Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior
Open accessAbstract
Compared to results from a generation of neuropharmacological work, the phenotype of mice lacking the oxytocin (OT) peptide gene was remarkably normal. An important component of the current experiments was to assay OT-knockout (OTKO) and wild-type (WT) littermate control mice living under controlled stressful conditions designed to mimic more closely the environment for which the mouse genome evolved. Furthermore, our experimental group was comprised of an all-female population, in contrast to previous studies which have focused on all-male populations. Our data indicated that aggressive behaviors initiated by OTKO during a food deprivation feeding challenge were considerably more intense and diverse than aggressive behaviors initiated by WT. From the measures of continuous social interaction in the intruder paradigm, it emerged that OTKO mice were more offensively aggressive (attacking rumps and tails) than WT. In a test of parental behaviors, OTKO mice were 100% infanticidal while WT were 16% infanticidal and 50% maternal. Finally, 'alpha females' (always OTKO) were identified in each experiment. They were the most aggressive, the first to feed and the most dominant at nesting behaviors. Semi-natural environments are excellent testing environments for elucidating behavioral differences between transgenic mice and their WT littermates which may not be ordinarily discernible. Future studies of mouse group behavior should include examining female groupings in addition to the more usual all-male groups.
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Subjects with autism spectrum disorder or schizophrenia often do not attend to the appropriate facial cues of others.
“Subjects with autism spectrum disorder or schizophrenia often do not attend to the appropriate facial cues of others [107, 108].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [108]
The Abstract and Discussion passages concern aggression in female oxytocin-knockout mice, not attention to facial cues in people with autism spectrum disorder or schizophrenia. Searches for those conditions and for facial cues, faces, and gaze found no passage addressing the claim; the camera descriptions in Semi-natural environment Experiment 1 concern recording mouse behavior. (LLM, conf=0.76)
Experimental — accuracy not yet measuredSeveral studies have demonstrated a reduction in aggressive behaviors upon treatment with exogenous OT or an increase in such behaviors in animals genetically lacking OT or OTR.
“Several studies have employed the RI paradigm to demonstrate a reduction in aggressive behaviors upon treatment with exogenous OT (Calcagnoli et al., 2013, Calcagnoli et al., 2014, Calcagnoli et al., 2015, Jong et al., 2014, Karpova et al., 2016) or an increase in such behaviors in animals genetically lacking OT or OTR (Dhakar et al., 2012, Pagani et al., 2015, Ragnauth et al., 2005, Takayanagi et”
From Wireless Optogenetic Stimulation of Oxytocin Neurons in a Semi-natural Setup Dynamically Elevates Both Pro-social and Agonistic Behaviors (2020) · cites this paper as Ragnauth et al., 2005
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Self-citation
- Authors
- Ragnauth, A. K., Devidze, N., Moy, V., Finley, K., Goodwillie, A., Kow, L. ‐., Muglia, L. J., & Pfaff, D. W.
- Affiliations
- Rockefeller University (US)
- Washington University in St. Louis (US)
- Corresponding author
- Ragnauth, A. K.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2005-02-16
- Volume
- 4
- Issue
- 4
- Pages
- 229-239
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- OpenAlex
- W1568196828
- Cited by
- 160
- References
- 55
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 21 · 2019: 4 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 11 · 2014: 5 · 2013: 11 · 2012: 9
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 38273, R01MH038273)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, female aggression, food deprivation, social interaction, infanticide, maternal behavior, alpha female, dominance, nesting behavior, semi-natural environments, stress, social behavior
- MeSH terms
- Aggression, Animals, Environment, Feeding Behavior, Female, Food Deprivation, Genotype, Immunohistochemistry, Maternal Behavior, Oxytocin, Vasopressins, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice
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