Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 681

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease

Open access
Weller, Roy O., Subash, Malavika, Preston, Stephen D., Mazanti, Ingrid, Carare, Roxana O.·2008·Brain Pathology
DOI 10.1111/j.1750-3639.2008.00133.x
Open this paper in CoChat — free account

Abstract

Alzheimer's disease is the commonest dementia. One major characteristic of its pathology is accumulation of amyloid‐β (Aβ) as insoluble deposits in brain parenchyma and in blood vessel walls [cerebral amyloid angiopathy (CAA)]. The distribution of Aβ deposits in the basement membranes of cerebral capillaries and arteries corresponds to the perivascular drainage pathways by which interstitial fluid (ISF) and solutes are eliminated from the brain—effectively the lymphatic drainage of the brain. Theoretical models suggest that vessel pulsations supply the motive force for perivascular drainage of ISF and solutes. As arteries stiffen with age, the amplitude of pulsations is reduced and insoluble Aβ is deposited in ISF drainage pathways as CAA, thus, further impeding the drainage of soluble Aβ. Failure of perivascular drainage of Aβ and deposition of Aβ in the walls of arteries has two major consequences: (i) intracerebral hemorrhage associated with rupture of Aβ‐laden arteries in CAA; and (ii) Alzheimer's disease in which failure of elimination of ISF, Aβ and other soluble metabolites from the brain alters homeostasis and the neuronal environment resulting in cognitive decline and dementia. Therapeutic strategies that improve elimination of Aβ and other soluble metabolites from the brain may prevent cognitive decline in Alzheimer's disease.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1750-3639.2008.00133.x

