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Lipoprotein(a): resurrected by genetics
Open accessAbstract
Plasma lipoprotein(a) [L p(a)] is a quantitative genetic trait with a very broad and skewed distribution, which is largely controlled by genetic variants at the LPA locus on chromosome 6q27. Based on genetic evidence provided by studies conducted over the last two decades, L p(a) is currently considered to be the strongest genetic risk factor for coronary heart disease (CHD). The copy number variation of kringle IV in the LPA gene has been strongly associated with both L p(a) levels in plasma and risk of CHD, thereby fulfilling the main criterion for causality in a M endelian randomization approach. Alleles with a low kringle IV copy number that together have a population frequency of 25–35% are associated with a doubling of the relative risk for outcomes, which is exceptional in the field of complex genetic phenotypes. The recently identified binding of oxidized phospholipids to L p(a) is considered as one of the possible mechanisms that may explain the pathogenicity of L p(a). Drugs that have been shown to lower L p(a) have pleiotropic effects on other CHD risk factors, and an improvement of cardiovascular endpoints is up to now lacking. However, it has been established in a proof of principle study that lowering of very high L p(a) by apheresis in high‐risk patients with already maximally reduced low‐density lipoprotein cholesterol levels can dramatically reduce major coronary events.
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“[Statement]Hyper-Lp(a)-lipoproteinemia is a risk factor for ASCVD. (Evidence level: E-1a)”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [221]
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“When the size of apolipoprotein (a) [apo(a)] is small, the concentration of Lp(a) is high, and there is a high risk of CVD.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [221]
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“Lp(a) is an independent risk factor for CAD and stroke.”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [221]
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Citations
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487
Self-citationNiacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
The AIM-HIGH Investigators (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1107579 · Cited by 2,911
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics · doi:10.1038/ng.784 · Cited by 1,866
Lipoprotein(a) as a cardiovascular risk factor: current status
Nordestgaard, B. G., Chapman, M. J., Ray, K., Borén, J., Andreotti, F., Watts, G. F., Ginsberg, H., Amarenco, P., Catapano, A., Descamps, O. S., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq386 · Cited by 1,807
(2009) · JAMA · doi:10.1001/jama.2009.1063 · Cited by 1,753
Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Clarke, R., Peden, J. F., Hopewell, J. C., Kyriakou, T., Goel, A., Heath, S. C., Parish, S., Barlera, S., Franzosi, M. G., Rust, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902604 · Cited by 1,671
Inflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
A NEW SERUM TYPE SYSTEM IN MAN—THE Lp SYSTEM
Berg, K. (1963) · Acta Pathologica Microbiologica Scandinavica · doi:10.1111/j.1699-0463.1963.tb01808.x · Cited by 1,383
Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction
Kamstrup, P. R. (2009) · JAMA · doi:10.1001/jama.2009.801 · Cited by 1,357
The mysteries of lipoprotein(a).
Utermann, G. (1989) · Science · doi:10.1126/science.2530631 · Cited by 1,257
Self-citationBoerwinkle, E., Leffert, C. C., Lin, J., Lackner, C., Chiesa, G., & Hobbs, H. H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115855 · Cited by 973
Raal, F. J., Santos, R. D., Blom, D. J., Marais, A. D., Charng, M., Cromwell, W. C., Lachmann, R., Gaudet, D., Tan, J. L., Chasan-Taber, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60284-x · Cited by 934
Utermann, G., Menzel, H., Kraft, H. G., Duba, H., Kemmler, H., & Seitz, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113093 · Cited by 887
Self-citationLoci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Aulchenko, Y. S., Janssens, A. C. J. W., Albert Hofman, D., Isaacs, A. J., Sijbrands, E. J. G., Witteman, J. C. M., van Duijn, C. M., Ripatti, S., Lindqvist, I., Perola, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.269 · Cited by 860
Self-citationOxidized Phospholipids, Lp(a) Lipoprotein, and Coronary Artery Disease
Tsimikas, S., Brilakis, E. S., Miller, E. R., McConnell, J. P., Lennon, R. J., Kornman, K. S., Witztum, J. L., & Berger, P. B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043175 · Cited by 782
Safety of anacetrapib in patients with or at high risk for coronary heart disease
Cannon, C. P., Shah, S., Dansky, H. M., Davidson, M., Brinton, E. A., Gotto, A. M., Stepanavage, M., Liu, S. X., Gibbons, P., Ashraf, T. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1009744 · Cited by 749
Salpeter, S. R., Walsh, J. M. E., Ormiston, T. M., Greyber, E., Buckley, N. S., & Salpeter, E. E. (2006) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00545.x · Cited by 640
Nicotinic acid: the broad‐spectrum lipid drug. A 50th anniversary review
Carlson, L. A. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2005.01528.x · Cited by 591
Seed, M., Hoppichler, F., Reaveley, D. A., McCarthy, S., Thompson, G. R., Boerwinkle, E., & Utermann, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222104 · Cited by 584
Self-citationA Prospective Study of Lipoprotein(a) and the Risk of Myocardial Infarction
Ridker, P. M. (1993) · JAMA · doi:10.1001/jama.1993.03510180065035 · Cited by 512
Trégouët, D., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel‐Nitschke, P., Perret, C., DeSuremain, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.314 · Cited by 483
A genome-wide association study identifies protein quantitative trait loci (pQTLs)
Melzer, D., Perry, J. R. B., Hernandez, D., Corsi, A.-M., Stevens, K., Rafferty, I., Lauretani, F., Murray, A., Gibbs, J. R., Paolisso, G., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000072 · Cited by 480
Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients.
