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A guided tour into subcellular colocalization analysis in light microscopy
Abstract
Summary: It is generally accepted that the functional compartmentalization of eukaryotic cells is reflected by the differential occurrence of proteins in their compartments. The location and physiological function of a protein are closely related; local information of a protein is thus crucial to understanding its role in biological processes. The visualization of proteins residing on intracellular structures by fluorescence microscopy has become a routine approach in cell biology and is increasingly used to assess their colocalization with well‐characterized markers. However, image‐analysis methods for colocalization studies are a field of contention and enigma. We have therefore undertaken to review the most currently used colocalization analysis methods, introducing the basic optical concepts important for image acquisition and subsequent analysis. We provide a summary of practical tips for image acquisition and treatment that should precede proper colocalization analysis. Furthermore, we discuss the application and feasibility of colocalization tools for various biological colocalization situations and discuss their respective strengths and weaknesses. We have created a novel toolbox for subcellular colocalization analysis under ImageJ, named JACoP, that integrates current global statistic methods and a novel object‐based approach.
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Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
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Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
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Mathieu, M., Névo, N., Jouve, M., Valenzuela, J. I., Maurin, M., Verweij, F. J., Palmulli, R., Lankar, D., Dingli, F., Loew, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24384-2 · Cited by 910
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Winslow, A. R., Chen, C.-W., Corrochano, S., Acevedo-Arozena, A., Gordon, D. E., Peden, A. A., Lichtenberg, M., Menzies, F. M., Ravikumar, B., Imarisio, S., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003122 · Cited by 825
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Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T., & Sato, T. (2017) · Nature · doi:10.1038/nature22081 · Cited by 728
Kim, M. S., Haney, M. J., Zhao, Y., Yuan, D., Deygen, I., Klyachko, N. L., Kabanov, A. V., & Batrakova, E. V. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.09.011 · Cited by 663
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Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629
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Waters, J. C. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903097 · Cited by 613
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Yuan, D., Zhao, Y., Banks, W. A., Bullock, K. M., Haney, M., Batrakova, E., & Kabanov, A. V. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.011 · Cited by 607
Microscopic examination of spatial transcriptome using Seq-Scope
Cho, C.-S., Xi, J., Si, Y., Park, S.-R., Hsu, J.-E., Kim, M., Jun, G., Kang, H. M., & Lee, J. H. (2021) · Cell · doi:10.1016/j.cell.2021.05.010 · Cited by 520
Arioz, B. I., Tastan, B., Tarakcioglu, E., Tufekci, K. U., Olcum, M., Ersoy, N., Bagriyanik, A., Genc, K., & Genc, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01511 · Cited by 516
Giorgetti, L., Galupa, R., Nora, E. P., Piolot, T., Lam, F., Dekker, J., Tiana, G., & Heard, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.025 · Cited by 460
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease
Saresella, M., La Rosa, F., Piancone, F., Zoppis, M., Marventano, I., Calabrese, E., Rainone, V., Nemni, R., Mancuso, R., & Clerici, M. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0088-1 · Cited by 489
