Cited by 127Seaweed-derived Bioactive CompoundsPhytochemicals and Antioxidant ActivitiesAgricultural and Biological Research

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Influence of pressurised liquid extraction and solid–liquid extraction methods on the phenolic content and antioxidant activities of Irish macroalgae

Tierney, Michelle S., Smyth, Thomas J., Hayes, Maria, Soler‐Vila, Anna, Croft, Anna K., Brunton, Nigel·2013·International Journal of Food Science & Technology

DOI 10.1111/ijfs.12038

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Abstract

Summary The efficiencies of pressurised liquid extraction (PLE) and a traditional solid–liquid extraction (SLE) at extracting antioxidant polyphenols from Irish macroalgae Ascophyllum nodosum, Pelvetia canaliculata, Fucus spiralis and Ulva intestinalis were compared. PLE was more effective for extracting polyphenols with acetone/water (80:20); however, when food‐friendly solvents of ethanol/water (80:20) and water were employed, SLE resulted in higher phenolic content in brown macroalgal extracts. For example, the Fucus spiralis SLE water and ethanol/water extracts displayed total phenolic contents (TPCs) of 130.58 ± 2.78 and 142.81 ± 1.77 μg phloroglucinol equivalents (PGE) mg−1 sample, respectively, compared with TPCs of 90.79 ± 1.16 and 124 ± 6.54 μg PGE mg−1 sample for the corresponding PLE extracts. All SLE aqueous ethanolic macroalgal extracts possessed higher DPPH radical scavenging abilities (RSA) and ferric reducing antioxidant power (FRAP) than their PLE equivalents. This study indicates that the application of high extraction temperatures (50–200 °C) and pressures (500–3000 psi) used in PLE does not enhance the antioxidant activities of macroalgal extracts relative to SLE extraction. The ability to produce antioxidant food‐friendly macroalgal extracts using SLE could represent significant cost reductions on an industrial scale further enhancing the potential of macroalgal polyphenols to be used in functional food preparations.

