Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 20

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome

Ong, Mei‐Lyn, Tuan, Ta A., Poh, Joann, Teh, Ai L., Chen, Li, Pan, Hong, MacIsaac, Julia L., Kobor, Michael S., Chong, Yap S., Kwek, Kenneth, Saw, Seang M., Godfrey, Keith M., Gluckman, Peter D., Fortier, Marielle V., Karnani, Neerja, Meaney, Michael J., Qiu, Anqi, Holbrook, Joanna D.·2019·Genes, Brain and Behavior
DOI 10.1111/gbb.12576
Open this paper in CoChat — free account

Abstract

The amygdala and hippocampus undergo rapid development in early life. The relative contribution of genetic and environmental factors to the establishment of their developmental trajectories has yet to be examined. We performed imaging on neonates and examined how the observed variation in volume and microstructure of the amygdala and hippocampus varied by genotype, and compared with prenatal maternal mental health and socioeconomic status. Gene × Environment models outcompeted models containing genotype or environment only to best explain the majority of measures but some, especially of the amygdaloid microstructure, were best explained by genotype only. Models including DNA methylation measured in the neonate umbilical cords outcompeted the Gene and Gene × Environment models for the majority of amygdaloid measures and minority of hippocampal measures. This study identified brain region‐specific gene networks associated with individual differences in fetal brain development. In particular, genetic and epigenetic variation within CUX1 was highlighted.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/gbb.12576

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 19 references

Research works printed but not linked: 84

  1. 10.1073/pnas.1415603112 · DOI
  2. 10.1073/pnas.1105829109 · DOI
  3. 10.1038/mp.2008.62 · DOI
  4. 10.1073/pnas.0901866106 · DOI
  5. 10.1371/journal.pone.0029809 · DOI
  6. 10.1073/pnas.0908454107 · DOI
  7. 10.1186/1471-2350-8-S1-S15 · DOI
  8. 10.1038/ng.2250 · DOI
  9. 10.1016/j.biopsych.2013.01.027 · DOI
  10. 10.1111/j.1601-183X.2007.00353.x · DOI
  11. 10.1038/tp.2013.126 · DOI
  12. 10.1016/j.biopsych.2012.08.017 · DOI
  13. 10.1371/journal.pone.0075083 · DOI
  14. 10.1038/nature14101 · DOI · Paper page
  15. 10.1016/j.neuron.2014.01.010 · DOI
  16. 10.1111/ejn.12201 · DOI
  17. 10.1016/j.neuroimage.2013.04.118 · DOI
  18. 10.1371/journal.pone.0061494 · DOI
  19. 10.1038/tp.2015.3 · DOI · Paper page
  20. 10.1038/tp.2013.79 · DOI · Paper page
  21. 10.1016/j.jaac.2015.01.013 · DOI · Paper page
  22. 10.1093/cercor/bhr350 · DOI
  23. 10.1016/j.biopsych.2007.04.041 · DOI · Paper page
  24. 10.1016/j.euroneuro.2012.07.001 · DOI
  25. 10.1111/j.1749-6632.2003.tb07068.x · DOI
  26. 10.1038/nrn2639 · DOI · Paper page
  27. Tottenham N, 2009, A review of adversity, the amygdala and the hippocampus: a consideration of developmental timing, Front Hum Neurosci, 3, 68
  28. 10.1192/bjp.150.6.782 · DOI · Paper page
  29. 10.1002/hbm.10062 · DOI · Paper page
  30. 10.1016/S0896-6273(02)00569-X · DOI · Paper page
  31. 10.1016/j.neuroimage.2012.09.032 · DOI
  32. 10.4161/epi.22102 · DOI
  33. 10.1093/biostatistics/kxj037 · DOI · Paper page
  34. 10.4161/epi.23470 · DOI
  35. 10.1186/1756-8935-6-4 · DOI
  36. 10.2217/epi.15.45 · DOI
  37. 10.1101/gr.136598.111 · DOI
  38. 10.1016/j.tig.2014.09.007 · DOI
  39. 10.1038/hr.2011.233 · DOI
  40. 10.1016/j.ajhg.2012.12.016 · DOI
  41. 10.1002/aur.1502 · DOI
  42. 10.1126/science.1138659 · DOI · Paper page
  43. 10.1002/ajmg.b.30867 · DOI
  44. 10.1210/edrv-12-2-118 · DOI · Paper page
  45. 10.1016/j.psyneuen.2015.07.398 · DOI
  46. 10.1038/nn.2270 · DOI · Paper page
  47. 10.2217/epi.15.28 · DOI
  48. 10.1017/S003329171500121X · DOI
  49. 10.1002/pam.21811 · DOI
  50. 10.1038/nn.2403 · DOI
  51. 10.1007/s00429-013-0589-4 · DOI
  52. 10.1007/s11010-008-9919-x · DOI
  53. 10.1016/j.ceca.2011.11.002 · DOI
  54. 10.1016/S0140-6736(12)62129-1 · DOI · Paper page
  55. 10.1002/pmic.200700499 · DOI
  56. 10.1007/s00018-005-5338-2 · DOI
  57. 10.1126/science.1161151 · DOI
  58. 10.1074/jbc.M110.157859 · DOI
  59. 10.1073/pnas.1408650111 · DOI
  60. 10.1038/nsmb.2521 · DOI
  61. 10.1093/hmg/ddt150 · DOI
  62. 10.1097/YPG.0000000000000052 · DOI
  63. 10.1371/journal.pone.0076978 · DOI
  64. 10.1126/scitranslmed.3002464 · DOI
  65. 10.1371/journal.pone.0046315 · DOI
  66. 10.3389/fnins.2012.00115 · DOI
  67. 10.1016/j.yhbeh.2015.06.009 · DOI
  68. 10.1210/EN.2015-1412 · DOI
  69. 10.1186/s12862-015-0398-x · DOI
  70. 10.1016/j.yhbeh.2015.05.024 · DOI
  71. 10.1016/j.yhbeh.2015.05.008 · DOI
  72. 10.1371/journal.pone.0018712 · DOI
  73. 10.1210/en.2011-1663 · DOI
  74. 10.1186/1742-9994-11-38 · DOI
  75. 10.1016/j.gene.2012.01.039 · DOI
  76. 10.1371/journal.pone.0138541 · DOI
  77. 10.1002/cne.20322 · DOI
  78. 10.1002/dneu.22215 · DOI
  79. 10.1093/cercor/bhv079 · DOI
  80. 10.1093/cercor/bhs400 · DOI · Paper page
  81. 10.1093/hmg/ddr594 · DOI
  82. 10.1002/aur.1536 · DOI
  83. 10.1038/tpj.2012.18 · DOI
  84. 10.1146/annurev-psych-010814-015340 · DOI · Paper page

