A guided tour into subcellular colocalization analysis in light microscopy

The Trans -Golgi Network Accessory Protein p56 Promotes Long-Range Movement of GGA/Clathrin-containing Transport Carriers and Lysosomal Enzyme Sorting

Mardones, G. A., Burgos, P. V., Brooks, D. A., Parkinson-Lawrence, E., Mattera, R., & Bonifacino, J. S. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-02-0190 · Cited by 52

Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons

Vevea, J. D., Kusick, G. F., Courtney, K. C., Chen, E., Watanabe, S., & Chapman, E. R. (2021) · eLife · doi:10.7554/elife.67261 · Cited by 51

Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion

Joutsen, J., Da Silva, A. J., Luoto, J. C., Budzynski, M. A., Nylund, A. S., de Thonel, A., Concordet, J.-P., Mezger, V., Sabéran-Djoneidi, D., Henriksson, E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.037 · Cited by 51

Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae

Marie, C., Leyde, S., & White, T. C. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.07.004 · Cited by 47

Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex

Patton, M. S., Lodge, D. J., Morilak, D. A., & Girotti, M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.236 · Cited by 44

Biogenesis of a bacterial metabolosome for propanediol utilization

Yang, M., Wenner, N., Dykes, G. F., Li, Y., Zhu, X., Sun, Y., Huang, F., Hinton, J. C. D., & Liu, L.-N. (2022) · Nature Communications · doi:10.1038/s41467-022-30608-w · Cited by 45

MT5-MMP Promotes Alzheimer’s Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Baranger, K., Bonnet, A. E., Girard, S. D., Paumier, J.-M., García-González, L., Elmanaa, W., Bernard, A., Charrat, E., Stephan, D., Bauer, C., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00163 · Cited by 44

Lysosomal LAMP 1 immunoreactivity exists in both diffuse and neuritic amyloid plaques in the human hippocampus

Hassiotis, S., Manavis, J., Blumbergs, P. C., Hattersley, K. J., Carosi, J. M., Kamei, M., & Sargeant, T. J. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13913 · Cited by 44

Novel method to analyze post-yield mechanical properties at trabecular bone tissue level

Carretta, R., Luisier, B., Bernoulli, D., Stüssi, E., Müller, R., & Lorenzetti, S. (2013) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2012.12.003 · Cited by 43

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice

Kovács, R. Á., Vadászi, H., Bulyáki, É., Török, G., Tóth, V., Mátyás, D., Kun, J., Hunyadi-Gulyás, É., Fedor, F. Z., Csincsi, Á., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599771 · Cited by 43

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy

Cavieres, V. A., González, A., Muñoz, V. C., Yefi, C. P., Bustamante, H. A., Barraza, R. R., Tapia-Rojas, C., Otth, C., Barrera, M. J., González, C., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136313 · Cited by 43

Cell surface dynamics and cellular distribution of endogenous FcRn

D’Hooghe, L., Chalmers, A. D., Heywood, S., & Whitley, P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0182695 · Cited by 42

Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation

Jansen, R. M., Peruzzo, R., Fromm, S. A., Yokom, A. L., Zoncu, R., & Hurley, J. H. (2022) · Science Advances · doi:10.1126/sciadv.add2926 · Cited by 42

“Fast” plasma membrane calcium pump PMCA2a concentrates in GABAergic terminals in the adult rat brain

Burette, A. C., Strehler, E. E., & Weinberg, R. J. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21909 · Cited by 40

The Rho-specific GAP protein DLC3 coordinates endocytic membrane trafficking

Braun, A. C., Hendrick, J., Eisler, S. A., Schmid, S., Hausser, A., & Olayioye, M. A. (2015) · Journal of Cell Science · doi:10.1242/jcs.163857 · Cited by 41

IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases

Capel, R. A., Bose, S. J., Collins, T. P., Rajasundaram, S., Ayagama, T., Zaccolo, M., Burton, R.-A. B., & Terrar, D. A. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00380.2020 · Cited by 40

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.

