-1947 · Cited by 347
Self-citationNeuromodulation by Extracellular ATP and P2X Receptors in the CNS
Khakh, B. S., & North, R. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.024 · Cited by 341
Jarvis, M. F., & Khakh, B. S. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.067 · Cited by 326
Self-citationStructural basis for subtype-specific inhibition of the P2X7 receptor
Karasawa, A., & Kawate, T. (2016) · eLife · doi:10.7554/elife.22153 · Cited by 303
Contribution of Calcium Ions to P2X Channel Responses
Egan, T. M., & Khakh, B. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5429-03.2004 · Cited by 296
Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression
Sanz, J. M., Chiozzi, P., Ferrari, D., Colaianna, M., Idzko, M., Falzoni, S., Fellin, R., Trabace, L., & Di Virgilio, F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803612 · Cited by 293
Di Virgilio, F., Schmalzing, G., & Markwardt, F. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.01.005 · Cited by 279
Self-citationAllosteric Control of Gating and Kinetics at P2X4Receptor Channels
Khakh, B. S., Proctor, W. R., Dunwiddie, T. V., Labarca, C., & Lester, H. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07289.1999 · Cited by 279
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
Donnelly‐Roberts, D. L., Namovic, M. T., Han, P., & Jarvis, M. F. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00233.x · Cited by 271
Self-citationNorth, R. A., & Jarvis, M. F. (2013) · Molecular Pharmacology · doi:10.1124/mol.112.083758 · Cited by 270
Self-citationMedicinal chemistry of adenosine, P2Y and P2X receptors
Jacobson, K. A., & Müller, C. E. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.001 · Cited by 262
Self-citationX-ray structures define human P2X3 receptor gating cycle and antagonist action
Mansoor, S. E., Lü, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E., & Gouaux, E. (2016) · Nature · doi:10.1038/nature19367 · Cited by 258
The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells
Borges da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., et al. (2018) · Nature · doi:10.1038/s41586-018-0282-0 · Cited by 258
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
McCarthy, A. E., Yoshioka, C., & Mansoor, S. E. (2019) · Cell · doi:10.1016/j.cell.2019.09.017 · Cited by 257
Update of P2Y receptor pharmacology: IUPHAR Review 27
Jacobson, K. A., Delicado, E. G., Gachet, C., Kennedy, C., von Kügelgen, I., Li, B., Miras‐Portugal, M. T., Novak, I., Schöneberg, T., Perez‐Sen, R., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15005 · Cited by 239
Self-citationPurinergic signaling, DAMPs, and inflammation
Di Virgilio, F., Sarti, A. C., & Coutinho-Silva, R. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00053.2020 · Cited by 236
Self-citationSluyter, R. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2017_59 · Cited by 235
Smith, J. A., Kitt, M. M., Morice, A. H., Birring, S. S., McGarvey, L. P., Sher, M. R., Li, Y.-P., Wu, W.-C., Xu, Z. J., Muccino, D. R., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30471-0 · Cited by 234
Rong, W., Gourine, A. V., Cockayne, D. A., Xiang, Z., Ford, A. P. D. W., Spyer, K. M., & Burnstock, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11315.2003 · Cited by 224
Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224
Self-citationMolecular and functional properties of P2X receptors—recent progress and persisting challenges
Kaczmarek-Hájek, K., Lörinczi, É., Hausmann, R., & Nicke, A. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9314-7 · Cited by 223
Self-citationA Role of the Fast ATP-gated P2X1 Cation Channel in Thrombosis of Small Arteries In Vivo
Hechler, B., Lenain, N., Marchese, P., Vial, C., Heim, V., Freund, M., Cazenave, J.-P., Cattaneo, M., Ruggeri, Z. M., Evans, R., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030144 · Cited by 220
Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody
Kaczmarek-Hajek, K., Zhang, J., Kopp, R., Grosche, A., Rissiek, B., Saul, A., Bruzzone, S., Engel, T., Jooss, T., Krautloher, A., et al. (2018) · eLife · doi:10.7554/elife.36217 · Cited by 209
Self-citationSubunit Arrangement in P2X Receptors
Jiang, L.-H., Kim, M., Spelta, V., Bo, X., Surprenant, A., & North, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08903.2003 · Cited by 206
P2X receptor channels in chronic pain pathways
Bernier, L., Ase, A. R., & Séguéla, P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.13957 · Cited by 200
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14751 · Cited by 192
Mechanism of Ivermectin Facilitation of Human P2X4 Receptor Channels
Priel, A., & Silberberg, S. D. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200308986 · Cited by 183
Neuronal P2X7 Receptors Revisited: Do They Really Exist?
