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Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning
Open accessAbstract
The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a “synaptic tagging” model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.
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Cites
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Metadata
- Authors
- Matsuo, N., Reijmers, L., & Mayford, M.
- Venue
- Science
- Published
- 2008-02-22
- Volume
- 319
- Issue
- 5866
- Pages
- 1104-1107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036855091
- Cited by
- 297
- References
- 7
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
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