Algae as Production Systems of Bioactive Compounds
Abstract
Algal extracts are gaining increasing interest due to their unique composition and possibilities of wide industrial applications. Various extraction techniques are used for conversion of algal biomass into extracts. Recently, attention of scientists has been paid to novel methods, such as enzyme‐assisted extraction, microwave‐assisted extraction, pressurized liquid extraction, supercritical fluid extraction, and ultrasound‐assisted extraction, which enable the extraction of biologically active compounds without their degradation. In this review, the properties of biologically active compounds extracted from the biomass of algae reported in the literature are presented in a structured way. Algal extracts contain compounds such as carbohydrates, proteins, minerals, oil, fats, polyunsaturated fatty acids as well as bioactive compounds such as antioxidants (polyphenols, tocopherols [vitamin E], vitamin C, mycosporine‐like amino acids), and pigments, such as carotenoids (carotene xanthophyll), chlorophylls, and phycobilins (phycocyanin, phycoerythrin), which possess antibacterial, antiviral, antifungal, antioxidative, anti‐inflammatory, and antitumor properties. Finally, we assemble a list of applications of algal extracts in different developing branches of agriculture (biostimulants, bioregulators, feed additives) and in pharmaceutical industry.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Algal components offer antioxidant, anti-inflammatory, and free radical scavenging properties, leading to applications in food, feed, supplements, pharmaceuticals, and cosmetics.
“These components offer exceptional antioxidant, anti-inflammatory, and free radical scavenging properties, leading to their widespread applications in food, feed, supplements, pharmaceuticals, and cosmetics [37,84,155,156].”
From A Review of Algae-Based Carbon Capture, Utilization, and Storage (Algae-Based CCUS) (2024) · cites this paper as [156]
Cites
Commercial Applications of Microalgae
Spolaore, P., Joannis-Cassan, C., Duran, E., & Isambert, A. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.87 · Cited by 4,285 · see citing works
Bioactive compounds in seaweed: functional food applications and legislation
Holdt, S. L., & Kraan, S. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-010-9632-5 · Cited by 2,135 · see citing works
Valuable Products from Biotechnology of Microalgae
Pulz, O., & Gross, W. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1647-x · Cited by 2,132 · cited 4× · see citing works
“Algae may constitute a valuable source of a new class of biological plant-protecting substances [23].”
BackgroundInfluentialSeaweed extracts as biostimulants of plant growth and development
Khan, W., Rayirath, U. P., Subramanian, S., Jithesh, M. N., Rayorath, P., Hodges, D. M., Critchley, A. T., Craigie, J. S., Norrie, J., & Prithiviraj, B. (2009) · Journal of Plant Growth Regulation · doi:10.1007/s00344-009-9103-x · Cited by 1,740 · see citing works
High-value products from microalgae—their development and commercialisation
Borowitzka, M. A. (2013) · Journal of Applied Phycology · doi:10.1007/s10811-013-9983-9 · Cited by 1,585 · see citing works
HERRERO, M., CIFUENTES, A., & IBANEZ, E. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2005.05.058 · Cited by 1,212 · see citing works
Seaweed extract stimuli in plant science and agriculture
Craigie, J. S. (2010) · Journal of Applied Phycology · doi:10.1007/s10811-010-9560-4 · Cited by 1,116 · see citing works
Extraction of oil from microalgae for biodiesel production: A review
Halim, R., Danquah, M. K., & Webley, P. A. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.01.001 · Cited by 1,043 · see citing works
Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960 · see citing works
Volkman, J. K. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1172-8 · Cited by 854 · see citing works
Supercritical fluid extraction: Recent advances and applications