Rath, M., Niendorf, A., Reblin, T., Dietel, M., Krebber, H.-J., & Beisiegel†, U. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.579 · Cited by 446
(2021) · Journal of Lipid Research · doi:10.1194/jlr · Cited by 435
Bergmark, C., Dewan, A. K., Orsoni, A., Merki, E., Miller, E. R., Shin, M., Binder, C. J., Hörkkö, S., Krauss, R. M., Chapman, M. J., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800174-jlr200 · Cited by 410
Lackner, C., Boerwinkle, E., Leffert, C. C., Rahmig, T., & Hobbs, H. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115248 · Cited by 407
Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a)
Grainger, D. J., Kirschenlohr, H. L., Metcalfe, J. C., Weissberg, P. L., Wade, D. P., & Lawn, R. M. (1993) · Science · doi:10.1126/science.8503012 · Cited by 407
Meier, C., Staub, J.-J., Roth, C.-B., Guglielmetti, M., Kunz, M., Miserez, A. R., Drewe, J., Huber, P., Herzog, R. F. K., & Müller-Stich, B. P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7973 · Cited by 397
Sandholzer, C., Hallman, D. M., Saha, N., Sigurðsson, G., Lackner, C., Cs�sz�r, A., Boerwinkle, E., & Utermann, G. (1991) · Human Genetics · doi:10.1007/bf00201550 · Cited by 384
Self-citationAPOUPOPROTEIN E ISOFORMS, SERUM CHOLESTEROL, AND CANCER
Katan, M. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92972-7 · Cited by 371
Godsland, I. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)01699-5 · Cited by 368
A comprehensive linkage analysis for myocardial infarction and its related risk factors
Broeckel, U., Hengstenberg, C., Mayer, B., Holmer, S., Martin, L. J., Comuzzie, A., Blangero, J., Nürnberg, P., Reis, A., Riegger, G., et al. (2002) · Nature Genetics · doi:10.1038/ng827 · Cited by 359
Marcovina, S. M., Albers, J. J., Gabel, B. R., Koschinsky, M. L., & Gaur, V. P. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.2.246 · Cited by 355
Jauhiainen, M., Koskinen, P., Ehnholm, C., Frick, M. H., Mänttäri, M., Manninen, V., & Huttunen, J. K. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90007-p · Cited by 354
Lipoprotein metabolism and lipid management in chronic kidney disease
Kwan, B. C. H., Kronenberg, F., Beddhu, S., & Cheung, A. K. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006091006 · Cited by 354
Self-citationApo(a) isoforms predict risk for coronary heart disease. A study in six populations.
Sandholzer, C., Saha, N., Kark, J. D., Rees, A., Jaroß, W., Dieplinger, H., Hoppichler, F., Boerwinkle, E., & Utermann, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.10.1214 · Cited by 350
Self-citationHMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.
Kostner, G. M., Gavish, D., Leopold, B., Bolzano, K., Weintraub, M. S., & Breslow, J. L. (1989) · Circulation · doi:10.1161/01.cir.80.5.1313 · Cited by 339
Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated Dyslipidemia
Ladenson, P. W., Kristensen, J. D., Ridgway, E. C., OLSSON, A. G., Carlsson, B., Klein, I. L., Baxter, J. D., & Angelin, B. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0905633 · Cited by 338
Apolipoprotein(a) Isoforms and the Risk of Vascular Disease
Erqou, S. A., Thompson, A., Angelantonio, E. D., Saleheen, D., Kaptoge, S., Marcovina, S. M., & Danesh, J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.080 · Cited by 330
Associations Between Lipoprotein(a) Levels and Cardiovascular Outcomes in Black and White Subjects
Virani, S. S., Brautbar, A., Davis, B., Nambi, V., Hoogeveen, R. C., Sharrett, A. R., Coresh, J., Mosley, T. H., Morrisett, J. D., Catellier, D., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.045120 · Cited by 325
Molecular definition of the extreme size polymorphism in apolipoprotein(a)
Lackner, C., Cohen, J. C., & Hobbs, H. H. (1993) · Human Molecular Genetics · doi:10.1093/hmg/2.7.933 · Cited by 319
Marcovina, S. M., Albers, J. J., Scanu, A. M., Kennedy, H., Giaculli, F., Berg, K., Couderc, R., Dati, F., Rifai, N., Sakurabayashi, I., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.12.1956 · Cited by 315
Jansen, A. C. M., van Aalst-Cohen, E. S., Tanck, M. W. T., Trip, M. D., Lansberg, P. J., Liem, A. H., van Lennep, H. W. O. R., Sijbrands, E. J. G., & Kastelein, J. J. P. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01405.x · Cited by 302
Jaeger, B. R., Richter, Y., Nagel, D., Heigl, F., Vogt, A., Roeseler, E., Parhofer, K. G., Ramlow, W., Koch, M., Utermann, G., et al. (2009) · Nature Reviews Cardiology · doi:10.1038/ncpcardio1456 · Cited by 295
Self-citationAtherogenesis in transgenic mice expressing human apolipoprotein(a)
Lawn, R. M., Wade, D. P., Hammer, R. E., Chiesa, G., Verstuyft, J. G., & Rubin, E. M. (1992) · Nature · doi:10.1038/360670a0 · Cited by 281
Turnover of Lipoprotein (a) in Man
Krempler, F., Kostner, G. M., Bolzano, K., & Sandhofer, F. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109813 · Cited by 278
Update in Lipid Alterations in Subclinical Hypothyroidism
Pearce, E. N. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2532 · Cited by 272