Illes, P., Khan, T. M., & Rubini, P. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3103-16.2017 · Cited by 179
Self-citationIn pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization
Ford, A. P. (2012) · Purinergic Signalling · doi:10.1007/s11302-011-9271-6 · Cited by 165
P2X Receptor Trafficking in Neurons Is Subunit Specific
Bobanovic, L. K., Royle, S. J., & Murrell-Lagnado, R. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04814.2002 · Cited by 164
Yan, D. L. S., Zhu, Y., Walsh, T., Xie, D., Yuan, H., Sırmacı, A., Fujikawa, T., Wong, A. C. Y., Loh, T. L., Du, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222285110 · Cited by 158
Karasawa, A., Michalski, K. R., Mikhelzon, P., & Kawate, T. (2017) · eLife · doi:10.7554/elife.31186 · Cited by 155
Mutini, C., Falzoni, S., Ferrari, D., Chiozzi, P., Morelli, A., Baricordi, O. R., Collo, G., Ricciardi‐Castagnoli, P., & Virgilio, F. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1958 · Cited by 151
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
Fountain, S. J., Parkinson, K., Young, M. T., Cao, L., Thompson, C. R. L., & North, R. A. (2007) · Nature · doi:10.1038/nature05926 · Cited by 151
Self-citationMorice, A. H., Kitt, M. M., Ford, A. P. D. W., Tershakovec, A. M., Wu, W., Brindle, K., Thompson, R., Thackray-Nocera, S., & Wright, C. (2019) · European Respiratory Journal · doi:10.1183/13993003.00439-2019 · Cited by 150
Molecular structure and function of P2X receptors
Habermacher, C., Dunning, K., Chataigneau, T., & Grütter, T. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.032 · Cited by 142
Pharmacological and Biophysical Properties of the Human P2X5 Receptor
Bo, X., Jiang, L., Wilson, H. L., Kim, M., Burnstock, G., Surprenant, A., & North, R. A. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1407 · Cited by 141
Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki‐Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M., et al. (2016) · Scientific Reports · doi:10.1038/srep32461 · Cited by 140
Trimeric Architecture of Homomeric P2X2 and Heteromeric P2X1+2 Receptor Subtypes
Aschrafi, A., Sadtler, S., Niculescu, C., Rettinger, J., & Schmalzing, G. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.06.092 · Cited by 126
Self-citationMembrane Topology of an ATP-gated Ion Channel (P2X Receptor)
Newbolt, A., Stoop, R., Virginio, C., Surprenant, A., North, R. A., Buell, G. N., & Rassendren, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15177 · Cited by 125
Gong, D., Zhang, J., Chen, Y., Xu, Y., Ma, J., Hu, G., Yi-ran, H., Zheng, J., Zhai, W., & Xue, W. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1223-y · Cited by 117
Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors
Nörenberg, W., Sobottka, H., Hempel, C., Plötz, T., Fischer, W., Schmalzing, G., & Schaefer, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01987.x · Cited by 116
Self-citationDruggable negative allosteric site of P2X3 receptors
Wang, J. Q., Wang, Y., Cui, W.-W., Huang, Y., Yang, Y., Liu, Y., Zhao, W., Cheng, X., Sun, W.-S., Cao, P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800907115 · Cited by 116
Perruzza, L., Gargari, G., Proietti, M., Fosso, B., D’Erchia, A. M., Faliti, C. E., Rezzonico-Jost, T., Scribano, D., Mauri, L., Colombo, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.061 · Cited by 114
Hernández‐Olmos, V., Abdelrahman, A., El‐Tayeb, A., Diana, F., Weinhausen, S., & Müller, C. E. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300845v · Cited by 111
Self-citationAstroglia-Derived ATP Modulates CNS Neuronal Circuits
Illés, P., Burnstock, G., & Tang, Y. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.09.006 · Cited by 110
Csölle, C., Andó, R. D., Kittel, Á., Gölöncsér, F., Baranyi, M., Soproni, K., Zelena, D., Haller, J., Németh, T., Mócsai, A., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001933 · Cited by 108 · cited 1×
“The beneficial effects of BBB-permeable P2X7 receptor antagonists in AD animal models also support the notion of pathological microglial activation in AD (Csölle et al., 2013).”
