ATR and ATRIP: Partners in Checkpoint Signaling

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.

Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221

A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S.-Y., Taya, Y., Prives, C., & Abraham, R. T. (1999) · Genes & Development · doi:10.1101/gad.13.2.152 · Cited by 1,046

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00159-3 · Cited by 601

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 550

Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., & Friend, S. H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.159 · Cited by 542

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

Durocher, D., & Jackson, S. P. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00201-5 · Cited by 523

Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry

Sirbu, B. M., McDonald, W. H., Dungrawala, H., Badu-Nkansah, A., Kavanaugh, G. M., Chen, Y., Tabb, D. L., & Cortez, D. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.511337 · Cited by 251

ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 Phosphorylation

Ball, H. L., Myers, J. S., & Cortez, D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1006 · Cited by 241

Preventing replication fork collapse to maintain genome integrity

Cortez, D. (2015) · DNA Repair · doi:10.1016/j.dnarep.2015.04.026 · Cited by 223

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

Lessel, D., Vaz, B., Halder, S., Lockhart, P. J., Marinovic‐Terzić, I., López-Mosqueda, J., Philipp, M., Sim, J. C. H., Smith, K. R., Oehler, J., et al. (2014) · Nature Genetics · doi:10.1038/ng.3103 · Cited by 234

How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis

Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234

DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A

Liu, Y., Rusinol, A., Sinensky, M., Wang, Y., & Zou, Y. (2006) · Journal of Cell Science · doi:10.1242/jcs.03263 · Cited by 228

Targeting the ATR-CHK1 Axis in Cancer Therapy

Rundle, S., Bradbury, A., Drew, Y., & Curtin, N. J. (2017) · Cancers · doi:10.3390/cancers9050041 · Cited by 242

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

Cuadrado, M., Martinez-Pastor, B., Murga, M., Toledo, L. I., Gutierrez-Martinez, P., Lopez, E., & Fernandez-Capetillo, O. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051923 · Cited by 232

Discovery of 4-{4-[(3 R )-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1 H -indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Foote, K. M., Blades, K., Cronin, A. S., Fillery, S. M., Guichard, S. S., Hassall, L. A., Hickson, I., Jacq, X., Jewsbury, P. J., McGuire, T. M., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301859s · Cited by 223

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage

Helt, C. E., Cliby, W. A., Keng, P. C., Bambara, R. A., & O'Reilly, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410873200 · Cited by 216

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5754 · Cited by 215

Genotoxic Anti-Cancer Agents and Their Relationship to DNA Damage, Mitosis, and Checkpoint Adaptation in Proliferating Cancer Cells

Swift, L. H., & Golsteyn, R. M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033403 · Cited by 230

A Murine Model of Nijmegen Breakage Syndrome

Williams, B. R., Mirzoeva, O. K., Morgan, W. F., Lin, J., Dunnick, W., & Petrini, J. H. J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00763-7 · Cited by 208

SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins

Traven, A., & Heierhorst, J. (2005) · BioEssays · doi:10.1002/bies.20204 · Cited by 224

Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpointPreprint

Silverman, J. S., Takai, H., Buonomo, S. B. C., Eisenhaber, F., & de Lange, T. (2004) · Genes & Development · doi:10.1101/gad.1216004 · Cited by 220

Common fragile sites as targets for chromosome rearrangements

Arlt, M. F., Durkin, S. G., Ragland, R. L., & Glover, T. W. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.010 · Cited by 207

An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

O’Driscoll, M., Gennery, A. R., Seidel, J., CONCANNON, P. J., & Jeggo, P. A. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.025 · Cited by 208

The DNA damage response: sensing and signaling

McGowan, C. H., & Russell, P. R. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.005 · Cited by 204

A minority of foci or pan-nuclear apoptotic staining of γH2AX in the S phase after UV damage contain DNA double-strand breaks

de Feraudy, S. M., Revet, I. M., Bezrookove, V., Feeney, L., & Cleaver, J. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002175107 · Cited by 197

Cancer Drug Discovery and Development

Humphrey, J. S., Price, K., Gupta, E., Baxter, A. R. W., Bird, J., Sonnichsen, D. S., & Naglich, J. G. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-325-5_21 · Cited by 195

Regulation of DNA repair in hypoxic cancer cells

Bindra, R. S., Crosby, M. E., & Glazer, P. M. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9061-3 · Cited by 194

The Recombinases DMC1 and RAD51 Are Functionally and Spatially Separated during Meiosis in Arabidopsis

Kurzbauer, M.-T., Uanschou, C., Chen, D., & Schlögelhofer, P. (2012) · The Plant Cell · doi:10.1105/tpc.112.098459 · Cited by 199

