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Coordination of autonomic and endocrine stress responses to the Trier Social Stress Test in adolescence
Abstract
Dysregulations in autonomic and endocrine stress responses are linked to the emergence of psychopathology in adolescence. However, most studies fail to consider the interplay between these systems giving rise to conflicting findings and a gap in understanding adolescent stress response regulation. A multisystem framework—investigation of parasympathetic (PNS), sympathetic (SNS), and hypothalamic pituitary adrenal (HPA) axis components and their coordination—is necessary to understand individual differences in stress response coordination which contribute to stress vulnerabilities. As the first investigation to comprehensively evaluate these three systems in adolescence, the current study employed the Trier Social Stress Test in 72 typically developing adolescents (mean age = 13) to address how PNS, SNS, and HPA stress responses are coordinated in adolescence. Hypotheses tested key predictions of the Adaptive Calibration Model (ACM) of stress response coordination. PNS and SNS responses were assessed via heart rate variability (HRV) and salivary alpha amylase (sAA) respectively. HPA responses were indexed by salivary cortisol. Analyses utilized piecewise growth curve modeling to investigate these aims. Supporting the ACM theory, there was significant hierarchical coordination between the systems such that those with low HRV had higher sAA and cortisol reactivity and those with high HRV had low‐to‐moderate sAA and cortisol responsivity. Our novel results reveal the necessity of studying multisystem dynamics in an integrative fashion to uncover the true mechanisms of stress response and regulation during development. Additionally, our findings support the existence of characteristic stress response profiles as predicted by the ACM model.
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“These results, including ours, support emerging theories in stress physiology, which emphasize the importance of considering the interrelation between the physiological components of the stress response system (18, 30).”
From Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction (2023) · cites this paper as [30]
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“Individual's raw data were converted to interbeat interval (IBI) format and passed to Kubios HRV software for automated artifact correction (Tarvainen et al., 2014).”
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“Additionally, sAA levels during and following stress have been associated with plasma catecholamines and other markers of sympathetic activation including cardiovascular indices and basal skin conductance levels (Bosch et al., 2003; Nater & Rohleder, 2009; Nater et al., 2005; Rohleder et al., 2004, 2006; van Stegeren…”
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“New evidence suggests that the coordination between these systems may underlie individual differences in stress responsivity, which may precede the onset of psychopathology in adolescence (Buss et al., 2018).”
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“…tone), a hallmark of a buffered response, are less reactive physiologically to psychosocial stressors, and this autonomic stability maintained by the PNS across stress may in turn attenuate HPA axis reactivity (conceptualized as an individual's sensitivity to a stressor) (Wolff et al., 2012).”
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Cited by
Xu, J., Chen, Y., Gu, L., Liu, X., Yang, J., Li, M., Rao, K., Dong, X., Yang, S., Huang, B., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1103621 · Cited by 13
Metadata
- Authors
- Glier, S., Campbell, A., Corr, R., Pelletier‐Baldelli, A., Yefimov, M., Guerra, C., Scott, K., Murphy, L., Bizzell, J., & Belger, A.
- Affiliations
- School of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA
- Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill North Carolina USA
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2022-03-30
- Volume
- 59
- Issue
- 9
- ISSN
- 0048-5772
- 1469-8986
- Cited by
- 17
- References
- 22
- Language
- en
- Funders
- National Institute of Mental Health (R01MH103790‐05)
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