ATR and ATRIP: Partners in Checkpoint Signaling

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 542

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 523

The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint

You, Z., Kong, L., & Newport, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204120200 · Cited by 114

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

Yan, S., & Michael, W. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200810185 · Cited by 107

Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

Nakada, D., Hirano, Y., & Sugimoto, K. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.10016-10025.2004 · Cited by 113

Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo

Ostrau, C., Hülsenbeck, J., Herzog, M., Schad, A., Torzewski, M., Lackner, K. J., & Fritz, G. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.06.020 · Cited by 113

Cyclin‐dependent kinase 9–cyclin K functions in the replication stress response

Yu, D. S., Zhao, R., Hsu, E., Cayer, J., Ye, F., Guo, Y. P., Shyr, Y., & Cortez, D. (2010) · EMBO Reports · doi:10.1038/embor.2010.153 · Cited by 114

Phosphorylation of Human Rad9 Is Required for Genotoxin-activated Checkpoint Signaling

Roos‐Mattjus, P., Hopkins, K. M., Oestreich, A. J., Vroman, B. T., Johnson, K. L., Naylor, S., Lieberman, H. B., & Karnitz, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301544200 · Cited by 112

ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset

Eykelenboom, J. K., Harte, E. C., Canavan, L. E., Pastor-Peidro, A., Calvo‐Asensio, I., Llorens-Agost, M., & Lowndes, N. F. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.027 · Cited by 118

Centrosomal localization of DNA damage checkpoint proteins

Zhang, S., Hemmerich, P. H., & Große, F. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21195 · Cited by 112

Chk1 and Claspin potentiate PCNA ubiquitination

Yang, X. H., Shiotani, B., Classon, M., & Zou, L. (2008) · Genes & Development · doi:10.1101/gad.1632808 · Cited by 111

γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

Cleaver, J. E. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00995.x · Cited by 112

Targeting the Checkpoint to Kill Cancer Cells

Benada, J., & Macůrek, L. (2015) · Biomolecules · doi:10.3390/biom5031912 · Cited by 115

The FANCM family of DNA helicases/translocases

Whitby, M. C. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.012 · Cited by 109

ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration

Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Adhil, M., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18580-9 · Cited by 111

ATRIP associates with replication protein A-coated ssDNA through multiple interactions

Namiki, Y., & Zou, L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510223103 · Cited by 111

Cell-cycle responses to DNA damage in G2

Cuddihy, A. R., & O'Connell, M. J. (2003) · International Review of Cytology · doi:10.1016/s0074-7696(02)22013-6 · Cited by 89

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

Gobbini, E., Cesena, D., Galbiati, A., Lockhart, A., & Longhese, M. P. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.07.009 · Cited by 98

Inhibition of Ataxia Telangiectasia- and Rad3 -Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor-Initiating Cell Fraction

Gallmeier, E., Hermann, P. C., Mueller, M.-T., Machado, J. G., Ziesch, A., Toni, E. N. D., Palagyi, A., Eisen, C., Ellwart, J. W., Rivera, J., et al. (2011) · Stem Cells · doi:10.1002/stem.595 · Cited by 106

Cdk2 is required for p53-independent G2/M checkpoint control

Chung, J. H., & Bunz, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000863 · Cited by 105

Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses

Smith, J. A., & Daniel, R. (2006) · ACS Chemical Biology · doi:10.1021/cb600131q · Cited by 113

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

Ruzankina, Y., Schoppy, D. W., Asare, A., Clark, C. E., Vonderheide, R. H., & Brown, E. J. (2009) · Nature Genetics · doi:10.1038/ng.441 · Cited by 97

SIRT2 directs the replication stress response through CDK9 deacetylation

Zhang, H., Park, S., Pantazides, B. G., Karpiuk, O., Warren, M. D., Hardy, C. W., Duong, D. M., Park, S., Kim, H. S., Vassilopoulos, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301463110 · Cited by 105

