ATR and ATRIP: Partners in Checkpoint Signaling

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

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A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

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ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 523

p62/SQSTM1 in cancer: phenomena, mechanisms, and regulation in DNA damage repair

Yang, X., Cao, X., & Zhu, Q. (2025) · Cancer and Metastasis Reviews · doi:10.1007/s10555-025-10250-w · Cited by 35

Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism

Bandhu, A., Kang, J., Fukunaga, K., Goto, G. H., & Sugimoto, K. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004136 · Cited by 32

PostExcision Events in Human Nucleotide Excision Repair

Kemp, M. G., & Hu, J. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12641 · Cited by 30

Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer

Yang, S., Kuo, T., Wu, H., Guo, J., Hsu, C., Hsu, C., Tien, Y., Yeh, K., Cheng, A., & Kuo, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7275 · Cited by 33

Dormant origin signaling during unperturbed replication

Moiseeva, T. N., & Bakkenist, C. J. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102655 · Cited by 32

Shelterin and the replisome: at the intersection of telomere repair and replication

Cicconi, A., & Chang, S. S. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.02.016 · Cited by 30

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against genotoxic stress

Umar, S. A., & Tasduq, S. A. (2020) · RSC Advances · doi:10.1039/d0ra05819j · Cited by 33

The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function

Xue, L., Furusawa, Y., Okayasu, R., Miura, M., Cui, X., Liu, C., Hirayama, R., Matsumoto, Y., Yajima, H., & Yu, D. S. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.11.004 · Cited by 31

General morphological and biological features of neoplasms: integration of molecular findings

Díaz-Cano, S. J. (2008) · Histopathology · doi:10.1111/j.1365-2559.2007.02937.x · Cited by 33

Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine

Fredebohm, J., Wolf, J. M., Hoheisel, J. D., & Boettcher, M. (2013) · Journal of Cell Science · doi:10.1242/jcs.124768 · Cited by 30

Roles of ATM and ATR in DNA double strand breaks and replication stress

Williams, R. M., & Zhang, X. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.03.007 · Cited by 39

Dominant TEL1-hy Mutations Compensate for Mec1 Lack of Functions in the DNA Damage Response

Baldo, V., Testoni, V., Lucchini, G., & Longhese, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01214-07 · Cited by 31

Activation of a DNA Damage Checkpoint Response in a TAF1-Defective Cell Line

Buchmann, A. M., Skaar, J. R., & DeCaprio, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5332-5339.2004 · Cited by 31

Functions of Saccharomyces cerevisiae 14-3-3 Proteins in Response to DNA Damage and to DNA Replication Stress

Lottersberger, F., Rubert, F., Baldo, V., Lucchini, G., & Longhese, M. P. (2003) · Genetics · doi:10.1093/genetics/165.4.1717 · Cited by 30

A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts

Bélanger, F., Rajotte, V., & Drobetsky, E. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085294 · Cited by 29

Improved lentiviral vector titers from a multi-gene knockout packaging line

Han, J., Tam, K. J., Tam, C., Hollis, R. P., & Kohn, D. B. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.11.012 · Cited by 32

Molecular Mechanisms of DNA Replication Checkpoint Activation

Recolin, B., van der Laan, S., Tsanov, N., & Maiorano, D. (2014) · Genes · doi:10.3390/genes5010147 · Cited by 34

Replication licensing and the DNA damage checkpoint

Cook, J. G. (2009) · Frontiers in bioscience · doi:10.2741/3584 · Cited by 30

Targeting endothelial cell metabolism for cardio-protection from the toxicity of antitumor agents

Morbidelli, L., Donnini, S., & Ziche, M. (2016) · Cardio-Oncology · doi:10.1186/s40959-016-0010-6 · Cited by 29

Chk1- and Claspin-Dependent but ATR/ATM– and Rad17-Independent DNA Replication Checkpoint Response in HeLa Cells

Rodríguez-Bravo, V., Guaita‐Esteruelas, S., Florensa, R., Bachs, O., & Agell, N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4443 · Cited by 29

ATR-dependent phosphorylation of ATRIP in response to genotoxic stress

Itakura, E., Umeda, K., Sekoguchi, E., Takata, H., Ohsumi, M., & Matsuura, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.228 · Cited by 29

