Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex
Open accessAbstract
Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathological samples of cortex that had to be removed for the surgical treatment of brain areas beneath association cortices of 58 patients aged 18 to 73 y. Simultaneous triple and quadruple whole-cell patch clamp recordings were performed testing mono- and polysynaptic potentials in target neurons following a single action potential fired by layer 2/3 pyramidal cells, and the temporal structure of events and underlying mechanisms were analyzed. In addition to monosynaptic postsynaptic potentials, individual action potentials in presynaptic pyramidal cells initiated long-lasting (37 +/- 17 ms) sequences of events in the network lasting an order of magnitude longer than detected previously in other species. These event series were composed of specifically alternating glutamatergic and GABAergic postsynaptic potentials and required selective spike-to-spike coupling from pyramidal cells to GABAergic interneurons producing concomitant inhibitory as well as excitatory feed-forward action of GABA. Single action potentials of human neurons are sufficient to recruit Hebbian-like neuronal assemblies that are proposed to participate in cognitive processes.
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There is evidence for significant neuronal differences between rodents and humans, including distinct membrane and synaptic properties and dendritic complexity of human neurons that might contribute to human-specific signal processing.
“Indeed there is evidence for significant neuronal differences between rodents and human; for example, distinct membrane8,9 and synaptic10–14 properties and dendritic complexity15–17 of human neurons might contribute to human specific signal processing.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [10]
Very large unitary EPSPs that drive human basket and axo-axonic cells to suprathreshold postsynaptic responses were not encountered on rosehip cells.
“Very large unitary EPSPs, described to drive human basket and axo-axonic cells to suprathreshold postsynaptic responses10,11,14, were not encountered on RCs.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [10]
The sample sizes used in this study are comparable to those in earlier publications.
“our sample sizes are similar to those reported in previous publications10,11,14.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [10]
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Self-citation
- Authors
- Molnár, G., Oláh, S., Komlósi, G., Füle, M., Szabadics, J., Varga, C., Barzó, P., & Tamás, G.
- Affiliations
- University of Szeged (HU)
- Corresponding author
- Tamás, Gábor
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-09-02
- Volume
- 6
- Issue
- 9
- Pages
- e222
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC2528052
- OpenAlex
- W2110519400
- Cited by
- 197
- References
- 43
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 12 · 2023: 22 · 2022: 17 · 2021: 9 · 2020: 13 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 9
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- Boehringer Ingelheim Fonds
- Hungarian Scientific Research Fund
- Magyar Tudományos Akadémia
- Nemzeti Kutatási és Technológiai Hivatal
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- human cerebral cortex, layer 2/3 pyramidal cells, synaptic interactions, GABAergic interneurons, glutamatergic synapses, feedforward inhibition
- MeSH terms
- Action Potentials, Adolescent, Adult, Aged, Cerebral Cortex, gamma-Aminobutyric Acid, Humans, Middle Aged, Nerve Net, Synapses, Pyramidal Cells, Patch-Clamp Techniques, Glutamic Acid, Excitatory Postsynaptic Potentials
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