Kraft, H. G., K�chl, S., Menzel, H., Sandholzer, C., & Utermann, G. (1992) · Human Genetics · doi:10.1007/bf00220066 · Cited by 270
Self-citationKraft, H. G., Menzel, H., Hoppichler, F., Vogel, W., & Utermann, G. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113849 · Cited by 263
Self-citationGenetics of the quantitative Lp(a) lipoprotein trait
Boerwinkle, E., Menzel, H. J., Kraft, H. G., & Utermann, G. (1989) · Human Genetics · doi:10.1007/bf00288277 · Cited by 261
Self-citationCushing, G. L., Gaubatz, J. W., Nava, M. L., Burdick, B., Bocan, T. M. A., Guyton, J. R., Weilbaecher, D., DeBakey, M. E., Lawrie, G. M., & Morrisett, J. D. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.5.593 · Cited by 252
Kiechl, S. J., Willeit, J., Mayr, M., Viehweider, B., Oberhollenzer, M., Kronenberg, F., Wiedermann, C. J., Oberthaler, S., Xu, Q., Witztum, J. L., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.145805 · Cited by 249
Self-citationLinton, M. F., Farese, R. V., Chiesa, G., Grass, D., Chin, P., Hammer, R. E., Hobbs, H. H., & Young, S. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116927 · Cited by 246
Kronenberg, F., Kuen, E., Ritz, E., Junker, R., Diaeresis]NIG, P. K., KRAATZ, G. D., Lhotta, K., Mann, J. F. E., DiaeresisLLER, G. A. M., Neyer, U., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v111105 · Cited by 246
Self-citationLipoprotein(a) and Risk of Type 2 Diabetes
Mora, S., Kamstrup, P. R., Rifai, N., Nordestgaard, B. G., Buring, J. E., & Ridker, P. M. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.146779 · Cited by 240
Teaching old dogmas new tricks
Brown, M. S., & Goldstein, J. L. (1987) · Nature · doi:10.1038/330113a0 · Cited by 239
Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans
Marcovina, S. M., Albers, J. J., Wijsman, E. M., ZHANG, Z., Chapman, N. H., & Kennedy, H. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37461-7 · Cited by 236
VIRUS-INFECTION OF URINARY-TRACT
Brouwers, T. M., Fontein, D. L., & Value, N. (1974) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 236
Rader, D. J., Cain, W. J., Ikewaki, K., Talley, G. D., Zech, L. A., Usher, D. C., & Brewer, H. B. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117292 · Cited by 235
Kronenberg, F., König, P., Neyer, U., Auinger, M., Pribasnig, A., Lang, U., Reitinger, J., Pinter, G., Utermann, G., & Dieplinger, H. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v61110 · Cited by 233
Self-citationApolipoprotein(a) Kringle IV Repeat Number Predicts Risk for Coronary Heart Disease
Kraft, H. G., Lingenhel, A., Köchl, S., Hoppichler, F., Kronenberg, F., Abe, A., Mühlberger, V., Schönitzer, D., & Utermann, G. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.6.713 · Cited by 232
Self-citationUtermann, G., Hoppichler, F., Dieplinger, H., Seed, M., Thompson, G. R., & Boerwinkle, E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4171 · Cited by 231
Self-citationChasman, D. I., Shiffman, D., Zee, R. Y. L., Louie, J. Z., Luke, M. M., Rowland, C. M., Catanese, J. J., Buring, J. E., Devlin, J. J., & Ridker, P. M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.019 · Cited by 230
Lipoprotein(a) in renal disease
Kronenberg, F., Utermann, G., & Dieplinger, H. (1996) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(96)90026-8 · Cited by 229
Self-citationSamaha, F. F., McKenney, J., Bloedon, L. T., Sasiela, W. J., & Rader, D. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1250 · Cited by 220
Edén, S., Wiklund, O., Oscarsson, J., Rosén, T., & Bengtsson, B. ‐. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.296 · Cited by 211
Genetics of the quantitative Lp(a) lipoprotein trait
Utermann, G., Duba, C., & Menzel, H. J. (1988) · Human Genetics · doi:10.1007/bf00291233 · Cited by 206
Self-citationApolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia
Wiklund, O., Olofsson, S.-O., Fager, G., Bondjers, G., Angelin, B., Erikson, M., & Berglund, L. (1990) · The Lancet · doi:10.1016/0140-6736(90)91242-3 · Cited by 197
Kamstrup, P. R., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.248765 · Cited by 193
Rhesus Monkey Apolipoprotein(a)
Tomlinson, J. E., McLean, J. W., & Lawn, R. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83643-2 · Cited by 186
Helgadóttir, A., Grétarsdóttir, S., Þorleifsson, G., Hólm, H., Patel, R. S., Guðnason, Þ., Jones, G. T., van Rij, A. M., Eapen, D. J., Baas, A. F., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.01.078 · Cited by 185
Hobbs, H. H., & White, A. L. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00005 · Cited by 178
The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans.
Rader, D. J., Mann, W. A., Cain, W., Kraft, H. G., Usher, D., Zech, L. A., Hoeg, J. M., Davignon, J., Lupien, P., & Grossman, M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117794 · Cited by 176
Paultre, F., Pearson, T. A., Weil, H., Tuck, C. H., Myerson, M. L., Rubin, J., Francis, C. K., Marx, H. F., Philbin, E. F., Reed, R. G., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2619 · Cited by 174
Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice.