BackgroundStructural insights into the competitive inhibition of the ATP-gated P2X receptor channel
Kasuya, G., Yamaura, T., Ma, X., Nakamura, R., Takemoto, M., Nagumo, H., Tanaka, E., Dohmae, N., Nakane, T., Yu, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00887-9 · Cited by 102
Baroni, M., Pizzirani, C., Pinotti, M., Ferrari, D., Adinolfi, E., Calzavarini, S., Caruso, P., Bernardi, F., & Virgilio, F. D. (2007) · The FASEB Journal · doi:10.1096/fj.06-7238com · Cited by 101
BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration
Garceau, D., & Chauret, N. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.03.007 · Cited by 99
An evolutionary history of P2X receptors
Fountain, S. J., & Burnstock, G. (2008) · Purinergic Signalling · doi:10.1007/s11302-008-9127-x · Cited by 98
Self-citationATPergic signalling during seizures and epilepsy
Engel, T., Alves, M., Sheedy, C., & Henshall, D. C. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.001 · Cited by 97
The therapeutic promise of ATP antagonism at P2X3 receptors in respiratory and urological disorders
Ford, A. P., & Undem, B. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00267 · Cited by 95
Lê, K., Paquet, M., Nouel, D., Babinski, K., & Séguéla, P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01380-x · Cited by 95
Richards, D., Gever, J. R., Ford, A. P. D. W., & Fountain, S. J. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14677 · Cited by 94
Self-citationPhosphoinositides Regulate P2X4ATP-Gated Channels through Direct Interactions
Bernier, L., Ase, A. R., Chevallier, S., Blais, D., Zhao, Q., Boué‐Grabot, É., Logothetis, D. E., & Séguéla, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3038-08.2008 · Cited by 92
Ase, A. R., Honson, N. S., Zaghdane, H., Pfeifer, T. A., & Séguéla, P. (2015) · Molecular Pharmacology · doi:10.1124/mol.114.096222 · Cited by 87
Allosteric modulation of ATP-gated P2X receptor channels
Coddou, C., Stojilković, S. S., & Huidobro-Toro, J. P. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.014 · Cited by 86
Roger, S., Gillet, L., Baroja‐Mazo, A., Surprenant, A., & Pelegrín, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053082 · Cited by 84
Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels
Kasuya, G., Fujiwara, Y., Takemoto, M., Dohmae, N., Nakada-Nakura, Y., Ishitani, R., Hattori, M., & Nureki, O. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.087 · Cited by 80
The evolution of P2X7 antagonists with a focus on CNS indications
Rech, J. C., Bhattacharya, A., Letavic, M. A., & Savall, B. M. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.06.048 · Cited by 80
Regulation of P2X7 receptor expression and function in the brain
Jimenez-Mateos, E. M., Smith, J., Nicke, A., & Engel, T. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.008 · Cited by 80
Self-citationContribution of P2X4 Receptors to CNS Function and Pathophysiology
Montilla, A., Mata, P., Matute, C., & Domercq, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155562 · Cited by 80
Pathological ATPergic Signaling in Major Depression and Bipolar Disorder
Illés, P., Verkhratsky, A., & Tang, Y. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00331 · Cited by 79
P2X3-Containing Receptors as Targets for the Treatment of Chronic Pain
Krajewski, J. L. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00934-2 · Cited by 75
Jones, C. A., Vial, C., Sellers, L. A., Humphrey, P. P. A., Evans, R. J., & Chessell, I. P. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.4.979 · Cited by 73
