Exposure to the Taste of Alcohol Elicits Activation of the Mesocorticolimbic Neurocircuitry
Open accessAbstract
A growing number of imaging studies suggest that alcohol cues, mainly visual, elicit activation in mesocorticolimbic structures. Such findings are consistent with the growing recognition that these structures play an important role in the attribution of incentive salience and the pathophysiology of addiction. The present study investigated whether the presentation of alcohol taste cues can activate brain regions putatively involved in the acquisition and expression of incentive salience. Using functional magnetic resonance imaging, we recorded BOLD activity while delivering alcoholic tastes to 37 heavy drinking but otherwise healthy volunteers. The results yielded a pattern of BOLD activity in mesocorticolimbic structures (ie prefrontal cortex, striatum, ventral tegmental area/substantia nigra) relative to an appetitive control. Further analyses suggested strong connectivity between these structures during cue-elicited urge and demonstrated significant positive correlations with a measure of alcohol use problems (ie the Alcohol Use Disorders Identification Test). Thus, repeated exposure to the taste alcohol in the scanner elicits activation in mesocorticolimbic structures, and this activation is related to measures of urge and severity of alcohol problems.
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Symptom-related, cue-induced hyperactivity in OFC and increased functional connectivity between OFC and striatum have been reported in patients with compulsive disorders.
“Symptom-related, cue-induced hyperactivity in the OFC and increased functional connectivity between the OFC and striatum have been reported in patients with compulsive disorders69–72.”
From Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior (2026) · cites this paper as [69]
The A Priori ROI Analyses report greater OFC activity during alcohol-taste cues than control cues, and the Correlation of Areas in the Reward Craving Pathway section reports correlated responses across ROIs, including OFC and striatum (Table 4). But the Participants section describes healthy frequent drinkers, not patients with diagnosed compulsive disorders. The paper reports OFC–striatal correlations, not an increase in functional connectivity relative to a comparator. (LLM, conf=0.88)
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Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
SAUNDERS, J. B., AASLAND, O. G., BABOR, T. F., DE LA FUENTE, J. R., & GRANT, M. (1993) · Addiction · doi:10.1111/j.1360-0443.1993.tb02093.x · Cited by 13,482 · see citing works
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 6,805 · see citing works
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923 · see citing works
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
Goldstein, R. Z., & Volkow, N. D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1642 · Cited by 2,667 · see citing works
Stereotaxic Display of Brain Lesions
Rorden, C., & Brett, M. (2000) · Behavioural Neurology · doi:10.1155/2000/421719 · Cited by 2,573 · see citing works
A three-dimensional statistical analysis for CBF activation studies in human brain
Worsley, K. J., Evans, A. C., Marrett, S., & Neelin, P. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.127 · Cited by 2,036 · see citing works
Multilevel linear modelling for FMRI group analysis using Bayesian inference
Woolrich, M. W., Behrens, T. E. J., Beckmann, C. F., Jenkinson, M., & Smith, S. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.023 · Cited by 1,719 · see citing works
General multilevel linear modeling for group analysis in FMRI
Beckmann, C. F., Jenkinson, M., & Smith, S. M. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00435-x · Cited by 1,464 · see citing works
Incentive-sensitization and addiction
Robinson, T. E., & Berridge, K. C. (2001) · Addiction · doi:10.1046/j.1360-0443.2001.9611038.x · Cited by 1,435 · see citing works
Damage to the insula disrupts addiction to cigarette smoking
Naqvi, N. H., Rudrauf, D., Damasio, H., & Bechara, A. (2007) · Science · doi:10.1126/science.1135926 · Cited by 1,245 · see citing works
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · cited 1× · see citing works
“Given that gustatory cues associated with food and beverages elicit activation of this same circuitry (O'Doherty et al, 2001, 2002; Small et al, 2001; Frank et al, 2003; ) and given the studies noted above, gustatory cues of alcoholic beverages may represent a means of activating these mesolimbic…”
BackgroundDopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
Interactions between frontal cortex and basal ganglia in working memory: A computational model
FRANK, M. J., LOUGHRY, B., & O'REILLY, R. C. (2001) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.1.2.137 · Cited by 879 · see citing works
Region of interest analysis for fMRI