Herrero, M., Mendiola, J. A., Cifuentes, A., & Ibáñez, E. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2009.12.019 · Cited by 849 · see citing works
Production of phycocyanin—a pigment with applications in biology, biotechnology, foods and medicine
Eriksen, N. T. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-008-1542-y · Cited by 714 · see citing works
Application of supercritical CO2 in lipid extraction – A review
Sahena, F., Zaidul, I. S. M., Jinap, S., Karim, A. A., Abbas, K. A., Norulaini, N. A. N., & Omar, A. K. M. (2009) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2009.06.026 · Cited by 644 · see citing works
Anupama, & Ravindra, P. (2000) · Biotechnology Advances · doi:10.1016/s0734-9750(00)00045-8 · Cited by 632 · see citing works
Bioactive potential and possible health effects of edible brown seaweeds
Gupta, S., & Abu-Ghannam, N. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.03.011 · Cited by 608 · see citing works
Phycobiliproteins as a commodity: Trends in applied research, patents and commercialization
Sekar, S., & Chandramohan, M. (2008) · Journal of Applied Phycology · doi:10.1007/s10811-007-9188-1 · Cited by 589 · see citing works
(2012) · Cited by 580 · see citing works
Application of Novel Extraction Technologies for Bioactives from Marine Algae
Kadam, S. U., Tiwari, B. K., & O’Donnell, C. P. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400819p · Cited by 547 · see citing works
In the search of new functional food ingredients from algae
Plaza, M., Cifuentes, A., & Ibáñez, E. (2007) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2007.07.012 · Cited by 540 · see citing works
Seaweeds: A sustainable functional food for complementary and alternative therapy
Mohamed, S., Hashim, S. N., & Rahman, H. A. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.09.001 · Cited by 529 · see citing works
Antioxidant activities of sulfated polysaccharides from brown and red seaweeds
de Souza, M. C. R., Marques, C. T., Dore, C. M. P. G., da Silva, F. R. F., Rocha, H. A. O., & Leite, E. L. (2006) · Journal of Applied Phycology · doi:10.1007/s10811-006-9121-z · Cited by 525 · see citing works
Innovative natural functional ingredients from microalgae
Plaza, M., Herrero, M., Cifuentes, A., & Ibáñez, E. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901070g · Cited by 509 · see citing works
Phlorotannins, brown algal polyphenols
Ragan, M. A., & Glombitza, K. (1986) · Medical Entomology and Zoology · Cited by 503 · see citing works
Screening for bioactive compounds from algae
Plaza, M., Santoyo, S., Jaime, L., Reina, G. G.-B., Herrero, M., Señoráns, F. J., & Ibáñez, E. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.03.016 · Cited by 493 · see citing works
Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed
Rodriguez-Jasso, R. M., Mussatto, S. I., Pastrana, L., Aguilar, C. N., & Teixeira, J. A. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.06.006 · Cited by 434 · see citing works
Antioxidant activity of dulse (Palmaria palmata) extract evaluated in vitro
Yuan, Y., Bone, D. E., & Carrington, M. F. (2004) · Food Chemistry · doi:10.1016/j.foodchem.2004.04.039 · Cited by 423 · see citing works
Progress in Phycological Research
MOSS, B. L. (1985) · Phycologia · doi:10.2216/i0031-8884-24-3-374a.1 · Cited by 397 · see citing works
Chlorophyll Extraction from Microalgae: A Review on the Process Engineering Aspects
Hosikian, A., Lim, S., Halim, R., & Danquah, M. K. (2010) · International Journal of Chemical Engineering · doi:10.1155/2010/391632 · Cited by 394 · see citing works
Vera, J., Castro, J., González, A., & Moenne, A. (2011) · Marine Drugs · doi:10.3390/md9122514 · Cited by 393 · see citing works
Brentner, L. B., Eckelman, M. J., & Zimmerman, J. B. (2011) · Environmental Science & Technology · doi:10.1021/es2006995 · Cited by 377 · see citing works
Study on the microalgal pigments extraction process: Performance of microwave assisted extraction
