Cited by 54Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: A randomized controlled trial

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Trabal, Joan, Forga, Maria, Leyes, Pere, Torres, Ferran, Rubio, Jordi, Prieto, Esther, Farran-Codina, Andreu·2015·Clinical Interventions in Aging

Abstract

OBJECTIVE: To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults. METHODS: This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation. RESULTS: Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes. CONCLUSION: Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.

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  1. [7]Rennie MJ Anabolic resistance: the effects of aging, sexual dimorphism, and immobilization on human muscle protein turnover Appl Physiol Nutr Metab 2009 34 3 377 381 19448702

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Authors
Trabal, J., Forga, M., Leyes, P., Torres, F., Rubio, J., Prieto, E., & Farran-Codina, A.
Affiliations
Hospital Clínic de Barcelona (ES)
Corresponding author
Trabal, Joan
Venue
Clinical Interventions in Aging
Published
2015-04
Volume
10
Pages
713
ISSN
  • 1176-9092 (ISSN-L)
  • 1178-1998
OpenAlex
W2016153774
Cited by
54
References
51
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 1
FWCI
3.91
Type
journal article
Language
en
Open access
Locations
  • Clinical Interventions in Aging (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
leucine supplementation, resistance training, older adults, muscle strength, functional status, nutritional status, body composition, health-related quality of life, depression, dietary intake, sarcopenia
MeSH terms
Aged, Aged, 80 and over, Body Composition, Depression, Double-Blind Method, Female, Health Status, Humans, Leucine, Male, Nutritional Status, Quality of Life, Dietary Supplements, Muscle Strength, Resistance Training

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