ATR and ATRIP: Partners in Checkpoint Signaling

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 542

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 523

A new in vitro system for activating the cell cycle checkpoint

Wang, J., Engle, S. E., & Zhang, Y. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14753 · Cited by 17

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

Helbig, L., Damrot, J., Hülsenbeck, J., Köberle, B., Brozović, A., Osmak, M., Fiket, Ž., Kaina, B., & Fritz, G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190645 · Cited by 17

Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting Protein

Feldkamp, M. D., Frank, A. O., Kennedy, J. P., Patrone, J. D., Vangamudi, B., Waterson, A. G., Fesik, S. W., & Chazin, W. (2013) · Biochemistry · doi:10.1021/bi400542z · Cited by 17

Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis

Waskiewicz, E., Vasiliou, M., Córcoles-Sáez, I., & Rita, S. (2021) · Communications Biology · doi:10.1038/s42003-021-01884-x · Cited by 17

Inhibition of poly(ADP‐ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks

Golla, R. M., Li, M., Shen, Y., Ji, M. H., Yan, Y., Fu, K., Greiner, T. C., McKeithan, T. W., & Chan, W. C. (2011) · Hematological Oncology · doi:10.1002/hon.1020 · Cited by 17

CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts

Ramírez-Lugo, J. S., Yoo, H. Y., Yoon, S. J., & Dunphy, W. G. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14711 · Cited by 18

Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein A

Patrone, J. D., Pelz, N. F., Bates, B. S., de Souza-Fagundes, E. M., Vangamudi, B., Camper, D. V., Kuznetsov, A. G., Browning, C. F., Feldkamp, M. D., Frank, A. O., et al. (2016) · ChemMedChem · doi:10.1002/cmdc.201500479 · Cited by 17

Quantitative mechanisms of DNA damage sensing and signaling

Bantele, S. C. S., & Pfander, B. (2019) · Current Genetics · doi:10.1007/s00294-019-01007-4 · Cited by 17

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response

Ragland, R. L., Arlt, M. F., Hughes, E. D., Saunders, T. L., & Glover, T. W. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9195-4 · Cited by 17

DNA-Damage Control: Claspin Destruction Turns off the Checkpoint

Gewurz, B. E., & Harper, J. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.046 · Cited by 17

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

Beumer, J. H., Fu, K. Y., Anyang, B. N., Siegfried, J. M., & Bakkenist, C. J. (2015) · BMC Cancer · doi:10.1186/s12885-015-1649-3 · Cited by 17

Structure of the Human TELO2-TTI1-TTI2 Complex

Kim, Y., Park, J., Joo, S. Y., Kim, B., Jo, A., Lee, H., & Cho, Y. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167370 · Cited by 15

Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic Potential

Lewicky, J. D., Martel, A. L., Gupta, M. R., Roy, R., Rodriguez, G. M., Vanderhyden, B. C., & Le, H. (2023) · Cancers · doi:10.3390/cancers15164127 · Cited by 16

LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer

HU, H., Yang, H., FAN, S., JIA, X., ZHAO, Y., & LI, H. (2024) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2024.044174 · Cited by 16

S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability

Crawley, C. D., Kang, S., Bernal, G. M., Wahlstrom, J. S., Voce, D. J., Cahill, K. E., Garofalo, A., Raleigh, D. R., Weichselbaum, R. R., & Yamini, B. (2015) · Cell Cycle · doi:10.4161/15384101.2014.991166 · Cited by 16

Influence of Human p53 on Plant Development

Ma, H., Song, T., Wang, T., & Wang, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162840 · Cited by 16

Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms

Choi, J. E., & Chung, W. (2019) · The Journal of Microbiology · doi:10.1007/s12275-020-9520-x · Cited by 17

Quantitative Protein Network Monitoring in Response to DNA Damage

Nishizuka, S., Ramalingam, S., Spurrier, B., Washburn, F. L., Krishna, R., Honkanen, P., Young, L., Shimura, T., Steeg, P. S., & Austin, J. (2008) · Journal of Proteome Research · doi:10.1021/pr0702971 · Cited by 16

Gene Targeting in Human Somatic Cells

Hendrickson, E. A. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-285-4_53 · Cited by 16

Genetic Interactions of the Aspergillus nidulans atmAATM Homolog With Different Components of the DNA Damage Response Pathway

Malavazi, I., Lima, J. F., de Castro, P. A., Savoldi, M., Goldman, M. H. S., & Goldman, G. H. (2008) · Genetics · doi:10.1534/genetics.107.080879 · Cited by 15