Pasquet, V., Cherouvrier, J., Farhat, F., Thiéry, V., Piot, J., Bérard, J., Kaas, R., Serive, B., Patrice, T., Cadoret, J., et al. (2010) · Process Biochemistry · doi:10.1016/j.procbio.2010.07.009 · Cited by 370 · see citing works
Gupta, S., & Abu‐Ghannam, N. (2011) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2011.07.004 · Cited by 369 · see citing works
Wijesinghe, W. A. J. P., & Jeon, Y. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.10.016 · Cited by 360 · see citing works
Functional properties of carotenoids originating from algae
Christaki, E., Bonos, E., Giannenas, I., & Florou‐Paneri, P. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5902 · Cited by 346 · see citing works
Evidence for the presence of plant growth regulators in commercial seaweed products
Crouch, I. J., & van Staden, J. (1993) · Plant Growth Regulation · doi:10.1007/bf00207588 · Cited by 328 · see citing works
Advanced analysis of nutraceuticals
Bernal, J., Mendiola, J. A., Ibáñez, E., & Cifuentes, A. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.11.033 · Cited by 321 · see citing works
Ibáñez, E., Herrero, M., Mendiola, J. A., & Castro‐Puyana, M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1247-2_2 · Cited by 319 · see citing works
Beneficial Effects of Marine Algal Compounds in Cosmeceuticals
Thomas, N. V., & Kim, S. (2013) · Marine Drugs · doi:10.3390/md11010146 · Cited by 305 · see citing works
Algal Polysaccharides, Novel Applications and Outlook
Kraan, S. (2012) · InTech eBooks · doi:10.5772/51572 · Cited by 291 · see citing works
Algal extracts: Technology and advances
Michalak, I., & Chojnacka, K. (2014) · Engineering in Life Sciences · doi:10.1002/elsc.201400139 · Cited by 289 · see citing works
Self-citationUse of compressed fluids for sample preparation: Food applications
Mendiola, J. A., Herrero, M., Cifuentes, A., & Ibáñez, E. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.02.046 · Cited by 284 · see citing works
Lee, S., & Jeon, Y. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.02.013 · Cited by 260 · see citing works
Antioxidant and antitumoural activities of some Phaeophyta from Brittany coasts
Zubia, M., Fabre, M. S., Kerjean, V., Lann, K. L., Stiger‐Pouvreau, V., Fauchon, M., & Deslandes, É. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.03.025 · Cited by 252 · see citing works
Seaweed Extracts in Agriculture and Horticulture: a Review
Verkleij, F. N. (1992) · Biological Agriculture & Horticulture · doi:10.1080/01448765.1992.9754608 · Cited by 249 · see citing works
Alekseyenko, T. V., Zhanayeva, S. Y., Venediktova, A. A., Zvyagintseva, T. N., Kuznetsova, T. A., Besednova, N. N., & Korolenko, T. A. (2007) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-007-0226-4 · Cited by 244 · see citing works
Jung, H. A., Jin, S. E., Ahn, B. R., Lee, C. M., & Choi, J. S. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.061 · Cited by 243 · see citing works
Chelating Properties of Extracellular Polysaccharides from Chlorella spp
Kaplan, D., Christiaen, D., & Arad, S. M. (1987) · Applied and Environmental Microbiology · doi:10.1128/aem.53.12.2953-2956.1987 · Cited by 236 · see citing works
Kong, C., Kim, J., Yoon, N., & Kim, S. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.04.013 · Cited by 233 · see citing works
Antibacterial substances from marine algae isolated from Jeddah coast of Red sea, Saudi Arabia
Alsaif, S. S. A.-L., Abdel-Raouf, N., El-Wazanani, H. A., & Aref, I. A. (2013) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2013.06.001 · Cited by 228 · see citing works
Biologically Active Compounds in Seaweed Extracts - the Prospects for the Application
Chojnacka, K. (2012) · The Open Conference Proceedings Journal · doi:10.2174/1876326x01203020020 · Cited by 226 · see citing works
Self-citationAlgae as a source of renewable chemicals: opportunities and challenges
Foley, P. M., Beach, E. S., & Zimmerman, J. B. (2011) · Green Chemistry · doi:10.1039/c1gc00015b · Cited by 219 · see citing works