Paumier, J.-M., Py, N. A., García-González, L., Bernard, A., Stephan, D., Louis, L., Checler, F., Khrestchatisky, M., Baranger, K., & Rivera, S. (2019) · The FASEB Journal · doi:10.1096/fj.201801076r · Cited by 40

A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle

Jansen, K. I., Iwanski, M. K., Burute, M., & Kapitein, L. C. (2023) · Journal of Cell Biology · doi:10.1083/jcb.202106105 · Cited by 39

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J.-H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1925-9 · Cited by 39

Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease

Rovelet-Lecrux, A., Feuillette, S., Miguel, L., Schramm, C., Pernet, S., Quenez, O., Ségalas-Milazzo, I., Guilhaudis, L., Rousseau, S., Riou, G., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01294-4 · Cited by 38

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection

Byrnes, A. E., Dominguez, S. L., Yen, C.-W., Laufer, B. I., Foreman, O., Reichelt, M., Lin, H., Sagolla, M., Hötzel, K., Ngu, H., et al. (2023) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2023.05.005 · Cited by 38

The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex

Fokin, A. I., David, V., Oguievetskaia, K., Derivery, E., Stone, C. E., Cao, L., Rocques, N., Molinie, N., Henriot, V., Aumont-Nicaise, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd5956 · Cited by 37

Rapid Turnover of the Cardiac L-Type CaV1.2 Channel by Endocytic Recycling Regulates Its Cell Surface Availability

Conrad, R., Stölting, G., Hendriks, J., Ruello, G., Kortzak, D., Jordan, N., Gensch, T., & Hidalgo, P. (2018) · iScience · doi:10.1016/j.isci.2018.08.012 · Cited by 35

Refining in vitro models for nanomaterial exposure to cells and tissues

Guggenheim, E. J., Milani, S., Röttgermann, P. J. F., Dusinska, M., Saout, C., Salvati, A., Rädler, J. O., & Lynch, I. (2018) · NanoImpact · doi:10.1016/j.impact.2018.02.008 · Cited by 36

A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila

Jacomin, A.-C., Fauvarque, M.-O., & Taillebourg, E. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0115-7 · Cited by 36

Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex

Duleh, S. N., & Welch, M. D. (2012) · Cytoskeleton · doi:10.1002/cm.21069 · Cited by 36

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number

Emechebe, U., Kumar P, P., Rozenberg, J. M., Moore, B., Firment, A., Mirshahi, T., & Moon, A. M. (2016) · eLife · doi:10.7554/elife.07897 · Cited by 36

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

Muthukumar, G., Stevens, T. A., Inglis, A. J., Esantsi, T. K., Saunders, R. A., Schulte, F., Voorhees, R. M., Guna, A., & Weissman, J. S. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.01.028 · Cited by 34

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

Hendrick, J., Franz-Wachtel, M., Moeller, Y., Schmid, S., Macek, B., & Olayioye, M. A. (2016) · Journal of Cell Science · doi:10.1242/jcs.190074 · Cited by 32

Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells

Watson, J. L., Krüger, L. K., Ben-Sasson, A. J., Bittleston, A., Shahbazi, M. N., Planelles-Herrero, V. J., Chambers, J. E., Manton, J. D., Baker, D., & Derivery, E. (2023) · Cell · doi:10.1016/j.cell.2023.08.034 · Cited by 32

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

Gusareva, E. S., Twizere, J.-C., Sleegers, K., Dourlen, P., Abisambra, J. F., Meier, S., Cloyd, R., Weiss, B., Dermaut, B., Bessonov, K., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.001 · Cited by 32

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Cao, H., Krueger, E. W., Chen, J., Drizyte-Miller, K., Schulz, M. E., & McNiven, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-14727-w · Cited by 25

Intracellular delivery of oxaliplatin conjugate via cell penetrating peptide for the treatment of colorectal carcinoma in vitro and in vivo

Singh, T., Kang, D. H., Kim, T. W., Kong, H. J., Ryu, J. S., Jeon, S., Ahn, T. S., Jeong, D., Baek, M. J., & Im, J. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120904 · Cited by 26

Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth

Tao, T., Sun, J., Peng, Y., Li, Y., Wang, P., Chen, X., Zhao, W., Zheng, Y.-Y., Wei, L., Wang, W., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.007318 · Cited by 26

Assorted dysfunctions of endosomal alkali cation/proton exchanger SLC9A6 variants linked to Christianson syndrome

Ilie, A., Boucher, A., Park, J., Berghuis, A. M., McKinney, R. A., & Orlowski, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.012614 · Cited by 24

Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

Das, M., Mao, W., Shao, E., Tamhankar, S., Yu, G.-Q., Yu, X., Ho, K., Wang, X., Wang, J., & Mucke, L. (2021) · iScience · doi:10.1016/j.isci.2021.103245 · Cited by 21

DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

Mondal, S., Kinatukara, P., Singh, S., Shambhavi, S., Patil, G. S., Dubey, N., Singh, S. H., Pal, B., Shekar, P. C., Kamat, S. S., et al. (2022) · eLife · doi:10.7554/elife.77665 · Cited by 19

Lusca: FIJI (ImageJ) based tool for automated morphological analysis of cellular and subcellular structures

Šimunić, I., Jagečić, D., Isaković, J., Dobrivojević Radmilović, M., & Mitrečić, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-57650-6 · Cited by 18

MT5‐MMP controls APP and β‐CTF/C99 metabolism through proteolytic‐dependent and ‐independent mechanisms relevant for Alzheimer's disease

García‐González, L., Paumier, J., Louis, L., Pilat, D., Bernard, A., Stephan, D., Jullien, N., Checler, F., Nivet, E., Khrestchatisky, M., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202100593r · Cited by 16

NRF3 activates mTORC1 arginine-dependently for cancer cell viability

Hirose, S., Waku, T., Tani, M., Masuda, H., Endo, K., Ashitani, S., Aketa, I., Kitano, H., Nakada, S., Wada, A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106045 · Cited by 15

Disrupting the transmembrane domain interface between PMP22 and MPZ causes peripheral neuropathy

(2024) · doi:10.1016/j.isci.2024.110989 · Cited by 15

The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis

Coleman, J. C., Tattersall, L., Yianni, V., Knight, L., Yu, H., Hallett, S. R., Johnson, P., Caetano, A. J., Cosstick, C., Ridley, A. J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109288 · Cited by 15

Sectoral activation of glia in an inducible mouse model of autosomal dominant retinitis pigmentosa

Massengill, M. T., Ash, N. F., Young, B. M., Ildefonso, C. J., & Lewin, A. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73749-y · Cited by 13

The structural basis of the talin–KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions

Li, X., Goult, B. T., Ballestrem, C., & Zacharchenko, T. (2023) · Open Biology · doi:10.1098/rsob.230058 · Cited by 13

Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

Bhattacharjee, R., Hall, A. R., Mangione, M. C., Igarashi, M. G., Roberts-Galbraith, R. H., Chen, J.-S., Vavylonis, D., & Gould, K. L. (2023) · eLife · doi:10.7554/elife.83062 · Cited by 12

Automated segmentation of soft X-ray tomography: Native cellular structure with submicron resolution at high-throughput for whole-cell quantitative imaging in yeast

(2025) · doi:10.1091/mbc.e24-10-0486 · Cited by 11

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

Ball, N. J., Ghimire, S., Follain, G., Pajari, A. O., Wurzinger, D., Vaitkevičiūtė, M., Cowell, A. R., Berki, B., Ivaska, J., Paatero, I., et al. (2024) · Journal of Cell Biology · doi:10.1083/jcb.202310030 · Cited by 11

PICALM regulates cathepsin D processing and lysosomal function

Hattersley, K. J., Carosi, J. M., Hein, L. K., Bensalem, J., & Sargeant, T. J. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.07.024 · Cited by 10

Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis

Andersen, R. C., Schmidt, J. H., Rombach, J., Lycas, M. D., Christensen, N. R., Lund, V. K., Stapleton, D. S., Pedersen, S. S., Olsen, M. A., Stoklund, M., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci144904 · Cited by 10