Cryo-EM structure of human ATR-ATRIP complex

Rao, Q., Liu, M., Tian, Y., Wu, Z., Hao, Y., Song, L., Qin, Z., Ding, C., Wang, H., Wang, J., et al. (2017) · Cell Research · doi:10.1038/cr.2017.158 · Cited by 106

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

Tsao, C., Geisen, C., & Abraham, R. T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600463 · Cited by 103

Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress InVitro and In Vivo

Zimmerman, E. S., Sherman, M. P., Blackett, J. L., Neidleman, J. A., Kreis, C., Mundt, P., Williams, S. A., Warmerdam, M. T., Kahn, J. O., Hecht, F. M., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01212-06 · Cited by 105

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

Leman, A. R., & Noguchi, E. (2013) · Genes · doi:10.3390/genes4010001 · Cited by 102

Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities

Ünsal-Kaçmaz, K., & Sancar, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1292-1300.2003 · Cited by 105

A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle Cell Lymphoma with ATM Loss-of-Function

Menezes, D. L. D., Holt, J., Tang, Y., Feng, J., Barsanti, P. A., Pan, Y., Ghoddusi, M., Zhang, W., Thomas, G., Holash, J. A., et al. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0240 · Cited by 106

Targeting DNA repair in cancer: current state and novel approaches

Klinakis, A., Karagiannis, D., & Rampias, T. N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03299-8 · Cited by 108

Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection

Wilkinson, D. E., & Weller, S. K. (2006) · Journal of Cell Science · doi:10.1242/jcs.02981 · Cited by 104

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities

Chang, D. J., Lupardus, P. J., & Cimprich, K. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606799200 · Cited by 101

ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1

Moiseeva, T. N., Hood, B. L., Schamus, S., O’Connor, M. J., Conrads, T. P., & Bakkenist, C. J. (2017) · Nature Communications · doi:10.1038/s41467-017-01401-x · Cited by 107

Regulation of the cellular DNA double-strand break response

Cann, K. L., & Hicks, G. G. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-135 · Cited by 105

Lovastatin Protects Human Endothelial Cells from Killing by Ionizing Radiation without Impairing Induction and Repair of DNA Double-Strand Breaks

Nübel, T., Damrot, J., Roos, W. P., Kaina, B., & Fritz, G. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1903 · Cited by 101

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

Daniel, R., Kao, G. D., Taganov, K. D., Greger, J., Favorova, O. O., Merkel, G. W., Yen, T. J., Katz, R. A., & Skalka, A. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0730887100 · Cited by 104

DNA damage response of A549 cells treated with particulate matter (PM 10 ) of urban air pollutants

Sánchez-Pérez, Y., Chirino, Y. I., Osornio-Vargas, Á. R., Morales‐Bárcenas, R., Gutiérrez‐Ruíz, M. C., Vázquez‐López, I., & García-Cuellar, C. M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.01.010 · Cited by 100

DDB1 Maintains Genome Integrity through Regulation of Cdt1

Lovejoy, C. A., Lock, K., Yenamandra, A. K., & Cortez, D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00819-06 · Cited by 101

Repair of naturally occurring mismatches can induce mutations in flanking DNA

Chen, J., Miller, B., & Furano, A. V. (2014) · eLife · doi:10.7554/elife.02001 · Cited by 99

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

Velic, D., Couturier, A. M., Ferreira, M., Rodrigue, A., Poirier, G. G., Fleury, F., & Masson, J. (2015) · Biomolecules · doi:10.3390/biom5043204 · Cited by 106

Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication

Aklilu, B. B., Soderquist, R. S., & Culligan, K. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1292 · Cited by 90

Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency

Kerzendorfer, C., & O’Driscoll, M. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.018 · Cited by 97

Checkpoint mechanisms at the intersection between DNA damage and repair

Lazzaro, F., Giannattasio, M., Puddu, F., Granata, M., Pellicioli, A., Plevani, P., & Muzi-Falconi, M. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.022 · Cited by 94