Photoprotective compounds in cyanobacteria, phytoplankton and macroalgae — a database
Gröniger, A., Sinha, R. P., Klisch, M., & Häder, D. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00112-3 · Cited by 207 · see citing works
Green algae Chlorococcum humicola-a new source of bioactive compounds with antimicrobial activity
Bhagavathy, S., Sumathi, P., & Bell, I. J. S. (2011) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(11)60111-1 · Cited by 201 · see citing works
Herrero, M., Jaime, L., Martín‐Álvarez, P. J., Cifuentes, A., & Ibáñez, E. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060546q · Cited by 194 · see citing works
Bouhlal, R., Haslin, C., Chermann, J., Colliec‐Jouault, S., Sinquin, C., Simon, G., Cérantola, S., Riadi, H., & Bourgougnon, N. (2011) · Marine Drugs · doi:10.3390/md9071187 · Cited by 188 · see citing works
Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus
Harden, E. A., Falshaw, R., Carnachan, S., Kern, E. R., & Prichard, M. N. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.06.007 · Cited by 183 · see citing works
(2011) · Wiley eBooks · doi:10.1002/9781119977087 · Cited by 180 · see citing works
Denery, J. R., Dragull, K., Tang, C. S., & Li, Q. X. (2003) · Analytica Chimica Acta · doi:10.1016/j.aca.2003.09.026 · Cited by 165 · see citing works
Yang, Y. J., Seo, J. M., Nguyen, A. T. H., Pham, T. X., Park, H. J., Park, Y., Kim, B., Bruno, R. S., & Lee, J. (2011) · Journal of Nutrition · doi:10.3945/jn.111.142109 · Cited by 159 · see citing works
Supercritical Carbon Dioxide Extraction of Molecules of Interest from Microalgae and Seaweeds
Crampon, C., Boutin, O., & Badens, E. (2011) · Industrial & Engineering Chemistry Research · doi:10.1021/ie102297d · Cited by 146 · see citing works
Islam, M. N., Ishita, I. J., Jin, S. E., Choi, R. J., Lee, C. M., Kim, Y. S., Jung, H. A., & Choi, J. S. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.054 · Cited by 146 · see citing works
Tasco: Influence of a brown seaweed on antioxidants in forages and livestock—A review
Allen, V. G., Pond, K. R., Saker, K. E., Fontenot, J. P., Bagley, C. P., Ivy, R. L., Evans, R., Schmidt, R. E., Fike, J. H., Zhang, X., et al. (2001) · Journal of Animal Science · doi:10.2527/jas2001.79e-supple21x · Cited by 143 · see citing works
Wang, H., Pan, J., Chen, C., Chiu, C.-C., Yang, M.-H., Chang, H., & Chang, J. (2010) · Process Biochemistry · doi:10.1016/j.procbio.2010.05.023 · Cited by 135 · see citing works
Algal biomass conversion to bioethanol – a step‐by‐step assessment
Harun, R., Yip, J. W. S., Thiruvenkadam, S., Ghani, W. A. W. A. K., Cherrington, T., & Danquah, M. K. (2013) · Biotechnology Journal · doi:10.1002/biot.201200353 · Cited by 134 · see citing works
Santoyo, S., Rodríguez-Meizoso, I., Cifuentes, A., Jaime, L., García-Blairsy Reina, G., Señorans, F. J., & Ibáñez, E. (2009) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2009.01.012 · Cited by 133 · see citing works
O’Doherty, J. V., Dillon, S., Figat, S., Callan, J. J., & Sweeney, T. (2010) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2010.03.004 · Cited by 131 · see citing works
Jaime, L., Mendiola, J. A., Herrero, M., Soler‐Rivas, C., Santoyo, S., Señoráns, F. J., Cifuentes, A., & Ibáñez, E. (2005) · Journal of Separation Science · doi:10.1002/jssc.200500185 · Cited by 131 · see citing works
Roh, M.-K., Uddin, M. S., & Chun, B.-S. (2008) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-008-0104-6 · Cited by 129 · see citing works
Pereira, H. D. S., Leão-Ferreira, L. R., Moussatché, N., Teixeira, V. L., Cavalcanti, D. N., COSTA, L., Diaz, R. S., & FRUGULHETTI, I. (2004) · Antiviral Research · doi:10.1016/j.antiviral.2004.06.006 · Cited by 128 · see citing works
Tierney, M. S., Smyth, T. J., Hayes, M., Soler‐Vila, A., Croft, A. K., & Brunton, N. (2013) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12038 · Cited by 127 · cited 2× · see citing works
