Cited by 192Schizophrenia research and treatmentFree Will and AgencyMental Health and Psychiatry

Dissecting corollary discharge dysfunction in schizophrenia

Ford, Judith M., Gray, Max, Faustman, William O., Roach, Brian J., Mathalon, Daniel H.·2007·Psychophysiology

Abstract

During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERP N1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said "ah" every 1-2 s. During agency, subjects pressed a button to deliver "ah" every 1-2 s. During expectancy, "ah" followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.

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Crossref · 10.1111/j.1469-8986.2007.00533.x

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Authors
Ford, J. M., Gray, M., Faustman, W. O., Roach, B. J., & Mathalon, D. H.
Affiliations
  • Yale University (US)
  • VA Palo Alto Health Care System (US)
Corresponding author
Ford, Judith M.
Venue
Psychophysiology
Publisher
Wiley
Published
2007-06-08
Volume
44
Issue
4
Pages
522-529
ISSN
  • 0048-5772 (ISSN-L)
  • 1469-8986
OpenAlex
W2072320766
Cited by
192
References
37
Citations by year
2026: 8 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 15
FWCI
3.82
Type
journal article
Language
en
Open access
closed
Locations
  • Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh058262-17)
  • National Institute of Mental Health (R01MH040052, MH067967, K02MH067967, MH-58262, MH40052, R01MH-058262)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
corollary discharge, schizophrenia, auditory N1, agency, expectancy, event-related potentials, speech production, schizoaffective disorder
MeSH terms
Adult, Auditory Cortex, Calibration, Data Interpretation, Statistical, Electroencephalography, Evoked Potentials, Female, Humans, Male, Photic Stimulation, Schizophrenia, Schizophrenic Psychology, Speech

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