Callow, M. J., Stoltzfus, L. J., Lawn, R. M., & Rubin, E. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2130 · Cited by 166
Sandholzer, C., Boerwinkle, E., Saha, N., Tong, M.-C., & Utermann, G. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115645 · Cited by 164
Self-citationPalabrica, T. M., Liu, A. C., Aronovitz, M. J., Furie, B., Lawn, R. M., & Furie, B. C. (1995) · Nature Medicine · doi:10.1038/nm0395-256 · Cited by 161
Luke, M. M., Kane, J. P., Liu, D. M., Rowland, C. M., Shiffman, D., Cassano, J., Catanese, J. J., Pullinger, C. R., Leong, D. U., Arellano, A. R., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.141291 · Cited by 159
Studies on the role of specific cell surface receptors in the removal of lipoprotein (a) in man.
Krempler, F., Kostner, G. M., Roscher, A., Haslauer, F., Bolzano, K., & Sandhofer, F. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110896 · Cited by 157
Kronenberg, F., Neyer, U., Lhotta, K., Trenkwalder, E., Auinger, M., Pribasnig, A., Meisl, T., König, P., & Dieplinger, H. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1051027 · Cited by 155
Self-citationGenetics of the quantitative Lp(a) lipoprotein trait
Utermann, G., Kraft, H. G., Menzel, H. J., Hopferwieser, T., & Seitz, C. (1988) · Human Genetics · doi:10.1007/bf00291232 · Cited by 155
Self-citationOxidation-Specific Biomarkers, Lipoprotein(a), and Risk of Fatal and Nonfatal Coronary Events
Tsimikas, S., Mallat, Z., Talmud, P. J., Kastelein, J. J. P., Wareham, N. J., Sandhu, M. S., Miller, E. R., Bénessiano, J., Tedgui, A., Witztum, J. L., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.048 · Cited by 152
Changes in Lipoprotein(a) Levels in Overt and Subclinical Hypothyroidism Before and During Treatment
Tzotzas, T., Krassas, G. E., Κωνσταντινίδης, Θ. Κ., & Bougoulia, M. (2000) · Thyroid · doi:10.1089/thy.2000.10.803 · Cited by 150
Sanan, D. A., Newland, D., Tao, R., Marcovina, S. M., Wang, J., Mooser, V., Hammer, R. E., & Hobbs, H. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4544 · Cited by 150
Koschinsky, M. L., & Marcovina, S. M. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200404000-00009 · Cited by 150
Apolipoprotein(a) size heterogeneity is related to variable number of repeat sequences in its mRNA
Koschinsky, M. L., Beisiegel†, U., Henne‐Bruns, D., Eaton, D., & Lawn, R. M. (1990) · Biochemistry · doi:10.1021/bi00455a007 · Cited by 149
Elevated Plasma Lipoprotein(a) in Patients with the Nephrotic Syndrome
Wanner, C., Rader, D. J., Bartens, W., Kramer, J., Brewer, H. B., Schollmeyer, P., & Wieland, H. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-4-199308150-00002 · Cited by 146
Dieplinger, H., Lackner, C., Kronenberg, F., Sandholzer, C., Lhotta, K., Hoppichler, F., Graf, H., & König, P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116213 · Cited by 142
Self-citationKraft, H. G., Lingenhel, A., Pang, R. W. C., Delport, R., Trommsdorff, M., Vermaak, H., Janus, E. D., & Utermann, G. (1996) · European Journal of Human Genetics · doi:10.1159/000472175 · Cited by 141
Self-citationEdelstein, C., Pfaffinger, D., Hinman, J., Miller, E. R., Lipkind, G. M., Tsimikas, S., Bergmark, C., Getz, G. S., Witztum, J. L., & Scanu, A. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310425200 · Cited by 137
Trommsdorff, M., Köchl, S., Lingenhel, A., Kronenberg, F., Delport, R., Vermaak, H., Lemming, L. E., Klausen, I. C., Færgeman, O., & Utermann, G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118015 · Cited by 137
Self-citationLanktree, M. B., Anand, S. S., Yusuf, S., & Hegele, R. A. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.907642 · Cited by 135
Lp(a): An Interloper into the Fibrinolytic System?
Miles, L. A., & Plow, E. F. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1645041 · Cited by 132
Apolipoprotein(a) Induces Monocyte Chemotactic Activity in Human Vascular Endothelial Cells
Poon, M., Zhang, X., Dunsky, K. G., Taubman, M. B., & Harpel, P. C. (1997) · Circulation · doi:10.1161/01.cir.96.8.2514 · Cited by 131
Cell surface assembly of lipoprotein(a) in primary cultures of baboon hepatocytes.
White, A. L., & Lanford, R. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61964-2 · Cited by 129
Lamon‐Fava, S., Jiménez, D., Christian, J. C., Fabsitz, R. R., Reed, T., Carmelli, D., Castelli, W. P., Ordovás, J. M., Wilson, P. W. F., & Schaefer, E. J. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90191-5 · Cited by 127
Relationship of lipoprotein(a) to variables of coagulation and fibrinolysis in a healthy population
Heinrich, J., Sandkamp, M., Kokott, R., Schulte, H., & Assmann, G. (1991) · Clinical Chemistry · doi:10.1093/clinchem/37.11.1950 · Cited by 126
Deshmukh, H., Colhoun, H. M., Johnson, T., McKeigue, P., Betteridge, D. J., Durrington, P. N., Fuller, J., Livingstone, S. J., Charlton-Menys, V., Neil, A., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p021113 · Cited by 126
Moliterno, D. J., Jokinen, E. V., Miserez, A. R., Lange, R. A., Willard, J. E., Boerwinkle, E., Hillis, L. D., & Hobbs, H. H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.850 · Cited by 126
Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma
Mooser, V., Mancini, F. P., Bopp, S., Pethö‐Schramm, A., Guerra, R., Boerwinkle, E., Müller, H.-J., & Hobbs, H. H. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.2.173 · Cited by 122
Lipoprotein(a) in Homozygous Familial Hypercholesterolemia
Kraft, H. G., Lingenhel, A., Raal, F. J., Hohenegger, M., & Utermann, G. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.2.522 · Cited by 121
Self-citationBenn, M. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.004 · Cited by 119
White, A. L., Rainwater, D., & Lanford, R. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40742-4 · Cited by 118
Brunner, C., Lobentanz, E., Pethö‐Schramm, A., Ernst, A., Kang, C., Dieplinger, H., Müller, H., & Utermann, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32403 · Cited by 117
Self-citationLipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.