Cited by

See all 20

Metadata

Authors
Ong, M., Tuan, T. A., Poh, J., Teh, A. L., Chen, L., Pan, H., MacIsaac, J. L., Kobor, M. S., Chong, Y. S., Kwek, K., Saw, S. M., Godfrey, K. M., Gluckman, P. D., Fortier, M. V., Karnani, N., Meaney, M. J., Qiu, A., & Holbrook, J. D.
Affiliations
  • Singapore Institute of Clinical sciences (SICS), A*STAR Brenner Centre for Molecular Medicine Singapore
  • Department of Biomedical Engineering, Clinical Imaging research Centre National University of Singapore Singapore
  • Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics University of British Columbia Vancouver British Columbia Canada
  • KK Women's and Children's Hospital Duke National University of Singapore Singapore
  • Yong Loo Lin School of Medicine National University of Singapore, National University Health System Singapore
  • MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2019-05-15
Volume
18
Issue
7
ISSN
  • 1601-1848
  • 1601-183X
DOI
10.1111/gbb.12576
Cited by
20
References
19
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • National Medical Research Council (NMRC/TCR/004‐NUS/2008, NMRC/TCR/012‐NUHS/2014)
  • Singapore Institute for Clinical Sciences
  • National Research Foundation Singapore

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. https://app.cochat.ai/papers/10.1111/gbb.12576
The paper
Ong, M., Tuan, T. A., Poh, J., Teh, A. L., Chen, L., Pan, H., MacIsaac, J. L., Kobor, M. S., Chong, Y. S., Kwek, K., Saw, S. M., Godfrey, K. M., Gluckman, P. D., Fortier, M. V., Karnani, N., Meaney, M. J., Qiu, A., & Holbrook, J. D. (2019). Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. Genes, Brain and Behavior. https://doi.org/10.1111/gbb.12576

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.