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Rojas, R., van Vlijmen, T., Mardones, G. A., Prabhu, Y., Rojas, A. L., Mohammed, S., Heck, A. J. R., Raposo, G., van der Sluijs, P., & Bonifacino, J. S. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200804048 · Cited by 455
Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., et al. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201506084 · Cited by 447
Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance
Kaushik, S., Rodriguez-Navarro, J. A., Arias, E., Kiffin, R., Sahu, S., Schwartz, G. J., Cuervo, A. M., & Singh, R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.008 · Cited by 382
Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome
Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal · doi:10.15252/embj.2018101064 · Cited by 351
Harterink, M., Port, F., Lorenowicz, M. J., McGough, I. J., Silhankova, M., Betist, M. C., van Weering, J. R. T., van Heesbeen, R. G. H. P., Middelkoop, T. C., Basler, K., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2281 · Cited by 327
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Zhao, S., Todorov, M. I., Cai, R., -Maskari, R. A., Steinke, H., Kemter, E., Mai, H., Rong, Z., Warmer, M., Stanic, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.030 · Cited by 292
TFEB and TFE3 are novel components of the integrated stress response
Martina, J. A., Diab, H. I., Brady, O. A., & Puertollano, R. (2016) · The EMBO Journal · doi:10.15252/embj.201593428 · Cited by 314
Patnala, R., Arumugam, T. V., Gupta, N., & Dheen, S. T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0149-z · Cited by 278
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Robin, L. M., Oliveira da Cruz, J. F., Langlais, V. C., Martin-Fernandez, M., Metna-Laurent, M., Busquets-Garcia, A., Bellocchio, L., Soria-Gomez, E., Papouin, T., Varilh, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.034 · Cited by 262
Vaillant-Beuchot, L., Mary, A., Pardossi-Piquard, R., Bourgeois, A., Lauritzen, I., Eysert, F., Kinoshita, P. F., Cazareth, J., Badot, C., Fragaki, K., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-020-02234-7 · Cited by 263
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Ilango, A., Kesner, A. J., Keller, K. L., Stuber, G. D., Bonci, A., & Ikemoto, S. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1703-13.2014 · Cited by 255
Sarkar, J., Wakefield, S., MacKenzie, G., Moss, S. J., & Maguire, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2560-11.2011 · Cited by 254
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Halt, A. R., Dallapiazza, R. F., Zhou, Y., Stein, I. S., Qian, H., Juntti, S., Wojcik, S., Brose, N., Silva, A. J., & Hell, J. W. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.482 · Cited by 243
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance
Wan, G., Fields, B. D., Spracklin, G., Shukla, A., Phillips, C. M., & Kennedy, S. (2018) · Nature · doi:10.1038/s41586-018-0132-0 · Cited by 207
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Deosaran, E., Larsen, K. B., Hua, R., Sargent, G., Wang, Y., Kim, S., Lamark, T., Jauregui, M., Law, K., Lippincott-Schwartz, J., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.114819 · Cited by 232
Absence of CX3CR1 impairs the internalization of Tau by microglia
Bolós, M., Llorens-Martín, M., Perea, J. R., Jurado-Arjona, J., Rábano, A., Hernández, F., & Avila, J. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0200-1 · Cited by 231
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The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
Franceschini, A., Capece, M., Chiozzi, P., Falzoni, S., Sanz, J. M., Sarti, A. C., Bonora, M., Pinton, P., & Di Virgilio, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-268714 · Cited by 225
Ritz, D., Vuk, M., Kirchner, P., Bug, M., Schütz, S., Hayer, A., Bremer, S., Lusk, C., Baloh, R. H., Lee, H., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2301 · Cited by 224