Poldrack, R. A. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm006 · Cited by 814 · see citing works
Predictability modulates human brain response to reward
Berns, G. S., McClure, S. M., Pagnoni, G., & Montague, P. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02793.2001 · Cited by 711 · see citing works
Representation of Pleasant and Aversive Taste in the Human Brain
O’Doherty, J. P., Rolls, E. T., Francis, S., Bowtell, R. W., & McGlone, F. P. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1315 · Cited by 674 · see citing works
Images of desire: food-craving activation during fMRI
Pelchat, M. L., Johnson, A., Chan, R., Valdez, J., & Ragland, J. D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.023 · Cited by 667 · see citing works
Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R. R., Goate, A., Hesselbrock, V., Jones, K., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383283 · Cited by 655 · see citing works
Development and Initial Validation of a Measure of Drinking Urges in Abstinent Alcoholics
Bohn, M. J., Krahn, D. D., & Staehler, B. A. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01554.x · Cited by 641 · see citing works
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598 · see citing works
Gustatory, olfactory, and visual convergence within the primate orbitofrontal cortex
Rolls, E., & Baylis, L. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05437.1994 · Cited by 587 · see citing works
Oslin, D. W., Berrettini, W., Kranzler, H. R., Pettinati, H., Gelernter, J., Volpicelli, J. R., & O'Brien, C. P. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300219 · Cited by 571 · see citing works
Myrick, H., Anton, R. F., Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300295 · Cited by 521 · see citing works
Historical review: molecular and cellular mechanisms of opiate and cocaine addiction
Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425 · see citing works
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408 · see citing works
George, M. S., Anton, R. F., Bloomer, C., Tenebäck, C. C., Drobes, D. J., Lorberbaum, J. P., Nahas, Z. H., & Vincent, D. J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.345 · Cited by 382 · see citing works
Neural Response to Alcohol Stimuli in Adolescents With Alcohol Use Disorder
Tapert, S. F., Cheung, E. H., Brown, G. G., Frank, L. R., Paulus, M. P., Schweinsburg, A. D., Meloy, M. J., & Brown, S. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.727 · Cited by 372 · see citing works
Paulus, M. P., Tapert, S. F., & Schuckit, M. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.7.761 · Cited by 369 · see citing works
A cognitive processing model of alcohol craving and compulsive alcohol use
Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.3.x · Cited by 356 · see citing works
Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients
Schneider, F. W., Habel, U., Wagner, M., Franke, P. E., Salloum, J. B., Shah, N. J., Toni, I., Sulzbach, C., Hönig, K., Maier, W., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1075 · Cited by 319 · see citing works
Ray, L. A., & Hutchison, K. E. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000148114.34000.b9 · Cited by 312 · see citing works
Self-citationVolkow, N. D., Wang, G.-J., Ma, Y., Fowler, J. S., Wong, C., Ding, Y.-S., Hitzemann, R., Swanson, J. M., & Kalivas, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0433-05.2005 · Cited by 304 · see citing works
What is craving? Models and implications for treatment.
Anton, R. F. (1999) · PubMed Central · Cited by 289 · see citing works
David, S. P., Munafo, M. R., Johansen‐Berg, H., Smith, S. M., Rogers, R. D., Matthews, P. M., & Walton, R. T. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.028 · Cited by 275 · see citing works
Allelic and haplotypic association of <i>GABRA2</i> with alcohol dependence
Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., & Kranzler, H. R. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30091 · Cited by 273 · cited 1× · see citing works
“In addition, genetic variation in GABA function (Edenberg et al, 2004; Covault et al, 2004), opioid function (Ray and Hutchison, 2004; Oslin et al, 2003), dopamine function (Hutchison et al, 2003; Hutchison et al, 2006) and cannabinoid function (Zhang et al, 2004) have also been linked to the…”
BackgroundFlavor processing: more than the sum of its parts
Small, D. M., Jones-Gotman, M., Zatorre, R. J., Petrides, M., & Evans, A. C. (1997) · Neuroreport · doi:10.1097/00001756-199712220-00014 · Cited by 265 · see citing works
A cognitive processing model of alcohol craving and compulsive alcohol use
Tiffany, S. T., & Conklin, C. A. (2000) · Addiction · doi:10.1080/09652140050111717 · Cited by 261 · see citing works
Neural substrates of conditioned-cued relapse to drug-seeking behavior
See, R. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00682-7 · Cited by 257 · see citing works
