Microglia: A Central Player in Depression
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Summary: Microglia are the major immune cells in the central nervous system and play a key role in the normal function of the brain. Microglia exhibit functional diversity, and they control the inflammation in central nervous system through releasing inflammatory cytokine, clearing apoptotic cells via phagocytosis, regulating synaptic plasticity and the formation of neural network by synapse pruning. Recent studies have strongly indicated that the microglial dysfunction is associated with a variety of neuropsychiatric diseases such as depression, which have been termed as “microgliopathy”. The emergency of advanced technologies and tools has enabled us to comprehensively understand the role of microglia in physiology and pathology, and growing studies have targetted microglia to explore the treatment of neuropsychiatric diseases. Here, we describe the key progress of microglia research, and review the recent developments in the understanding of the role of microglia in physiology and etiology of depression.
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The occurrence and development of depression may be associated with neuroglial cells.
“Therefore, the occurrence and development of depression may be associated with neuroglial cells.269”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [269]
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- Authors
- Deng, S.-L., Chen, J.-G., & Wang, F.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Wang, Fang
- Venue
- Current Medical Science
- Published
- 2020-06
- Volume
- 40
- Issue
- 3
- Pages
- 391-400
- ISSN
- 2096-5230 (ISSN-L)
- 2523-899X
- OpenAlex
- W3042758594
- Cited by
- 119
- References
- 127
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 18 · 2023: 24 · 2022: 25 · 2021: 20 · 2020: 2
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Medical Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81721005)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- microglia, depression, neuroinflammation, inflammatory cytokines, phagocytosis, synaptic pruning, synaptic plasticity, neuropsychiatric disorders, microglial dysfunction, etiology of depression, depression treatment
- MeSH terms
- Animals, Brain, Depression, Humans, Inflammation, Neuronal Plasticity, Microglia
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