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Arnold, J., Mahamid, J., Lucic, V., de Marco, A., Fernandez, J.-J., Laugks, T., Mayer, T., Hyman, A. A., Baumeister, W., & Plitzko, J. M. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.10.053 · Cited by 221
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Laganenka, L., Colin, R., & Sourjik, V. (2016) · Nature Communications · doi:10.1038/ncomms12984 · Cited by 218
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Fang, L., Choi, S.-H., Baek, J. S., Liu, C., Almazan, F., Ulrich, F., Wiesner, P., Taleb, A., Deer, E., Pattison, J., et al. (2013) · Nature · doi:10.1038/nature12166 · Cited by 192
Zona, L., Lupberger, J., Sidahmed-Adrar, N., Thumann, C., Harris, H. J., Barnes, A., Florentin, J., Tawar, R. G., Xiao, F., Turek, M., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.006 · Cited by 182
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Tiede-Lewis, L. M., Xie, Y., Hulbert, M. A., Campos, R., Dallas, M. R., Dusevich, V., Bonewald, L. F., & Dallas, S. L. (2017) · Aging · doi:10.18632/aging.101308 · Cited by 176
Harris, L., Rigo, P., Stiehl, T., Gaber, Z. B., Austin, S. H. L., Masdeu, M. D. M., Edwards, A., Urbán, N., Marciniak-Czochra, A., & Guillemot, F. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.003 · Cited by 173
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Khadka, S., Vangeloff, A. D., Zhang, C., Siddavatam, P., Heaton, N. S., Wang, L., Sengupta, R., Sahasrabudhe, S., Randall, G., Gribskov, M., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.012187 · Cited by 175
Knupp, A., Mishra, S., Martinez, R., Braggin, J. E., Szabo, M., Kinoshita, C., Hailey, D. W., Small, S. A., Jayadev, S., & Young, J. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107719 · Cited by 165
Laulagnier, K., Javalet, C., Hemming, F. J., Chivet, M., Lachenal, G., Blot, B., Chatellard, C., & Sadoul, R. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2664-0 · Cited by 164
Retromer has a selective function in cargo sorting via endosome transport carriers
Cui, Y., Carosi, J. M., Yang, Z., Ariotti, N., Kerr, M. C., Parton, R. G., Sargeant, T. J., & Teasdale, R. D. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201806153 · Cited by 152
HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia
Arlet, J.-B., Ribeil, J.-A., Guillem, F., Negre, O., Hazoume, A., Marcion, G., Beuzard, Y., Dussiot, M., Moura, I. C., Demarest, S., et al. (2014) · Nature · doi:10.1038/nature13614 · Cited by 151
Herskowitz, J. H., Feng, Y., Mattheyses, A. L., Hales, C. M., Higginbotham, L. A., Duong, D. M., Montine, T. J., Troncoso, J. C., Thambisetty, M., Seyfried, N. T., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2508-13.2013 · Cited by 150
Mansuroglu, Z., Benhelli-Mokrani, H., Marcato, V., Sultan, A., Violet, M., Chauderlier, A., Delattre, L., Loyens, A., Talahari, S., Bégard, S., et al. (2016) · Scientific Reports · doi:10.1038/srep33047 · Cited by 146
Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., et al. (2014) · Diabetes · doi:10.2337/db13-0665 · Cited by 145
Eva, R., Dassie, E., Caswell, P. T., Dick, G., ffrench-Constant, C., Norman, J. C., & Fawcett, J. W. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2425-10.2010 · Cited by 138
BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching
Lazo, O. M., Gonzalez, A., Ascaño, M., Kuruvilla, R., Couve, A., & Bronfman, F. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4630-12.2013 · Cited by 137
Shaikh, S. R., Rockett, B. D., & Carraway, K. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.108720 · Cited by 132
Pitt, J., Roth, W., Lacor, P., Smith, A. B., Blankenship, M., Velasco, P., De Felice, F., Breslin, P., & Klein, W. L. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.018 · Cited by 134
Baranger, K., Marchalant, Y., Bonnet, A. E., Crouzin, N., Carrete, A., Paumier, J.-M., Py, N. A., Bernard, A., Bauer, C., Charrat, E., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1992-1 · Cited by 133
Human Papillomavirus L2 Facilitates Viral Escape from Late Endosomes via Sorting Nexin 17
