Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder
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Baby tooth analysis shows that fetal and early postnatal zinc-copper metabolic rhythms predict autism risk.
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A follow-up study examining three independent teeth samples from the USA and UK identified alterations in fetal and postnatal zinc-copper rhythms in ASD in terms of cycling duration, regularity, and number of complex features.
“These findings have been further corroborated in a follow-up study examining three independent teeth samples from the USA and UK, which identified the presence of alterations in fetal and postnatal zinc–copper rhythms in ASD in terms of cycling duration, regularity, and number of complex features [176].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [176]
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- Authors
- Curtin, P., Austin, C., Curtin, A., Gennings, C., Arora, M., (for the Emergent Dynamical Systems Group), Tammimies, K., Willfors, C., Berggren, S., Siper, P., Rai, D., Meyering, K., Kolevzon, A., Mollon, J., David, A. S., Lewis, G., Zammit, S., Heilbrun, L., Palmer, R. F., Wright, R. O., Bölte, S., & Reichenberg, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Region Stockholm (SE)
- University of Bristol (GB)
- King's College London (GB)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Curtin, Paul
- Austin, Christine
- Curtin, Austen
- Gennings, Chris
- Arora, Manish
- Reichenberg, Abraham
- ORCID
- Curtin, Paul
- Austin, Christine
- Gennings, Chris
- Arora, Manish
- Tammimies, Kristiina
- Willfors, Charlotte
- Berggren, Steve
- Siper, Paige
- Rai, Dheeraj
- Meyering, Kristin
- Kolevzon, Alexander
- Mollon, Josephine
- David, Anthony S.
- Lewis, Glyn
- Zammit, Stanley
- Heilbrun, Lynne
- Palmer, Raymond F.
- Wright, Robert O.
- Bölte, Sven
- Reichenberg, Abraham
- Venue
- Science Advances
- Published
- 2018-05-04
- Volume
- 4
- Issue
- 5
- Pages
- eaat1293-eaat1293
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5976276
- OpenAlex
- W2806188324
- Cited by
- 90
- References
- 49
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 7 · 2023: 11 · 2022: 21 · 2021: 15 · 2020: 10 · 2019: 7 · 2018: 2
- FWCI
- 7.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Science Advances (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eSpace (Curtin University) (submittedVersion, cc-by-nc)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion, cc-by-nc)
- Funders
- National Institute of Environmental Health Sciences (DP2ES025453, R21ES023604, R01ES026033, P30ES023515, U2CES026561, P30ES023515)
- Swedish Research Council (523-2009-7054; 521-2013-2531)
- Knut and Alice Wallenberg foundation
- Beatrice and Samuel A. Seaver Foundation
- UK Medical Research Council and Wellcome (102215/2/13/2)
- Innovative Medicines Initiatives Joint Undertaking (115300)
- European Federation of Pharmaceutical Industries and Associations
- Swedish Research Council for Health, Working Life and Welfare, Formas and VINNOVA (259-2012-24)
- Stiftelsen Frimurare Barnhuset, Sunnerdahls, Handikappfond, Hjärnfonden and the Swedish Foundation for International Cooperation in Research and Higher Education (STINT, PT2016-6871).)
- European Union’s Seventh Framework Programme (FP7/2007 – 2013)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- autism spectrum disorder, zinc, copper, fetal development, postnatal development, metal metabolism, biomarkers, ASD prediction, classification models
- MeSH terms
- Autism Spectrum Disorder, Child, Copper, Female, Humans, Male, Pregnancy, Prognosis, ROC Curve, Sensitivity and Specificity, Mass Spectrometry, Zinc, Biomarkers, Case-Control Studies
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