“spiralis Ulva intestinalis SLE and PLE was employed to extract algae with 100% water, ethanol/water (80:20, v:v), and acetone/water (80:20, v:v) DPPH Ferric reducing antioxidant power Ferrous ion chelating capability assay [16]”
BackgroundMethodFunctional biscuits with PUFA‐ω3 from <i>Isochrysis galbana</i>
Gouveia, L., Coutinho, C., Mendonça, E., Batista, A. P., Sousa, I., Bandarra, N. M., & Raymundo, A. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3166 · Cited by 126 · see citing works
Microwave-Assisted Extraction of Phycobiliproteins from Porphyridium purpureum
Juin, C., Cherouvrier, J., Thiéry, V., Gagez, A.-L., Bérard, J., Joguet, N., Kaas, R., Cadoret, J., & Picot, L. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-1250-2 · Cited by 124 · see citing works
Effect of seaweed saps on growth and yield improvement of green gram
Pramanick, B., Koushik, B., & Arup, G. (2013) · African Journal of Agricultural Research · doi:10.5897/ajar12.1894 · Cited by 118 · see citing works
Hassan, S. M., El-Twab, S. M. A., Hetta, M. H., & Mahmoud, B. (2011) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2011.01.005 · Cited by 117 · see citing works
Distribution of catechins in Japanese seaweeds
Yoshie, Y., Wang, W., Petillo, D., & Suzuki, T. (2000) · Fisheries Science · doi:10.1046/j.1444-2906.2000.00160.x · Cited by 114 · see citing works
Ryu, B., Qian, Z.-J., Kim, M.-M., Nam, K. W., & Kim, S.-K. (2009) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2008.09.001 · Cited by 113 · see citing works
Cheung, P. C. K., Leung, A. Y. H., & Ang, P. O. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980346h · Cited by 108 · see citing works
Gardiner, G. E., Campbell, A. J., O’Doherty, J. V., Pierce, E., Lynch, P. B., Leonard, F. C., Stanton, C., Ross, R. P., & Lawlor, P. G. (2007) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2007.06.011 · Cited by 103 · see citing works
Pandian, V., Vaseela, N., & Thirumaran, G. (2012) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(12)60082-x · Cited by 100 · see citing works
Choudhury, S., Sree, A., Mukherjee, S., et al. (2005) · Asian Fisheries Science · doi:10.33997/j.afs.2005.18.3.009 · Cited by 100 · see citing works
WS14 The EU ban of antibiotics as feed additives (2006): alternatives and consumer safety
Anadón, A. (2006) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.2006.00775_2.x · Cited by 89 · see citing works
Gahan, D. A., Lynch, M. B., Callan, J. J., O’Sullivan, J. T., & O’Doherty, J. V. (2008) · animal · doi:10.1017/s1751731108003017 · Cited by 87 · see citing works
Preparation and antioxidant property of extract and semipurified fractions of Caulerpa racemosa
Li, Z., Wang, B., Zhang, Q., Qu, Y., Xu, H., & Li, G. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-012-9813-5 · Cited by 84 · see citing works
Zhu, W., Chiu, L. C. M., Ooi, V. E. C., Chan, P. K. S., & Ang, P. O. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.02.022 · Cited by 82 · see citing works
Antimicrobial Activity of Sub- and Supercritical CO2 Extracts of the Green Alga Dunaliella salina
Mendiola, J. A., Santoyo, S., Cifuentes, A., Reglero, G., Ibáñez, E., & Señoráns, F. J. (2008) · Journal of Food Protection · doi:10.4315/0362-028x-71.10.2138 · Cited by 80 · see citing works
Gellenbeck, K. W. (2012) · Journal of Applied Phycology · doi:10.1007/s10811-011-9722-z · Cited by 79 · see citing works
Abrantes, J. L., Barbosa, J. P., Cavalcanti, D. N., Pereira, R., Fontes, C. F. L., Teixeira, V. L., Souza, T. M. L., & Paixão, I. C. N. D. P. (2009) · Planta Medica · doi:10.1055/s-0029-1186144 · Cited by 79 · see citing works
Antiviral Activity of Extracts from Marine Algae
Richards, J. T., Kern, E. R., Glasgow, L. A., et al. (1978) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.14.1.24 · Cited by 79 · see citing works
Evaluation of antifungal activity of seaweed extracts
Peres, J. C. F., de Carvalho, L. R., Gonçalez, E., Beriam, L. O. S., & Felicio, J. D. (2012) · Ciência e Agrotecnologia · doi:10.1590/s1413-70542012000300004 · Cited by 78 · see citing works
