Tract‐specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder
Open accessAbstract
BACKGROUND: Previous diffusion tensor imaging (DTI) studies have shown white matter compromise in children and adults with autism spectrum disorder (ASD), which may relate to reduced connectivity and impaired function of distributed networks. However, tract-specific evidence remains limited in ASD. We applied tract-based spatial statistics (TBSS) for an unbiased whole-brain quantitative estimation of the fractional anisotropy (FA), mean diffusion (MD) and axial and radial diffusion of the white matter tracts in children and adolescents with ASD. METHODS: DTI was performed in 26 ASD and 24 typically developing (TD) participants, aged 9-20 years. Groups were matched for age and IQ. Each participant's aligned FA, MD and axial and radial diffusion data were projected onto the mean FA skeleton representing the centers of all tracts and the resulting data fed into voxelwise group statistics. RESULTS: TBSS revealed decreased FA and increased MD and radial diffusion in the ASD group compared to the TD group in the corpus callosum, anterior and posterior limbs of the internal capsule, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, and corticospinal tract. No single site with inverse effects (increased FA, reduced MD or radial diffusion in the ASD group) was detected. In clusters of significant group difference, age was positively correlated with FA and negatively correlated with MD and radial diffusion in the TD, but not the ASD group. CONCLUSIONS: Our findings reveal white matter compromise affecting numerous tracts in children and adolescents with ASD. Slightly varying patterns of diffusion abnormalities detected for some tracts may suggest tract-specific patterns of white matter abnormalities associated with ASD. Age-dependent effects further show that maturational changes (increasing FA, decreasing MD and radial diffusion with age) are diminished in ASD from school-age childhood into young adulthood.
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Reduced FA in the dorsal cingulum is a frequent feature of ASD.
“reduced FA in the dorsal cingulum is also a frequent feature of ASD (Rane et al., 2015; Shukla et al., 2011; Travers et al., 2012; but see Aoki et al., 2013; Table 2).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Shukla et al., 2011
The Results report reduced FA in the cingulum in the ASD group, and the Discussion reiterates that finding. Neither passage identifies the affected portion as the dorsal cingulum or establishes how frequently this specific finding occurs in ASD. (LLM, conf=0.84)
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- Authors
- Shukla, D. K., Keehn, B., & Müller, R.
- Affiliations
- San Diego State University (US)
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2010-11-12
- Volume
- 52
- Issue
- 3
- Pages
- 286-295
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- PMC
- PMC4547854
- OpenAlex
- W1923605364
- Cited by
- 230
- References
- 13
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 11 · 2020: 10 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 19 · 2015: 21 · 2014: 24 · 2013: 29 · 2012: 27
- FWCI
- 14.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH081023)
- National Institute on Deafness and Other Communication Disorders (R01DC006155, T32DC007361)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- autism spectrum disorder, white matter abnormalities, white matter tracts, fractional anisotropy, radial diffusion, corpus callosum, internal capsule, inferior longitudinal fasciculus, superior longitudinal fasciculus, cingulum, anterior thalamic radiation, corticospinal tract, tract-based spatial statistics, children and adolescents
- MeSH terms
- Adolescent, Age Factors, Brain, Child, Child Development Disorders, Pervasive, Corpus Callosum, Female, Humans, Magnetic Resonance Imaging, Male, Pyramidal Tracts, Case-Control Studies, Anisotropy, White People, Young Adult, Diffusion Tensor Imaging
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