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

Goto, G. H., Ogi, H., Biswas, H., Ghosh, A. K., Tanaka, S., & Sugimoto, K. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006873 · Cited by 16

Known types of membrane-less organelles and biomolecular condensates

Darling, A. L., & Uversky, V. N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823967-4.00002-6 · Cited by 15

Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks

Lee, E.-M., Trinh, T. T. B., Shim, H. J., Park, S.-K., Nguyen, T. T. T., Kim, M., & Song, Y. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.06.007 · Cited by 15

Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death

Hinterleitner, C., Huelsenbeck, J., Henninger, C., Wartlick, F., Schorr, A., Kaina, B., & Fritz, G. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0842-6 · Cited by 15

N-Methyl-N′-nitro-N-nitrosoguanidine Activates Cell-Cycle Arrest through Distinct Mechanisms Activated in a Dose-Dependent Manner

Beardsley, D. I., Kim, W.-J., & Brown, K. D. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.013888 · Cited by 15

DNA Replication proteins in primary microcephaly syndromes

Tingler, M., Philipp, M., & Burkhalter, M. D. (2022) · Biology of the Cell · doi:10.1111/boc.202100061 · Cited by 13

Variants in ATRIP are associated with breast cancer susceptibility in the Polish population and UK Biobank

Cybulski, C., Zamani, N., Kluźniak, W., Milano, L., Wokołorczyk, D., Stempa, K., Rudnicka, H., Zhang, S., Zadeh, M., Huzarski, T., et al. (2023) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2023.03.002 · Cited by 15

Design, synthesis, and biological evaluation of pyrido[3,2-d]pyrimidine derivatives as novel ATR inhibitors

Duan, Y., Zhuang, L., Xu, Y., Cheng, H., Xia, J., Lu, T., & Chen, Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106535 · Cited by 14

Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response

Malysa, A., Zhang, X. M., & Bepler, G. (2024) · Cells · doi:10.3390/cells14010012 · Cited by 14

Proteomic Studies of Primary Acute Myeloid Leukemia Cells Derived from Patients Before and during Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid and Valproic Acid

Hernandez-Valladares, M., Wangen, R., Aasebø, E., Reikvam, H., Berven, F. S., Selheim, F., & Bruserud, Ø. (2021) · Cancers · doi:10.3390/cancers13092143 · Cited by 14

Mind the replication gap

Mocanu, C., & Chan, K. (2021) · Royal Society Open Science · doi:10.1098/rsos.201932 · Cited by 14

ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment

Wan, C., Kulkarni, A., & Wang, Y. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.12.012 · Cited by 14

Mutation of Serine 1333 in the ATR HEAT Repeats Creates a Hyperactive Kinase

Luzwick, J. W., Nam, E. A., Zhao, R., & Cortez, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099397 · Cited by 14

Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis

Longhese, M. P., Guerini, I., Baldo, V., & Clerici, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.09.006 · Cited by 15

Analysis of Mutations That Dissociate G2 and Essential S Phase Functions of Human Ataxia Telangiectasia-mutated and Rad3-related (ATR) Protein Kinase

Nam, E. A., Zhao, R., & Cortez, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.276113 · Cited by 13

Checkpoint Regulation of DNA Replication

Boye, E., Skjølberg, H. C., & Grallert, B. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-815-7_4 · Cited by 17

Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR

Chatterjee, N., Lin, Y., & Wilson, J. H. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.03.016 · Cited by 13

MicroRNAs that affect the Fanconi Anemia/BRCA pathway are downregulated in imatinib-resistant chronic myeloid leukemia patients without detectable BCR-ABL kinase domain mutations

Yap, E., Norziha, Z. A., Simbun, A., Tumian, N. R., Cheong, S.-K., Cf, L., & Wong, C. L. (2017) · Leukemia Research · doi:10.1016/j.leukres.2017.05.015 · Cited by 14

Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3

Lian, X., Bao, C., Li, X., Zhang, X., Chen, H., Jung, Y., & Qian, Y. (2019) · Journal of Virology · doi:10.1128/jvi.02290-18 · Cited by 14

Current Implications of microRNAs in Genome Stability and Stress Responses of Ovarian Cancer

Gajek, A., Gralewska, P., Marczak, A., & Rogalska, A. (2021) · Cancers · doi:10.3390/cancers13112690 · Cited by 14

p53 suppression overwhelms DNA polymerase η deficiency in determining the cellular UV DNA damage response

Laposa, R. R., Feeney, L., Crowley, E., de Feraudy, S. M., & Cleaver, J. E. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.07.005 · Cited by 14