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Background
Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813
Purcell, D., Packer, M. A., & Hayes, M. (2022) · Foods · doi:10.3390/foods11121792 · Cited by 30
Effects of extraction methods for a new source of biostimulant from Sargassum horneri on the growth of economically important red algae, Neopyropia yezoensis
Han, S., Park, J., Umanzor, S., Yarish, C., & Kim, J. K. (2022) · Scientific Reports · doi:10.1038/s41598-022-16197-0 · Cited by 28
An Overview on Effects of Processing on the Nutritional Content and Bioactive Compounds in Seaweeds
de Quirós, A. R. B., & López-Hernández, J. (2021) · Foods · doi:10.3390/foods10092168 · Cited by 28
“intestinalis Generally, PLE provided lower values of Total Polyphenol Content (TPC) compared with SLE, which could be due to the higher temperatures employed in PLE [40]”
Background
Production of Lectins from Marine Algae: Current Status, Challenges, and Opportunities for Non-Destructive Extraction
Maliki, I. M., Misson, M., Teoh, P. L., Rodrigues, K. F., & Yong, W. T. L. (2022) · Marine Drugs · doi:10.3390/md20020102 · Cited by 27
Preservative Effect of Algae Extracts on Lipid Composition and Rancidity Development in Brine‐Canned Atlantic Chub Mackerel (Scomber colias)
Barbosa, R. G., Trigo, M., Campos, C. A., & Aubourg, S. P. (2019) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201900129 · Cited by 27
Fatty acid composition from the marine red algae Pterocladiella capillacea (S. G. Gmelin) Santelices & Hommersand 1997 and Osmundaria obtusiloba (C. Agardh) R. E. Norris 1991 and its antioxidant activity
de Alencar, D. B., Diniz, J. C., Rocha, S. A. S., PIRES-CAVALCANTE, K. M. S., Lima, R. L., de Sousa, K. C., Freitas, J. O., Bezerra, R. M., Baracho, B. M., Sampaio, A. H., et al. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201820160315 · Cited by 26
Advancing quantification methods for polyphenols in brown seaweeds—applying a selective qNMR method compared with the TPC assay
Wekre, M. E., Hellesen Brunvoll, S., & Jordheim, M. (2022) · Phytochemical Analysis · doi:10.1002/pca.3162 · Cited by 29
Water Sorption Isotherms and Air Drying Kinetics ofFucus vesiculosusBrown Seaweed
Moreira, R., Chenlo, F., Sineiro, J., Arufe, S., & Sexto, S. (2016) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12997 · Cited by 24
Antimicrobial and antioxidant effect of lyophilized Fucus spiralis addition on gelatin film during refrigerated storage of mackerel
Trigo, M., Nozal, P., Miranda, J. M., Aubourg, S. P., & Barros‐Velázquez, J. (2021) · Food Control · doi:10.1016/j.foodcont.2021.108416 · Cited by 24
Effect of different extraction conditions on phlorotannin content and antioxidant activity of extract from brown algae ( Sargassum angustifolium )
Hodhodi, A., Babakhani, A., & Rostamzad, H. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16307 · Cited by 24
Bioactive Polysaccharides Extracts fromSargassum muticumby High Hydrostatic Pressure
Rodrigues, D., Freitas, A. C., Queirós, R. P., Rocha‐Santos, T., Saraiva, J. A., Gomes, A., & Duarte, A. C. (2016) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12977 · Cited by 24
“According to several authors, application of high extraction temperatures and pressures used in pressurized liquid extraction did not increase antioxidant activities for several seaweeds extracts and species in comparison to solid/liquid extraction (Tierney et al. 2013; Heffernan et al. 2014).”
Background
Impact of a packing medium with alga Bifurcaria bifurcata extract on canned Atlantic mackerel ( Scomber scombrus ) quality
Barbosa, R. G., Trigo, M., Fett, R., & Aubourg, S. P. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8861 · Cited by 21
Marine Algal Derived Phenolic Compounds and their Biological Activities for Medicinal and Cosmetic Applications
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RP-HPLC-DAD determination of the differences in the polyphenol content of Fucus vesiculosus extracts with similar antioxidant activity
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Impact of icing systems with aqueous, ethanolic and ethanolic‐aqueous extracts of alga Fucus spiralis on microbial and biochemical quality of chilled hake (Merluccius merluccius)
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“This alga 385 showed a profitable content on polyphenols (90-205 µg phloroglucinol equivalents mg-386 1) (Tierney et al., 2013a) and α-tocopherol (511.4 mg kg-1) (Paiva et al., 2014).”
BackgroundInfluential
Sustainable approach in phlorotannin recovery from macroalgae
Chia, S. R., Show, P. L., Phang, S., Ling, T. C., & Ong, H. C. (2018) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2018.02.015 · Cited by 20
Effect of Prior Chilling Period and Alga-Extract Packaging on the Quality of a Canned Underutilised Fish Species
Aubourg, S. P., Trigo, M., Martínez, B., & Rodrı́guez, A. (2020) · Foods · doi:10.3390/foods9091333 · Cited by 19
“spiralis extracts has already been proved in in vitro tests [12], showing a marked content on different kinds of antioxidant molecules such as polyphenols [15], alpha-tocopherol [13] and phlorotannins [14].”
Background
Microalgae-derived tocopherols: Biotechnological advances in production and its therapeutic potentials
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“Several publications have already highlighted its efficiency in the extraction of phenolic compounds from seaweeds [12,27,29,34,37–39].”
BackgroundMethodInfluential
Seaweed in the Diet as a Source of Bioactive Metabolites and a Potential Natural Immunity Booster: A Comprehensive Review
Mandal, A. K., Parida, S., Behera, A. K., Adhikary, S. P., Lukatkin, A. A., Lukatkin, A. S., & Jena, M. (2025) · Pharmaceuticals · doi:10.3390/ph18030367 · Cited by 22
“…Ecklonia stolonifera [303] Crude phlorotannin Eisenia bicyclis [303] Aqueous extract Laminaria ochroleuca [304] Polyphenol Ascophyllum nodosum [305] Polyphenol Pelvetia canaliculate [305] Polyphenol Fucus spiralis [305] Polyphenol Ulva intestinalis [305] Polyphenol Saccharina japonica [306]…”
Optimisation of pressurised liquid extraction for antioxidative polyphenolic compound from Momordica charantia using response surface methodology
Abidin, S. Z., Torkamani, A. E., Hani, N. M., Mahmood, W. A. K., & Juliano, P. (2016) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13304 · Cited by 18
“Pressurised liquid extraction (PLE) has become an attractive alternative extraction method to obtain plant bioactive extracts in comparison with conventional near-ambient temperature and atmospheric pressure methods (Santos et al., 2012; Tierney et al., 2013).”