Knocking Out P2X Receptors Reduces Transmitter Secretion in Taste Buds
Huang, Y.-J., Stone, L. M., Pereira, E., Yang, R., Kinnamon, J. C., Dvoryanchikov, G. A., Chaudhari, N., Finger, T. E., Kinnamon, S. C., & Roper, S. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3356-11.2011 · Cited by 70
ATP as a cotransmitter in the autonomic nervous system
Kennedy, C. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.004 · Cited by 68
Self-citationXu, J. P., Bernstein, A. M., Wong, A., Lu, X., Khoja, S., Yang, X. W., Davies, D. L., Micevych, P. E., Sofroniew, M. V., & Khakh, B. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1496-16.2016 · Cited by 68
Abdelrahman, A., Namasivayam, V., Hinz, S., Schiedel, A. C., Köse, M., Burton, M., El‐Tayeb, A., Gillard, M. R., Bajorath, J., Ryck, M. D., et al. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.11.016 · Cited by 66
Self-citationKim, H., Walsh, M. C., Takegahara, N., Middleton, S. A., Shin, H., Kim, J., & Choi, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00139-2 · Cited by 65
Subtype-specific control of P2X receptor channel signaling by ATP and Mg 2 +
Li, M., Silberberg, S. D., & Swartz, K. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308088110 · Cited by 63
Role of the P2X4 receptor in neuropathic pain
Inoue, K. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.02.001 · Cited by 63
Roles of Individual N-Glycans for ATP Potency and Expression of the Rat P2X1 Receptor
Rettinger, J., Aschrafi, A., & Schmalzing, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002918200 · Cited by 62
Self-citationJacobson, K. A., Kim, Y. C., Wildman, S. S. P., Mohanram, A., Harden, T. K., Boyer, J. L., King, B. F., & Burnstock, G. (1998) · Journal of Medicinal Chemistry · doi:10.1021/jm980183o · Cited by 62
Self-citationTeixeira, J. M., dos Santos, G. G., Neves, A. F., Athié, M. C. P., Bonet, I. J. M., Nishijima, C. M., Farias, F. H., Figueiredo, J. G., Hernández‐Olmos, V., Alshaibani, S., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.003 · Cited by 60
Self-citationStokes, L., Scurrah, K. J., Ellis, J. A., Cromer, B. A., Skarratt, K. K., Gu, B. J., Harrap, S. B., & Wiley, J. S. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.176180 · Cited by 59
Duckwitz, W., Hausmann, R., Aschrafi, A., & Schmalzing, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606113200 · Cited by 58
Self-citationWerner, S., Mesch, S., Hillig, R. C., ter Laak, A., Klint, J. K., Berindan‐Neagoe, I., Laux‐Biehlmann, A., Dahllöf, H., Bräuer, N., Puetter, V., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01304 · Cited by 58
Maître, B., Magnenat, S., Heim, V., Ravanat, C., Evans, R. J., de la Salle, H., Gachet, C., & Hechler, B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401786 · Cited by 57
Fan, Z., Zhang, Y., Yi-hong, G., Huang, N., Ma, H., Huang, H., & Yu, H. (2016) · Scientific Reports · doi:10.1038/srep35804 · Cited by 56
Bertin, É., Deluc, T., Pilch, K. S., Martínez, A., Pougnet, J.-T., Doudnikoff, É., Allain, A., Bergmann, P., Russeau, M., Toulmé, E., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0641-8 · Cited by 56
Allosteric Modulation of Ligand Gated Ion Channels by Ivermectin
Zemkova, H. W., Tvrdoňová, V., Bhattacharya, A., & Jindřichová, M. (2014) · Physiological Research · doi:10.33549/physiolres.932711 · Cited by 55
Yang, A., Sonin, D. L., Jones, L. R., Barry, W. H., & Liang, B. T. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00079.2004 · Cited by 50
The P2X7 receptor: a new therapeutic target in Alzheimer’s disease
