Cited by 225Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Contributions of the ventromedial prefrontal cortex to goal-directed action selection

O’Doherty, John P.·2011·Annals of the New York Academy of Sciences

Abstract

In this article, it will be argued that one of the key contributions of the ventromedial prefrontal cortex (vmPFC) to goal-directed action selection lies both in retrieving the value of goals that are the putative outcomes of the decision process and in establishing a relative preference ranking for these goals by taking into account the value of each of the different goals under consideration in a given decision-making scenario. These goal-value signals are then suggested to be used as an input into the on-line computation of action values mediated by brain regions outside of the vmPFC, such as parts of the parietal cortex, supplementary motor cortex, and dorsal striatum. Collectively, these areas can be considered to be constituent elements of a multistage decision process whereby the values of different goals must first be represented and ranked before the value of different courses of action available for the pursuit of those goals can be computed.

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Crossref · 10.1111/j.1749-6632.2011.06290.x

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  • The idea that prospective outcomes are explicitly represented allows states to be valued according to their current worth and choices to be immediately sensitive to devaluation.

    “Critically, the idea that prospective outcomes are explicitly represented allows these states to be valued (putatively via the orbitofrontal or ventromedial prefrontal cortex) (Valentin et al., 2007; Fellows, 2011; O’Doherty, 2011) according to their current worth and so choices can be immediately sensitive to devaluation.”

    From Goals and Habits in the Brain (2013) · cites this paper as O’Doherty, 2011

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Authors
O’Doherty, J. P.
Affiliations
California Institute of Technology (US)
Corresponding author
O’Doherty, John P.
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2011-12
Volume
1239
Issue
1
Pages
118-129
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W1766116129
Cited by
225
References
60
Citations by year
2026: 8 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 13 · 2020: 41 · 2019: 8 · 2018: 13 · 2017: 16 · 2016: 15 · 2015: 22 · 2014: 17 · 2013: 17 · 2012: 10
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
ventromedial prefrontal cortex, decision-making, dorsal striatum, supplementary motor area, parietal cortex, multi-stage decision making
MeSH terms
Animals, Behavior, Animal, Brain Mapping, Corpus Striatum, Decision Making, Frontal Lobe, Goals, Humans, Models, Psychological, Motor Cortex, Neurons, Parietal Lobe, Physiology, Comparative, Reward, Social Behavior, Social Values

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