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair

Lima, M. D. S., Bouzid, H., Soares, D. G., Selle, F., Morel, C., Galmarini, C. M., Henriques, J. A. P., Larsen, A. K., & Escargueil, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.8292 · Cited by 31

The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1

Lee, M.-Y., Rivera-Rivera, Y., Moreno, C. S., & Saavedra, H. I. (2017) · Oncotarget · doi:10.18632/oncotarget.20765 · Cited by 27

Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Liptay, M., Barbosa, J. S., & Rottenberg, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00670 · Cited by 30

The Rad4TopBP1 ATR-Activation Domain Functions in G1/S Phase in a Chromatin-Dependent Manner

Lin, S.-J., Wardlaw, C. P., Morishita, T., Miyabe, I., Chahwan, C., Caspari, T., Schmidt, U. G., Carr, A. M., & Garcia, V. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002801 · Cited by 26

A UVB‐hypersensitive mutant in Arabidopsis thaliana is defective in the DNA damage response

Sakamoto, A. N., Lan, V. T. T., Puripunyavanich, V., Hase, Y., Yokota, Y., Shikazono, N., Nakagawa, M., Narumi, I., & Tanaka, A. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03974.x · Cited by 28

The Arabidopsis ATRIP ortholog is required for a programmed response to replication inhibitors

Sweeney, P. R., Britt, A., & Culligan, K. M. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03975.x · Cited by 31

RISKS FROM LOW DOSE/DOSE RATE RADIATION: WHAT AN UNDERSTANDING OF DNA DAMAGE RESPONSE MECHANISMS CAN TELL US

Jeggo, P. A. (2009) · Health Physics · doi:10.1097/hp.0b013e3181aff9c8 · Cited by 29

Shaping chromatin for repair

Gospodinov, A. G., & Herceg, Z. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.10.001 · Cited by 28

ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

Kim, W., Zhao, F., Wu, R., Qin, S., Nowsheen, S., Huang, J., Zhou, Q., Chen, Y., Deng, M., Guo, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13321-z · Cited by 28

Late Activation of Stress Kinases (SAPK/JNK) by Genotoxins Requires the DNA Repair Proteins DNA-PKcsand CSB

Fritz, G., & Kaina, B. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0606 · Cited by 28

Running into problems: how cells cope with replicating damaged DNA

McGowan, C. H. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.011 · Cited by 28

Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity

Silva, A. M., Barbosa, I. A., Seabra, C., Beltrão, N., Pereira-Santos, A. R., Vega‐Naredo, I., Oliveira, P. J., & Cunha‐Oliveira, T. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.06.001 · Cited by 27

Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells

Stuhldreier, F., Kassel, S., Schumacher, L., Wesselborg, S., Proksch, P., & Fritz, G. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.02.030 · Cited by 27

Fabrication of Cell Chip for Detection of Cell Cycle Progression Based on Electrochemical Method

Kafi, M. A., Kim, T. P., An, J. H., & Choi, J. (2011) · Analytical Chemistry · doi:10.1021/ac102895b · Cited by 27

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops

Ma, T. S., Worth, K. R., Maher, C., Ng, N., Beghè, C., Gromak, N., Rose, A. M., & Hammond, E. M. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad858 · Cited by 25

BID Binds to Replication Protein A and Stimulates ATR Function following Replicative Stress

Liu, Y., Vaithiyalingam, S., Shi, Q., Chazin, W., & Zinkel, S. S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05737-11 · Cited by 26

Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells

Schmidt, F., Kunze, M., Loock, A.-C., & Dobbelstein, M. (2014) · Oncotarget · doi:10.18632/oncotarget.2710 · Cited by 27

Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin

Zhang, J., Song, Y., Brannigan, B. W., Wahrer, D. C. R., Schiripo, T. A., Harris, P. L., Haserlat, S. M., Ulkus, L. E., Shannon, K., Garber, J. E., et al. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0033 · Cited by 27

Phosphorylation of ATR-Interacting Protein on Ser239 Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function

Venere, M., Snyder, A. R., Zgheib, O., & Halazonetis, T. D. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0369 · Cited by 27

Amino‐terminal domain of ATRIP contributes to intranuclear relocation of the ATR–ATRIP complex following DNA damage

Itakura, E., Takai, K., Umeda, K., Kimura, M., Ohsumi, M., Tamai, K., & Matsuura, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.026 · Cited by 24

Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombinationPreprint

Moquin, D., Genois, M., Zhang, J., Ouyang, J., Yadav, T., Buisson, R., Yazinski, S. A., Tan, J. J., Boukhali, M., Gagné, J., et al. (2018) · Genes & Development · doi:10.1101/gad.315978.118 · Cited by 23

The human ATR-mediated DNA damage checkpoint in a reconstituted system

Choi, J.-H., Sancar, A., & Lindsey-Boltz, L. A. (2009) · Methods · doi:10.1016/j.ymeth.2009.02.006 · Cited by 23

Profound synthetic lethality between SMARCAL1 and FANCM

Feng, S., Liu, K., Shang, J., Hoeg, L., Pastore, G., Yang, W. E., Roy, S., Sastre-Moreno, G., Young, J. T. F., Wu, W., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.10.016 · Cited by 24

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

Bertolin, A. P., Canal, B., Yekezare, M., Early, A. E., Zeng, J., Instrell, R., Howell, M., & Diffley, J. F. X. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.06.002 · Cited by 27

PICOT (GLRX3) is a positive regulator of stress-induced DNA-damage response

Pandya, P., Braiman, A., & Isakov, N. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.06.005 · Cited by 24

A DNA replication fork-centric view of the budding yeast DNA damage response

McClure, A. W., Canal, B., & Diffley, J. F. X. (2022) · DNA repair · doi:10.1016/j.dnarep.2022.103393 · Cited by 24

Roles of DNA damage in renal tubular epithelial cells injury

Wang, P., Ouyang, J., Jia, Z., Zhang, A., & Yang, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1162546 · Cited by 27

Replication stress: Driver and therapeutic target in genomically instable cancers

Schoonen, P. M., Llobet, S. G., & van Vugt, M. A. T. M. (2018) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.10.006 · Cited by 26

Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complexPreprint

Kapoor, P., Bao, Y., Xiao, J., Luo, J., Shen, J., Persinger, J., Peng, G., Ranish, J. A., Bartholomew, B., & Shen, X. (2015) · Genes & Development · doi:10.1101/gad.257626.114 · Cited by 26

Asf1 facilitates dephosphorylation of Rad53 after DNA double-strand break repairPreprint

Tsabar, M., Waterman, D. P., Aguilar, F., Katsnelson, L., Eapen, V. V., Memişoğlu, G., & Haber, J. E. (2016) · Genes & Development · doi:10.1101/gad.280685.116 · Cited by 26

Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation

Musich, P. R., Li, Z., & Zou, Y. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-56017-5_4 · Cited by 23

Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1

Roche, K. C., Rocha, S., Bracken, C. P., & Perkins, N. D. (2007) · Oncogene · doi:10.1038/sj.onc.1210233 · Cited by 23

C17orf53 is identified as a novel gene involved in inter-strand crosslink repair

Wang, C., Chen, Z., Su, D., Tang, M., Nie, L., Zhang, H., Feng, X., Wang, R., Shen, X. H., Srivastava, M., et al. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102946 · Cited by 23

DNA damage responses that enhance resilience to replication stress

Yoshida, K., & Fujita, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03926-3 · Cited by 27

Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

Sugitani, N., Vendetti, F. P., Cipriano, A. J., Pandya, P., Deppas, J. J., Moiseeva, T. N., Schamus-Haynes, S., Wang, Y., Palmer, D., Osmanbeyoglu, H. U., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111371 · Cited by 22

The position of the amino group on the benzene ring is critical for mesalamineʼs improvement of replication fidelity

Campregher, C., Luciani, M. G., Biesenbach, P., Evstatiev, R., Lyakhovich, A., & Gasché, C. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21112 · Cited by 23

Meier–Gorlin syndrome and Wolf–Hirschhorn syndrome: Two developmental disorders highlighting the importance of efficient DNA replication for normal development and neurogenesis

Kerzendorfer, C., Colnaghi, R., Abramowicz, I., Carpenter, G., & O’Driscoll, M. (2013) · DNA repair · doi:10.1016/j.dnarep.2013.04.016 · Cited by 23

NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis

Ming, H., Tan, J. S., Cao, S., Yu, C., Qi, Y., Wang, C., Zhang, L., Liu, Y., Yuan, J., Yin, M., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01179-5 · Cited by 22