Salonen, E., Jauhiainen, M., Zardi, L., Vaheri, A. I., & Ehnholm, C. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08586.x · Cited by 115
Johannsson, G., Oscarsson, J., Rosén, T., Wiklund, O., Olsson, G., Wilhelmsen, L., & Bengtsson, B. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.12.2142 · Cited by 115
Lipoprotein(a) in women twins: heritability and relationship to apolipoprotein(a) phenotypes.
The University of North Carolina at Chapel Hill University Libraries (2020) · PubMed · doi:10.17615/rq9q-tm46 · Cited by 115
Farnesoid X receptor represses hepatic human APOA gene expression
Chennamsetty, I., Claudel, T., Kostner, K., Baghdasaryan, A., Kratky, D., Levak‐Frank, S., Frank, S., Gonzalez, F. J., Trauner, M. A., & Kostner, G. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45277 · Cited by 112
Urinary Excretion of Apo(a) Fragments
Kostner, K., Maurer, G., Huber, K., Stefenelli, T., Dieplinger, H., Steyrer, E., & Kostner, G. M. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.905 · Cited by 110
Kronenberg, F., Trenkwalder, E., Lingenhel, A., Friedrich, G. J., Lhotta, K., Schober, M., Moes, N., König, P., Utermann, G., & Dieplinger, H. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37150-9 · Cited by 109
Self-citationIn vivo turnover study demonstrates diminished clearance of lipoprotein(a) in hemodialysis patients
Frischmann, M. E., Kronenberg, F., Trenkwalder, E., Schaefer, J. R., Schweer, H., Dieplinger, B., Koenig, P., Ikewaki, K., & Dieplinger, H. (2007) · Kidney International · doi:10.1038/sj.ki.5002131 · Cited by 101
Self-citationPersson, L., Henriksson, P., Westerlund, E., Hovatta, O., Angelin, B., & Rudling, M. J. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.242461 · Cited by 100
Rainwater, D. L., & Haffner, S. M. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.8.1335 · Cited by 99
Menzel, H.-J., Dieplinger, H., Lackner, C., Hoppichler, F., Lloyd, J. K., Muller, D. P. R., Labeur, C., Talmud, P. J., & Utermann, G. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40146-4 · Cited by 98
Self-citationHeid, I. M., Boes, E., Müller‐Nurasyid, M., Kollerits, B., Lamina, C., Coassin, S., Gieger, C., Döring, A., Klopp, N., Frikke‐Schmidt, R., et al. (2008) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.776708 · Cited by 97
Self-citationQi, Q., Workalemahu, T., Zhang, C., Hu, F. B., & Qi, L. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr350 · Cited by 97
Convergent evolution of apolipoprotein(a) in primates and hedgehog
Lawn, R. M., Schwartz, K., & Patthy, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11992 · Cited by 95
Mooser, V., Marcovina, S. M., White, A. L., & Hobbs, H. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119055 · Cited by 95
Ober, C., Nord, A. S., Thompson, E. E., Pan, L., Tan, Z., Cusanovich, D. A., Sun, Y., Nicolae, R. I., Edelstein, C., Schneider, D., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800515-jlr200 · Cited by 93
Longenecker, J. C., Klag, M. J., Marcovina, S. M., Liu, Y., Jaar, B. G., Powe, N. R., Fink, N. E., Levey, A. S., & Coresh, J. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004110922 · Cited by 93
Genetic architecture and evolution of the lipoprotein(a) trait
Utermann, G. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199904000-00007 · Cited by 92
Self-citationLIPOPROTEIN(α) IN HEALTH AND DISEASE
Byrne, C. D., & Wild, S. (1994) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.1994.tb09808.x · Cited by 92
Lipoprotein(a) in Health and Disease
Kronenberg, F., Steinmetz, A., Kostner, G. M., & Dieplinger, H. (1996) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369609080056 · Cited by 90
Self-citationKronenberg, F., König, P., Lhotta, K., Öfner, D., Sandholzer, C., Margreiter, R., Dosch, E., Utermann, G., & Dieplinger, H. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.9.1399 · Cited by 89
Self-citationThe Apo(a) Gene is the Major Determinant of Variation in Plasma Lp(a) Levels in African Americans
Mooser, V., Scheer, D., Marcovina, S. M., Wang, J., Guerra, R., Cohen, J. C., & Hobbs, H. H. (1997) · The American Journal of Human Genetics · doi:10.1086/514851 · Cited by 86
Mooser, V., Seabra, M. C., Abedin, M., Landschulz, K. T., Marcovina, S. M., & Hobbs, H. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118487 · Cited by 86
Neele, D. M., de Wit, E. C. M., & Princen, H. M. G. (1999) · Diabetologia · doi:10.1007/s001250051110 · Cited by 84
Evidence for increased synthesis of lipoprotein(a) in the nephrotic syndrome.