Zhang, P. J., Ishiguro, H., Ohtsuki, T., Hess, J., Carillo, F., Walther, D. M., Onaivi, E. S., Arinami, T., & Uhl, G. R. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001560 · Cited by 247 · see citing works
Separate neural substrates for skill learning and performance in the ventral and dorsal striatum
Atallah, H. E., Lopez-Paniagua, D., Rudy, J. W., & O'Reilly, R. C. (2007) · Nature Neuroscience · doi:10.1038/nn1817 · Cited by 241 · see citing works
fMRI BOLD response to alcohol stimuli in alcohol dependent young women
Tapert, S. F., Brown, G. G., Baratta, M. V., & Brown, S. A. (2003) · Addictive Behaviors · doi:10.1016/j.addbeh.2003.07.003 · Cited by 211 · see citing works
Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics
Braus, D. F., Wrase, J., Grüsser, S. M., Hermann, D., Ruf, M., Flor, H., Mann, K. F., & Heinz, A. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170038 · Cited by 192 · see citing works
Development of alcohol-associated cues and cue-induced brain activation in alcoholics
Wrase, J., Grüsser, S. M., Vollstädt‐Klein, S., Diener, C., Hermann, D., Flor, H., Mann, K. F., Braus, D. F., & Heinz, A. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00676-4 · Cited by 192 · see citing works
Kareken, D. A., Claus, E. D., Sabri, M., Džemidžić, M., Kosobud, A., Radnovich, A. J., Hector, D. H., Ramchandani, V. A., O’Connor, S., Lowe, M. J., et al. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000122764.60626.af · Cited by 122 · see citing works
Self-citationOlanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction
Hutchison, K. E., Wooden, A., Swift, R. M., Smolen, A., McGeary, J. E., Adler, L. E., & Paris, L. L. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300264 · Cited by 118 · see citing works
Self-citationA Multi-site Dose Ranging Study of Nalmefene in the Treatment of Alcohol Dependence
Anton, R. F., Pettinati, H. M., Zweben, A., Kranzler, H. R., Johnson, B. A., Bohn, M. J., McCaul, M. E., Anthenelli, R. M., Salloum, I. M., Galloway, G. P., et al. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000130555.63254.73 · Cited by 117 · see citing works
The Effect of Olanzapine on Craving and Alcohol Consumption
Hutchison, K. E., Ray, L. A., Sandman, E., Goodworth, M.-C. R., Peters, A., Davidson, D., & Swift, R. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300917 · Cited by 117 · see citing works
Self-citationBrain substrates of craving to alcohol cues in subjects with alcohol use disorder
Park, M., Sohn, J., Ra, J. S., Kim, S. H., Sohn, S., & Sparacio, R. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl117 · Cited by 111 · see citing works
Investigating the neural basis for functional and effective connectivity. Application to fMRI
Horwitz, B., Warner, B. T., Fitzer, J., Tagamets, M.-A., Husain, F. T., & Long, T. W. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1647 · Cited by 104 · see citing works
Where arousal meets attention: a simultaneous fMRI and EEG recording study
Foucher, J., Otzenberger, H., & Gounot, D. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.048 · Cited by 104 · see citing works
Hermann, D., Smolka, M. N., Wrase, J., Vollstädt‐Klein, S., Nikitopoulos, J. A., Georgi, A., Braus, D. F., Flor, H., Mann, K. F., & Heinz, A. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00174.x · Cited by 98 · see citing works
Modell, J. G., Mountz, J. M., & Beresford, T. P. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.2.123 · Cited by 75 · see citing works
Nielsen, F. Å., & Hansen, L. K. (2008) · Cited by 74 · see citing works
Effects of Topiramate in the Treatment of Alcohol Dependence
Rubio, G., Ponce, G., Jiménez‐Arriero, M. Á., Palomo, T., Manzanares, J., & Ferre, F. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-815473 · Cited by 71 · see citing works
Mechanisms of Alcohol Craving and Their Clinical Implications
Singleton, E. G., & Gorelick, D. A. (1998) · Springer eBooks · doi:10.1007/0-306-47148-5_8 · Cited by 65 · see citing works
Reducing susceptibility artifacts in fMRI using volume‐selective z‐shim compensation
Du, Y. P., Dalwani, M. S., Wylie, K. P., Claus, E. D., & Tregellas, J. R. (2007) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21150 · Cited by 63 · see citing works
Self-citationFrank, G., Kaye, W. H., Carter, C. S., Brooks, S., May, C. J., Fissell, K., & Stenger, V. A. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00240-1 · Cited by 62 · see citing works
Acamprosate in the treatment of alcohol dependence
Mason, B. J. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.12.2103 · Cited by 46 · see citing works
Naltrexone Treatment for Alcohol Dependency
Ameisen, O. (2005) · JAMA · doi:10.1001/jama.294.8.899-b · Cited by 23 · see citing works
Lurito (2000) · doi:10.1002/1097-0193(200007)10:3
Flagged first, then by citations
Research works printed but not linked: 1
- Tailarach J, Tournoux P (1988). Coplanar Stereotaxic Atlas of the Human Brain. Thieme Medical: New York.