DNA Instability at Chromosomal Fragile Sites in Cancer

Dillon, L. W., Burrow, A. A., & Wang, Y. (2010) · Current Genomics · doi:10.2174/138920210791616699 · Cited by 96

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

Cescutti, R., Negrini, S., Kohzaki, M., & Halazonetis, T. D. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.238 · Cited by 97

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

Hilton, B. A., Li, Z., Musich, P. R., Wang, H., Cartwright, B. M., Serrano, M., Zhou, X. Z., Lu, K. P., & Zou, Y. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.008 · Cited by 95

G2 damage checkpoints: what is the turn-on?

O’Connell, M. J., & Cimprich, K. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01626 · Cited by 97

DNA Methyltransferase 1 Knockdown Activates a Replication Stress Checkpoint

Unterberger, A., Andrews, S. D., Weaver, I. C. G., & Szyf, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01887-05 · Cited by 94

Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks

Sobeck, A., Stone, S., Costanzo, V., de Graaf, B., Reuter, T., de Winter, J. P., Wallisch, M., Akkari, Y. M. N., Olson, S. B., Wang, W., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.425-437.2006 · Cited by 95

Supreme EnLIGHTenment: Damage Recognition and Signaling in the Mammalian UV Response

Herrlich, P. A., Karin, M., & Weiß, C. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.001 · Cited by 94

Cdc5L interacts with ATR and is required for the S‐phase cell‐cycle checkpoint

Zhang, N., Kaur, R., Akhter, S., & Legerski, R. J. (2009) · EMBO Reports · doi:10.1038/embor.2009.122 · Cited by 94

Retention but Not Recruitment of Crb2 at Double-Strand Breaks Requires Rad1 and Rad3 Complexes

Du, L.-L., Nakamura, T., Moser, B. A., & Russell, P. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.17.6150-6158.2003 · Cited by 94

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

Carson, C. T., Orazio, N. I., Lee, D. V., Suh, J., Bekker‐Jensen, S., Araujo, F. D., Lakdawala, S. S., Lilley, C. E., Bártek, J., Lukas, J., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.15 · Cited by 95

CK2 Inhibits Apoptosis and Changes Its Cellular Localization Following Ionizing Radiation

Yamane, K., & Kinsella, T. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3941 · Cited by 92

Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1Preprint

Sivasubramaniam, S., Sun, X., Pan, Y.-R., Wang, S., & Lee, E. Y.-H. P. (2008) · Genes & Development · doi:10.1101/gad.1627708 · Cited by 97

Activation of the ATR Pathway by Human Immunodeficiency Virus Type 1 Vpr Involves Its Direct Binding to Chromatin In Vivo

Lai, M., Zimmerman, E. S., Planelles, V., & Chen, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.24.15443-15451.2005 · Cited by 94

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

Bi, X., Srikanta, D., Fanti, L., Pimpinelli, S., Badugu, R., Kellum, R., & Rong, Y. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504981102 · Cited by 89

Estrogen Inhibits ATR Signaling to Cell Cycle Checkpoints and DNA Repair

Pedram, A., Razandi, M., Evinger, A. J., Lee, E., & Levin, E. R. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0085 · Cited by 97

Radiation and the cell cycle, revisited

Wilson, G. D. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031762.91306.b4 · Cited by 91

Functional cdc25C Dual-Specificity Phosphatase Is Required for S-Phase Entry in Human Cells

Turowski, P., Franckhauser, C., Morris, M. C., Vaglio, P., Fernandez, A., & Lamb, N. J. C. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0515 · Cited by 89

Coordination of DNA Damage Responses via the Smc5/Smc6 Complex

Harvey, S. H., Sheedy, D. M., Cuddihy, A. R., & O’Connell, M. J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.662-674.2004 · Cited by 89

DNA double-strand breaks in meiosis: Checking their formation, processing and repair

