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Cited by 114Autism Spectrum Disorder ResearchChild Nutrition and Feeding IssuesDown syndrome and intellectual disability research

Association of Hospitalization for Infection in Childhood With Diagnosis of Autism Spectrum Disorders: A Danish Cohort Study

Atladóttir, Hjördís Ósk, Thorsen, Poul, Schendel, Diana E., Østergaard, Lars, Lemcke, Saane, Parner, Erik T.·2010·Archives of Pediatrics & Adolescent Medicine
DOI 10.1001/archpediatrics.2010.9
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Abstract

OBJECTIVE: To investigate the association between hospitalization for infection in the perinatal/neonatal period or childhood and the diagnosis of autism spectrum disorders (ASDs). DESIGN: A population-based cohort study. SETTING: Denmark. PARTICIPANTS: All children born in Denmark from January 1, 1980, through December 31, 2002, comprising a total of 1 418 152 children. EXPOSURE: Infection requiring hospitalization. MAIN OUTCOME MEASURE: The adjusted hazard ratio (HR) for ASDs among children hospitalized for infection compared with other children. RESULTS: A total of 7379 children were diagnosed as having ASDs. Children admitted to the hospital for any infectious disease displayed an increased rate of ASD diagnoses (HR, 1.38 [95% confidence interval, 1.31-1.45]). This association was found to be similar for infectious diseases of bacterial and viral origin. Furthermore, children admitted to the hospital for noninfectious disease also displayed an increased rate of ASD diagnoses (HR, 1.76 [95% confidence interval, 1.68-1.86]), and admissions for infection increased the rate of mental retardation (2.18 [2.06-2.31]). CONCLUSIONS: The association between hospitalization for infection and ASDs observed in this study does not suggest causality because a general association is observed across different infection groups. Also, the association is not specific for infection or for ASDs. We discuss a number of noncausal explanatory models.

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  • The link between MIA and enhanced risk for ASD is bolstered by large-scale population-based studies showing small but significantly increased risk due to maternal prenatal infections.

    “The link between MIA and enhanced risk for ASD is bolstered by large-scale population-based studies showing small but significantly increased risk due to maternal prenatal infections [117–122].”

    From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [118]

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Authors
Atladóttir, H. Ó., Thorsen, P., Schendel, D. E., Østergaard, L., Lemcke, S., & Parner, E. T.
Affiliations
Aarhus University (DK)
ORCID
Venue
Archives of Pediatrics & Adolescent Medicine
Publisher
American Medical Association (AMA)
Published
2010-05-01
Volume
164
Issue
5
Pages
470-7
ISSN
1072-4710 (ISSN-L)
DOI
10.1001/archpediatrics.2010.9
OpenAlex
W1986945466
Cited by
114
References
38
Citations by year
2026: 3 · 2025: 3 · 2024: 9 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 14 · 2012: 15
FWCI
7.74
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Pediatrics and Adolescent Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Keywords
autism spectrum disorder, infection hospitalization, infectious diseases, pediatric infection, intellectual disability, bacterial infection, viral infection
MeSH terms
Autistic Disorder, Birth Weight, Child, Child, Hospitalized, Child, Preschool, Denmark, Female, Gestational Age, Hospitalization, Humans, Infant, Infant, Newborn, Infant, Premature, Infections, Male, Registries, Risk Factors, Sex Factors, Incidence, Proportional Hazards Models

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