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Mild cognitive impairment: a concept in evolution
Open accessAbstract
The construct of mild cognitive impairment ( MCI ) has evolved over the past 10 years since the publication of the new MCI definition at the K ey S ymposium in 2003, but the core criteria have remained unchanged. The construct has been extensively used worldwide, both in clinical and in research settings, to define the grey area between intact cognitive functioning and clinical dementia. A rich set of data regarding occurrence, risk factors and progression of MCI has been generated. Discrepancies between studies can be mostly explained by differences in the operationalization of the criteria, differences in the setting where the criteria have been applied, selection of subjects and length of follow‐up in longitudinal studies. Major controversial issues that remain to be further explored are algorithmic versus clinical classification, reliability of clinical judgment, temporal changes in cognitive performances and predictivity of putative biomarkers. Some suggestions to further develop the MCI construct include the tailoring of the clinical criteria to specific populations and to specific contexts. The addition of biomarkers to the clinical phenotypes is promising but requires deeper investigation. Translation of findings from the specialty clinic to the population setting, although challenging, will enhance uniformity of outcomes. More longitudinal population‐based studies on cognitive ageing and MCI need to be performed to clarify all these issues.
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Metadata
- Authors
- Petersen, R. C., Caracciolo, B., Brayne, C., Gauthier, S., Jelic, V., & Fratiglioni, L.
- Affiliations
- Mayo Clinic (US)
- Stockholm University (SE)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- Division of Clinical Geriatrics Department of Neurobiology, Care Sciences and Society Karolinska Institutet and Stockholm University Stockholm Sweden
- Corresponding author
- Petersen, R. C.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2014-03
- Volume
- 275
- Issue
- 3
- Pages
- 214-228
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- PMC
- PMC3967548
- OpenAlex
- W1963487177
- Cited by
- 1,694
- References
- 101
- Citations by year
- 2026: 158 · 2025: 196 · 2024: 189 · 2023: 152 · 2022: 153 · 2021: 190 · 2020: 154 · 2019: 146 · 2018: 108 · 2017: 91 · 2016: 79 · 2015: 59 · 2014: 18
- FWCI
- 62.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50 AG016574, U01 AG006786)
- Swedish Council for Working Life and Social Research
- Swedish Brain Power Initiative and Stockholm University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- mild cognitive impairment, dementia risk, biomarkers, cognitive aging, population-based study, clinical phenotype
- MeSH terms
- Aged, Aging, Alzheimer Disease, Follow-Up Studies, Humans, Memory Disorders, Neuropsychological Tests, Risk Factors, Reproducibility of Results, Biomarkers, Mental Competency, Disease Progression, Critical Pathways, Cognitive Dysfunction
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