Mammalian DNA Damage Response Pathway

Lou, Z., & Chen, J. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_15 · Cited by 19

ERK1 and ERK2 kinases activate hydroxyurea-induced S-phase checkpoint in MCF7 cells by mediating ATR activation

Wei, F., Xie, Y., He, L., Tao, L., & Tang, D. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.09.010 · Cited by 22

RAP80 Responds to DNA Damage Induced by Both Ionizing Radiation and UV Irradiation and Is Phosphorylated at Ser205

Yan, J., Yang, X.-P., Kim, Y. S., & Jetten, A. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5950 · Cited by 22

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Yang, S. F., Nelson, C. B., Wells, J., Fernando, M., Lu, R., Allen, J. A. M., Malloy, L., Lamm, N., Murphy, V. J., Mackay, J. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46578-0 · Cited by 22

Chemical strategies for development of ATR inhibitors

Llona‐Minguez, S., Höglund, A., Jacques, S. A., Koolmeister, T., & Helleday, T. (2014) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2014.10 · Cited by 22

The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation

Hammond, E. M., Freiberg, R. A., & Giaccia, A. J. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.06.029 · Cited by 21

Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides

Wanrooij, P. H., Tannous, E., Kumar, S., Navadgi, V. M., & Burgers, P. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.687145 · Cited by 21

Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

Kang, S., Lim, Y., Kim, Y. J., Jung, E. S., Suh, D. H., Lee, C. H., Park, E., Hong, J., Velliquette, R. A., Kwon, O., et al. (2019) · Nutrients · doi:10.3390/nu11010101 · Cited by 21

Phosphorylation-Dependent Pin1 Isomerization of ATR: Its Role in Regulating ATR’s Anti-apoptotic Function at Mitochondria, and the Implications in Cancer

Makinwa, Y., Musich, P. R., & Zou, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00281 · Cited by 23

Fission Yeast Hsk1 (Cdc7) Kinase Is Required After Replication Initiation for Induced Mutagenesis and Proper Response to DNA Alkylation Damage

Dolan, W. P., Le, A.-H., Schmidt, H., Yuan, J., Green, M., & Forsburg, S. L. (2010) · Genetics · doi:10.1534/genetics.109.112284 · Cited by 21

The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR

Brem, R., Fernet, M., Chapot, B., & Hall, J. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.02.002 · Cited by 20

Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2

Oo, J. A., Pálfi, K., Warwick, T., Wittig, I., Prieto‐Garcia, C., Matković, V., Tomašković, I., Boos, F., Ponce, J. I., Teichmann, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111670 · Cited by 21

DNA Replication Arrest in Response to Genotoxic Stress Provokes Early Activation of Stress-Activated Protein Kinases (SAPK/JNK)

Damrot, J., Helbig, L., Roos, W. P., Quirós, S., Kaina, B., & Fritz, G. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.12.015 · Cited by 20

Activation of p53/ATM-dependent DNA damage signaling pathway by shiga toxin in mammalian cells

Talukder, K. A., Azmi, I. J., Ahmed, K. A., Hossain, M., Kabir, Y., Cravioto, A., Sack, D. A., & Nur‐E‐Kamal, A. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.02.007 · Cited by 20

The radiation response of androgen-refractory prostate cancer cell line C4-2 derived from androgen-sensitive cell line LNCaP

Xie, B.-X., Zhang, H., Lan, Y., Wang, J., Pang, B., Wu, R.-Q., Qian, X. L., Li, S.-H., Shi, Q., Wang, L.-L., et al. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2009.91 · Cited by 20

Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication

Yates, M., & Maréchal, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102909 · Cited by 19

Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1

Landsverk, H. B., Sandquist, L. E., Sridhara, S. R. C., Rødland, G. E., Sabino, J. C., de Almeida, S. F., Grallert, B., Trinkle‐Mulcahy, L., & Syljuåsen, R. G. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1233 · Cited by 24

The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine

Parvathaneni, S., & Sharma, S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008420 · Cited by 20

ATR activation is regulated by dimerization of ATR activating proteins

Thada, V., & Cortez, D. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100455 · Cited by 24

The p53 Tumor Suppressor Pathway and Cancer

Zambetti, G. P. (2005) · Springer eBooks · doi:10.1007/0-387-30127-5 · Cited by 20