Antioxidant effect of the constituents of susabinori (Porphyra yezoensis)
Nakayama, R., Tamura, Y., Kikuzaki, H., & Nakatani, N. (1999) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-999-0017-3 · Cited by 78 · see citing works
Commercial-Scale Biodiesel Production from Algae
Silva, C., Soliman, E., Cameron, G. M., Fabiano, L. A., Seider, W. D., Dunlop, E. H., & Coaldrake, A. K. (2013) · Industrial & Engineering Chemistry Research · doi:10.1021/ie403273b · Cited by 71 · see citing works
Kim, S.-Y., Kim, S. R., Oh, M., et al. (2011) · The Journal of Microbiology · doi:10.1007/s12275-011-1035-z · Cited by 70 · see citing works
Francavilla, M., Colaianna, M., Zotti, M., Morgese, M. G., Trotta, P., Tucci, P., Schiavone, S., Cuomo, V., & Trabace, L. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800672021 · Cited by 70 · see citing works
Pereira, H. D. S., LEAOFERREIRA, L., Moussatché, N., et al. (2004) · Antiviral Research · doi:10.1016/s0166-3542(04)00122-6 · Cited by 70 · see citing works
Aslam, M. N., Paruchuri, T., Bhagavathula, N., et al. (2010) · Integrative Cancer Therapies · doi:10.1177/1534735409360360 · Cited by 67 · see citing works
Cardioprotective activity of polysaccharides derived from marine algae: An overview
Vijayakumar, M., Kannappan, P., Abdullah, N., & Ahmed, A. B. A. (2013) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2013.01.007 · Cited by 65 · see citing works
Blunden, G., Morse, P. F., Máthé, I., et al. (2010) · Natural Product Communications · doi:10.1177/1934578x1000500418 · Cited by 60 · see citing works
Mycosporine-like Amino Acids from Red Algae Protect against Premature Skin-Aging
Schmid, D., Schürch, C., & Zülli, F. (2006) · Cited by 58 · see citing works
Stirk, W. A. (2006) · South African Journal of Botany · doi:10.1016/j.sajb.2006.06.007 · Cited by 58 · see citing works
Shu, M., Appleton, D., Zandi, K., et al. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-61 · Cited by 53 · see citing works
Khaled, N., Mawlawi, H., & Chbani, A. (2012) · Cited by 51 · see citing works
Murphy, P., Bello, F. D., O’Doherty, J. V., Arendt, E. K., Sweeney, T., & Coffey, A. (2013) · animal · doi:10.1017/s1751731113000165 · Cited by 44 · see citing works
Enzyme‐assisted Extraction and Recovery of Bioactive Components from Seaweeds
Jeon, Y., Wijesinghe, W. A. J. P., & Kim, S. (2011) · doi:10.1002/9781119977087.ch10 · Cited by 38 · see citing works
Ko, S., Lee, S., Ahn, G., Kim, K., Cha, S., Kim, S., Jeon, B.-T., Park, P., Lee, K.-W., & Jeon, Y. (2011) · Journal of Applied Phycology · doi:10.1007/s10811-011-9685-0 · Cited by 38 · see citing works
Production of Seaweed Extracts by Biological and Chemical Methods
Michalak, I., & Chojnacka, K. (2015) · Wiley eBooks · doi:10.1002/9783527679577.ch7 · Cited by 37 · see citing works
Self-citationDiterpene content of the alga Dictyota ciliolata from a Moroccan lagoon
Manzo, E., Ciavatta, M. L., Bakkas, S., Villani, G., Varcamonti, M., Zanfardino, A., & Gavagnin, M. (2009) · Phytochemistry Letters · doi:10.1016/j.phytol.2009.08.003 · Cited by 35 · see citing works
(2013) · CRC Press eBooks · doi:10.1201/b13904 · Cited by 33 · see citing works
Manilal, A., Sujith, S., Selvin, J., et al. (2009) · Cited by 31 · see citing works
Distribution of free L-cysteine and glutathione in seaweeds
Kakinuma, M., Park, C. S., & Amano, H. (2001) · Fisheries Science · doi:10.1046/j.1444-2906.2001.00223.x · Cited by 27 · see citing works
Validation of impregnation process for homeopathic globules by spectrophotometric-UV method
Pinheiro, M. S., de Aguiar, P. F., Holandino, C., & Garcia, S. (2011) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502011000100014 · Cited by 24 · see citing works
Wang, B., Tong, G. Z., Qu, Y. L., & Li, L. (2011) · Applied Mechanics and Materials · doi:10.4028/www.scientific.net/amm.79.204 · Cited by 19 · see citing works