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 25 references

Research works printed but not linked: 81

  1. 10.1016/0014-4886(84)90192-4 · DOI
  2. 10.1111/j.1365-2990.1988.tb00862.x · DOI · Paper page
  3. 10.1148/radiology.217.3.r00dc42877 · DOI · Paper page
  4. 10.1016/j.jns.2007.01.013 · DOI
  5. 10.1093/jnen/59.4.308 · DOI
  6. Bergsneider M, 2001, Evolving concepts of Cerebrospinal Fluid, Neurosurg Clin N Am, 36, 631, 10.1016/S1042-3680(18)30021-4 · DOI
  7. 10.1111/j.1750-3639.1996.tb00793.x · DOI
  8. 10.1002/ana.410420116 · DOI
  9. 10.1152/ajpregu.1999.276.3.R818 · DOI
  10. 10.1111/j.1365-2990.2007.00926.x · DOI · Paper page
  11. 10.1002/1097-4547(20001101)62:3<451::AID-JNR15>3.0.CO;2-F · DOI
  12. 10.1016/j.neuron.2005.10.028 · DOI · Paper page
  13. 10.1016/0167-5699(92)90027-5 · DOI · Paper page
  14. Davson H, 1987, Physiology and Pathophysiology of the Cerebrospinal Fluid
  15. 10.1097/01.jnen.0000171644.00180.fc · DOI
  16. Ely M, 1996, Estimating the numbers and characteristics of elderly people with cognitive disability in local populations, Res Policy Plan, 14, 13
  17. 10.1017/CBO9780511526886 · DOI
  18. 10.1007/s004010000195 · DOI · Paper page
  19. 10.2353/ajpath.2007.070105 · DOI
  20. 10.1093/jnen/64.1.82 · DOI
  21. 10.1016/j.it.2006.11.004 · DOI · Paper page
  22. 10.1038/ng0106-11 · DOI
  23. 10.1038/nm0706-756 · DOI
  24. 10.1016/S0165-5728(99)00130-7 · DOI
  25. 10.1016/0165-5728(89)90136-7 · DOI · Paper page
  26. 10.1002/1096-9896(200106)194:2<262::AID-PATH882>3.0.CO;2-W · DOI
  27. 10.1111/j.1750-3639.2006.tb00560.x · DOI · Paper page
  28. 10.1111/j.1600-0447.1987.tb02906.x · DOI · Paper page
  29. 10.1111/j.1750-3639.2002.tb00451.x · DOI · Paper page
  30. 10.1111/j.1365-2990.1993.tb00476.x · DOI · Paper page
  31. 10.1385/JMN:24:1:167 · DOI
  32. 10.1080/13506120601116419 · DOI
  33. 10.1002/(SICI)1096-9896(199901)187:2<259::AID-PATH212>3.0.CO;2-H · DOI
  34. 10.1111/j.1365-2990.2006.00747.x · DOI
  35. 10.1016/S0896-6273(03)00787-6 · DOI · Paper page
  36. 10.1111/j.1750-3639.2006.tb00562.x · DOI
  37. 10.1016/S0002-9440(10)65184-X · DOI · Paper page
  38. 10.1111/j.1365-2990.1984.tb00351.x · DOI · Paper page
  39. 10.1097/00005072-199907000-00005 · DOI · Paper page
  40. 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M · doi:10.1002/1531-8249(199912)46:6<860::aid-ana8>3.0.co;2-m
  41. 10.1097/01.jnen.0000240463.87886.9a · DOI
  42. 10.1111/j.1460-9568.2004.03534.x · DOI
  43. Nagasawa S, 1979, Mechanical properties of human cerebral arteries. Part 1: effects of age and vascular smooth muscle activation, Surg Neurol, 12, 297
  44. 10.1016/S0014-4886(03)00315-7 · DOI
  45. 10.3171/jns.1988.69.2.0276 · DOI · Paper page
  46. 10.1097/01.jnen.0000240466.10758.ce · DOI · Paper page
  47. 10.1016/j.neurobiolaging.2004.02.003 · DOI · Paper page
  48. 10.1111/j.1750-3639.2006.tb00561.x · DOI
  49. 10.1002/(SICI)1096-9896(199708)182:4<457::AID-PATH870>3.0.CO;2-Y · DOI
  50. 10.1046/j.1365-2990.2003.00424.x · DOI · Paper page
  51. 10.1111/j.1750-3639.1996.tb00798.x · DOI
  52. 10.1093/jnen/62.9.885 · DOI · Paper page
  53. 10.1007/BF03402043 · DOI · Paper page
  54. 10.1002/ana.20596 · DOI · Paper page
  55. 10.1016/S0002-9440(10)63824-2 · DOI · Paper page
  56. 10.1038/nm1635 · DOI · Paper page
  57. Salzman KL, 2005, Giant Tumefactive Perivascular Spaces, Am J Neuroradiol, 26, 298
  58. 10.1007/BF02890989 · DOI · Paper page
  59. 10.1152/physrev.2001.81.2.741 · DOI · Paper page
  60. 10.3233/JAD-2006-9S319 · DOI
  61. 10.1093/brain/awm156 · DOI · Paper page
  62. Subash M, 2003, Cerebral amyloid angiopathy: differential preservation of endothelial cell basement membranes, Neuropath Appl Neurobiol, 29, 184
  63. 10.1073/pnas.0408235102 · DOI · Paper page
  64. 10.1152/ajprenal.1984.246.6.F835 · DOI · Paper page
  65. 10.1097/RCT.0b013e318038fc5d · DOI
  66. 10.1016/S0140-6736(03)13555-6 · DOI · Paper page
  67. 10.1016/S0002-9440(10)64644-5 · DOI · Paper page
  68. 10.1007/s004010100414 · DOI
  69. 10.1042/BST0350416 · DOI
  70. Weller RO, 1995, Gray's Anatomy, 1202
  71. 10.1016/S1286-0115(05)83235-7 · DOI · Paper page
  72. 10.1002/ana.20622 · DOI
  73. 10.1179/016164103101202057 · DOI
  74. 10.1093/brain/92.4.819 · DOI
  75. 10.1016/S0002-9440(10)65616-7 · DOI · Paper page
  76. 10.1186/1742-2094-1-24 · DOI
  77. 10.1007/BF00296738 · DOI · Paper page
  78. 10.1111/j.1749-6632.2002.tb04844.x · DOI
  79. 10.1016/S0002-9440(10)64713-X · DOI · Paper page
  80. 10.1007/s004010050935 · DOI
  81. 10.1111/j.1750-3639.2006.tb00559.x · DOI · Paper page

Cited by

See all 681

Metadata

Authors
Weller, R. O., Subash, M., Preston, S. D., Mazanti, I., & Carare, R. O.
Venue
Brain Pathology
Publisher
Wiley
Published
2008-01-03
Volume
18
Issue
2
Pages
253-266
ISSN
  • 1015-6305 (ISSN-L)
  • 1750-3639
DOI
10.1111/j.1750-3639.2008.00133.x
OpenAlex
W2143238511
Cited by
681
References
25
FWCI
13.08
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease. https://app.cochat.ai/papers/10.1111/j.1750-3639.2008.00133.x
The paper
Weller, R. O., Subash, M., Preston, S. D., Mazanti, I., & Carare, R. O. (2008). SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease. Brain Pathology. https://doi.org/10.1111/j.1750-3639.2008.00133.x

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.