The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence

Li, X., Xu, H., Chong-an, X., Lin, M., Song, X., Yi, F., Feng, Y., Coughlan, K. A., Cho, W., Kim, S. W., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14022431 · Cited by 18

Novel Cellular Functions of ATR for Therapeutic Targeting: Embryogenesis to Tumorigenesis

Biswas, H., Makinwa, Y., & Zou, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411684 · Cited by 13

The Potential for Targeting G2/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy

Melia, E., & Parsons, J. L. (2024) · Cancers · doi:10.3390/cancers16173016 · Cited by 14

Involvement of ATM/ATR-p38 MAPK cascade in MNNG induced G1-S arrest

Zhu, K. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i9.2073 · Cited by 13

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Kafer, G. R., & Cesare, A. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00416 · Cited by 12

Cohesin in DNA damage response and double-strand break repair

Hou, W., Li, Y., Zhang, J., Xia, Y., Wang, X., Chen, H., & Lou, H. (2022) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2022.2027336 · Cited by 15

Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding

Takeishi, Y., Iwaya-Omi, R., Ohashi, E., & Tsurimoto, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.669002 · Cited by 13

Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis

So, E.-Y., Ausman, M., Saeki, T., & Ouchi, T. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.9 · Cited by 13

HIF1‐regulated ATRIP expression is required for hypoxia induced ATR activation

Ding, G., Liu, H., Liang, H., Ni, R.-F., Ding, Z.-Y., Ni, G.-Y., Hua, H.-W., & Xu, W. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.02.020 · Cited by 13

Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks

Willis, N. A., Zhou, C., Elia, A. E. H., Murray, J. M., Carr, A. M., Elledge, S. J., & Rhind, N. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525620113 · Cited by 15

Fission yeast Rad26 responds to DNA damage independently of Rad3

Wolkow, T. D., & Enoch, T. (2003) · BMC Genetics · doi:10.1186/1471-2156-4-6 · Cited by 13

Schizosaccharomyces pombeOrc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle

Kato, H., Matsunaga, F., Miyazaki, S., Yin, L., D’Urso, G., Tanaka, K., & Murakami, Y. (2008) · Cell Cycle · doi:10.4161/cc.7.8.5710 · Cited by 13

Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease

Zhang, J. Q. J., Saravanabavan, S., & Rangan, G. K. (2021) · Cells · doi:10.3390/cells10030532 · Cited by 11

A Genomic Approach to Delineating the Occurrence of Scoliosis in Arthrogryposis Multiplex Congenita

Latypova, X., Creadore, S. G., Dahan‐Oliel, N., Gustafson, A. G., Hwang, S. W.-H., Bedard, T., Shazand, K., van Bosse, H. J. P., Giampietro, P. F., & Dieterich, K. D. (2021) · Genes · doi:10.3390/genes12071052 · Cited by 12

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates

Yilmaz, S., Sancar, A., & Kemp, M. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022986 · Cited by 12

The Neurospora crassa UVS-3 epistasis group encodes homologues of the ATR/ATRIP checkpoint control system

Kazama, Y., Ishii, C., Schroeder, A. L., Shimada, H., Wakabayashi, M., & Inoue, H. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.09.011 · Cited by 12

X-RAY IRRADIATION AFFECTS MORPHOLOGY, PROLIFERATION AND MIGRATION RATE OF HEALTHY AND CANCER CELLS

Panzetta, V., Menna, M. D., BUCCI, D., GIOVANNINI, V., Pugliese, M., Quarto, M., Fusco, S., & Netti, P. A. (2015) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519415400229 · Cited by 12

RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

Kar, A., Kaur, M., Ghosh, T., Khan, M. M., Sharma, A., Shekhar, R., Varshney, A., & Saxena, S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv369 · Cited by 12

Prexasertib: an investigational checkpoint kinase inhibitor for the treatment of high-grade serous ovarian cancer

Evangelisti, G., Barra, F., Moioli, M., Sala, P., Stigliani, S., Gustavino, C., Costantini, S., & Ferrero, S. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1783238 · Cited by 12

ATRIP protects progenitor cells against DNA damage in vivo

Matos-Rodrigues, G. E., Grigaravičius, P., López, B. S., Hofmann, T. G., Frappart, P., & Martins, R. A. P. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03090-9 · Cited by 12

Recognition and Repair Pathways of Damaged DNA in Higher Plants

Biedermann, S., Mooney, S., & Hellm, H. (2011) · InTech eBooks · doi:10.5772/21380 · Cited by 13

Two serine phosphorylation sites in the C ‐terminus of R ad9 are critical for 9‐1‐1 binding to T op BP 1 and activation of the DNA damage checkpoint response in H e L a cells

Ueda, S., Takeishi, Y., Ohashi, E., & Tsurimoto, T. (2012) · Genes to Cells · doi:10.1111/j.1365-2443.2012.01630.x · Cited by 12

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases

Fan, H., Chi, C.-S., Cheng, S.-N., Lee, H.-F., Tsai, J., Lin, S., & Harn, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010026 · Cited by 12

High dose interferon alpha-2b therapy for chronic hepatitis C: an open label study of the response and predictors of response.