der Velden, M. G. M. D. S., Reijngoud, D., Kaysen, G. A., Gadellaa, M. M., Voorbij, H. A. M., Stellaard, F., Koomans, H. A., & Rabelink, T. J. (1998) · Journal of the American Society of Nephrology · doi:10.1681/asn.v981474 · Cited by 83
Molecular basis of congenital lp(a) deficiency: a frequent apo(a) 'null' mutation in caucasians
Ogorelkova, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.11.2087 · Cited by 82
Lipoprotein(a) and Apolipoprotein(a) Isoforms
Guerra, R., Yu, Z., Marcovina, S. M., Peshock, R. M., Cohen, J. C., & Hobbs, H. H. (2005) · Circulation · doi:10.1161/01.cir.0000159263.50305.bd · Cited by 80
Deo, R. C., Wilson, J. G., Xing, C., Lawson, K., Kao, W. H. L., Reich, D., Tandon, A., Akylbekova, E. L., Patterson, N. J., Mosley, T. H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014581 · Cited by 79
Effect of thyroid function on concentrations of lipoprotein(a)
Engler, H., & Riesen, W. F. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.12.2466 · Cited by 79
Influence of Allelic Variation on Apolipoprotein(a) Folding in the Endoplasmic Reticulum
White, A. L., Guerra, B., & Lanford, R. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.8.5048 · Cited by 78
Apo(a)-isoform size, nutritional status and inflammatory markers in chronic renal failure
Stenvinkel, P., Heimbürger, O., Tuck, C. H., & Berglund, L. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00880.x · Cited by 76
Identification of Megalin/gp330 as a Receptor for Lipoprotein(a) In Vitro
Niemeier, A., Willnow, T. E., Dieplinger, H., Jacobsen, C. B., Meyer, N., Hilpert, J., & Beisiegel†, U. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.552 · Cited by 76
Holmes, D. T., Schick, B. A., Humphries, K. H., & Frohlich, J. J. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.055228 · Cited by 73
Lipid lowering with thyroid hormone and thyromimetics
Angelin, B., & Rudling, M. J. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283402e9c · Cited by 71
Novel Interaction of Apolipoprotein(a) With β-2 Glycoprotein I Mediated by the Kringle IV Domain
Köchl, S., Fresser, F., Lobentanz, E., Baier, G., & Utermann, G. (1997) · Blood · doi:10.1182/blood.v90.4.1482 · Cited by 70
Self-citationGenetic control of lipoprotein(a) concentrations is different in Africans and Caucasians
Scholz, M., Kraft, H.-G., Lingenhel, A. W., Delport, R., Vorster, E., Bickeböller, H., & Utermann, G. (1999) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200290 · Cited by 69
Self-citationStimulation of Interleukin-8 Production in Human THP-1 Macrophages by Apolipoprotein(a)
Klezovitch, O., Edelstein, C., & Scanu, A. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107943200 · Cited by 68
Ogorelkova, M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.8.815 · Cited by 66
Nicotinic acid inhibits hepatic APOA gene expression: studies in humans and in transgenic mice
Chennamsetty, I., Kostner, K., Claudel, T., Vinod, M., Frank, S., Weiß, T. S., Trauner, M. A., & Kostner, G. M. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m029769 · Cited by 66
Genetic Variants in the Apolipoprotein(a) Gene and Coronary Heart Disease
Li, Y., Luke, M. M., Shiffman, D., & Devlin, J. J. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959601 · Cited by 65
Hemelaar, M., van der Mooren, M. J., Rad, M., Kluft, C., & Kenemans, P. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.07.1298 · Cited by 64
Serum Lipoprotein(a) Levels in Racially Different Populations
Cobbaert, C. M., & Kesteloot, H. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116517 · Cited by 64
Lipoprotein(a) Is a Potent Chemoattractant for Human Peripheral Monocytes
Syrovets, T., Thillet, J., Chapman, M. J., & Simmet, T. (1997) · Blood · doi:10.1182/blood.v90.5.2027 · Cited by 64
Berglund, L., Carlström, K., Stege, R., Gottlieb, C., Eriksson, M., Angelin, B., & Henriksson, P. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675589 · Cited by 63
Kronenberg, F., Lingenhel, A., Lhotta, K., Rantner, B., Kronenberg, M. F., König, P., Thiery, J., Koch, M., von Eckardstein, A., & Dieplinger, H. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00737.x · Cited by 62
Self-citationChretien, J.-P., Coresh, J., Berthier‐Schaad, Y., Kao, W. H. L., Fink, N. E., Klag, M. J., Marcovina, S. M., Giaculli, F., & Smith, M. W. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2006.042119 · Cited by 61
Mika Kivimaki, B., Magnussen, C. G., Juonala, M., Kähönen, M. A. P., Kettunen, J., Loo, B.-M., Lehtimäki, T. J., Viikari, J. S. A., & Raitakari, O. T. (2010) · International Journal of Epidemiology · doi:10.1093/ije/dyq205 · Cited by 61
Geethanjali, F. S., Luthra, K., Lingenhel, A., Kanagasabapathy, A. S., Jacob, J., Srivastava, L. M., Vasisht, S., Kraft, H.-G., & Utermann, G. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00143-6 · Cited by 57
Self-citationBiosynthesis and metabolism of lipoprotein (a)
White, A. L., & Lanford, R. E. (1995) · Current Opinion in Lipidology · doi:10.1097/00041433-199504000-00003 · Cited by 57
Tancevski, I., Demetz, E., Eller, K., Duwensee, K., Hoefer, J., Heim, C., Stanzl, U., Wehinger, A., Auer, K., Karer, R., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008722 · Cited by 53
Growth Hormone Induces Low-Density Lipoprotein Clearance but not Bile Acid Synthesis in Humans
Lind, S., Rudling, M. J., Ericsson, S., Olivecrona, H., Eriksson, M., Borgström, B., Eggertsen, G., Berglund, L., & Angelin, B. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110657.67317.90 · Cited by 50
Jamieson, D. G., Usher, D. C., Rader, D. J., & Lavi, E. (1995) · Europe PMC (PubMed Central) · Cited by 49
Apolipoprotein (a) alleles determine lipoprotein (a) particle density and concentration in plasma.