Bergant Marušič, M., Ozbun, M. A., Campos, S. K., Myers, M. P., & Banks, L. (2012) · Traffic · doi:10.1111/j.1600-0854.2011.01320.x · Cited by 130
Oligodendrocytes express synaptic proteins that modulate myelin sheath formation
Hughes, A. N., & Appel, B. (2019) · Nature Communications · doi:10.1038/s41467-019-12059-y · Cited by 128
The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
Mishra, S., Knupp, A., Szabo, M. P., Williams, C. A., Kinoshita, C., Hailey, D. W., Wang, Y., Andersen, O. M., & Young, J. E. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04182-9 · Cited by 126
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Yatskevich, S., Muir, K. W., Bellini, D., Zhang, Z., Yang, J., Tischer, T., Predin, M., Dendooven, T., McLaughlin, S. H., & Barford, D. (2022) · Science · doi:10.1126/science.abn3810 · Cited by 120
Moriwaki, K., Farias Luz, N., Balaji, S., De Rosa, M. J., O’Donnell, C. L., Gough, P. J., Bertin, J., Welsh, R. M., & Chan, F. K.-M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501662 · Cited by 116
Abeliovich, H., Zarei, M., Rigbolt, K. T. G., Youle, R. J., & Dengjel, J. (2013) · Nature Communications · doi:10.1038/ncomms3789 · Cited by 114
Spurrier, J., Nicholson, L., Fang, X. T., Stoner, A. J., Toyonaga, T., Holden, D., Siegert, T. R., Laird, W., Allnutt, M. A., Chiasseu, M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abi8593 · Cited by 114
Digiacomo, L., Cardarelli, F., Pozzi, D., Palchetti, S., Digman, M. A., Gratton, E., Capriotti, A. L., Mahmoudi, M., & Caracciolo, G. (2017) · Nanoscale · doi:10.1039/c7nr06437c · Cited by 109
Identification of two pathways mediating protein targeting from ER to lipid droplets
Song, J., Mizrak, A., Lee, C.-W., Cicconet, M., Lai, Z. W., Tang, W.-C., Lu, C.-H., Mohr, S. E., Farese, R. V., & Walther, T. C. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00974-0 · Cited by 106
Jiang, T., Munguia-Lopez, J. G., Gu, K., Bavoux, M. M., Flores-Torres, S., Kort-Mascort, J., Grant, J., Vijayakumar, S., De Leon-Rodriguez, A., Ehrlicher, A. J., et al. (2020) · Biofabrication · doi:10.1088/1758-5090/ab3a5c · Cited by 106
High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons
Andreska, T., Aufmkolk, S., Sauer, M., & Blum, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00107 · Cited by 100
Li, X., Standley, C., Sapp, E., Valencia, A., Qin, Z.-H., Kegel, K. B., Yoder, J., Comer-Tierney, L. A., Esteves, M., Chase, K., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00420-09 · Cited by 105
A Role for EHD4 in the Regulation of Early Endosomal Transport
Sharma, M., Naslavsky, N., & Caplan, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00732.x · Cited by 101
Kadiu, I., & Gendelman, H. E. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9298-z · Cited by 100
Pihlaja, R., Koistinaho, J., Kauppinen, R., Sandholm, J., Tanila, H., & Koistinaho, M. (2011) · Glia · doi:10.1002/glia.21212 · Cited by 96
Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission
Korinek, M., Gonzalez-Gonzalez, I. M., Smejkalova, T., Hajdukovic, D., Skrenkova, K., Krusek, J., Horak, M., & Vyklicky, L. (2020) · Scientific Reports · doi:10.1038/s41598-020-69454-5 · Cited by 93
Wu, Y., Torabi, S.-F., Lake, R. J., Hong, S., Yu, Z., Wu, P., Yang, Z., Nelson, K., Guo, W., Pawel, G. T., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade7622 · Cited by 91
Fast transcription rates of RNA polymerase II in human cells
Maiuri, P., Knezevich, A., De Marco, A., Mazza, D., Kula, A., McNally, J. G., & Marcello, A. (2011) · The EMBO Reports · doi:10.1038/embor.2011.196 · Cited by 91
Kim, I., Mlsna, L. M., Yoon, S., Le, B., Yu, S., Xu, D., & Koh, S. (2015) · Brain and Behavior · doi:10.1002/brb3.403 · Cited by 91
“To examine changes in the number and size of microglia during development and after FS or KA-SE, six sections spanning the extent of the dorsal hippocampus were selected from each animal (n = 3–4 animals/group).”