Bellary, S., Smith, D. G., Bankes, P. F., Harris, A. W., Shayiq, R. M., & Black, M. (1995) · PubMed · Cited by 12

APE1 is a master regulator of the ATR-/ATM-mediated DNA damage response

Zhao, H., Richardson, C. A., Marriott, I., Yang, I. H., & Yan, S. (2024) · DNA repair · doi:10.1016/j.dnarep.2024.103776 · Cited by 14

Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM)

Tannous, E., & Burgers, P. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1925218 · Cited by 11

Pentacyclic Triterpenoids-Based Ionic Compounds: Synthesis, Study of Structure–Antitumor Activity Relationship, Effects on Mitochondria and Activation of Signaling Pathways of Proliferation, Genome Reparation and Early Apoptosis

Dzhemileva, L. U., Tuktarova, R. A., Dzhemilev, U. M., & D'yakonov, V. A. (2023) · Cancers · doi:10.3390/cancers15030756 · Cited by 11

Whole-genome sequencing reveals adaptations of hairy-footed jerboas (Dipus, Dipodidae) to diverse desert environments

Peng, X., Cheng, J., Li, H., Feijó, A., Xia, L., Ge, D., Wen, Z., & Yang, Q. (2023) · BMC Biology · doi:10.1186/s12915-023-01680-5 · Cited by 10

TopBP1 in DNA Damage Response

Forma, E., Bryś, M., & Wanda, M. (2011) · InTech eBooks · doi:10.5772/22274 · Cited by 11

Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906

Soares, D. G., Battistella, A., Rocca, C. J., Matuo, R., Henriques, J. A. P., Larsen, A. K., & Escargueil, A. E. (2011) · Biochemical Journal · doi:10.1042/bj20101770 · Cited by 11

Cyclooxygenase-2 Up-Regulates Ataxia Telangiectasia and Rad3 Related through Extracellular Signal-Regulated Kinase Activation

Kim, Y., Lee, E. J., Park, S., Cho, K. H., Kim, J. Y., & Pyo, H. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0493 · Cited by 11

Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses

Choi, S. H., & Yoo, H. Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.158 · Cited by 11

DNA repair investigations using siRNA

Miller, H., & Grollman, A. P. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00042-9 · Cited by 11

RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery inCaenorhabditis elegans

Ossareh‐Nazari, B., Katsiarimpa, A., Merlet, J., & Pintard, L. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.033043 · Cited by 10

Canonical and Noncanonical Functions of the BH3 Domain Protein Bid in Apoptosis, Oncogenesis, Cancer Therapeutics, and Aging

Makinwa, Y., Luo, Y., Musich, P. R., & Zou, Y. (2024) · Cancers · doi:10.3390/cancers16122199 · Cited by 12

Inflammasome protein scaffolds the DNA damage complex during tumor development

Shen, C. X., Pandey, A., Tuipulotu, D. E., Mathur, A., Liu, L., Yang, H., Adikari, N. K., Ngo, C., Jing, W., Feng, S., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01988-6 · Cited by 13

ATM and ATR checkpoint kinase pathways: A concise review

Chauhan, N., Wagh, V., Joshi, P., & Jariyal, H. (2020) · Advances in Human Biology · doi:10.4103/aihb.aihb_78_19 · Cited by 9

Phosphorylation of the BRCA1 C Terminus (BRCT) Repeat Inhibitor of hTERT (BRIT1) Protein Coordinates TopBP1 Protein Recruitment and Amplifies Ataxia Telangiectasia-mutated and Rad3-related (ATR) Signaling

Zhang, B., Wang, E., Dai, H., Shen, J., Hsieh, H.-J., Lu, X., & Peng, G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.587113 · Cited by 11

Fanconi anemia pathway regulates convergent transcription-induced cell death at trinucleotide repeats in human cells

Chatterjee, N., Lin, Y., & Wilson, J. H. (2016) · Postdoc Journal · doi:10.14304/surya.jpr.v4n5.1 · Cited by 11

