Cited by 90Trace Elements in HealthAutism Spectrum Disorder ResearchHeavy Metal Exposure and Toxicity

Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder

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Curtin, Paul, Austin, Christine, Curtin, Austen, Gennings, Chris, Arora, Manish, (for the Emergent Dynamical Systems Group), Tammimies, Kristiina, Willfors, Charlotte +14 more·2018·Science Advances

Abstract

Baby tooth analysis shows that fetal and early postnatal zinc-copper metabolic rhythms predict autism risk.

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Crossref · 10.1126/sciadv.aat1293

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  • A follow-up study examining three independent teeth samples from the USA and UK identified alterations in fetal and postnatal zinc-copper rhythms in ASD in terms of cycling duration, regularity, and number of complex features.

    “These findings have been further corroborated in a follow-up study examining three independent teeth samples from the USA and UK, which identified the presence of alterations in fetal and postnatal zinc–copper rhythms in ASD in terms of cycling duration, regularity, and number of complex features [176].”

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Research works printed but not linked: 5

  1. [40]C. Lord, M. Rutter, P. C. DiLavore, S. Risi, K. Gotham, S. L. Bishop, Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Manual (Part 1) (Western Pscyhological Services, 2012).
  2. [41]J. N. Constantino, C. P. Gruber, Social Responsiveness Scale, Second Edition (SRS-2) (Western Psychological Services, 2012).
  3. [43]D. Wechsler, The Wechsler Adult Intelligence Scale (Pearson Assessment, ed. 4, 2004).
  4. [44]D. Wechsler, The Wechsler Adult Intelligence Scale (Pearson Assessment, ed. 4, 2008).
  5. [51]C. Lord, M. Rutter, P. C. DiLavore, S. Risi, K. Gotham, S. L. Bishop, ADOS. Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). Manual (Part I): Modules 1–4 (Western Psychological Services, 2012).

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Authors
Curtin, P., Austin, C., Curtin, A., Gennings, C., Arora, M., (for the Emergent Dynamical Systems Group), Tammimies, K., Willfors, C., Berggren, S., Siper, P., Rai, D., Meyering, K., Kolevzon, A., Mollon, J., David, A. S., Lewis, G., Zammit, S., Heilbrun, L., Palmer, R. F., Wright, R. O., Bölte, S., & Reichenberg, A.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Region Stockholm (SE)
  • University of Bristol (GB)
  • King's College London (GB)
  • The University of Texas at San Antonio Health Science Center (US)
Corresponding author
  • Curtin, Paul
  • Austin, Christine
  • Curtin, Austen
  • Gennings, Chris
  • Arora, Manish
  • Reichenberg, Abraham
Venue
Science Advances
Published
2018-05-04
Volume
4
Issue
5
Pages
eaat1293-eaat1293
ISSN
2375-2548 (ISSN-L)
OpenAlex
W2806188324
Cited by
90
References
49
Citations by year
2026: 10 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 21 · 2021: 15 · 2020: 10 · 2019: 7 · 2018: 2
FWCI
7.03
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Science Advances (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion, cc-by-nc)
  • Research Portal (King's College London) (submittedVersion, other-oa)
  • Bristol Research (University of Bristol) (submittedVersion, cc-by-nc)
Funders
  • National Institute of Environmental Health Sciences (DP2ES025453, R21ES023604, R01ES026033, P30ES023515, U2CES026561, P30ES023515)
  • Swedish Research Council (523-2009-7054; 521-2013-2531)
  • Knut and Alice Wallenberg foundation
  • Beatrice and Samuel A. Seaver Foundation
  • UK Medical Research Council and Wellcome (102215/2/13/2)
  • Innovative Medicines Initiatives Joint Undertaking (115300)
  • European Federation of Pharmaceutical Industries and Associations
  • Swedish Research Council for Health, Working Life and Welfare, Formas and VINNOVA (259-2012-24)
  • Stiftelsen Frimurare Barnhuset, Sunnerdahls, Handikappfond, Hjärnfonden and the Swedish Foundation for International Cooperation in Research and Higher Education (STINT, PT2016-6871).)
  • European Union’s Seventh Framework Programme (FP7/2007 – 2013)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
autism spectrum disorder, zinc, copper, fetal development, postnatal development, metal metabolism, biomarkers, ASD prediction, classification models
MeSH terms
Autism Spectrum Disorder, Child, Copper, Female, Humans, Male, Pregnancy, Prognosis, ROC Curve, Sensitivity and Specificity, Mass Spectrometry, Zinc, Biomarkers, Case-Control Studies

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