Fine-tuning of auditory cortex during speech production
Abstract
The cortex suppresses sensory information when it is the result of a self-produced motor act, including the motor act of speaking. The specificity of the auditory cortical suppression to self-produced speech, a prediction derived from the posited operation of a precise forward model system, has not been established. We examined the auditory N100 component of the event-related brain potential elicited during speech production. While subjects uttered a vowel, they heard real-time feedback of their unaltered voice, their pitch-shifted voice, or an alien voice substituted for their own. The subjects' own unaltered voice feedback elicited a dampened auditory N100 response relative to the N100 elicited by altered or alien auditory feedback. This is consistent with the operation of a precise forward model modulating the auditory cortical response to self-generated speech and allowing immediate distinction of self and externally generated auditory stimuli.
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Self-generated vocalizations elicit an N1 component of smaller amplitude than the N1 component elicited when passively listening to the same sounds.
“Numerous electroencephalographic (EEG) and magnetoencephalographic (MEG) studies have found that self-generated vocalizations elicit an N1 component (M100 in the MEG) of smaller amplitude than the N1 component elicited when passively listening to the same sounds (Ford et al., 2007a; Curio et al., 2000; Heinks-Maldonado et al., 2005; Oestreich et al., 2015; Houde et al., 2002).”
From Neurophysiological evidence of efference copies to inner speech (2017) · cites this paper as Heinks-Maldonado et al., 2005
Auditory imagery during speech production might play an essential role in predicting intended speech production or providing an internal model to which auditory feedback should be matched.
“Auditory imagery during speech production might play an essential role in predicting the intended speech production, or even providing an internal model to which the auditory feedback should be matched (Heinks-Maldonado et al., 2005).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Heinks-Maldonado et al., 2005
The closer the match between the predicted and experienced sensation, the greater the suppression of auditory cortex responsiveness in human subjects.
“Our data (Heinks-Maldonado, Mathalon, Gray, & Ford, 2005) and data of others (Behroozmand, Karvelis, Liu, & Larson, 2009; Curio, Neuloh, Numminen, Jousmaki, & Hari, 2000; Eliades & Wang, 2003; Eliades & Wang, 2005; Heinks-Maldonado, Nagarajan, & Houde, 2006; Houde, Nagarajan, Sekihara, & Merzenich, 2002) suggest that the closer the match between the predicted and experienced sensation, the greater”
From Anticipating the future: Automatic prediction failures in schizophrenia (2012) · cites this paper as Heinks-Maldonado, Mathalon, Gray, & Ford, 2005
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Self-citation
- Authors
- Heinks‐Maldonado, T. H., Mathalon, D. H., Gray, M., & Ford, J. M.
- Affiliations
- Yale University (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Ford, Judith M.
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2005-02-09
- Volume
- 42
- Issue
- 2
- Pages
- 180-190
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- OpenAlex
- W2008299010
- Cited by
- 251
- References
- 39
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 13 · 2021: 5 · 2020: 13 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 14 · 2014: 12 · 2013: 25 · 2012: 22
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (MH067967, K02MH067967, MH-58262, R01MH-058262)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- auditory cortex, speech production, self-produced speech, forward model, auditory feedback, event-related potentials
- MeSH terms
- Adult, Auditory Cortex, Biofeedback, Psychology, Electroencephalography, Evoked Potentials, Female, Humans, Male, Middle Aged, Speech
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