Divergence of cAMP signalling pathways mediating augmented nucleotide excision repair and pigment induction in melanocytes

Horrell, E. M. W., Jarrett, S. G., Carter, K. M., & D'Orazio, J. A. (2017) · Experimental Dermatology · doi:10.1111/exd.13291 · Cited by 11

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

Liu, R., King, A., Hoch, N. C., Chang, C. W. T., Kelly, G. L., Deans, A. J., & Heierhorst, J. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.06.022 · Cited by 10

DNA damage response and repair in pancreatic cancer development and therapy

Farnood, P. R., Pazhooh, R. D., Asemi, Z., & Yousefi, B. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103116 · Cited by 11

Cell Cycle

Ventura, E., & Giordano, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.90189-4 · Cited by 11

Prolyl Isomerization-Mediated Conformational Changes Define ATR Subcellular Compartment-Specific Functions

Biswas, H., Zhao, S., Makinwa, Y., Bassett, J. S., Musich, P. R., Liu, J., & Zou, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.826576 · Cited by 10

The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization

Baschal, E. E., Chen, K. J., Elliott, L. G., Herring, M., Verde, S. C., & Wolkow, T. D. (2006) · BMC Cell Biology · doi:10.1186/1471-2121-7-32 · Cited by 10

Cycle cellulaire, mitose et applications thérapeutiques

Lévy, A., Albiges, L. K., Massard, C., Soria, J., & Deutsch, É. (2011) · Bulletin du Cancer · doi:10.1684/bdc.2011.1382 · Cited by 10

TOWARD MAINTAINING THE GENOME

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Cited by 10

MUS81 Inhibition Enhances the Anticancer Efficacy of Talazoparib by Impairing ATR/CHK1 Signaling Pathway in Gastric Cancer

Wang, T., Zhang, P., Li, C., Liu, W., Shen, Q., Yang, L., Xie, G., Bai, J., Li, R., Tao, K., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.844135 · Cited by 9

A novel role for ATR/Rad3 in G1 phase

Bøe, C. A., Håland, T. W., Boye, E., Syljuåsen, R. G., & Grallert, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-25238-6 · Cited by 9

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes

Kucherlapati, M. H. (2018) · BMC Cancer · doi:10.1186/s12885-018-4705-y · Cited by 9

KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma

Hu, S., Zeng, W., Zhang, W., Xu, J., Yu, D., Peng, J., & Wei, Y. (2020) · Aging · doi:10.18632/aging.104144 · Cited by 9

CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair

O’Meara, M. J., Rapala, J. R., Nichols, C. B., Alexandre, C., Billmyre, R. B., Steenwyk, J. L., Alspaugh, J. A., & O’Meara, T. R. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011158 · Cited by 8

v-Src inhibits the interaction between Rad17 and Rad9 and induces replication fork collapse

Fukumoto, Y., Miura, T., Morii, M., Kubota, S., Honda, T., Kubota, S., Morinaga, T., Yamaguchi, N., Nakayama, Y., & Yamaguchi, N. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.078 · Cited by 9

Caenorhabditis elegans ATR checkpoint kinase ATL-1 influences life span through mitochondrial maintenance

Suetomi, K., Mereiter, S., Mori, C., Takanami, T., & Higashitani, A. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.02.004 · Cited by 9

Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site

Hasegawa, M., Yamaguchi, S., Aizawa, S., Ikeda, H., Tatsumi, K., Noda, Y., Hirokawa, K., & Kitagawa, M. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.01.016 · Cited by 10

TTT and PIKK Complex Genes Reverted to Single Copy Following Polyploidization and Retain Function Despite Massive Retrotransposition in Maize

Garcia, N., & Messing, J. W. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01723 · Cited by 8

Mechanisms of topoisomerase I inhibition by anticancer drugs

Pommier, Y. G., Barceló, J. M., Furuta, T., Takemura, H., & Sordet, O. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0141-1_2 · Cited by 10

A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks

Suzuki, K., Yamauchi, M., Oka, Y., Suzuki, M., & Yamashita, S. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq226 · Cited by 10

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

Marmolejo, C. A. O., Sanchez, C., Helms, E., McEvoy, M. J., Lee, J., Werner, M., Roberts, P. A., Hamperl, S., & Saldivar, J. C. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.005 · Cited by 10

Coordinated Effort Against DNA Damage

(2001) · Science Signaling · doi:10.1126/scisignal.1102001tw436

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Identifying Inhibitors of ATM and ATR Kinase Activities

Sarkaria, J. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-380-1:49 · Cited by 15

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint*

(2001)