Longhese, M. P., Bonetti, D., Guerini, I., Manfrini, N., & Clerici, M. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.04.005 · Cited by 93

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

Bomgarden, R. D., Lupardus, P. J., Soni, D. V., Yee, M., Ford, J. M., & Cimprich, K. A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601123 · Cited by 87

Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A

Shell, S. M., Li, Z., Shkriabai, N., Kvaratskhelia, M., Brosey, C., Serrano, M. A., Chazin, W. J., Musich, P. R., & Zou, Y. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000745 · Cited by 86

RPA Phosphorylation Inhibits DNA Resection

Soniat, M. M., Myler, L. R., Kuo, H., Paull, T. T., & Finkelstein, I. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.05.005 · Cited by 80

Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation

Zhang, J., Bao, S., Furumai, R., Kucera, K. S., Ali, A., Dean, N. M., & Wang, X.-F. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.9910-9919.2005 · Cited by 86

A Novel DNA Damage Response

Zhang, S., Zhou, Y., Trusa, S., Xiao, M., Lee, E. Y. C., & Lee, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610356200 · Cited by 86

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.

Cortez, D. (2005) · Genes & Development · doi:10.1101/gad.1316905 · Cited by 84

ATMIN defines an NBS1‐independent pathway of ATM signalling

Kanu, N., & Behrens, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601733 · Cited by 90

Xeroderma pigmentosum genes: Functions inside and outside DNA repair

Sugasawa, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm282 · Cited by 83

Filtering of Ineffective siRNAs and Improved siRNA Design Tool

Yiu, S., Wong, P. W. H., Lam, T., Mui, Y.-C., Kung, H. F., Lin, M. C. M., & Cheung, Y.-T. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth498 · Cited by 81

DNA damage response in nephrotoxic and ischemic kidney injury

Yan, M., Tang, C., Ma, Z., Huang, S., & Dong, Z. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.10.022 · Cited by 83

The Mre11-Rad50-Nbs1 Complex Acts Both Upstream and Downstream of Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR) to Regulate the S-phase Checkpoint following UV Treatment

Olson, E. E., Nievera, C. J., Lee, A. Y., Chen, L., & Wu, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702162200 · Cited by 86

Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR

Chen, Y., Chen, C., Riley, D. J., & Chen, P. (2011) · Cell Cycle · doi:10.4161/cc.10.4.14814 · Cited by 84

How Cells Respond to DNA Breaks in Mitosis

Blackford, A. N., & Stucki, M. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2019.12.010 · Cited by 83

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide

Damrot, J., Nübel, T., Epe, B., Roos, W. P., Kaina, B., & Fritz, G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706953 · Cited by 81

DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D

Shah, S. N., Opresko, P. L., Meng, X., Lee, M., & Eckert, K. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1131 · Cited by 81

Hsp90 Inhibitor–Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

Ha, K., Fiskus, W. C., Rao, R., Balusu, R., Venkannagari, S., Nalabothula, N. R., & Bhalla, K. N. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0094 · Cited by 81

Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication inXenopus

Luciani, M. G., Oehlmann, M., & Blow, J. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01400 · Cited by 83

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

Zhou, Z., Liu, C., Li, T., Bruhn, C., Krueger, A., Min, W., Wang, Z., & Carr, A. M. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003702 · Cited by 80

5-ASA Affects Cell Cycle Progression in Colorectal Cells by Reversibly Activating a Replication Checkpoint

Luciani, M. G., Campregher, C., Fortune, J. M., Kunkel, T. A., & Gasché, C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.016 · Cited by 80

HERC2-USP20 axis regulates DNA damage checkpoint through Claspin

Yuan, J., Luo, K., Deng, M., Li, Y., Yin, P., Gao, B., Fang, Y., Wu, P., Liu, T., & Lou, Z. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1034 · Cited by 78

