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Cited by 93Cannabis and Cannabinoid ResearchSchizophrenia research and treatmentHallucinations in medical conditions

Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness

Koethe, Dagmar, Gerth, Christoph W., Neatby, Miriam A., Haensel, Anita, Thies, Martin, Schneider, Udo, Emrich, Hinderk M., Klosterkötter, Joachim +2 more·2006·Schizophrenia Research
DOI 10.1016/j.schres.2006.07.023
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Abstract

Recent data on alterations of the endogenous cannabinoid system in schizophrenia have raised the question of its functional role in this disease. The psychoactive compound of Cannabis sativa, delta-9-tetrahydrocannabinol (Delta9-THC), has been shown to induce psychotic symptoms, but it is unknown to what extend prodromal states of psychoses are reflected by these experimental approaches. This study compares four groups of subjects: antipsychotic-naïve patients suffering from acute paranoid schizophrenic or schizophreniform psychosis (SZ), patients in the prodromal state (IPS), healthy controls without any pharmacological intervention (HC) and a second group of healthy volunteers who were orally administered synthetic Delta9-THC (Dronabinol) (HC-THC). Neither SZ and IPS nor HC received the experimental drug. All subjects were assessed using the Brief Psychiatric Rating Scale (BPRS) and the Binocular Depth Inversion Illusion Test (BDII). The latter represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. BDII values were well comparable in SZ, IPS and HC-THC, and all groups differed significantly to HC. The BPRS revealed no significant difference between HC-THC and IPS while both were significantly different from SZ and HC, respectively. Our results suggest that Delta9-THC-induced altered states of consciousness may serve as a useful tool for modeling psychotic disorders, particularly their prodromal states. Furthermore, they provide insight into the perceptual and psychopathological alterations induced by Delta9-THC, which is essential for the understanding of the pro-psychotic effects of herbal cannabis preparations with highly enriched Delta9-THC content.

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Crossref · 10.1016/j.schres.2006.07.023

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  • Induction of pro-psychotic states in non-clinical populations via acute cannabinoids, chronic intoxication, or sleep deprivation experimentally reduces sensitivity to visual illusions.

    “other studies have suggested that the induction of “pro-psychotic” states in non-clinical populations, via, for example, acute cannabinoids (Emrich et al., 1997; Leweke et al., 1999; Koethe et al., 2006), chronic intoxication (Semple et al., 2003) or sleep deprivation (Sternemann et al., 1997), enable to experimentally reduce sensitivity to VIs.”

    From What visual illusions teach us about schizophrenia (2014) · cites this paper as Koethe et al., 2006

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Authors
Koethe, D., Gerth, C. W., Neatby, M. A., Haensel, A., Thies, M., Schneider, U., Emrich, H. M., Klosterkötter, J., Schultze-Lutter, F., & Leweke, F. M.
Affiliations
  • University of Cologne (DE)
  • Medizinische Hochschule Hannover (DE)
Corresponding author
Leweke, F. Markus
ORCID
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2006-12
Volume
88
Issue
1-3
Pages
142-150
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2006.07.023
OpenAlex
W2111223938
Cited by
93
References
52
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 6
FWCI
4.15
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Stanley Medical Research Institute
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords
delta-9-tetrahydrocannabinol, dronabinol
MeSH terms
Acute Disease, Adolescent, Adult, Consciousness Disorders, Depth Perception, Female, Hallucinogens, Humans, Male, Brief Psychiatric Rating Scale, Perceptual Disorders, Psychometrics, Psychoses, Substance-Induced, Schizophrenia, Paranoid, Severity of Illness Index, Dronabinol, Visual Perception, Vision, Binocular

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