Illés, P., Rubini, P., Huang, L., & Tang, Y. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1575811 · Cited by 50
Obrecht, A. S., Urban, N. D., Schaefer, M., Röse, A., Kless, A., Meents, J., Lampert, A., Abdelrahman, A., Müller, C. E., Schmalzing, G., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107749 · Cited by 50
Self-citationATP‐gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation
Lecut, C., Faccinetto, C., Delierneux, C., van Oerle, R., Spronk, H. M. H., Evans, R. J., Benna, J. E., Bours, V., & Oury, C. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04606.x · Cited by 49
Structural insights into the nucleotide base specificity of P2X receptors
Kasuya, G., Fujiwara, Y., Tsukamoto, H., Morinaga, S., Ryu, S., Touhara, K., Ishitani, R., Furutani, Y., Hattori, M., & Nureki, O. (2017) · Scientific Reports · doi:10.1038/srep45208 · Cited by 49
Primitive ATP-activated P2X receptors: discovery, function and pharmacology
Fountain, S. J. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00247 · Cited by 48
Self-citationMedicinal Chemistry of P2X Receptors: Agonists and Orthosteric Antagonists
Lambertucci, C., Ben, D. D., Buccioni, M., Marucci, G., Thomas, A., & Volpini, R. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867321666141215093513 · Cited by 48
Greve, A., Skals, M., Fagerberg, S. K., Tonnus, W., Ellermann‐Eriksen, S., Evans, R. J., Linkermann, A., & Prætorius, H. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00113 · Cited by 48
Rozmer, K., Gao, P., Araújo, M. G. L., Khan, M. T., Liu, J., Rong, W., Tang, Y., Franke, H., Krügel, U., Fernandes, M. J. D. S., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw178 · Cited by 46
ATP-Gated P2X7 Receptors Require Chloride Channels To Promote Inflammation in Human Macrophages
Janks, L., Sprague, R. S., & Egan, T. M. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801101 · Cited by 45
Medicinal Chemistry of P2X Receptors: Allosteric Modulators
Müller, C. E. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666141210155610 · Cited by 45
Self-citationMarucci, G., Ben, D. D., Buccioni, M., Navia, A. M., Spinaci, A., Volpini, R., & Lambertucci, C. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2019.1693542 · Cited by 44
Kotnis, S., Bingham, B., Vasilyev, D. V., Miller, S. W., Bai, Y., Yeola, S. W., Chanda, P. K., Bowlby, M. R., Kaftan, E. J., Samad, T. A., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.063636 · Cited by 42
Díaz-Pérez, J. A., Killeen, M. E., Yang, Y., Carey, C. D., Falo, L. D., & Mathers, A. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.05.018 · Cited by 39
The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis
Kim, H., Kajikawa, T., Walsh, M. C., Takegahara, N., Jeong, Y. H., Hajishengallis, G., & Choi, Y. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.9.126 · Cited by 36
Purinergic signaling pathways in endocrine system
Bjelobaba, I. M., Janjic, M. M., & Stojilković, S. S. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.04.010 · Cited by 32
Ginsenosides Act As Positive Modulators of P2X4 Receptors
Dhuna, K., Felgate, M., Bidula, S. M., Walpole, S. J., Bibič, L., Cromer, B. A., Angulo, J., Sanderson, J., Stebbing, M. J., & Stokes, L. (2018) · Molecular Pharmacology · doi:10.1124/mol.118.113696 · Cited by 32
P2X7 receptor antagonists for the treatment of systemic inflammatory disorders
Gelin, C. F., Bhattacharya, A., & Letavic, M. A. (2020) · Progress in medicinal chemistry · doi:10.1016/bs.pmch.2019.11.002 · Cited by 28