White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells

Yeung, S. H., Lee, R. H., Cheng, G. W., Ma, I. W., Kofler, J., Kent, C., Ma, F., Herrup, K., Fornage, M., Arai, K., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202400689rr · Cited by 10

Simultaneous selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment

Sekar, T. V., Elghonaimy, E. A., Swancutt, K. L., Diegeler, S., Gonzalez, I., Hamilton, C., Leung, P. Q., Meiler, J., Martina, C. E., Whitney, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43038-z · Cited by 8

A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

(2023) · doi:10.1016/j.celrep.2023.113001 · Cited by 8

Differential phosphorylation of the phosphoinositide 3-phosphatase MTMR2 regulates its association with early endosomal subtypes

Franklin, N. E., Bonham, C. A., Xhabija, B., & Vacratsis, P. O. (2013) · Journal of Cell Science · doi:10.1242/jcs.113928 · Cited by 8

RECQ4-MUS81 interaction contributes to telomere maintenance with implications to Rothmund-Thomson syndrome

Ashraf, R., Polasek-Sedlackova, H., Marini, V., Prochazkova, J., Hasanova, Z., Zacpalova, M., Boudova, M., & Krejci, L. (2025) · Nature Communications · doi:10.1038/s41467-025-56518-1 · Cited by 6

A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis

Pöhl, S., Osorio-Valeriano, M., Cserti, E., Harberding, J., Hernandez-Tamayo, R., Biboy, J., Sobetzko, P., Vollmer, W., Graumann, P. L., & Thanbichler, M. (2024) · eLife · doi:10.7554/elife.86577 · Cited by 5

Aberrant tau accumulation caused by MAPT mutations induces early pathological changes in axonal transport that are rescued by p38α inhibition

Moretto, E., Masato, A., Panzi, C., Lopes, A. T., Stuart, S., De La-Rocque, S., Caso, M. G., White, I. J., Harris, S. S., Busche, M. A., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02266-4 · Cited by 4

On the role of VP3-PI3P interaction in birnavirus endosomal membrane targeting

Zanetti, F. A., Fernandez, I., Baquero, E., Guardado-Calvo, P., Ferrino-Iriarte, A., Dubois, S., Morel, E., Alfonso, V., Aguilera, M. O., Celayes, M. E., et al. (2025) · eLife · doi:10.7554/elife.97261 · Cited by 4

Uncharacterized protein C17orf80 – a novel interactor of human mitochondrial nucleoids

(2023) · doi:10.1242/jcs.260822 · Cited by 3

Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity

Reimann, R. R., Puzio, M., Rosati, A., Emmenegger, M., Schneider, B. L., Valdés, P., Huang, D., Caflisch, A., & Aguzzi, A. (2023) · Brain Pathology · doi:10.1111/bpa.13130 · Cited by 3

On the Role of VP3-PI3P Interaction in Birnavirus Endosomal Membrane Targeting

(2024) · doi:10.1101/2024.02.20.581221 · Cited by 1

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

(2025) · doi:10.7554/elife.106839 · Cited by 1

A high-resolution analysis of arrestin2 interactions responsible for CCR5 endocytosis

Petrovic, I., Desai, S., Isaikina, P., Abiko, L. A., Spang, A., & Grzesiek, S. (2026) · eLife · doi:10.7554/elife.106839.4

Bioorthogonal click chemistry to visualize an immunogenic HLA-A2-restricted hepatitis B virus epitope in human monocyte-derived dendritic cells

Mostert, T. P., Kessler, A. L., Luijten, R. J., Doelman, W., Isendoorn, M. M. E., Filippov, D. V., van Kasteren, S. I., & Buschow, S. I. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkaf312

A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis

(2023) · doi:10.1101/2023.02.27.530196

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegans

Medwig-Kinney, T. N., Kinney, B. A., Martinez, M. A. Q., Yee, C., Sirota, S. S., Mullarkey, A. A., Somineni, N., Hippler, J., Zhang, W., Shen, K., et al. (2023) · doi:10.7554/elife.84355.2