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Cited by 431

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

: what do we know, and what do we still need to know?

Open access
Levine, Benjamin D.·2008·The Journal of Physiology
DOI 10.1113/jphysiol.2007.147629
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Abstract

Maximal oxygen uptake is a physiological characteristic bounded by the parametric limits of the Fick equation: (left ventricular (LV) end‐diastolic volume − LV end‐systolic volume) × heart rate × arterio‐venous oxygen difference. ‘Classical’ views of emphasize its critical dependence on convective oxygen transport to working skeletal muscle, and recent data are dispositive, proving convincingly that such limits must and do exist. ‘Contemporary’ investigations into the mechanisms underlying peripheral muscle fatigue due to energetic supply/demand mismatch are clarifying the local mediators of fatigue at the skeletal muscle level, though the afferent signalling pathways that communicate these environmental conditions to the brain and the sites of central integration of cardiovascular and neuromotor control are still being worked out. Elite endurance athletes have a high due primarily to a high cardiac output from a large compliant cardiac chamber (including the myocardium and pericardium) which relaxes quickly and fills to a large end‐diastolic volume. This large capacity for LV filling and ejection allows preservation of blood pressure during extraordinary rates of muscle blood flow and oxygen transport which support high rates of sustained oxidative metabolism. The magnitude and mechanisms of cardiac phenotype plasticity remain uncertain and probably involve underlying genetic factors, as well as the length, duration, type, intensity and age of initiation of the training stimulus

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Metadata

Authors
Levine, B. D.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2008-01
Volume
586
Issue
1
Pages
25-34
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2007.147629
OpenAlex
W1926550845
Cited by
431
References
7
FWCI
37.68
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.