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Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome

Ong, Mei‐Lyn, Tuan, Ta A., Poh, Joann, Teh, Ai L., Chen, Li, Pan, Hong, MacIsaac, Julia L., Kobor, Michael S., Chong, Yap S., Kwek, Kenneth, Saw, Seang M., Godfrey, Keith M., Gluckman, Peter D., Fortier, Marielle V., Karnani, Neerja, Meaney, Michael J., Qiu, Anqi, Holbrook, Joanna D.·2019·Genes, Brain and Behavior
DOI 10.1111/gbb.12576
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Abstract

The amygdala and hippocampus undergo rapid development in early life. The relative contribution of genetic and environmental factors to the establishment of their developmental trajectories has yet to be examined. We performed imaging on neonates and examined how the observed variation in volume and microstructure of the amygdala and hippocampus varied by genotype, and compared with prenatal maternal mental health and socioeconomic status. Gene × Environment models outcompeted models containing genotype or environment only to best explain the majority of measures but some, especially of the amygdaloid microstructure, were best explained by genotype only. Models including DNA methylation measured in the neonate umbilical cords outcompeted the Gene and Gene × Environment models for the majority of amygdaloid measures and minority of hippocampal measures. This study identified brain region‐specific gene networks associated with individual differences in fetal brain development. In particular, genetic and epigenetic variation within CUX1 was highlighted.

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Metadata

Authors
Ong, M., Tuan, T. A., Poh, J., Teh, A. L., Chen, L., Pan, H., MacIsaac, J. L., Kobor, M. S., Chong, Y. S., Kwek, K., Saw, S. M., Godfrey, K. M., Gluckman, P. D., Fortier, M. V., Karnani, N., Meaney, M. J., Qiu, A., & Holbrook, J. D.
Affiliations
  • Singapore Institute of Clinical sciences (SICS), A*STAR Brenner Centre for Molecular Medicine Singapore
  • Department of Biomedical Engineering, Clinical Imaging research Centre National University of Singapore Singapore
  • Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics University of British Columbia Vancouver British Columbia Canada
  • KK Women's and Children's Hospital Duke National University of Singapore Singapore
  • Yong Loo Lin School of Medicine National University of Singapore, National University Health System Singapore
  • MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre University of Southampton and University Hospital Southampton NHS Foundation Trust Southampton UK
ORCID
Venue
Genes, Brain and Behavior
Publisher
Wiley
Published
2019-05-15
Volume
18
Issue
7
ISSN
  • 1601-1848
  • 1601-183X
DOI
10.1111/gbb.12576
Cited by
20
References
19
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
  • National Medical Research Council (NMRC/TCR/004‐NUS/2008, NMRC/TCR/012‐NUHS/2014)
  • Singapore Institute for Clinical Sciences
  • National Research Foundation Singapore

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.