Kraft, H. G., Sandholzer, C., Menzel, H.-J., & Utermann, G. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.3.302 · Cited by 49
Self-citationWildbrett, J., Markolf Hanefeld, E., Fücker, K., Pinzer, T., Bergmann, S., Siegert, G., & Breidert, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211774 · Cited by 48
The seventh myth of lipoprotein(a)
Dieplinger, H., & Utermann, G. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199906000-00010 · Cited by 48
Self-citationThompson, G. R. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833e13fd · Cited by 48
The apolipoprotein(a) size polymorphism is associated with nephrotic syndrome
Kronenberg, F., Lingenhel, A., Lhotta, K., Rantner, B., Kronenberg, M. F., König, P., Thiery, J., Koch, M., von Eckardstein, A., & Dieplinger, H. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00418.x · Cited by 47
Self-citationDumitrescu, L. C., Glenn, K., Brown-Gentry, K. D., Shephard, C., Wong, M., Rieder, M. J., Smith, J. D., Nickerson, D. A., & Crawford, D. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016604 · Cited by 46
FGF19 Signaling Cascade Suppresses APOA Gene Expression
Chennamsetty, I., Claudel, T., Kostner, K., Trauner, M. A., & Kostner, G. M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.243055 · Cited by 46
Puckey, L. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.7.1099 · Cited by 46
Mancini, F. P., Newland, D., Mooser, V., Murata, J., Marcovina, S. M., Young, S. G., Hammer, R. E., Sanan, D. A., & Hobbs, H. H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1911 · Cited by 44
Lipoprotein[a] in the chimpanezee: relationship of apo[a] phenotype to elevated plasma Lp[a] levels.
Doucet, C., Huby, T., Chapman, J., & Thillet, J. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41215-5 · Cited by 43
Lingenhel, A., Kraft, H. G., Kotze, M., Peeters, A. V., Kronenberg, F., Kruse, R., & Utermann, G. (1998) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200152 · Cited by 43
Self-citationNovel Insights Into Lp(a) Physiology and Pathogenicity: More Questions Than Answers?
Koschinsky, M. L. (2006) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/187152906779010764 · Cited by 42
Lin, J. P., Schwaiger, J. P., Cupples, L. A., O’Donnell, C. J., Zheng, G., Schoenborn, V., Hunt, S. C., Joo, J., & Kronenberg, F. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.039 · Cited by 42
Self-citationAssembly of Lipoprotein (a) in Transgenic Rabbits Expressing Human Apolipoprotein (a)
Fan, J., Araki, M., Wu, L., Challah, M., Shimoyamada, H., Lawn, R. M., Kakuta, H., Shikama, H., & Watanabe, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0242 · Cited by 39
Anuurad, E., Rubin, J., Chiem, A. T., Tracy, R. P., Pearson, T. A., & Berglund, L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2416 · Cited by 39
Kerschdorfer, L., König, P., Neyer, U., Bösmüller, C., Lhotta, K., Auinger, M., Hohenegger, M., Riegler, P., Margreiter, R., Utermann, G., et al. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00014-3 · Cited by 38
Self-citationBecker, L., Nesheim, M. E., & Koschinsky, M. L. (2006) · Biochemistry · doi:10.1021/bi060283t · Cited by 37
Reblin, T., Meyer, N., Labeur, C., Henne‐Bruns, D., & Beisiegel†, U. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05445-o · Cited by 37
Trenkwalder, E., Gruber, A. C., König, P., Dieplinger, H., & Kronenberg, F. (1997) · Kidney International · doi:10.1038/ki.1997.503 · Cited by 36
Self-citationDecreased urinary apolipoprotein (a) excretion in patients with impaired renal function
Kostner, Clodi, Bodlaj, Watschinger, Hörl, Derfler, K., & Huber, K. (1998) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1998.00319.x · Cited by 34
The thyromimetic T-0681 protects from atherosclerosis
Tancevski, I., Wehinger, A., Demetz, E., Hoefer, J., Eller, K., Huber, E., Stanzl, U., Duwensee, K., Auer, K., Schgoer, W., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800553-jlr200 · Cited by 33
Scanu, A. M., & Hinman, J. (2002) · Lipids · doi:10.1007/s11745-002-0915-1 · Cited by 33
Genetics of the Lp(a)/apo(a) system in an autochthonous Black African population from the Gabon
Schmidt, K., Kraft, H., Parson, W., & Utermann, G. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201512 · Cited by 31
Self-citationLópez, S., Buil, A., Ordóñez‐Llanos, J., Souto, J. C., Almasy, L. A., Lathrop, M. G., Blangero, J., Blanco‐Vaca, F., Fontcuberta, J., & Soria, J. M. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.114 · Cited by 31
Kapetanopoulos, A., Fresser, F., Millonig, G., Shaul, Y., Baier, G., & Utermann, G. (2002) · Molecular Genetics and Genomics · doi:10.1007/s00438-002-0673-6 · Cited by 31
Self-citationSex hormones and lipoprotein(a) concentration
Gaeta, G. B., Lanero, S., Barra, S., Silvestri, N., Cuomo, V., Materazzi, C., & Vitagliano, G. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.548804 · Cited by 30
Heald, A. H., Kaushal, K., Anderson, S. G., Redpath, M., Durrington, P. N., Selby, P. L., & Gibson, M. (2005) · Gynecological Endocrinology · doi:10.1080/09513590400027406 · Cited by 30
LPA and PLG Sequence Variation and Kringle IV-2 Copy Number in Two Populations
Crawford, D. C., Peng, Z., Cheng, J., Boffelli, D., Ahearn, M., Nguyen, D. D., Shaffer, T. S., Qian, Y., Livingston, R. J., Rieder, M. J., et al. (2008) · Human Heredity · doi:10.1159/000143403 · Cited by 30
Lack of association between sex hormones and Lp(a) concentrations in American and Finnish men.