Method
Phenolic compounds of brown algae
Barzkar, N., Ivanova, S. A., Сухих, С. А., Malkov, D., Носкова, С., & Babich, O. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105374 · Cited by 18
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Polyphenols extraction kinetics from Ascophyllum nodosum seaweed employing water and saltwater: Effect of ultrasound sonication
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“7,8 Inflammation, a fundamental biological response triggered by injury and infection, is characterized by redness, swelling, heat, and discomfort.”
Evaluation of the antioxidant and neuroprotective activity of the seaweed Durvillaea antarctica (cochayuyo) extracts using pressurized liquids
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Optimized Extraction Protocols for Bioactive Antioxidants from Commercial Seaweeds in Portugal: A Comparative Study of Techniques
Santos, F., Soares, C. M. D., Morais, S. L., Neves, C., Grosso, C., Ramalhosa, M. J., Vieira, M., Delerue-Matos, C. M., & Domingues, V. F. (2025) · Foods · doi:10.3390/foods14030453 · Cited by 16
Advancements in sustainable extraction of seaweed phenolics: Integrating extraction technologies with natural deep eutectic solvents (NADES)
Zeb, L., Shafiq, M., & Jordheim, M. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144941 · Cited by 17
Pressurized Liquid Extraction of Antioxidant and α-Amylase-Inhibitory Compounds from Red Seaweed Using Water–Ethanol Mixtures
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An Overview of the Biological Functions and Mechanisms of Action of Medicinal Plants and Seaweeds in the Shrimp Culture
Pourmozaffar, S., Reverter, M., Jahromi, S. T., Harikrishnan, R., Pazir, M. K., Barzkar, N., Mozanzadeh, M. T., Sarvi, B., Abolfathi, M., Adeshına, İ., et al. (2024) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.14049 · Cited by 12
Influence of Carbon Sources on the Phenolic Compound Production by Euglena gracilis Using an Untargeted Metabolomic Approach
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“Previo s studies reported better phenolic extraction with organic aqueous mixtures [51] and a better extraction yield using methanol [50].”
Background
Ubiquitous Phlorotannins Prospects and Perspectives
Creis, E., Gall, E. A., & Potin, P. (2018) · Blue Biotechnology · doi:10.1002/9783527801718.ch3 · Cited by 12
Mediterranean Seaweed Polysaccharides: Insight into Chemical Structures, Applications, and Structure/Application Correlations
Fanina, S., Casillo, A., & Corsaro, M. M. (2025) · Marine Drugs · doi:10.3390/md24010011 · Cited by 12
“Additionally, while it is possible to target specific compounds, incorrect parameter selection may lead to the co-extraction of other compounds, such as polyphenols or pigments [141,142].”
Functional characterisation of Euglena gracilis following growth medium enrichment
Lanzoni, D., Rebucci, R., Cheli, F., Cavaliere, R., Ghilardi, G., Marchetti, L., Crotti, A., Baldi, A., & Giromini, C. (2023) · Italian Journal of Animal Science · doi:10.1080/1828051x.2023.2289564 · Cited by 9
“This result is also confirmed by Tierney et al. (2013).”
Bark tannins: Extraction methods, characterization, and reactivity
Abda, E. B., Bentis, A., Amaral-Labat, G., Pizzi, A., Lacoste, C., Koubaa, A., & Braghiroli, F. L. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.121745 · Cited by 11
Biorefinery as a tool to obtain multiple seaweed extracts for cosmetic applications
Meirelles, B. G., Pagels, F., Sousa‐Pinto, I., & Guedes, A. C. (2023) · Journal of Applied Phycology · doi:10.1007/s10811-023-03089-7 · Cited by 10
“In addition, other studies (Tierney et al. 2012; Farvin and Jacobsen 2013) also showed that water extraction resulted in higher yields than other solvents, such as ethanol, as would be expected given that the seaweeds are known to have a high content of water soluble polysaccharides (Rioux et al.…”
Background
Recent Trends in Extraction Techniques for High Value Compounds from Algae as Food Additives
Akyıl, S., İlter, I., Koç, M., & Kaymak‐Ertekin, F. (2018) · Turkish Journal of Agriculture - Food Science and Technology · doi:10.24925/turjaf.v6i8.1008-1014.1895 · Cited by 8
“The extraction efficiency of polyphenols with PLE technique was higher than convectional extraction techniques (Tierney et al., 2013).”
Method
Application of pressurized liquids to extract high-value compounds from marine biomass
Poojary, M. M., Laurora, A., Lund, M. N., & Tiwari, B. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820096-4.00005-5 · Cited by 7
Rapid and cost-efficient microplate assay for the accurate quantification of total phenolics in seaweeds
Martínez-López, R., & Tuohy, M. G. (2023) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2023.100166 · Cited by 7
The Potential of Using Cochayuyo (Durvillaea incurvata) Extract Obtained by Ultrasound-Assisted Extraction to Fight against Aging-Related Diseases
Muñoz-Molina, N., Parada, J., Simirgiotis, M. J., & Montecinos-González, R. (2024) · Foods · doi:10.3390/foods13020269 · Cited by 7
“The antiradical activity, 2,2-diphenyl-1-picrylhydracil (DPPH), was measured by using the method of Tierney et al. [17].”
Method
Revealing the Potential of Fucus vesiculosus Linnaeus for Cosmetic Purposes: Chemical Profile and Biological Activities of Commercial and Wild Samples
Muñoz-Quintana, M., Padrón-Sanz, C., Dolbeth, M., Arenas, F., Vasconcelos, V. M., & Lopes, G. (2024) · Marine Drugs · doi:10.3390/md22120548 · Cited by 6
Eco-Friendly Extraction of Phlorotannins from Padina pavonica: Identification Related to Purification Methods Towards Innovative Cosmetic Applications
Nour, M., Stiger‐Pouvreau, V., Guenneguez, A., Meslet‐Cladière, L., Cérantola, S., Ali, A., Simon, G., Daher, A., & Petek, S. (2024) · Marine Drugs · doi:10.3390/md23010015 · Cited by 6
“Several studies have shown significant results for extracting phenolic compounds from ASE algae [30,46,52].”
A novel micro pressurized liquid extraction method for very rapid solid sample preparation
Alkhateeb, F. L., & Thurbide, K. B. (2015) · Analytical Methods · doi:10.1039/c4ay02876g · Cited by 5
Extraction Technologies to Recover Dietary Polyphenols from Macro‐ and Microalgae
Shanmugam, M., Ganesan, A. R., & Rajauria, G. (2021) · Wiley eBooks · doi:10.1002/9781119542650.ch7 · Cited by 5
Recent advances in biochemistry of marine phaeophyta: chemical analysis, structural studies and applications
Боголицын, К. Г., Parshina, A., Mamatmyrodov, K., Polomarchuk, D., & Popov, N. (2023) · Studies in natural products chemistry · doi:10.1016/b978-0-443-18961-6.00007-x · Cited by 4