Cited by
Sorted by citations
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Schacht, J. P., Anton, R. F., & Myrick, H. (2013) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00464.x · Cited by 583 · see citing works
Jasinska, A. J., Stein, E. A., Kaiser, J., Naumer, M. J., & Yalachkov, Y. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.013 · Cited by 513 · see citing works
Vollstädt‐Klein, S., Wichert, S., Rabinstein, J., Bühler, M., Klein, O., Ende, G., Hermann, D., & Mann, K. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03022.x · Cited by 357 · see citing works
The insula: a critical neural substrate for craving and drug seeking under conflict and risk
Naqvi, N. H., Gaznick, N., Tranel, D., & Bechara, A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12415 · Cited by 336 · see citing works
Chase, H. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.025 · Cited by 316 · see citing works
Measuring wanting and liking from animals to humans: a systematic review
Pool, E., Sennwald, V., Delplanque, S., Brosch, T., & Sander, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.01.006 · Cited by 211 · see citing works
Feldstein Ewing, S. W., Sakhardande, A., & Blakemore, S.-J. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.06.011 · Cited by 185 · see citing works
Striatal ups and downs: Their roles in vulnerability to addictions in humans
Leyton, M., & Vezina, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.018 · Cited by 165 · see citing works
Brain activity and desire for Internet video game play
Han, D. H., Bolo, N., Daniels, M. A., Arenella, L., Lyoo, I. K., & Renshaw, P. F. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2010.04.004 · Cited by 164 · see citing works
Cservenka, A., & Brumback, T. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01111 · Cited by 152 · see citing works
Food‐Related Odor Probes of Brain Reward Circuits During Hunger: A Pilot fMRI Study
Bragulat, V., Dzemidzic, M., Bruno, C., Cox, C. A., Talavage, T., Considine, R. V., & Kareken, D. A. (2010) · Obesity · doi:10.1038/oby.2010.57 · Cited by 128 · see citing works
The neural basis of unconditional love
Beauregard, M., Courtemanche, J., Paquette, V., & St-Pierre, É. L. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.11.003 · Cited by 106 · see citing works
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Hutchison, K. E., Haughey, H., Niculescu, M., Schacht, J., Kaiser, A., Stitzel, J., Horton, W. J., & Filbey, F. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.841 · Cited by 102 · see citing works
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Jaramillo, A. A., Randall, P. A., Frisbee, S., & Besheer, J. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13374 · Cited by 42 · see citing works
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Asaoka, N., Pagano, D., & Hayashi, Y. (2026) · Nature Communications · doi:10.1038/s41467-026-75706-1
“Symptom-related, cue-induced hyperactivity in the OFC and increased functional connectivity between the OFC and striatum have been reported in patients with compulsive disorders 69 – 72 .”
- Authors
- Filbey, F. M., Claus, E., Audette, A. R., Niculescu, M., Banich, M. T., Tanabe, J., Du, Y. P., & Hutchison, K. E.
- Affiliations
- University of Colorado Boulder (US)
- University of Colorado Denver (US)
- Corresponding author
- Hutchison, Kent E
- Venue
- Neuropsychopharmacology
- Published
- 2007-07-25
- Volume
- 33
- Issue
- 6
- Pages
- 1391-1401
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC2856647
- OpenAlex
- W2171811782
- Cited by
- 270
- References
- 71
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 60 · 2019: 15 · 2018: 11 · 2017: 10 · 2016: 18 · 2015: 22 · 2014: 26 · 2013: 17 · 2012: 11
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA012238)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- mesocorticolimbic circuitry, incentive salience, alcohol craving, alcoholism, ventral tegmental area, substantia nigra, striatum, prefrontal cortex, alcohol cue reactivity, heavy drinkers
- MeSH terms
- Adult, Alcohols, Brain Mapping, Cerebral Cortex, Cues, Female, Humans, Image Processing, Computer-Assisted, Limbic System, Male, Nerve Net, Oxygen, Photic Stimulation, Taste
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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