Checkpoint and Coordinated Cellular Responses to DNA Damage

Yang, X. H., & Zou, L. (2006) · Springer eBooks · doi:10.1007/b136684 · Cited by 20

Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

Bai, L., Michael, W. M., & Yan, S. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.01.006 · Cited by 19

Systematic expression analysis of the CELSR family reveals the importance of CELSR3 in human lung adenocarcinoma

Li, Y., Zhu, L., Hao, R., Li, Y., Zhao, Q., & Li, S. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16497 · Cited by 19

A Link between Replicative Stress, Lamin Proteins, and Inflammation

Willaume, S., Rass, E., Fontanilla-Ramirez, P., Moussa, A., Wanschoor, P., & Bertrand, P. (2021) · Genes · doi:10.3390/genes12040552 · Cited by 28

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

Lin, Y., Li, J., Zhao, H., McMahon, A., McGhee, K., & Yan, S. (2023) · eLife · doi:10.7554/elife.82324 · Cited by 18

Function of the ATR N-terminal domain revealed by an ATM/ATR chimera

Chen, X., Zhao, R., Glick, G. G., & Cortez, D. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.02.015 · Cited by 19

DNA Damage Response in Neonatal and Adult Stromal Cells Compared With Induced Pluripotent Stem Cells

Liedtke, S., Biebernick, S., Radke, T. F., Stapelkamp, D., Coenen, C., Zaehres, H., Fritz, G., & Kögler, G. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0209 · Cited by 19

The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

Rai, R., Gu, P., Broton, C., Kumar‐Sinha, C., Chen, Y., & Chang, S. S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.012 · Cited by 21

Conditional inactivation of the mouse cell cycle checkpoint gene

Levitt, P. S., Liu, H., Manning, C., & WEISS, R. (2005) · Genomics · doi:10.1016/j.ygeno.2005.04.007 · Cited by 20

Chapters 6 and 7

Valentin, J. (2005) · Annals of the ICRP · doi:10.1016/j.icrp.2005.11.005 · Cited by 20

ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability

Chen, S., Pan, C., Huang, J., & Liu, T. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00066-9 · Cited by 19

Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns

Jang, E. R., Lee, J. H., Lim, D., & Lee, J. (2004) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-003-0522-y · Cited by 17

Diphenylpyrazoles as Replication Protein A Inhibitors

Waterson, A. G., Kennedy, J. P., Patrone, J. D., Pelz, N. F., Feldkamp, M. D., Frank, A. O., Vangamudi, B., de Souza-Fagundes, E. M., Rossanese, O. W., Chazin, W., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml5003629 · Cited by 18

The role of shelterin in maintaining telomere integrity

Longhese, M. P. (2011) · Frontiers in bioscience · doi:10.2741/4014 · Cited by 20

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR

Lyu, K., Kumagai, A., & Dunphy, W. G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1598728 · Cited by 20

ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1

Wakeman, T. P., & Xu, B. (2006) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2006.06.007 · Cited by 18

The Aspergillus nidulans npkA Gene Encodes a Cdc2-Related Kinase That Genetically Interacts With the UvsBATR KinaseSequence data from this article have been deposited with the NCBI under accession no. AY166593.

Kress, M. R. V. Z., Lima, J. F., Savoldi, M., Malavazi, I., Larson, R. E., Goldman, M. H. S., & Goldman, G. H. (2004) · Genetics · doi:10.1534/genetics.103.024166 · Cited by 19

Structure and function of the apical PIKKs in double-strand break repair

Xu, J., Bradley, N. P., & He, Y. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102651 · Cited by 15

p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis

Elfar, G. A., Aning, O. A., Ngai, T. W., Yeo, P., Chan, J. W. K., Sim, S. H., Goh, L., Ju, Y., Phua, C. Z. J., Yeo, J. Z. Z., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae811 · Cited by 17

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts

Kumar, S., Yoo, H. Y., Kumagai, A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19636 · Cited by 17

Coordinated Effort Against DNA Damage

(2001) · Science Signaling · doi:10.1126/scisignal.1102001tw436

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Identifying Inhibitors of ATM and ATR Kinase Activities

Sarkaria, J. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-380-1:49 · Cited by 15

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint*

(2001)