Time-dependent effects of corticosterone on reward-based decision-making in a rodent model of the Iowa Gambling Task
Abstract
Corticosteroid hormones, released after stress, are known to change neuronal activity in two time-domains: within minutes via non-genomic pathways and with a delay of >1 h through pathways involving transcriptional regulation. Recent evidence in rodents and humans indicates that these two modes of corticosteroid action differently affect cognitive tasks. Here, we investigated whether reward-based decision-making, in a rat model of the Iowa Gambling Task (rIGT), is also differently altered by rapid versus delayed actions of corticosterone. We targeted the rapid and delayed time domain by injecting corticosterone (CORT, 1 mg/kg, s.c.) at 30 min (rapid) or 180 min (delayed) respectively prior to behavioural testing, during the final 3 days of the behavioural paradigm. In saline treated rats, the number of visits to the disadvantageous arm decreased over trial blocks, whilst this was attenuated when CORT was administered 30 min before testing. This attenuation was associated with a significantly increased c-Fos expression in the lateral orbitofrontal cortex and insular cortex, and a trend for an increase in the infralimbic cortex. The rapid corticosteroid effect contrasted with treatment 180 min before testing, where the number of visits to the disadvantageous arm as well as c-Fos labelling was not affected. These findings indicate that rapid corticosteroid actions impair reward-based decision-making.
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Injections of corticosterone prevented animals from improving their decision-making and avoiding disadvantageous options in the rodent Gambling Task.
“In animals, studies using the rodent Gambling Task demonstrated that injections of corticosterone prevented animals from improving their decision-making and avoiding disadvantageous options (Koot, Baars, Hesseling, van den Bos, & Joëls, 2013).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Koot, Baars, Hesseling, van den Bos, & Joëls, 2013
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- Authors
- Koot, S., Baars, A., Hesseling, P., van den Bos, R., & Joëls, M.
- Affiliations
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Joëls, Marian
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 70
- Pages
- 306-315
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2028060047
- Cited by
- 46
- References
- 92
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2022: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 9 · 2013: 4
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- corticosterone, reward-based decision-making, Iowa Gambling Task, non-genomic steroid action, Fos expression, lateral orbitofrontal cortex, insula, infralimbic cortex, stress, rats
- MeSH terms
- Animals, Cerebral Cortex, Corticosterone, Decision Making, Dose-Response Relationship, Drug, Frontal Lobe, Gambling, Male, Models, Psychological, Reward, Time Factors, Proto-Oncogene Proteins c-fos, Prefrontal Cortex, Models, Animal, Rats
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