Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: A randomized controlled trial
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OBJECTIVE: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults. METHODS: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation. RESULTS: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes. CONCLUSION: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.
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Some of the included RCTs had a small sample size.
“some of the included RCTs had a small sample size [43,48,59]”
From Effects of Protein Supplementation Combined with Exercise Intervention on Frailty Indices, Body Composition, and Physical Function in Frail Older Adults (2018) · cites this paper as [59]
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Leite, M. A. F. D. J., Marques, B. O., Cardoso, L. G., & Cândido, R. F. (2019) · Arquivos de Ciências do Esporte · doi:10.17648/aces.v6n4.2930
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Benzinger, P., Bauer, J. M., Schwenk, M., Grund, S., & Goisser, S. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-037531
The Leucine Requirement of Older Adult Men Determined by Indicator Amino Acid Oxidation Method
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Effect of Nutritional Intervention on the Temporal Dynamics of Muscle Strength Adaptation
Smith, K. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.46.007312
- Authors
- Trabal, J., Forga, M., Leyes, P., Torres, F., Rubio, J., Prieto, E., & Farran-Codina, A.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Corresponding author
- Trabal, Joan
- ORCID
- Trabal, Joan
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2015-04
- Volume
- 10
- Pages
- 713
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC4403814
- OpenAlex
- W2016153774
- Cited by
- 54
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- leucine supplementation, resistance training, older adults, muscle strength, functional status, nutritional status, body composition, health-related quality of life, depression, dietary intake, sarcopenia
- MeSH terms
- Aged, Aged, 80 and over, Body Composition, Depression, Double-Blind Method, Female, Health Status, Humans, Leucine, Male, Nutritional Status, Quality of Life, Dietary Supplements, Muscle Strength, Resistance Training
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