Murphya, P., Bello, F. D., O’Doherty, J. V., Arendt, E. K., Sweeney, T., & Coffey, A. (2013) · Anaerobe · doi:10.1016/j.anaerobe.2013.03.002 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Fabris, M., Abbriano, R. M., Pernice, M., Sutherland, D. L., Commault, A. S., Hall, C. C., Labeeuw, L., McCauley, J. I., Kuzhiuparambil, U., Ray, P., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00279 · Cited by 382 · see citing works
Levy Karin, E., Mirdita, M., & Söding, J. (2020) · Microbiome · doi:10.1186/s40168-020-00808-x · Cited by 299 · see citing works
Concepts and studies on lipid and pigments of microalgae: A review
D’Alessandro, E. B., & Antoniosi Filho, N. R. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.12.162 · Cited by 289 · see citing works
Microalgae as Biostimulants: A New Approach in Agriculture
González-Pérez, B. K., Rivas-Castillo, A. M., Valdez-Calderón, A., & Gayosso-Morales, M. A. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-021-03192-2 · Cited by 128 · see citing works
Algae as an Attractive Source for Cosmetics to Counter Environmental Stress
Aslam, A., Bahadar, A., Liaquat, R., Saleem, M., Waqas, A., & Zwawi, M. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.144905 · Cited by 105 · see citing works
Fratelli, C., Burck, M., Amarante, M. C. A., & Braga, A. R. C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.10.043 · Cited by 100 · see citing works
Karabulut, G., Purkiewicz, A., & Goksen, G. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13372 · Cited by 85 · see citing works
A Review of Algae-Based Carbon Capture, Utilization, and Storage (Algae-Based CCUS)
Li, G., & Yao, J. (2024) · Gases · doi:10.3390/gases4040024 · Cited by 80 · see citing works
Renewable Sources: Applications in Personal Care Formulations
Mellou, F., Varvaresou, A., & Papageorgiou, S. (2019) · International Journal of Cosmetic Science · doi:10.1111/ics.12564 · Cited by 52 · see citing works
Antioxidant Production in Dunaliella
Roy, U. K., Nielsen, B. V., & Milledge, J. J. (2021) · Applied Sciences · doi:10.3390/app11093959 · Cited by 51 · see citing works
Cepas, V., López, Y., Gabasa, Y., Martins, C. B., Ferreira, J. D., Correia, M. J., Santos, L. M. A., Oliveira, F., Ramos, V., Reis, M., et al. (2019) · Antibiotics · doi:10.3390/antibiotics8020077 · Cited by 48 · see citing works
Chauton, M. S., Forbord, S., Mäkinen, S., Sarno, A., Slizyte, R., Mozuraityte, R., Standal, I. B., & Skjermo, J. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13391 · Cited by 28 · see citing works
Abdullah, M. A., & Hussein, H. A. (2021) · Bioresources and Bioprocessing · doi:10.1186/s40643-021-00396-0 · Cited by 19 · see citing works
- Authors
- Michalak, I., & Chojnacka, K.
- Affiliations
- Wrocław University of Science and Technology (PL)
- Venue
- Engineering in Life Sciences
- Publisher
- Wiley
- Published
- 2015-01-28
- Volume
- 15
- Issue
- 2
- Pages
- 160-176
- ISSN
- 1618-0240 (ISSN-L)
- 1618-2863
- OpenAlex
- W2002276787
- Cited by
- 576
- References
- 112
- Citations by year
- 2026: 30 · 2025: 58 · 2024: 69 · 2023: 84 · 2022: 71 · 2021: 67 · 2020: 62 · 2019: 46 · 2018: 36 · 2017: 30 · 2016: 17 · 2015: 5
- FWCI
- 26.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Engineering in Life Sciences (publishedVersion)
- Funders
- The National Science Centre in Poland (2012/05/D/ST5/03379)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Growth Enhancement Techniques
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Keywords
- algae, algal extracts, bioactive compounds, extraction methods, enzymatic extraction, microwave-assisted extraction, accelerated solvent extraction, supercritical fluid extraction, ultrasound-assisted extraction, antioxidants, polyphenols, mycosporine-like amino acids, carotenoids, phycocyanin, phycoerythrin, chlorophyll, polyunsaturated fatty acids, antibacterial activity, antifungal activity, anti-inflammatory activity, anticancer activity, biostimulants, feed additives, pharmaceutical applications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review