Authors: Tierney, M. S., Smyth, T. J., Hayes, M., Soler‐Vila, A., Croft, A. K., & Brunton, N.
Affiliations: Teagasc - The Irish Agriculture and Food Development Authority (IE)
Food Biosciences Department Teagasc Food Research Centre Ashtown Dublin 15 Ireland
Ollscoil na Gaillimhe – University of Galway (IE)
Bangor University (GB)
Corresponding author: Tierney, Michelle S.
ORCID: Tierney, Michelle S.
Smyth, Thomas J.
Croft, Anna K.
Brunton, Nigel
Venue: International Journal of Food Science & Technology
Publisher: Oxford University Press (OUP)
Published: 2012-12-03
Volume: 48
Issue: 4
Pages: 860-869
ISSN: 0950-5423 (ISSN-L)
1365-2621
DOI: 10.1111/ijfs.12038
OpenAlex: W1987997155
Cited by: 127
References: 56
Citations by year: 2026: 4 · 2025: 14 · 2024: 13 · 2023: 9 · 2022: 10 · 2021: 12 · 2020: 12 · 2019: 12 · 2018: 13 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 1
FWCI: 7.49
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: International Journal of Food Science & Technology (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
Keywords: accelerated solvent extraction, solid-liquid extraction, seaweed, polyphenols, antioxidant activity, Ascophyllum nodosum, Pelvetia canaliculata, Fucus spiralis, Ulva intestinalis, extraction solvents, extraction pressure and temperature, DPPH radical scavenging, ferric reducing antioxidant power, functional foods, brown algae

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Influence of pressurised liquid extraction and solid–liquid extraction methods on the phenolic content and antioxidant activities of Irish macroalgae

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