Scaling DNA data storage with nanoscale electrode wells
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A demonstration of DNA synthesis control at over 1000x higher density shows the path to large scale DNA data storage.
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Nguyen et al. produced an electrode array and demonstrated independent electrode-specific control of DNA synthesis with electrode sizes and pitches that enabled a synthesis density of 25 million oligonucleotides/cm2.
“For example, Nguyen et al.35 produced an electrode array and demonstrated independent electrode-specific control of DNA synthesis with electrode sizes and pitches that enabled a synthesis density of 25 million oligonucleotides/cm2 (Figure 3C).”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [35]
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Parallel enzymatic DNA synthesis using a semiconductor chip
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System Design Considerations for Automated Digital Data Storage in DNA
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The phosphodiester dissociative hydrolysis of a DNA model promoted by metal dications
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DNA framework array enables ultra-high throughput DNA synthesisPreprint
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Primer‐Disk‐Enabled DNA Data Storage System with Index and Record‐Many‐Read‐Many Features
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A Hybridization-Based Novel DNA Storage Technology with Rapid Read PerformancePreprint
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The Natural Coding of Language: SPECTRA is All You NeedPreprint
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- Authors
- Nguyen, B. H., Takahashi, C. N., Gupta, G., Smith, J. A., Rouse, R., Berndt, P., Yekhanin, S., Ward, D. P., Ang, S. D., Garvan, P., Parker, H.-Y., Carlson, R., Carmean, D., Ceze, L., & Strauss, K.
- Affiliations
- Microsoft (United States) (US)
- University of Washington (US)
- Microsoft Research, Redmond, WA, USA.
- Corresponding author
- Nguyen, Bichlien H.
- Strauss, Karin
- ORCID
- Venue
- Science Advances
- Published
- 2021-11-26
- Volume
- 7
- Issue
- 48
- Pages
- eabi6714-eabi6714
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC8612674
- OpenAlex
- W3216341106
- Cited by
- 90
- References
- 29
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 21 · 2023: 17 · 2022: 12
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Science Advances (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Keywords
- DNA data storage, nanoelectrode arrays, DNA synthesis, parallel synthesis, DNA sequencing, data storage density, write throughput
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