Regulation of DNA replication by ATR: signaling in response to DNA intermediates

Shechter, D., Costanzo, V., & Gautier, J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.020 · Cited by 198

Common fragile sites

Arlt, M. F., Casper, A. M., & Glover, T. W. (2003) · Cytogenetic and Genome Research · doi:10.1159/000072843 · Cited by 189

Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

Marteijn, J. A., Bekker-Jensen, S., Mailand, N., Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, J., & Vermeulen, W. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200902150 · Cited by 184

Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

Polo, S. E., Blackford, A. N., Chapman, J. R., Baskcomb, L., Gravel, S., Rusch, A., Thomas, A., Blundred, R., Smith, P., Kzhyshkowska, J. G., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.035 · Cited by 193

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

Wang, Y., & Qin, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536810100 · Cited by 181

Chk2 Activation and Phosphorylation-Dependent Oligomerization

Xu, X., Tsvetkov, L. M., & Stern, D. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4419-4432.2002 · Cited by 183

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo, L. I., Murga, M., Gutierrez-Martinez, P., Soria, R., & Fernandez-Capetillo, O. (2008) · Genes & Development · doi:10.1101/gad.452308 · Cited by 183

DNA damage response at functional and dysfunctional telomeresPreprint

Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 184

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway

Alderton, G. K., Joenje, H., Varon, R., Børglum, A. D., Jeggo, P. A., & O’Driscoll, M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh335 · Cited by 178

Preferential binding of ATR protein to UV-damaged DNA

Ünsal-Kaçmaz, K., Makhov, A. M., Griffith, J. D., & Sancar, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102167799 · Cited by 176

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

Toledo, L. I., Murga, M., & Fernández-Capetillo, Ó. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.07.002 · Cited by 180

Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway

Yazinski, S. A., & Zou, L. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-121415-121658 · Cited by 178

Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?

Bradbury, A., Hall, S., Curtin, N. J., & Drew, Y. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107450 · Cited by 180

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

Hewitt, G., & Korolchuk, V. I. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.011 · Cited by 175

DNA damage response inhibitors: Mechanisms and potential applications in cancer therapy

Carrassa, L., & Damia, G. L. M. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.08.013 · Cited by 178

The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling

Xu, X., Vaithiyalingam, S., Glick, G. G., Mordes, D. A., Chazin, W., & Cortez, D. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01079-08 · Cited by 171

CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy

McNeely, S., Beckmann, R. P., & Bence, A. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.005 · Cited by 167

Evidence That the ATR/Chk1 Pathway Maintains Normal Replication Fork Progression during Unperturbed S Phase

Petermann, E., & Caldecott, K. W. (2006) · Cell Cycle · doi:10.4161/cc.5.19.3256 · Cited by 170

Mechanisms of replication fork protection: a safeguard for genome stability

Errico, A., & Costanzo, V. (2012) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.655374 · Cited by 159

Targeting the DNA Damage Response in Cancer

Ljungman, M. E. (2009) · Chemical Reviews · doi:10.1021/cr900047g · Cited by 164

miRNA dysregulation is an emerging modulator of genomic instability

Cardoso, A. P. F., Banerjee, M., Nail, A. N., Lykoudi, A., & States, J. C. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.004 · Cited by 173

A requirement for replication in activation of the ATR-dependent DNA damage checkpointPreprint

Lupardus, P. J., Byun, T. S., Yee, M., Hekmat-Nejad, M., & Cimprich, K. A. (2002) · Genes & Development · doi:10.1101/gad.1013502 · Cited by 163

Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans

García‐Muse, T., & Boulton, S. J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600896 · Cited by 163

Chromosomal Instability at Common Fragile Sites in Seckel Syndrome

Casper, A. M., Durkin, S. G., Arlt, M. F., & Glover, T. W. (2004) · The American Journal of Human Genetics · doi:10.1086/422701 · Cited by 160

ATR activation and replication fork restart are defective in FANCM‐deficient cells

Schwab, R. A., Blackford, A. N., & Niedźwiedź, W. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.385 · Cited by 161

A shared DNA-damage-response pathway for induction of stem-cell death by UVB and by gamma irradiation

Furukawa, T., Curtis, M. J., Tominey, C. M., Duong, Y., Wilcox, B. W. L., Aggoune, D., Hays, J. B., & Britt, A. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.06.006 · Cited by 158

Roles of UVA radiation and DNA damage responses in melanoma pathogenesis

Khan, A. Q., Travers, J. B., & Kemp, M. G. (2018) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22176 · Cited by 152

Breaking Bad: How Viruses Subvert the Cell Cycle

Fan, Y., Sanyal, S., & Bruzzone, R. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00396 · Cited by 150

Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest

Capasso, H., Palermo, C., Wan, S., Rao, H., John, U. P., O’Connell, M. J., & Walworth, N. C. (2002) · Journal of Cell Science · doi:10.1242/jcs.00133 · Cited by 150

Many commonly used siRNAs risk off-target activity

Snøve, O., & Holen, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.175 · Cited by 148

Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication

Ardeljan, D., Steranka, J. P., Liu, C., Li, Z., Taylor, M. S., Payer, L. M., Gorbounov, M., Sarnecki, J. S., Deshpande, V., Hruban, R. H., et al. (2020) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-0372-1 · Cited by 135

Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345

Jiang, K., Pereira, E., Maxfield, M. D., Russell, B., Goudelock, D. M., & Sánchez, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300070200 · Cited by 147

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

Manic, G., Obrist, F., Sistigu, A., & Vitale, I. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1012976 · Cited by 152

Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases

Cortez, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307088200 · Cited by 149

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

Lee, Y.-C., Zhou, Q., Chen, J., & Yuan, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.10.030 · Cited by 152

Mechanisms of common fragile site instability

Glover, T. W., Arlt, M. F., Casper, A. M., & Durkin, S. G. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi265 · Cited by 155

Common fragile sites

Glover, T. W. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.08.032 · Cited by 144

Activation of a Meiotic Checkpoint during Drosophila Oogenesis Regulates the Translation of Gurken through Chk2/Mnk

Abdu, U., Brodsky, M., & Schüpbach, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01165-x · Cited by 143

A New XRCC1-Containing Complex and Its Role in Cellular Survival of Methyl Methanesulfonate Treatment

Luo, H., Chan, D. W., Yang, T., Rodriguez, M. A., Chen, B. P.-C., Leng, M., Mu, J., Chen, D. J., Songyang, Z., Wáng, Y., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8356-8365.2004 · Cited by 144

ATR Pathway Inhibition Is Synthetically Lethal in Cancer Cells with ERCC1 Deficiency

Mohni, K. N., Kavanaugh, G. M., & Cortez, D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3229 · Cited by 143

DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint

Bi, X., Slater, D., Ohmori, H., & Vaziri, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501562200 · Cited by 141

Diseases Associated with Defective Responses to DNA DamagePreprint

O’Driscoll, M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012773 · Cited by 145

Engagement of the ATR-Dependent DNA Damage Response at the Human Papillomavirus 18 Replication Centers during the Initial Amplification

Reinson, T., Toots, M., Kadaja, M., Pipitch, R., Allik, M., Ustav, E., & Ustav, M. (2012) · Journal of Virology · doi:10.1128/jvi.01943-12 · Cited by 141

The ATR barrier to replication-born DNA damage

Lopez-Contreras, A. J., & Fernández-Capetillo, Ó. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.09.012 · Cited by 148

Claspin and the Activated Form of ATR-ATRIP Collaborate in the Activation of Chk1

Kumagai, A., Kim, S.-M., & Dunphy, W. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408353200 · Cited by 138

Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins

Ball, H. L., Ehrhardt, M. R., Mordes, D. A., Glick, G. G., Chazin, W., & Cortez, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02238-06 · Cited by 143

Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond

Dueva, R., & Iliakis, G. E. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa022 · Cited by 139

Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex

Kim, D., & Sabatini, D. M. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_15 · Cited by 134

Rad17 Phosphorylation Is Required for Claspin Recruitment and Chk1 Activation in Response to Replication Stress

Wang, X., Zou, L., Lu, T., Bao, S., Hurov, K. E., Hittelman, W. N., Elledge, S. J., & Li, L. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.06.022 · Cited by 138

DNA structure dependent checkpoints as regulators of DNA repair

Carr, A. M. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00165-9 · Cited by 136

The interplay between DNA repair and autophagy in cancer therapy

Zhang, D., Tang, B., Xie, X., Xiao, Y., Yang, S., & Zhang, J. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1046022 · Cited by 132

Progress towards a clinically-successful ATR inhibitor for cancer therapy

Barnieh, F. M., Loadman, P. M., & Falconer, R. A. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100017 · Cited by 134

Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2

Rao, F., Cha, J., Xu, J., Xu, R., Vandiver, M. S., Tyagi, R., Tokhunts, R. A., Koldobskiy, M. A., Fu, C., Barrow, R. K., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.020 · Cited by 126

Genome instability, cancer and aging

Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 134

DNA replication as a target of the DNA damage checkpoint

Zegerman, P., & Diffley, J. F. X. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.023 · Cited by 128

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

Nam, E. A., Zhao, R., Glick, G. G., Bansbach, C. E., Friedman, D. B., & Cortez, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248914 · Cited by 129

Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

Nishida, H., Tatewaki, N., Nakajima, Y., Magara, T., Ko, K. M., Hamamori, Y., & Konishi, T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp593 · Cited by 133

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

Finn, K., Lowndes, N. F., & Grenon, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0875-3 · Cited by 127

Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 Binding

Hein, J., Boichuk, S., Wu, J., Cheng, Y., Freire, R., Jat, P., Roberts, T. M., & Gjoerup, O. V. (2008) · Journal of Virology · doi:10.1128/jvi.01515-08 · Cited by 125

ATM and ATR: Sensing DNA damage

Yang, J. J., Xu, Z., Huang, Y., Hamrick, H. E., Duerksen-Hughes, P. J., & Yu, Y. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i2.155 · Cited by 129

Human Cytomegalovirus Disrupts both Ataxia Telangiectasia Mutated Protein (ATM)- and ATM-Rad3-Related Kinase-Mediated DNA Damage Responses during Lytic Infection

Luo, M. H., Rosenke, K., Czornak, K., & Fortunato, E. A. (2006) · Journal of Virology · doi:10.1128/jvi.01670-06 · Cited by 129

DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress

Leung‐Pineda, V., Huh, J., & Piwnica-Worms, H. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3382 · Cited by 130

Checkpoint responses to replication fork barriers

Lambert, S., & Carr, A. M. (2004) · Biochimie · doi:10.1016/j.biochi.2004.10.020 · Cited by 125

Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress

Kemp, M. G., Akan, Z., Yilmaz, S., Grillo, M., Smith‐Roe, S. L., Kang, T., Cordeiro‐Stone, M., Kaufmann, W. K., Abraham, R. T., Sancar, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.110304 · Cited by 129

ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer stem cells

Ronco, C., Martin, A. R., Demange, L., & Benhida, R. (2016) · MedChemComm · doi:10.1039/c6md00439c · Cited by 131

A Genome-wide Camptothecin Sensitivity Screen Identifies a Mammalian MMS22L-NFKBIL2 Complex Required for Genomic Stability

O'Connell, B. C., Adamson, B., Lydeard, J. R., Sowa, M. E., Ciccia, A., Bredemeyer, A. L., Schlabach, M., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.022 · Cited by 122

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors

Tomicic, M. T., & Kaina, B. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.09.002 · Cited by 123

The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.

Chen, Y., & Poon, R. Y. C. (2008) · PubMed · doi:10.2741/3060 · Cited by 119

Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM

Yoo, H. Y., Kumagai, A., Shevchenko, A., Shevchenko, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701770200 · Cited by 118

BRCA1 Is Required for Common-Fragile-Site Stability via Its G 2 /M Checkpoint Function

Arlt, M. F., Xu, B., Durkin, S. G., Casper, A. M., Kastan, M. B., & Glover, T. W. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.15.6701-6709.2004 · Cited by 125

Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G2/M DNA Damage Checkpoint Response

Zhang, X., Succi, J., Feng, Z., Prithivirajsingh, S., Story, M. D., & Legerski, R. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9207-9220.2004 · Cited by 119

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

Ogi, T., Walker, S., Stiff, T., Hobson, E., Limsirichaikul, S., Carpenter, G., Prescott, K., Suri, M., Byrd, P. J., Matsuse, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002945 · Cited by 120

Fanconi Anemia Signaling and Cancer

Nepal, M. K., Che, R., Zhang, J., Ma, C., & Fei, P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.10.005 · Cited by 125

The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation

Baroni, E., Viscardi, V., Cartagena‐Lirola, H., Lucchini, G., & Longhese, M. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4151-4165.2004 · Cited by 125

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

Lopez-Contreras, A. J., Gutierrez‐Martinez, P., Specks, J., Rodrigo-Perez, S., & Fernández-Capetillo, Ó. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112147 · Cited by 121

NFBD1/KIAA0170 Is a Chromatin-associated Protein Involved in DNA Damage Signaling Pathways

Xu, X., & Stern, D. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211392200 · Cited by 116

Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells

Li, L., & Zou, L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20355 · Cited by 117

Coordinated Effort Against DNA Damage

(2001) · Science Signaling · doi:10.1126/scisignal.1102001tw436

Mechanisms of ATR-mediated checkpoint signalling

Smits, V. A. J. (2010) · Frontiers in bioscience · doi:10.2741/3649 · Cited by 46

Interplay between ATM and ATR for the regulation of cellular responses to DNA damage

Fan, X. (2010) · DuEPublico (University of Duisburg-Essen)

Identifying Inhibitors of ATM and ATR Kinase Activities

Sarkaria, J. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-380-1:49 · Cited by 15

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint*

(2001)