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Programmed cell death in spinal cord injury pathogenesis and therapy

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Shi, Zhongju, Yuan, Shiyang, Shi, Linlin, Li, Jiahe, Ning, Guangzhi, Kong, Xiaohong, Feng, Shiqing·2021·Cell Proliferation

DOI 10.1111/cpr.12992

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Abstract

Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes including cell death. In recent years, programmed cell death (PCD) is considered to be a critical process after SCI, and various forms of PCD were discovered in recent years, including apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis. Unlike necrosis, PCD is known as an active cell death mediated by a cascade of gene expression events, and it is crucial for elimination unnecessary and damaged cells, as well as a defence mechanism. Therefore, it would be meaningful to characterize the roles of PCD to not only enhance our understanding of the pathophysiological processes, but also improve functional recovery after SCI. This review will summarize and explore the most recent advances on how apoptosis, necroptosis, autophagy, ferroptosis, pyroptosis and paraptosis are involved in SCI. This review can help us to understand the various functions of PCD in the pathological processes of SCI, and contribute to our novel understanding of SCI of unknown aetiology in the near future.

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See all 293

Authors: Shi, Z., Yuan, S., Shi, L., Li, J., Ning, G., Kong, X., & Feng, S.
Venue: Cell Proliferation
Publisher: Wiley
Published: 2021-01-27
Volume: 54
Issue: 3
Pages: e12992-e12992
ISSN: 0960-7722 (ISSN-L)
1365-2184
DOI: 10.1111/cpr.12992
OpenAlex: W3124756354
Cited by: 293
References: 114
FWCI: 25.94
Type: journal article
Language: en
Open access: gold

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Programmed cell death in spinal cord injury pathogenesis and therapy

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