Cdc7-Dbf4 and the Human S Checkpoint Response to UVC

Heffernan, T. P., Ünsal-Kaçmaz, K., Heinloth, A. N., Simpson, D. A., Paules, R. S., Sancar, A., Cordeiro‐Stone, M., & Kaufmann, W. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611292200 · Cited by 81

ATR maintains select progenitors during nervous system development

Lee, Y., Shull, E. R. P., Frappart, P., Katyal, S., Enriquez-Rios, V. D., Zhao, J., Russell, H. R., Brown, E. J., & McKinnon, P. J. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.493 · Cited by 78

How ATR turns on: TopBP1 goes on ATRIP with ATR: Figure 1.Preprint

Burrows, A. E., & Elledge, S. J. (2008) · Genes & Development · doi:10.1101/gad.1685108 · Cited by 79

Persistent repair intermediates induce senescence

Feringa, F. M., Raaijmakers, J. A., Hadders, M. A., Vaarting, C., Macůrek, L., Heitink, L. S., Krenning, L., & Medema, R. H. (2018) · Nature Communications · doi:10.1038/s41467-018-06308-9 · Cited by 79

The Emerging Role of Cohesin in the DNA Damage Response

Litwin, I., Pilarczyk, E., & Wysocki, R. (2018) · Genes · doi:10.3390/genes9120581 · Cited by 80

Cellular and Clinical Impact of Haploinsufficiency for Genes Involved in ATR Signaling

O’Driscoll, M., Dobyns, W. B., van Hagen, J. M., & Jeggo, P. A. (2007) · The American Journal of Human Genetics · doi:10.1086/518696 · Cited by 74

Chromatin Remodeling and Epigenetic Regulation in Plant DNA Damage Repair

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Improved methods for the generation of human gene knockout and knockin cell lines

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Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation

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ATRIP Oligomerization Is Required for ATR-dependent Checkpoint Signaling

Ball, H. L., & Cortez, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504961200 · Cited by 78

DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications

Mirza‐Aghazadeh‐Attari, M., Darband, S. G., Kaviani, M., Mihanfar, A., Aghazadeh-Attari, J., Yousefi, B., & Majidinia, M. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.07.005 · Cited by 79

ATM and ATR signaling at a glance

Awasthi, P., Foiani, M., & Kumar, A. (2016) · Journal of Cell Science · doi:10.1242/jcs.188631 · Cited by 78

Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability

Broderick, S., Rehmet, K., Concannon, C., & Nasheuer, H. (2009) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-3471-7_8 · Cited by 78

Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling

Liu, S., Ho, C. K., Ouyang, J., & Zou, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217781110 · Cited by 76

Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

Blackford, A. N., Patel, R. N., Forrester, N. A., Theil, K., Groitl, P., Stewart, G. S., Taylor, A. M. R., Morgan, I. M., Dobner, T., Grand, R. J. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914605107 · Cited by 77

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair

McGee, J. S., Phillips, J. A., Chan, A., Sabourin, M., Paeschke, K., & Zakian, V. A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1947 · Cited by 74

An extending ATR–CHK1 circuitry: the replication stress response and beyond

Simoneau, A., & Zou, L. (2021) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2021.07.003 · Cited by 74

The Mre11-Rad50-Nbs1 Complex Mediates Activation of TopBP1 by ATM

Yoo, H. Y., Kumagai, A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1190 · Cited by 76

Assessment of ATM phosphorylation on Ser‐1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser‐139‐histone H2AX phosphorylation, cell cycle phase, and apoptosis

Kurose, A., Tanaka, T., Huang, X., Halicka, H. D., Traganos, F., Dai, W. H., & Darżynkiewicz, Z. (2005) · Cytometry Part A · doi:10.1002/cyto.a.20186 · Cited by 74

Coordinated Effort Against DNA Damage

(2001) · Science Signaling · doi:10.1126/scisignal.1102001tw436

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Identifying Inhibitors of ATM and ATR Kinase Activities

Sarkaria, J. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-380-1:49 · Cited by 15

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint*

(2001)