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Plantard, L., Arjonen, A., Lock, J. G., Nurani, G., Ivaska, J., & Strömblad, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.069609 · Cited by 84
Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy
Hoffmann, A., Ettle, B., Battis, K., Reiprich, S., Schlachetzki, J. C. M., Masliah, E., Wegner, M., Kuhlmann, T., Riemenschneider, M. J., & Winkler, J. (2019) · Brain Pathology · doi:10.1111/bpa.12678 · Cited by 83
Digital images are data: and should be treated as such
Cromey, D. W. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-056-4_1 · Cited by 82
Chaperone mediated autophagy degrades TDP-43 protein and is affected by TDP-43 aggregation
Ormeño, F., Hormazabal, J., Moreno, J., Riquelme, F., Rios, J., Criollo, A., Albornoz, A., Alfaro, I. E., & Budini, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00019 · Cited by 80
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Zhu, Y., Yao, L., Gallo-Ferraz, A. L., Bombassaro, B., Simões, M. R., Abe, I., Chen, J., Sarker, G., Ciccarelli, A., Zhou, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07863-6 · Cited by 78
Clawson, B. C., Pickup, E. J., Ensing, A., Geneseo, L., Shaver, J., Gonzalez-Amoretti, J., Zhao, M., York, A. K., Kuhn, F. R., Swift, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21471-2 · Cited by 73
Buggia-Prévot, V., Fernandez, C. G., Udayar, V., Vetrivel, K. S., Elie, A., Roseman, J., Sasse, V. A., Lefkow, M., Meckler, X., Bhattacharyya, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.12.006 · Cited by 77
Actin Polymerization Controls the Organization of WASH Domains at the Surface of Endosomes
Derivery, E., Helfer, E., Henriot, V., & Gautreau, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039774 · Cited by 77
Klontzas, M. E., Reakasame, S., Silva, R., Morais, J. C. F., Vernardis, S., MacFarlane, R. J., Heliotis, M., Tsiridis, E., Panoskaltsis, N., Boccaccini, A. R., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.02.017 · Cited by 77
Lee, S., Chang, J., & Blackstone, C. (2016) · Nature Communications · doi:10.1038/ncomms10939 · Cited by 73
Mesnage, B., Gaillard, S., Godin, A. G., Rodeau, J., Hammer, M., Von Engelhardt, J., Wiseman, P. W., De Koninck, Y., Schlichter, R., & Cordero‐Erausquin, M. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22668 · Cited by 71
Silencing of the CHM Gene Alters Phagocytic and Secretory Pathways in the Retinal Pigment Epithelium
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Guivernau, B., Bonet, J., Valls-Comamala, V., Bosch-Morató, M., Godoy, J. A., Inestrosa, N. C., Perálvarez-Marín, A., Fernández-Busquets, X., Andreu, D., Oliva, B., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1081-16.2016 · Cited by 69
Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E., Patel, V., Kannan, S., Kim, Y.-H., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110182 · Cited by 68
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Didiot, M.-C., Ferguson, C. M., Ly, S., Coles, A. H., Smith, A. O., Bicknell, A. A., Hall, L. M., Sapp, E., Echeverria, D., Pai, A. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.106 · Cited by 64
Jordà‐Siquier, T., Petrel, M., Kouskoff, V., Smailovic, U., Cordelières, F., Frykman, S., Müller, U., Mulle, C., & Barthet, G. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12546 · Cited by 63
Self-citationRapid macropinocytic transfer of α-synuclein to lysosomes
Bayati, A., Banks, E., Han, C., Luo, W., Reintsch, W. E., Zorca, C. E., Shlaifer, I., Del Cid Pellitero, E., Vanderperre, B., McBride, H. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111102 · Cited by 57
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Yakhine-Diop, S. M. S., Niso-Santano, M., Rodríguez-Arribas, M., Gómez-Sánchez, R., Martínez-Chacón, G., Uribe-Carretero, E., Navarro-García, J. A., Ruiz-Hurtado, G., Aiastui, A., Cooper, J. M., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1206-6 · Cited by 57
Moya-Alvarado, G., Gonzalez, A., Stuardo, N., & Bronfman, F. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00493 · Cited by 57
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(2023) · doi:10.1038/s41564-022-01305-7 · Cited by 55
Dahhan, D. A., Reynolds, G. D., Cárdenas, J. J., Eeckhout, D., Johnson, A., Yperman, K., Kaufmann, W. A., Vang, N., Yan, X., Hwang, I., et al. (2022) · The Plant Cell · doi:10.1093/plcell/koac071 · Cited by 54
Syed, A. U., Reddy, G. R., Ghosh, D., Prada, M. P., Nystoriak, M. A., Morotti, S., Grandi, E., Sirish, P., Chiamvimonvat, N., Hell, J. W., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124705 · Cited by 52
Metadata
- Authors
- BOLTE, S., & CORDELIÈRES, F. P.
- Venue
- Journal of Microscopy
- Publisher
- Wiley
- Published
- 2006-12
- Volume
- 224
- Issue
- 3
- Pages
- 213-232
- ISSN
- 0022-2720 (ISSN-L)
- 1365-2818
- OpenAlex
- W2124733101
- Cited by
- 5,324
- References
- 0
- FWCI
- 23.89
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
