Dissecting corollary discharge dysfunction in schizophrenia
Abstract
During talking, a corollary discharge prepares cortex for self-generated sounds, minimizing responsiveness and providing a way to recognize sounds as self-generated. When we talk, we are the agent producing the sound and know what sound to expect. The auditory ERP N1 is normally suppressed during talking, but less so in schizophrenia, perhaps due to deficits in agency and expectancy inherent to talking. N1 was assessed in 27 patients (23 schizophrenia, 4 schizoaffective) and 26 controls. During talking, subjects said "ah" every 1-2 s. During agency, subjects pressed a button to deliver "ah" every 1-2 s. During expectancy, "ah" followed a visual warning. Talking yielded greatest N1 suppression in controls and greatest suppression failure in patients. Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients.
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In the case of voice hearing this can result in attribution of inner speech to an external source such as another agent.
“In the case of voice hearing this can result in attribution of inner speech to an external source such as another agent (Ford and Mathalon 2005; Ford et al. 2007).”
From Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution (2021) · cites this paper as Ford et al. 2007
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“In the case of voice hearing this can result in attribution of inner speech to an external source such as another agent (Ford and Mathalon 2005; Ford et al. 2007).”
BackgroundPredictive coding in neuropsychiatric disorders: a systematic transdiagnostic review.
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“…to attention (e.g., ignoring deviant stimulus in repetitive stimulus presentation), while P3 reflects the encoding of predictive information: (Ford et al., 2007; N ¨ a ¨ at ¨ anen, 1990; Patel and Azzam, 2005); while P3a is a subcomponent of P3 and reflects the passive maintenance of the…”
- Authors
- Ford, J. M., Gray, M., Faustman, W. O., Roach, B. J., & Mathalon, D. H.
- Affiliations
- Yale University (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Ford, Judith M.
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2007-06-08
- Volume
- 44
- Issue
- 4
- Pages
- 522-529
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- OpenAlex
- W2072320766
- Cited by
- 192
- References
- 37
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 9 · 2023: 12 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 12 · 2017: 10 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 15 · 2012: 15
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh058262-17)
- National Institute of Mental Health (R01MH040052, MH067967, K02MH067967, MH-58262, MH40052, R01MH-058262)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- corollary discharge, schizophrenia, auditory N1, agency, expectancy, event-related potentials, speech production, schizoaffective disorder
- MeSH terms
- Adult, Auditory Cortex, Calibration, Data Interpretation, Statistical, Electroencephalography, Evoked Potentials, Female, Humans, Male, Photic Stimulation, Schizophrenia, Schizophrenic Psychology, Speech
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