Cited by 46Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Time-dependent effects of corticosterone on reward-based decision-making in a rodent model of the Iowa Gambling Task

Koot, Susanne, Baars, Annemarie, Hesseling, Peter, van den Bos, Ruud, Joëls, Marian·2013·Neuropharmacology

Abstract

Corticosteroid hormones, released after stress, are known to change neuronal activity in two time-domains: within minutes via non-genomic pathways and with a delay of >1 h through pathways involving transcriptional regulation. Recent evidence in rodents and humans indicates that these two modes of corticosteroid action differently affect cognitive tasks. Here, we investigated whether reward-based decision-making, in a rat model of the Iowa Gambling Task (rIGT), is also differently altered by rapid versus delayed actions of corticosterone. We targeted the rapid and delayed time domain by injecting corticosterone (CORT, 1 mg/kg, s.c.) at 30 min (rapid) or 180 min (delayed) respectively prior to behavioural testing, during the final 3 days of the behavioural paradigm. In saline treated rats, the number of visits to the disadvantageous arm decreased over trial blocks, whilst this was attenuated when CORT was administered 30 min before testing. This attenuation was associated with a significantly increased c-Fos expression in the lateral orbitofrontal cortex and insular cortex, and a trend for an increase in the infralimbic cortex. The rapid corticosteroid effect contrasted with treatment 180 min before testing, where the number of visits to the disadvantageous arm as well as c-Fos labelling was not affected. These findings indicate that rapid corticosteroid actions impair reward-based decision-making.

Integrity signals

Registry

Crossref · 10.1016/j.neuropharm.2013.02.008

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Koot, S., Baars, A., Hesseling, P., van den Bos, R., & Joëls, M.
Affiliations
  • Utrecht University (NL)
  • University Medical Center Utrecht (NL)
Corresponding author
Joëls, Marian
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2013-07
Volume
70
Pages
306-315
ISSN
0028-3908 (ISSN-L)
OpenAlex
W2028060047
Cited by
46
References
92
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2022: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 4
FWCI
3.93
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
corticosterone, reward-based decision-making, Iowa Gambling Task, non-genomic steroid action, Fos expression, lateral orbitofrontal cortex, insula, infralimbic cortex, stress, rats
MeSH terms
Animals, Cerebral Cortex, Corticosterone, Decision Making, Dose-Response Relationship, Drug, Frontal Lobe, Gambling, Male, Models, Psychological, Reward, Time Factors, Proto-Oncogene Proteins c-fos, Prefrontal Cortex, Models, Animal, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review