Haffner, S. M., Mykkänen, L. M., Gruber, K. K., Rainwater, D. L., & Laakso, M. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.19 · Cited by 29
Functional Analysis of the Chimpanzee and Humanapo(a) Promoter Sequences
Huby, T., Dachet, C., Lawn, R. M., Wickings, J., Chapman, M. J., & Thillet, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102204200 · Cited by 28
Erdel, M., Hubalek, M., Lingenhel, A., Kofler, K., Duba, H., & Utermann, G. (1999) · Nature Genetics · doi:10.1038/7681 · Cited by 26
Self-citationZabaneh, D., Meena Kumari, B., Sandhu, M. S., Wareham, N. J., Wainwright, N. W. J., Papamarkou, T., Hopewell, J. C., Clarke, R., Li, K., Palmen, J., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.015 · Cited by 25
Self-citationApolipoprotein(a) isoform-specific changes of lipoprotein(a) after kidney transplantation
Kronenberg, F., Lhotta, K., König, P., Margreiter, R., Dieplinger, H., & Utermann, G. (2003) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201016 · Cited by 24
Self-citationEdelstein, C., Pfaffinger, D., Yang, M., Hill, J. S., & Scanu, A. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.03.009 · Cited by 22
Umahara, T., Uchihara, T., Yamada, S., Hashimoto, T., Akimoto, J., Haraoka, J., & Iwamoto, T. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.10.048 · Cited by 19
van der Hoek, Y. Y., Lingenhel, A., Kraft, H. G., Defesche, J. C., Kastelein, J. J. P., & Utermann, G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119402 · Cited by 19
Self-citationHANSEN, P. S., Kassem, M. S., Brixen, K., Klausen, I. C., Mosekilde, L., & Færgeman, O. (1995) · Metabolism · doi:10.1016/0026-0495(95)90184-1 · Cited by 19
Chasman, D. I., Ballantyne, C. M., Nambi, V., Devlin, J. J., Boerwinkle, E., & Shiffman, D. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-01-0037 · Cited by 19
Barlera, S., Specchia, C., Farrall, M., Chiodini, B., Franzosi, M. G., Rust, S., Green, F. R., Nicolis, E., Peden, J. F., Assmann, G., et al. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201732 · Cited by 19
Thyroid hormone (fT4) reduces lipoprotein(a) plasma levels
Hoppichler, F., Sandholzer, C., Moncayo, R., Utermann, G., & Kraft, H. G. (1995) · Atherosclerosis · doi:10.1016/0021-9150(94)05500-i · Cited by 18
Self-citationLDL-mediated interaction of Lp[a] with HepG2 cells: a novel fluorescence microscopy approach
Hofer, G., Steyrer, E., Kostner, G. M., & Hermetter, A. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30026-2 · Cited by 18
Jauhiainen, M., Metso, J., Koskinen, P., & Ehnholm, C. (1991) · Biochemical Journal · doi:10.1042/bj2740491 · Cited by 17
Variation in Lp(a) levels and apo(a) isoform frequencies in five baboon subspecies.
Williams‐Blangero, S., & Rainwater, D. L. (1991) · PubMed · Cited by 16
Research works printed but not linked: 2
- Utermann G, 2000, The Metabolic & Molecular Bases of Inherited Disease, 2753
- 10.1210/jc.81.7.2633 · DOI
Cited by
Sorted by citations
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162
Padmanabhan, A., Connelly‐Smith, L. S., Aqui, N. A., Balogun, R. A., Klingel, R., Meyer, E., Pham, H. P., Schneiderman, J., Witt, V., Wu, Y., et al. (2019) · Journal of Clinical Apheresis · doi:10.1002/jca.21705 · Cited by 2,260
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.08.018 · Cited by 1,582
Kronenberg, F., Mora, S., Stroes, E. S. G., Ference, B. A., Arsenault, B. J., Berglund, L., Dweck, M. R., Koschinsky, M., Lambert, G., Mach, F., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac361 · Cited by 1,449
Self-citation
Metadata
- Authors
- Kronenberg, F., & Utermann, G.
- Affiliations
- Innsbruck Medical University (AT)
- Corresponding author
- Utermann, G.
- ORCID
- Kronenberg, F.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2012-11-12
- Volume
- 273
- Issue
- 1
- Pages
- 6-30
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W1988877980
- Cited by
- 521
- References
- 203
- Citations by year
- 2026: 40 · 2025: 38 · 2024: 39 · 2023: 41 · 2022: 45 · 2021: 42 · 2020: 36 · 2019: 48 · 2018: 35 · 2017: 36 · 2016: 42 · 2015: 38 · 2014: 20 · 2013: 17 · 2012: 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund
- Oesterreichische Nationalbank
- Standortagentur Tirol
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- lipoprotein(a), LPA gene, coronary heart disease risk, genetic risk factors, Mendelian randomization, apheresis, cardiovascular risk reduction
- MeSH terms
- Alleles, Coronary Artery Disease, DNA, Gene Frequency, Humans, Polymorphism, Genetic, Lipoprotein(a), Genetic Predisposition to Disease, Mendelian Randomization Analysis
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