In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling
Verkhratsky, A., Zimmermann, H., Abbracchio, M. P., Illés, P., & Virgilio, F. D. (2020) · Function · doi:10.1093/function/zqaa006 · Cited by 26
Development of a Mouse Reporter Strain for the Purinergic P2X2Receptor
Kim, S.-H., Bahia, P. K., Patil, M. J., Sutton, S. N., Sowells, I., Hadley, S. H., Kollárik, M., & Taylor‐Clark, T. E. (2020) · eNeuro · doi:10.1523/eneuro.0203-20.2020 · Cited by 25
A P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice
Er-Lukowiak, M., Duan, Y., Rassendren, F., Ulmann, L., Nicke, A., Ufer, F., Friese, M. A., Koch‐Nolte, F., Magnus, T. U., & Rissiek, B. (2020) · iScience · doi:10.1016/j.isci.2020.101870 · Cited by 24
Self-citationMittal, R., Chan, B., Grati, M., Mittal, J., Patel, K., Debs, L. H., Patel, A. P., Yan, D. L. S., Chapagain, P. P., & Liu, X. Z. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25274 · Cited by 22
P2X1 ion channel deficiency causes massive bleeding in inflamed intestine and increases thrombosis
Wéra, O., Lecut, C., Servais, L., Hego, A., Delierneux, C., Jiang, Z., Keutgens, A., Evans, R. J., Delvenne, P., Lancellotti, P., et al. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14620 · Cited by 20
Bragança, B., & Correia‐de‐Sá, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145005 · Cited by 20
Tian, M., Abdelrahman, A., Baqi, Y., Eduardo Fuentes, Q., Azazna, D., Spanier, C., Densborn, S., Hinz, S., Schmid, R., & Müller, C. E. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00435 · Cited by 19
Self-citationSynthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating
Sivcev, S., Slavı́ková, B., Rupert, M., Ivetic, M., Nekardová, M., Kudová, E., & Zemkova, H. W. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14718 · Cited by 17
Can anti-inflammatory strategies light up the dim depression pipeline?
Cully, M. (2020) · Nature Reviews Drug Discovery · doi:10.1038/d41573-020-00049-5 · Cited by 15
Bile acids inhibit human purinergic receptor P2X4 in a heterologous expression system
Ilyaskin, A. V., Sure, F., Nesterov, V., Haerteis, S., & Korbmacher, C. (2019) · The Journal of General Physiology · doi:10.1085/jgp.201812291 · Cited by 13
Díaz‐Hernandéz, J. I., Sebastián‐Serrano, Á., Gómez‐Villafuertes, R., Dı́az-Hernández, M., & Miras‐Portugal, M. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123121 · Cited by 12
Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors
Sun, L.-F., Liu, Y., Wang, J., Huang, L., Yang, Y., Cheng, X., Fan, Y., Zhu, M. X., Liang, H., Tian, Y., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009959 · Cited by 10
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Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists
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Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists
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Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists
Sheng, D., Yue, C.-X., Jin, F., Wang, Y., Ichikawa, M., Yu, Y., Guo, C.-R., & Hattori, M. (2024) · eLife · doi:10.7554/elife.92829.3
Metadata
- Authors
- Illes, P., Müller, C. E., Jacobson, K. A., Grutter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilkovic, S. S., King, B. F., & Di Virgilio, F.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2020-12-21
- Volume
- 178
- Issue
- 3
- Pages
- 489-514
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W3097463406
- Cited by
- 313
- References
- 140
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
