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Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
Open accessAbstract
Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans , which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.
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Metadata
- Authors
- Wang, M. C., O'Rourke, E. J., & Ruvkun, G.
- Venue
- Science
- Published
- 2008-11-07
- Volume
- 322
- Issue
- 5903
- Pages
- 957-960
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2032306298
- Cited by
- 400
- References
- 2
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- green
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